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Tara Man Kadayat, PhD - Publications

Affiliations: 
2021- Pharmaceutical Sciences University of Kentucky, Lexington, KY 
Area:
Medicinal Chemistry
Website:
https://pharmacy.uky.edu/people/taraman-kadayat
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7/31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Carrillo AK, Kadayat TM, Hwang JY, Chen Y, Zhu F, Holbrook G, Gillingwater K, Connelly MC, Yang L, Kaiser M, Guy RK. Antitrypanosomal Chloronitrobenzamides. Journal of Medicinal Chemistry. PMID 38363074 DOI: 10.1021/acs.jmedchem.3c01680  0.493
2023 Kim HS, Ortiz D, Kadayat TM, Fargo CM, Hammill JT, Chen Y, Rice AL, Begley KL, Shoeran G, Pistel W, Yates PA, Sanchez MA, Landfear SM, Guy RK. Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides. Journal of Medicinal Chemistry. PMID 37216489 DOI: 10.1021/acs.jmedchem.3c00056  0.334
2021 Kunwar S, Hwang SY, Katila P, Park S, Jeon KH, Kim D, Kadayat TM, Kwon Y, Lee ES. Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison. European Journal of Medicinal Chemistry. 226: 113860. PMID 34597897 DOI: 10.1016/j.ejmech.2021.113860  0.318
2020 Kadayat TM, Shrestha A, Jeon YH, An H, Kim J, Cho SJ, Chin J. Targeting Peroxisome Proliferator-activated Receptor delta (PPARδ): A Medicinal Chemistry Perspective. Journal of Medicinal Chemistry. PMID 32539376 DOI: 10.1021/acs.jmedchem.9b01882  0.357
2018 Kim DS, Lee J, Londhe AM, Kadayat TM, Joo J, Hwang H, Kim KH, Pae AN, Chin J, Cho SJ, Kang H. Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist. Bioorganic & Medicinal Chemistry. PMID 30054191 DOI: 10.1016/j.bmc.2018.06.044  0.333
2018 Magar TBT, Seo SH, Kadayat TM, Jo H, Shrestha A, Bist G, Katila P, Kwon Y, Lee ES. Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents. Bioorganic & Medicinal Chemistry. PMID 29510948 DOI: 10.1016/j.bmc.2018.02.035  0.304
2015 Kadayat TM, Park C, Jun KY, Thapa Magar TB, Bist G, Yoo HY, Kwon Y, Lee ES. Hydroxylated 2,4-diphenyl indenopyridine derivatives as a selective non-intercalative topoisomerase IIα catalytic inhibitor. European Journal of Medicinal Chemistry. 90: 302-14. PMID 25437617 DOI: 10.1016/J.Ejmech.2014.11.046  0.315
Low-probability matches (unlikely to be authored by this person)
2017 Park S, Thapa Magar TB, Kadayat TM, Lee HJ, Bist G, Shrestha A, Lee ES, Kwon Y. Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor. European Journal of Medicinal Chemistry. 127: 318-333. PMID 28068603 DOI: 10.1016/j.ejmech.2017.01.003  0.288
2015 Kadayat TM, Song C, Kwon Y, Lee ES. Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study. Bioorganic Chemistry. 62: 30-40. PMID 26218799 DOI: 10.1016/j.bioorg.2015.07.002  0.285
2016 Karki R, Jun KY, Kadayat TM, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. European Journal of Medicinal Chemistry. 113: 228-245. PMID 26945111 DOI: 10.1016/J.Ejmech.2016.02.050  0.284
2014 Karki R, Park C, Jun KY, Jee JG, Lee JH, Thapa P, Kadayat TM, Kwon Y, Lee ES. Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors. European Journal of Medicinal Chemistry. 84: 555-65. PMID 25062006 DOI: 10.1016/J.Ejmech.2014.07.058  0.281
2021 Hwang SY, Shrestha A, Park S, Bist G, Kunwar S, Kadayat TM, Jang H, Seo M, Sheen N, Kim S, Jeon KH, Lee ES, Kwon Y. Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. European Journal of Medicinal Chemistry. 227: 113916. PMID 34678573 DOI: 10.1016/j.ejmech.2021.113916  0.281
2020 Kim J, Hwang H, Yoon H, Lee JE, Oh JM, An H, Ji HD, Lee S, Cha E, Ma MJ, Kim DS, Lee SJ, Kadayat TM, Song J, Lee SW, et al. An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer. European Journal of Medicinal Chemistry. 205: 112501. PMID 32758860 DOI: 10.1016/j.ejmech.2020.112501  0.275
2016 Thapa P, Kadayat TM, Park S, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents. Bioorganic Chemistry. 66: 145-159. PMID 27174797 DOI: 10.1016/J.Bioorg.2016.04.007  0.272
