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Kun-Che Chang, Ph.D. - Publications

Affiliations: 
2012-2016 Ophthalmology University of Colorado at HSC 
 2016-2020 Ophthalmology Stanford University, Palo Alto, CA 
 2021- Ophthalmology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Stem cell, RGC development, Axon regeneration
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Rao M, Liu CC, Wang S, Chang KC. Generating ESC-Derived RGCs for Cell Replacement Therapy. Methods in Molecular Biology (Clifton, N.J.). 2848: 187-196. PMID 39240524 DOI: 10.1007/978-1-0716-4087-6_12  0.368
2024 Wang S, Chen CY, Liu CC, Stavropoulos D, Rao M, Petrash JM, Chang KC. GDF-15 Attenuates the Epithelium-Mesenchymal Transition and Alleviates TGFβ2-Induced Lens Opacity. Translational Vision Science & Technology. 13: 2. PMID 38949633 DOI: 10.1167/tvst.13.7.2  0.522
2024 Luo Z, Shah S, Tanasa B, Chang KC, Goldberg JL. Gene regulatory roles of growth and differentiation factors in retinal development. Iscience. 27: 110100. PMID 38947520 DOI: 10.1016/j.isci.2024.110100  0.737
2023 Cameron EG, Nahmou M, Toth AB, Heo L, Tanasa B, Dalal R, Yan W, Nallagatla P, Xia X, Hay S, Knasel C, Stiles TL, Douglas C, Atkins M, Sun C, ... ... Chang KC, et al. A molecular switch for neuroprotective astrocyte reactivity. Nature. PMID 38086421 DOI: 10.1038/s41586-023-06935-3  0.744
2023 Irshad K, Huang YK, Rodriguez P, Lo J, Aghoghovwia BE, Pan Y, Chang KC. The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma. Brain Sciences. 13. PMID 37891793 DOI: 10.3390/brainsci13101424  0.342
2023 Luo Z, Chang KC. Cell replacement with stem cell-derived retinal ganglion cells from different protocols. Neural Regeneration Research. 19: 807-810. PMID 37843215 DOI: 10.4103/1673-5374.381494  0.398
2023 Lo J, Mehta K, Dhillon A, Huang YK, Luo Z, Nam MH, Al Diri I, Chang KC. Therapeutic strategies for glaucoma and optic neuropathies. Molecular Aspects of Medicine. 94: 101219. PMID 37839232 DOI: 10.1016/j.mam.2023.101219  0.391
2023 Ning K, Bhuckory MB, Lo CH, Sendayen BE, Kowal TJ, Chen M, Bansal R, Chang KC, Vollrath D, Berbari NF, Mahajan VB, Hu Y, Sun Y. Cilia-associated wound repair mediated by IFT88 in retinal pigment epithelium. Scientific Reports. 13: 8205. PMID 37211572 DOI: 10.1038/s41598-023-35099-3  0.329
2023 Rao M, Huang YK, Liu CC, Meadows C, Cheng HC, Zhou M, Chen YC, Xia X, Goldberg JL, Williams AM, Kuwajima T, Chang KC. Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation. Scientific Reports. 13: 5592. PMID 37019993 DOI: 10.1038/s41598-023-32702-5  0.726
2022 Luo Z, Chang KC, Wu S, Sun C, Xia X, Nahmou M, Bian M, Wen RR, Zhu Y, Shah S, Tanasa B, Wernig M, Goldberg JL. Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo. Stem Cell Reports. PMID 36368332 DOI: 10.1016/j.stemcr.2022.10.011  0.785
2022 Noro T, Shah SH, Yin Y, Kawaguchi R, Yokota S, Chang KC, Madaan A, Sun C, Coppola G, Geschwind D, Benowitz LI, Goldberg JL. Elk-1 regulates retinal ganglion cell axon regeneration after injury. Scientific Reports. 12: 17446. PMID 36261683 DOI: 10.1038/s41598-022-21767-3  0.744
2022 Chang KC. Influence of Sox protein SUMOylation on neural development and regeneration. Neural Regeneration Research. 17: 477-481. PMID 34380874 DOI: 10.4103/1673-5374.320968  0.316
2021 Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, et al. NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature. PMID 34040258 DOI: 10.1038/s41586-021-03580-6  0.652
2021 Chang KC, Bian M, Xia X, Madaan A, Sun C, Wang Q, Li L, Nahmou M, Noro T, Yokota S, Galvao J, Kreymerman A, Tanasa B, Hu Y, Goldberg JL. Post-translational modification of Sox11 regulates RGC survival and axon regeneration. Eneuro. PMID 33441400 DOI: 10.1523/ENEURO.0358-20.2020  0.778
2020 Xia X, Yu CY, Bian M, Sun CB, Tanasa B, Chang KC, Bruffett DM, Thakur H, Shah SH, Knasel C, Cameron EG, Kapiloff MS, Goldberg JL. MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury. Plos One. 15: e0242884. PMID 33315889 DOI: 10.1371/journal.pone.0242884  0.801
2020 Wang Q, Zhuang PS, Huang H, Li L, Liu L, Webber HC, Dalal R, Siew L, Fligor CM, Chang KC, Nahmou M, Kreymerman A, Sun Y, Meyer JS, Goldberg JL, et al. Mouse gamma-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32300046 DOI: 10.1523/Jneurosci.0102-20.2020  0.791
2019 Zhang X, Tenerelli K, Wu S, Xia X, Yokota S, Sun C, Galvao J, Venugopalan P, Li C, Madaan A, Goldberg JL, Chang KC. Cell transplantation of retinal ganglion cells derived from hESCs. Restorative Neurology and Neuroscience. PMID 31815704 DOI: 10.3233/Rnn-190941  0.776
