| Year |
Citation |
Score |
| 2022 |
Zhang Y, Truong B, Fahl SP, Martinez E, Cai K, Dulaimi E, Gong Y, Liebermann DA, Soboloff J, Dunbrack R, Levine RL, Fletcher S, Kappes DJ, Sykes S, Shapiro P, et al. The ERK2 DBP domain opposes pathogenesis of a JAK2V617F-driven myeloproliferative neoplasm. Blood. PMID 35436326 DOI: 10.1182/blood.2021013068 |
0.398 |
|
| 2022 |
Martinez R, Huang W, Buck H, Rea S, Defnet AE, Kane MA, Shapiro P. Proteomic Changes in the Monolayer and Spheroid Melanoma Cell Models of Acquired Resistance to BRAF and MEK1/2 Inhibitors. Acs Omega. 7: 3293-3311. PMID 35128241 DOI: 10.1021/acsomega.1c05361 |
0.409 |
|
| 2020 |
Martinez R, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P. Mechanistic analysis of an ERK2-interacting compound that inhibits mutant-BRAF expressing melanoma cells by inducing oxidative stress. The Journal of Pharmacology and Experimental Therapeutics. PMID 33109619 DOI: 10.1124/jpet.120.000266 |
0.516 |
|
| 2019 |
Defnet AE, Huang W, Polischak S, Yadav SK, Kane MA, Shapiro P, Deshpande DA. Effects of ATP-competitive and function-selective ERK inhibitors on airway smooth muscle cell proliferation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900680R. PMID 31266368 DOI: 10.1096/Fj.201900680R |
0.331 |
|
| 2019 |
Deredge D, Wintrode PL, Tulapurkar ME, Nagarsekar A, Zhang Y, Weber DJ, Shapiro P, Hasday JD. A temperature-dependent conformational shift in p38α MAP kinase substrate binding region associated with changes in substrate phosphorylation profile. The Journal of Biological Chemistry. PMID 31213525 DOI: 10.1074/Jbc.Ra119.007525 |
0.329 |
|
| 2019 |
Shapiro P. A promiscuous kinase inhibitor reveals secrets to cancer cell survival. The Journal of Biological Chemistry. 294: 8674-8675. PMID 31127063 DOI: 10.1074/jbc.H119.009103 |
0.477 |
|
| 2018 |
Shapiro P. Chk-mate on resistance to kinase inhibitors. Oncotarget. 9: 31560-31561. PMID 30167074 DOI: 10.18632/oncotarget.25802 |
0.384 |
|
| 2017 |
Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, et al. Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (ulixertinib). Molecular Cancer Therapeutics. PMID 28939558 DOI: 10.1158/1535-7163.Mct-17-0456 |
0.379 |
|
| 2017 |
Li Z, Li D, Choi EY, Lapidus R, Zhang L, Huang SM, Shapiro P, Wang H. Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells. The Journal of Biological Chemistry. PMID 28655760 DOI: 10.1074/jbc.M117.783860 |
0.379 |
|
| 2017 |
Shah NG, Tulapurkar ME, Ramarathnam A, Brophy A, Martinez R, Hom K, Hodges T, Samadani R, Singh IS, MacKerell AD, Shapiro P, Hasday JD. Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity. Journal of Immunology (Baltimore, Md. : 1950). PMID 28298524 DOI: 10.4049/jimmunol.1602059 |
0.316 |
|
| 2015 |
Samadani R, Zhang J, Brophy A, Oashi T, Priyakumar UD, Raman EP, St John FJ, Jung KY, Fletcher S, Pozharski E, MacKerell AD, Shapiro P. Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf. The Biochemical Journal. 467: 425-38. PMID 25695333 DOI: 10.1042/Bj20131571 |
0.51 |
|
| 2014 |
Hartman KG, Vitolo MI, Pierce AD, Fox JM, Shapiro P, Martin SS, Wilder PT, Weber DJ. Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK. The Journal of Biological Chemistry. 289: 12886-95. PMID 24627490 DOI: 10.1074/Jbc.M114.561613 |
