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Kevin G. Chen, M.D., Ph.D - Publications

Affiliations: 
2005- NINDS National Institutes of Health, Bethesda, MD 
Area:
Pluripotent stem cells, genome stability, differentiation
Website:
http://www.linkedin.com/pub/kevin-g-chen/37/364/702
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lin Y, Gil CH, Banno K, Yokoyama M, Wingo M, Go E, Prasain N, Liu Y, Hato T, Naito H, Wakabayashi T, Sominskaia M, Gao M, Chen K, Geng F, et al. ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels. Circulation. PMID 38682338 DOI: 10.1161/CIRCULATIONAHA.122.061833  0.319
2024 Chen KG, Park K, Maric D, Johnson KR, Robey PG, Mallon BS. Metabolic Quadrivalency in RSeT Human Embryonic Stem Cells. Biorxiv : the Preprint Server For Biology. PMID 38496581 DOI: 10.1101/2024.02.21.581486  0.745
2024 Chen KG, Johnson KR, Park K, Maric D, Yang F, Liu WF, Fann YC, Mallon BS, Robey PG. Resistance to Naïve and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells. Biorxiv : the Preprint Server For Biology. PMID 38410444 DOI: 10.1101/2024.02.16.580778  0.784
2021 Chen K, Ozturk K, Liefeld T, Reich M, Mesirov JP, Carter H, Fraley SI. A phenotypically supervised single-cell analysis protocol to study within-cell-type heterogeneity of cultured mammalian cells. Star Protocols. 2: 100561. PMID 34095869 DOI: 10.1016/j.xpro.2021.100561  0.318
2021 Johnson KR, Mallon BS, Fann YC, Chen KG. Multivariate meta-analysis reveals global transcriptomic signatures underlying distinct human naive-like pluripotent states. Plos One. 16: e0251461. PMID 33984026 DOI: 10.1371/journal.pone.0251461  0.71
2021 Chen K, Ozturk K, Contreras RL, Simon J, McCann S, Chen WJ, Carter H, Fraley SI. Phenotypically supervised single-cell sequencing parses within-cell-type heterogeneity. Iscience. 24: 101991. PMID 33490901 DOI: 10.1016/j.isci.2020.101991  0.311
2020 Chen KG, Duran GE, Mogul MJ, Wang YC, Ross KL, Jaffrézou JP, Huff LM, Johnson KR, Fojo T, Lacayo NJ, Sikic BI. Genomic stability at the coding regions of the multidrug transporter gene : insights into the development of alternative drug resistance mechanisms in human leukemia cells. Cancer Drug Resistance (Alhambra, Calif.). 3: 959-979. PMID 34541464 DOI: 10.20517/cdr.2020.51  0.756
2019 Chen KG, Zhong P, Zheng W, Beekman JM. Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids. Drug Discovery Today. PMID 31173911 DOI: 10.1016/J.Drudis.2019.05.029  0.331
2019 Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W. Induced pluripotent stem cells for neural drug discovery. Drug Discovery Today. PMID 30664937 DOI: 10.1016/J.Drudis.2019.01.007  0.409
2018 Tang C, Chen K, Bajic A, Choi WT, Baluya DL, Maletic-Savatic M. Analytical Platforms and Techniques to Study Stem Cell Metabolism. Methods in Molecular Biology (Clifton, N.J.). 1842: 265-281. PMID 30196417 DOI: 10.1007/978-1-4939-8697-2_20  0.306
2018 Chen KG, Mallon BS, Park K, Robey PG, McKay RDG, Gottesman MM, Zheng W. Pluripotent Stem Cell Platforms for Drug Discovery. Trends in Molecular Medicine. PMID 30006147 DOI: 10.1016/J.Molmed.2018.06.009  0.8
2017 Chen KG, Johnson KR, Robey PG. Mouse Genetic Analysis of Bone Marrow Stem Cell Niches: Technological Pitfalls, Challenges, and Translational Considerations. Stem Cell Reports. PMID 29056332 DOI: 10.1016/J.Stemcr.2017.09.014  0.616
2017 Chen KG, Johnson KR, McKay RDG, Robey PG. Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities. Stem Cells (Dayton, Ohio). PMID 28948674 DOI: 10.1002/Stem.2711  0.631
2015 Chen RJ, Zhang G, Garfield SH, Shi YJ, Chen KG, Robey PG, Leapman RD. Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. Plos One. 10: e0142554. PMID 26565809 DOI: 10.1371/Journal.Pone.0142554  0.721
2014 Padmanabhan R, Chen KG, Gottesman MM. Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells. Journal of Stem Cell Research & Therapy. 4. PMID 25405071 DOI: 10.4172/2157-7633.1000180  0.685
2014 Chen KG, Hamilton RS, Robey PG, Mallon BS. Alternative cultures for human pluripotent stem cell production, maintenance, and genetic analysis. Journal of Visualized Experiments : Jove. PMID 25077932 DOI: 10.3791/51519  0.786
2014 Phillips MD, Kuznetsov SA, Cherman N, Park K, Chen KG, McClendon BN, Hamilton RS, McKay RD, Chenoweth JG, Mallon BS, Robey PG. Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in vitro versus in vivo assays. Stem Cells Translational Medicine. 3: 867-78. PMID 24855277 DOI: 10.5966/Sctm.2013-0154  0.793
2014 Chen KG, Mallon BS, Johnson KR, Hamilton RS, McKay RD, Robey PG. Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation. Stem Cell Research. 12: 610-21. PMID 24603366 DOI: 10.1016/J.Scr.2014.02.002  0.808