2019 Kadayat TM, Park S, Shrestha A, Jo H, Hwang SY, Katila P, Shrestha R, Nepal MR, Noh K, Kim SK, Koh WS, Kim KS, Jeon YH, Jeong TC, Kwon Y, et al. Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-]pyridinol Derivatives as Potent Topoisomerase IIα-targeted Chemotherapeutic Agents for Breast Cancer. Journal of Medicinal Chemistry. PMID 31398033 DOI: 10.1021/acs.jmedchem.9b00970  0.269
2015 Kadayat TM, Park C, Jun KY, Magar TB, Bist G, Yoo HY, Kwon Y, Lee ES. Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity. Bioorganic & Medicinal Chemistry. 23: 160-73. PMID 25481396 DOI: 10.1016/J.Bmc.2014.11.010  0.264
2016 Kadayat TM, Park S, Jun KY, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry Letters. PMID 26927425 DOI: 10.1016/J.Bmcl.2016.02.053  0.26
2015 Karki R, Park C, Jun KY, Kadayat TM, Lee ES, Kwon Y. Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison. European Journal of Medicinal Chemistry. 90: 360-78. PMID 25437622 DOI: 10.1016/J.Ejmech.2014.11.045  0.259
2017 Kadayat TM, Banskota S, Gurung P, Bist G, Thapa Magar TB, Shrestha A, Kim JA, Lee ES. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. European Journal of Medicinal Chemistry. 137: 575-597. PMID 28646757 DOI: 10.1016/j.ejmech.2017.06.018  0.256
2015 Kadayat TM, Song C, Shin S, Magar TB, Bist G, Shrestha A, Thapa P, Na Y, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry. 23: 3499-512. PMID 26022080 DOI: 10.1016/J.Bmc.2015.04.031  0.253
2015 Kwon HB, Park C, Jeon KH, Lee E, Park SE, Jun KY, Kadayat TM, Thapa P, Karki R, Na Y, Park MS, Rho SB, Lee ES, Kwon Y. A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases. Journal of Medicinal Chemistry. 58: 1100-22. PMID 25603122 DOI: 10.1021/Jm501023Q  0.252
2015 Karki R, Song C, Kadayat TM, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines. Bioorganic & Medicinal Chemistry. 23: 3638-54. PMID 25936262 DOI: 10.1016/j.bmc.2015.04.002  0.251
2012 Thapa P, Karki R, Yun M, Kadayat TM, Lee E, Kwon HB, Na Y, Cho WJ, Kim ND, Jeong BS, Kwon Y, Lee ES. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety. European Journal of Medicinal Chemistry. 52: 123-36. PMID 22503656 DOI: 10.1016/J.Ejmech.2012.03.010  0.238
2017 Thapa Magar TB, Kadayat TM, Lee HJ, Park S, Bist G, Shrestha A, Kwon Y, Lee ES. 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent. Bioorganic & Medicinal Chemistry Letters. PMID 28633898 DOI: 10.1016/j.bmcl.2017.06.025  0.238
2018 Kadayat TM, Banskota S, Bist G, Gurung P, Magar TBT, Shrestha A, Kim JA, Lee ES. Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease. Bioorganic & Medicinal Chemistry Letters. PMID 29910080 DOI: 10.1016/j.bmcl.2018.06.012  0.231
2015 Thapa P, Jun KY, Kadayat TM, Park C, Zheng Z, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents. Bioorganic & Medicinal Chemistry. PMID 26361737 DOI: 10.1016/J.Bmc.2015.08.018  0.226
2012 Karki R, Thapa P, Yoo HY, Kadayat TM, Park PH, Na Y, Lee E, Jeon KH, Cho WJ, Choi H, Kwon Y, Lee ES. Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. European Journal of Medicinal Chemistry. 49: 219-28. PMID 22318164 DOI: 10.1016/j.ejmech.2012.01.015  0.223
2016 Park S, Kadayat TM, Jun KY, Thapa Magar TB, Bist G, Shrestha A, Lee ES, Kwon Y. Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. European Journal of Medicinal Chemistry. 125: 14-28. PMID 27643560 DOI: 10.1016/J.Ejmech.2016.09.019  0.22
2018 Lee SJ, Samala M, Woo SY, Hahn D, Kim D, Kadayat TM, Jung K, Kim J, Kim DS, Kwon S, Kim S, Kim KH, Nam SJ, Cho SJ, Chin J. Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist. Acs Omega. 3: 1970-1976. PMID 30023820 DOI: 10.1021/acsomega.7b01689  0.217
2021 Shrestha A, Kim N, Lee SJ, Jeon YH, Song JJ, An H, Cho SJ, Kadayat TM, Chin J. Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives. Journal of Medicinal Chemistry. PMID 34488340 DOI: 10.1021/acs.jmedchem.1c01116  0.146
2018 Gurung P, Banskota S, Katila N, Gautam J, Kadayat TM, Choi DY, Lee ES, Jeong TC, Kim JA. Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling. European Journal of Pharmacology. PMID 29555502 DOI: 10.1016/j.ejphar.2018.03.027  0.07
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