0.547 |
|
| 2014 |
Yang H, Garzel B, Heyward S, Moeller T, Shapiro P, Wang H. Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling. Molecular Pharmacology. 85: 249-60. PMID 24252946 DOI: 10.1124/mol.113.089763 |
0.407 |
|
| 2013 |
Jung KY, Samadani R, Chauhan J, Nevels K, Yap JL, Zhang J, Worlikar S, Lanning ME, Chen L, Ensey M, Shukla S, Salmo R, Heinzl G, Gordon C, Dukes T, ... ... Shapiro P, et al. Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling. Organic & Biomolecular Chemistry. 11: 3706-32. PMID 23624850 DOI: 10.1039/c3ob40199e |
0.401 |
|
| 2012 |
Zhang J, Shapiro P, Pozharski E. Structure of extracellular signal-regulated kinase 2 in complex with ATP and ADP. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1434-9. PMID 23192020 DOI: 10.1107/S1744309112042972 |
0.487 |
|
| 2011 |
Barr D, Oashi T, Burkhard K, Lucius S, Samadani R, Zhang J, Shapiro P, MacKerell AD, van der Vaart A. Importance of domain closure for the autoactivation of ERK2. Biochemistry. 50: 8038-48. PMID 21842857 DOI: 10.1021/Bi200503A |
0.434 |
|
| 2011 |
Dai B, Zhao XF, Mazan-Mamczarz K, Hagner P, Corl S, Bahassi el M, Lu S, Stambrook PJ, Shapiro P, Gartenhaus RB. Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma. Nature Communications. 2: 402. PMID 21772273 DOI: 10.1038/Ncomms1404 |
0.474 |
|
| 2011 |
Boston SR, Deshmukh R, Strome S, Priyakumar UD, MacKerell AD, Shapiro P. Characterization of ERK docking domain inhibitors that induce apoptosis by targeting Rsk-1 and caspase-9. Bmc Cancer. 11: 7. PMID 21219631 DOI: 10.1186/1471-2407-11-7 |
0.51 |
|
| 2011 |
Yap JL, Worlikar S, MacKerell AD, Shapiro P, Fletcher S. Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics. Chemmedchem. 6: 38-48. PMID 21110380 DOI: 10.1002/Cmdc.201000354 |
0.534 |
|
| 2011 |
Burkhard KA, Chen F, Shapiro P. Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity. The Journal of Biological Chemistry. 286: 2477-85. PMID 21098038 DOI: 10.1074/jbc.M110.177899 |
0.326 |
|
| 2010 |
Burkhard K, Shapiro P. Use of inhibitors in the study of MAP kinases. Methods in Molecular Biology (Clifton, N.J.). 661: 107-22. PMID 20811979 DOI: 10.1007/978-1-60761-795-2_6 |
0.532 |
|
| 2010 |
Porasuphatana S, Cao GL, Tsai P, Tavakkoli F, Huwar T, Baillie L, Cross AS, Shapiro P, Rosen GM. Bacillus anthracis endospores regulate ornithine decarboxylase and inducible nitric oxide synthase through ERK1/2 and p38 mitogen-activated protein kinases. Current Microbiology. 61: 567-73. PMID 20440620 DOI: 10.1007/s00284-010-9654-x |
0.313 |
|
| 2009 |
Dai B, Zhao XF, Hagner P, Shapiro P, Mazan-Mamczarz K, Zhao S, Natkunam Y, Gartenhaus RB. Extracellular signal-regulated kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell lymphoma. Cancer Research. 69: 7835-43. PMID 19789340 DOI: 10.1158/0008-5472.Can-09-1606 |
0.559 |
|
| 2009 |
Burkhard K, Smith S, Deshmukh R, MacKerell AD, Shapiro P. Development of extracellular signal-regulated kinase inhibitors. Current Topics in Medicinal Chemistry. 9: 678-89. PMID 19689374 DOI: 10.2174/156802609789044416 |
0.414 |
|
| 2008 |
