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Caren L Freel Meyers - Publications

Affiliations: 
Johns Hopkins University School of Medicine, Baltimore, MD, United States 
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Coco LB, Toci EM, Chen PY, Drennan CL, Freel Meyers CL. Potent Inhibition of DXP Synthase by a -Diaryl Bisubstrate Analog. Acs Infectious Diseases. PMID 38513073 DOI: 10.1021/acsinfecdis.3c00734  0.323
2022 Johnston ML, Bonett EM, DeColli AA, Freel Meyers CL. Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction. Biochemistry. PMID 35998648 DOI: 10.1021/acs.biochem.2c00274  0.373
2021 Johnston ML, Freel Meyers CL. Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism. Biochemistry. PMID 33660509 DOI: 10.1021/acs.biochem.1c00019  0.404
2019 Chen PY, DeColli AA, Freel Meyers CL, Drennan CL. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1‑deoxy‑d‑xylulose 5-phosphate synthase reaction coordinate. The Journal of Biological Chemistry. PMID 31239351 DOI: 10.2210/Pdb6Ouv/Pdb  0.348
2019 Bartee D, Sanders S, Phillips PD, Harrison MJ, Koppisch AT, Freel Meyers CL. Enamide Prodrugs of Acetyl Phosphonate DXP Synthase Inhibitors as Potent Antibacterial Agents. Acs Infectious Diseases. PMID 30614674 DOI: 10.1021/Acsinfecdis.8B00307  0.359
2018 Bartee D, Freel Meyers CL. Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism. Accounts of Chemical Research. PMID 30203647 DOI: 10.1021/acs.accounts.8b00321  0.409
2018 Bartee D, Wheadon MJ, Freel Meyers CL. Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogs of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens. The Journal of Organic Chemistry. PMID 29870251 DOI: 10.1021/acs.joc.8b00686  0.387
2017 Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schön A, Freire E, Freel Meyers CL, Prigge ST. A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species. Molecular Microbiology. PMID 28836704 DOI: 10.1111/Mmi.13776  0.338
2017 Sanders S, Vierling RJ, Bartee D, DeColli AA, Harrison MJ, Aklinski JL, Koppisch AT, Freel Meyers CL. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase. Acs Infectious Diseases. PMID 28636325 DOI: 10.1021/Acsinfecdis.6B00168  0.327
2014 Smith JM, Warrington NV, Vierling RJ, Kuhn ML, Anderson WF, Koppisch AT, Freel Meyers CL. Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate. The Journal of Antibiotics. 67: 77-83. PMID 24169798 DOI: 10.1038/Ja.2013.105  0.396
2013 Morris F, Vierling R, Boucher L, Bosch J, Freel Meyers CL. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem : a European Journal of Chemical Biology. 14: 1309-15. PMID 23824585 DOI: 10.1002/cbic.201300187  0.397
2010 Gómez García I, Stevenson CE, Usón I, Freel Meyers CL, Walsh CT, Lawson DM. The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily. Journal of Molecular Biology. 395: 390-407. PMID 19857499 DOI: 10.1016/J.Jmb.2009.10.045  0.505
2009 Nyland RL, Xiao Y, Liu P, Freel Meyers CL. IspG converts an epoxide substrate analogue to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis. Journal of the American Chemical Society. 131: 17734-5. PMID 19919056 DOI: 10.1021/ja907470n  0.497
2009 Majumdar A, Shah MH, Bitok JK, Hassis-LeBeau ME, Freel Meyers CL. Probing phosphorylation by non-mammalian isoprenoid biosynthetic enzymes using (1)H-(31)P-(31)P correlation NMR spectroscopy. Molecular Biosystems. 5: 935-44. PMID 19668858 DOI: 10.1039/b903513c  0.332
2008 Gómez García I, Freel Meyers CL, Walsh CT, Lawson DM. Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 1000-2. PMID 18997325 DOI: 10.1107/S1744309108030145  0.359
2007 Stevenson CE, Freel Meyers CL, Walsh CT, Lawson DM. Crystallization and preliminary X-ray analysis of the O-methyltransferase NovP from the novobiocin-biosynthetic cluster of Streptomyces spheroides. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 236-8. PMID 17329822 DOI: 10.1107/S1744309107008287  0.391
2006 Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chemical Communications (Cambridge, England). 1079-81. PMID 16514445 DOI: 10.1039/B515763C  0.362
2005 Pacholec M, Freel Meyers CL, Oberthür M, Kahne D, Walsh CT. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. Biochemistry. 44: 4949-56. PMID 15779922 DOI: 10.1021/Bi047303G  0.675
2004 Freel Meyers CL, Oberthür M, Heide L, Kahne D, Walsh CT. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry. 43: 15022-36. PMID 15554710 DOI: 10.1021/Bi048457Z  0.517
2004 Wu W, Freel Meyers CL, Borch RF. A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates. Organic Letters. 6: 2257-60. PMID 15200334 DOI: 10.1021/Ol049267J  0.647
2003 Walsh C, Freel Meyers CL, Losey HC. Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming. Journal of Medicinal Chemistry. 46: 3425-36. PMID 12877577 DOI: 10.1021/Jm030257I  0.645
2003 Jakimowicz P, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM. Crystallization and preliminary X-ray studies on the putative dTDP sugar epimerase NovW from the novobiocin biosynthetic cluster of Streptomyces spheroides. Acta Crystallographica. Section D, Biological Crystallography. 59: 1507-9. PMID 12876368 DOI: 10.1107/S0907444903012848  0.393
2003 Freel Meyers CL, Borch RF. Novel method for the immobilization of nucleotides. Organic Letters. 5: 341-4. PMID 12556187 DOI: 10.1021/Ol0273607  0.65
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