Paul D. Shepard, Ph.D. - Publications

Affiliations: 
Psychiatry University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Dopamine, Ion channels, habenula

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Brown PL, Palacorolla H, Brady D, Riegger K, Elmer GI, Shepard PD. Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 217-225. PMID 28053043 DOI: 10.1523/Jneurosci.1353-16.2016  0.555
2016 Brown PL, Palacorolla H, Brady D, Riegger K, Elmer GI, Shepard PD. Habenula-induced inhibition of midbrain dopamine neurons is diminished by lesions of the rostromedial tegmental nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27909103 DOI: 10.1523/JNEUROSCI.1353-16.2016  0.478
2016 Brown PL, Shepard PD. Functional evidence for a direct excitatory projection from the lateral habenula to the ventral tegmental area in the rat. Journal of Neurophysiology. jn.00305.2016. PMID 27358317 DOI: 10.1152/Jn.00305.2016  0.572
2015 Wang L, Lu H, Brown PL, Rea W, Vaupel B, Yang Y, Stein E, Shepard PD. Manganese-Enhanced MRI Reflects Both Activity-Independent and Activity-Dependent Uptake within the Rat Habenulomesencephalic Pathway. Plos One. 10: e0127773. PMID 26009889 DOI: 10.1371/Journal.Pone.0127773  0.456
2014 Yu N, Tucker KR, Levitan ES, Shepard PD, Canavier CC. Implications of cellular models of dopamine neurons for schizophrenia. Progress in Molecular Biology and Translational Science. 123: 53-82. PMID 24560140 DOI: 10.1016/B978-0-12-397897-4.00011-5  0.535
2012 Ji H, Tucker KR, Putzier I, Huertas MA, Horn JP, Canavier CC, Levitan ES, Shepard PD. Functional characterization of ether-à-go-go-related gene potassium channels in midbrain dopamine neurons - implications for a role in depolarization block. The European Journal of Neuroscience. 36: 2906-16. PMID 22780096 DOI: 10.1111/J.1460-9568.2012.08190.X  0.508
2012 Brown PL, Shepard PD, Elmer GI, Stockman S, McFarland R, Mayo CL, Cadet JL, Krasnova IN, Greenwald M, Schoonover C, Vogel MW. Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia-related endophenotypes. The European Journal of Neuroscience. 36: 2773-81. PMID 22762562 DOI: 10.1111/J.1460-9568.2012.08204.X  0.315
2012 Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EØ, Strøbæk D, Shepard PD, Christophersen P. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Frontiers in Pharmacology. 3: 11. PMID 22347859 DOI: 10.3389/Fphar.2012.00011  0.572
2011 Huertas MA, Ji H, Tucker K, Levitan E, Shepard PD, Canavier CC. The role of ERG current in pacemaking and bursting in dopamine neurons Bmc Neuroscience. 12. DOI: 10.1186/1471-2202-12-S1-P27  0.439
2010 Herrik KF, Christophersen P, Shepard PD. Pharmacological modulation of the gating properties of small conductance Ca2+-activated K+ channels alters the firing pattern of dopamine neurons in vivo. Journal of Neurophysiology. 104: 1726-35. PMID 20660424 DOI: 10.1152/Jn.01126.2009  0.528
2009 Ji H, Hougaard C, Herrik KF, Strøbaek D, Christophersen P, Shepard PD. Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels. The European Journal of Neuroscience. 29: 1883-95. PMID 19473240 DOI: 10.1111/J.1460-9568.2009.06735.X  0.478
2008 Hikosaka O, Sesack SR, Lecourtier L, Shepard PD. Habenula: crossroad between the basal ganglia and the limbic system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11825-9. PMID 19005047 DOI: 10.1523/Jneurosci.3463-08.2008  0.622
2008 Shepard PD, Trudeau MC. Emerging roles for ether-á-go-go-related gene potassium channels in the brain. The Journal of Physiology. 586: 4785-6. PMID 18854431 DOI: 10.1113/Jphysiol.2008.162669  0.366
2007 Shepard PD, Canavier CC, Levitan ES. Ether-a-go-go-related gene potassium channels: what's all the buzz about? Schizophrenia Bulletin. 33: 1263-9. PMID 17905786 DOI: 10.1093/Schbul/Sbm106  0.493
2007 Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD. Computational model predicts a role for ERG current in repolarizing plateau potentials in dopamine neurons: implications for modulation of neuronal activity. Journal of Neurophysiology. 98: 3006-22. PMID 17699694 DOI: 10.1152/Jn.00422.2007  0.434
2007 Ji H, Shepard PD. Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6923-30. PMID 17596440 DOI: 10.1523/Jneurosci.0958-07.2007  0.582
2006 Shepard PD, Holcomb HH, Gold JM. Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes. Schizophrenia Bulletin. 32: 417-21. PMID 16717257 DOI: 10.1093/Schbul/Sbj083  0.421
2006 Ji H, Shepard PD. SK Ca2+-activated K+ channel ligands alter the firing pattern of dopamine-containing neurons in vivo. Neuroscience. 140: 623-33. PMID 16564639 DOI: 10.1016/J.Neuroscience.2006.02.020  0.549
2004 Canavier CC, Perla SR, Shepard PD. Scaling of prediction error does not confirm chaotic dynamics underlying irregular firing using interspike intervals from midbrain dopamine neurons. Neuroscience. 129: 491-502. PMID 15501606 DOI: 10.1016/j.neuroscience.2004.08.003  0.36
2004 Sarpal D, Koenig JI, Adelman JP, Brady D, Prendeville LC, Shepard PD. Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells. Synapse (New York, N.Y.). 53: 104-13. PMID 15170822 DOI: 10.1002/Syn.20042  0.485