2014 Chen KG, Mallon BS, McKay RD, Robey PG. Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell. 14: 13-26. PMID 24388173 DOI: 10.1016/J.Stem.2013.12.005  0.796
2013 Chen K, Hsu LT, Wu CY, Chang SY, Huang HT, Chen W. CBARA1 plays a role in stemness and proliferation of human embryonic stem cells. Plos One. 8: e63653. PMID 23667653 DOI: 10.1371/journal.pone.0063653  0.388
2013 Mallon BS, Chenoweth JG, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, McKay RD. StemCellDB: the human pluripotent stem cell database at the National Institutes of Health. Stem Cell Research. 10: 57-66. PMID 23117585 DOI: 10.1016/J.Scr.2012.09.002  0.812
2012 Chen KG, Mallon BS, Hamilton RS, Kozhich OA, Park K, Hoeppner DJ, Robey PG, McKay RD. Non-colony type monolayer culture of human embryonic stem cells. Stem Cell Research. 9: 237-48. PMID 22910561 DOI: 10.1016/J.Scr.2012.06.003  0.802
2012 Padmanabhan R, Chen KG, Gillet JP, Handley M, Mallon BS, Hamilton RS, Park K, Varma S, Mehaffey MG, Robey PG, McKay RD, Gottesman MM. Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. Stem Cells (Dayton, Ohio). 30: 2175-87. PMID 22887864 DOI: 10.1002/Stem.1195  0.774
2012 Chen KG, Sikic BI. Molecular pathways: regulation and therapeutic implications of multidrug resistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 1863-9. PMID 22344233 DOI: 10.1158/1078-0432.Ccr-11-1590  0.673
2011 Wang ZQ, Chen K, Ying QL, Li P, Shih JC. Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 997-1001. PMID 21607742 DOI: 10.1007/S00702-011-0655-0  0.351
2009 Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM. Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell & Melanoma Research. 22: 740-9. PMID 19725928 DOI: 10.1111/J.1755-148X.2009.00630.X  0.791
2009 Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, Gottesman MM. Influence of melanosome dynamics on melanoma drug sensitivity. Journal of the National Cancer Institute. 101: 1259-71. PMID 19704071 DOI: 10.1093/Jnci/Djp259  0.793
2007 Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature Biotechnology. 25: 803-16. PMID 17572666 DOI: 10.1038/Nbt1318  0.802
2007 Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Jenkins LM, Nagashima K, Appella E, Hearing VJ. Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. The Journal of Biological Chemistry. 282: 11266-80. PMID 17303571 DOI: 10.1074/Jbc.M608449200  0.691
2006 Rouzaud F, Costin GE, Yamaguchi Y, Valencia JC, Berens WF, Chen KG, Hoashi T, Böhm M, Abdel-Malek ZA, Hearing VJ. Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1927-9. PMID 16877522 DOI: 10.1096/Fj.06-5922Fje  0.689
2006 Chen KG, Valencia JC, Lai B, Zhang G, Paterson JK, Rouzaud F, Berens W, Wincovitch SM, Garfield SH, Leapman RD, Hearing VJ, Gottesman MM. Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proceedings of the National Academy of Sciences of the United States of America. 103: 9903-7. PMID 16777967 DOI: 10.1073/Pnas.0600213103  0.784
2006 Valencia JC, Watabe H, Chi A, Rouzaud F, Chen KG, Vieira WD, Takahashi K, Yamaguchi Y, Berens W, Nagashima K, Shabanowitz J, Hunt DF, Appella E, Hearing VJ. Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes. Journal of Cell Science. 119: 1080-91. PMID 16492709 DOI: 10.1242/Jcs.02804  0.705
2006 Mallon BS, Park KY, Chen KG, Hamilton RS, McKay RD. Toward xeno-free culture of human embryonic stem cells. The International Journal of Biochemistry & Cell Biology. 38: 1063-75. PMID 16469522 DOI: 10.1016/J.Biocel.2005.12.014  0.796
2006 Chen KG, Gottesman MM. How melanoma cells evade chemotherapy role of transporter-dependent and -independent resistance mechanisms From Melanocytes to Melanoma: the Progression to Malignancy. 591-603. DOI: 10.1007/978-1-59259-994-3_33  0.596
2005 Chen KG, Wang YC, Schaner ME, Francisco B, Durán GE, Juric D, Huff LM, Padilla-Nash H, Ried T, Fojo T, Sikic BI. Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line. Cancer Research. 65: 9388-97. PMID 16230402 DOI: 10.1158/0008-5472.Can-04-4133  0.765
2005 Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM. Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 18: 102-12. PMID 15760339 DOI: 10.1111/J.1600-0749.2005.00214.X  0.752
2005 Chen KG, Gottesman MM. Useful tool to generate unidirectional deletion vectors by utilizing the star activity of BamHI in an NcoI-BamHI-XhoI cassette. Biotechniques. 38: 198, 200, 202, 204. PMID 15727125 DOI: 10.2144/05382Bm05  0.546
2005 Liang XJ, Shen DW, Chen KG, Wincovitch SM, Garfield SH, Gottesman MM. Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum. Journal of Cellular Physiology. 202: 635-41. PMID 15546142 DOI: 10.1002/Jcp.20253  0.64
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