2019 Kreymerman A, Buickians DN, Nahmou MM, Tran T, Galvao J, Wang Y, Sun N, Bazik L, Huynh SK, Cho IJ, Boczek T, Chang KC, Kunzevitzky NJ, Goldberg JL. MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses. Scientific Reports. 9: 10669. PMID 31337818 DOI: 10.1038/S41598-019-46956-5  0.714
2019 Xia X, Atkins M, Dalal R, Kuzmenko O, Chang KC, Sun CB, Benatti CA, Rak DJ, Nahmou M, Kunzevitzky NJ, Goldberg JL. Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy. Investigative Ophthalmology & Visual Science. 60: 2438-2448. PMID 31158276 DOI: 10.1167/Iovs.18-26001  0.742
2019 Chang KC, Sun C, Cameron EG, Madaan A, Wu S, Xia X, Zhang X, Tenerelli K, Nahmou M, Knasel CM, Russano KR, Hertz J, Goldberg JL. Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification. Current Biology : Cb. PMID 31155355 DOI: 10.1016/J.Cub.2019.05.011  0.799
2019 Chang KC, Shieh B, Petrash JM. Role of aldose reductase in diabetes-induced retinal microglia activation. Chemico-Biological Interactions. PMID 30682331 DOI: 10.1016/J.Cbi.2019.01.020  0.613
2018 Chang KC, Petrash JM. Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease. Advances in Experimental Medicine and Biology. 1032: 173-202. PMID 30362099 DOI: 10.1007/978-3-319-98788-0_13  0.587
2018 Wu S, Chang KC, Nahmou M, Goldberg JL. Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant. Investigative Ophthalmology & Visual Science. 59: 1571-1576. PMID 29625481 DOI: 10.1167/Iovs.17-23648  0.635
2018 Wu S, Chang KC, Goldberg JL. Retinal Cell Fate Specification. Trends in Neurosciences. 41: 165-167. PMID 29602333 DOI: 10.1016/J.Tins.2018.02.002  0.594
2017 Chang KC, Hertz J. SoxC transcription factors in retinal development and regeneration. Neural Regeneration Research. 12: 1048-1051. PMID 28852381 DOI: 10.4103/1673-5374.211178  0.67
2017 Chang KC, Hertz J, Zhang X, Jin XL, Shaw P, Derosa BA, Li JY, Venugopalan P, Valenzuela DA, Patel RD, Russano KR, Alshamekh SA, Sun C, Tenerelli K, Li C, et al. Novel regulatory mechanisms for the SoxC transcriptional network required for visual pathway development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28411269 DOI: 10.1523/Jneurosci.3430-13.2017  0.78
2017 Chang KC, Shieh B, Petrash JM. Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chemico-Biological Interactions. PMID 28137510 DOI: 10.1016/J.Cbi.2017.01.017  0.625
2016 Chang KC, Li L, Sanborn TM, Shieh B, Lenhart P, Ammar D, LaBarbera DV, Petrash JM. Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. Journal of Natural Products. PMID 27140653 DOI: 10.1021/Acs.Jnatprod.6B00185  0.572
2016 Chang KC, Shieh B, Petrash JM. Aldose Reductase Mediates Retinal Microglia Activation. Biochemical and Biophysical Research Communications. PMID 27033597 DOI: 10.1016/J.Bbrc.2016.03.122  0.613
2015 Chang KC, Petrash JM. Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. Investigative Ophthalmology & Visual Science. 56: 4198-210. PMID 26132779 DOI: 10.1167/iovs.15-16557  0.552
2015 Snow A, Shieh B, Chang KC, Pal A, Lenhart P, Ammar D, Ruzycki P, Palla S, Reddy GB, Petrash JM. Aldose reductase expression as a risk factor for cataract. Chemico-Biological Interactions. 234: 247-53. PMID 25541468 DOI: 10.1016/J.Cbi.2014.12.017  0.589
2015 Chang KC, Snow A, LaBarbera DV, Petrash JM. Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chemico-Biological Interactions. 234: 254-60. PMID 25451566 DOI: 10.1016/J.Cbi.2014.10.007  0.661
2014 Chang KC, Ponder J, Labarbera DV, Petrash JM. Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Investigative Ophthalmology & Visual Science. 55: 2853-61. PMID 24677107 DOI: 10.1167/Iovs.13-13487  0.652
2014 Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. Journal of Medicinal Chemistry. 57: 71-7. PMID 24341381 DOI: 10.1021/Jm401311D  0.567
2014 Chang KC, Snow A, LaBarbera DV, Petrash JM. Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells Chemico-Biological Interactions. DOI: 10.1016/j.cbi.2014.10.007  0.613
2013 Chang KC, Laffin B, Ponder J, Enzsöly A, Németh J, LaBarbera DV, Petrash JM. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chemico-Biological Interactions. 202: 283-7. PMID 23247009 DOI: 10.1016/J.Cbi.2012.12.001  0.582
2010 Chang KC, Lo CW, Fan TC, Chang MD, Shu CW, Chang CH, Chung CT, Fang SL, Chao CC, Tsai JJ, Lai YK. TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells. Bmc Cell Biology. 11: 6. PMID 20089176 DOI: 10.1186/1471-2121-11-6  0.321
2009 Lo CW, Chang YS, Chao CC, Chang MD, Chang KC, Lai YK. Control mechanisms of differential translation of Hsp90 isoforms in 9L rat gliosarcoma cells. Journal of Cellular Biochemistry. 107: 418-27. PMID 19308988 DOI: 10.1002/Jcb.22138  0.312
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