2004 Kiss C, Shepard PD, Bari F, Schwarcz R. Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. Brain Research. 1002: 129-35. PMID 14988042 DOI: 10.1016/J.Brainres.2004.01.004  0.394
2001 Lovejoy LP, Shepard PD, Canavier CC. Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic. Neuroscience. 104: 829-40. PMID 11440813 DOI: 10.1016/S0306-4522(01)00121-X  0.52
1999 Kitai ST, Shepard PD, Callaway JC, Scroggs R. Afferent modulation of dopamine neuron firing patterns. Current Opinion in Neurobiology. 9: 690-7. PMID 10607649 DOI: 10.1016/S0959-4388(99)00040-9  0.571
1999 Shepard PD, Connelly ST. Pertussis toxin lesions of the rat substantia nigra block the inhibitory effects of the gamma-hydroxybutyrate agent, S(-)HA-966 without affecting the basal firing properties of dopamine neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 650-61. PMID 10516961 DOI: 10.1016/S0893-133X(99)00063-9  0.486
1999 Ping HX, Shepard PD. Blockade of SK-type Ca2+-activated K+ channels uncovers a Ca2+-dependent slow afterdepolarization in nigral dopamine neurons. Journal of Neurophysiology. 81: 977-84. PMID 10085326 DOI: 10.1152/Jn.1999.81.3.977  0.438
1999 Shepard PD, Stump D. Nifedipine blocks apamin-induced bursting activity in nigral dopamine-containing neurons. Brain Research. 817: 104-9. PMID 9889338 DOI: 10.1016/S0006-8993(98)01231-1  0.535
1997 Connelly ST, Shepard PD. Competitive NMDA receptor antagonists differentially affect dopamine cell firing pattern. Synapse (New York, N.Y.). 25: 234-42. PMID 9068121 DOI: 10.1002/(Sici)1098-2396(199703)25:3<234::Aid-Syn2>3.0.Co;2-C  0.533
1997 Grobaski KC, Ping H, daSilva HM, Bowery NG, Connelly ST, Shepard PD. Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro. British Journal of Pharmacology. 120: 575-80. PMID 9051293 DOI: 10.1038/Sj.Bjp.0700938  0.452
1996 Ping HX, Shepard PD. Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons. Neuroreport. 7: 809-14. PMID 8733751  0.473
1995 Shepard PD, Connelly ST, Lehmann H, Grobaski KC. Effects of the enantiomers of (+/-)-HA-966 on dopamine neurons: an electrophysiological study of a chiral molecule. European Journal of Pharmacology. 285: 79-88. PMID 8846814 DOI: 10.1016/0014-2999(95)00390-7  0.564
1994 Shepard PD, Lehmann H, Connelly ST. Effects of NPC16377, a potent and selective sigma receptor ligand, on the activity of mesencephalic dopamine-containing neurons in the rat. European Journal of Pharmacology. 265: 141-9. PMID 7875229 DOI: 10.1016/0014-2999(94)90424-3  0.525
1994 Wu HQ, Schwarcz R, Shepard PD. Excitatory amino acid-induced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid. Synapse (New York, N.Y.). 16: 219-30. PMID 7515199 DOI: 10.1002/Syn.890160307  0.42
1992 McMillen BA, Williams HL, Lehmann H, Shepard PD. On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966. Journal of Neural Transmission. General Section. 89: 11-25. PMID 1329854 DOI: 10.1007/Bf01245348  0.442
1991 Shepard PD, Bunney BS. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca(2+)-activated K+ conductance. Experimental Brain Research. 86: 141-50. PMID 1756785 DOI: 10.1007/Bf00231048  0.683
1988 Shepard PD, German DC. Electrophysiological and pharmacological evidence for the existence of distinct subpopulations of nigrostriatal dopaminergic neuron in the rat. Neuroscience. 27: 537-46. PMID 3217003 DOI: 10.1016/0306-4522(88)90287-4  0.677
1988 Shepard PD, Bunney BS. Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro. Brain Research. 463: 380-4. PMID 3196925 DOI: 10.1016/0006-8993(88)90414-3  0.7
1988 Bean AJ, Shepard PD, Bunney BS, Nestler EJ, Roth RH. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology. 34: 715-8. PMID 2974120  0.612
1988 Shepard PD, Mihailoff GA, German DC. Anatomical and electrophysiological characterization of presumed dopamine-containing neurons within the supramammillary region of the rat. Brain Research Bulletin. 20: 307-14. PMID 2896530 DOI: 10.1016/0361-9230(88)90060-3  0.684
1984 Shepard PD, German DC. A subpopulation of mesocortical dopamine neurons possesses autoreceptors. European Journal of Pharmacology. 98: 455-6. PMID 6723785 DOI: 10.1016/0014-2999(84)90300-5  0.692
1984 Matthews RT, McMillen BA, Speciale SG, Jarrah H, Shore PA, Sanghera MK, Shepard PD, German DC. Effects of zoxazolamine and related centrally acting muscle relaxants on nigrostriatal dopaminergic neurons. Brain Research Bulletin. 12: 479-86. PMID 6467036 DOI: 10.1016/0361-9230(84)90163-1  0.637
1984 German DC, Shepard PD. SOME CORTICAL-PROJECTING DOPAMINERGIC NEURONS POSSESS AUTORECEPTORS Clinical Neuropharmacology. 7: S40. DOI: 10.1097/00002826-198406001-00039  0.605
1983 McMillen BA, Matthews RT, Sanghera MK, Shepard PD, German DC. Dopamine receptor antagonism by the novel antianxiety drug, buspirone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 3: 733-8. PMID 6131948 DOI: 10.1523/Jneurosci.03-04-00733.1983  0.591
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