Chen F, Mackerell AD, Luo Y, Shapiro P. Using Caenorhabditis elegans as a model organism for evaluating extracellular signal-regulated kinase docking domain inhibitors. Journal of Cell Communication and Signaling. 2: 81-92. PMID 19105050 DOI: 10.1007/s12079-008-0034-2 |
0.346 |
|
| 2008 |
Sallmyr A, Fan J, Datta K, Kim KT, Grosu D, Shapiro P, Small D, Rassool F. Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. Blood. 111: 3173-82. PMID 18192505 DOI: 10.1182/Blood-2007-05-092510 |
0.335 |
|
| 2006 |
Chen F, Hancock CN, Macias AT, Joh J, Still K, Zhong S, MacKerell AD, Shapiro P. Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. Bioorganic & Medicinal Chemistry Letters. 16: 6281-7. PMID 17000106 DOI: 10.1016/J.Bmcl.2006.09.038 |
0.49 |
|
| 2006 |
Shapiro P. Discovering new MAP kinase inhibitors. Chemistry & Biology. 13: 807-9. PMID 16931329 DOI: 10.1016/j.chembiol.2006.08.001 |
0.394 |
|
| 2006 |
Eves EM, Shapiro P, Naik K, Klein UR, Trakul N, Rosner MR. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Molecular Cell. 23: 561-74. PMID 16916643 DOI: 10.1016/J.Molcel.2006.07.015 |
0.62 |
|
| 2006 |
Hancock CN, Macias AT, Mackerell AD, Shapiro P. Mitogen activated protein (MAP) kinases: development of ATP and non-ATP dependent inhibitors. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 2: 213-22. PMID 16787369 DOI: 10.2174/157340606776056151 |
0.508 |
|
| 2006 |
Raines KW, Cao GL, Lee EK, Rosen GM, Shapiro P. Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity. The Biochemical Journal. 397: 329-36. PMID 16569214 DOI: 10.1042/BJ20052002 |
0.341 |
|
| 2006 |
Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. The Journal of Biological Chemistry. 281: 7118-28. PMID 16407259 DOI: 10.1074/Jbc.M508162200 |
0.506 |
|
| 2006 |
Cha H, Dangi S, Machamer CE, Shapiro P. Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells. Cellular Signalling. 18: 93-104. PMID 15923109 DOI: 10.1016/j.cellsig.2005.03.028 |
0.668 |
|
| 2005 |
Pandey PK, Udayakumar TS, Lin X, Sharma D, Shapiro PS, Fondell JD. Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Molecular and Cellular Biology. 25: 10695-710. PMID 16314496 DOI: 10.1128/Mcb.25.24.10695-10710.2005 |
0.576 |
|
| 2005 |
Hancock CN, Macias A, Lee EK, Yu SY, Mackerell AD, Shapiro P. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. Journal of Medicinal Chemistry. 48: 4586-95. PMID 15999996 DOI: 10.1021/jm0501174 |
0.551 |
|
| 2005 |
Dangi S, Shapiro P. Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis. The Journal of Biological Chemistry. 280: 24524-31. PMID 15888452 DOI: 10.1074/jbc.M414079200 |
0.467 |
|
| 2005 |
Roy SK, Shuman JD, Platanias LC, Shapiro PS, Reddy SP, Johnson PF, Kalvakolanu DV. A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-{beta}-dependent gene expression in response to interferon-{gamma}. The Journal of Biological Chemistry. 280: 24462-71. PMID 15878863 DOI: 10.1074/Jbc.M413661200 |
0.375 |
|
| 2005 |
Hancock CN, Dangi S, Shapiro P. Protein phosphatase 2A activity associated with Golgi membranes during the G2/M phase may regulate phosphorylation of ERK2. The Journal of Biological Chemistry. 280: 11590-8. PMID 15654082 DOI: 10.1074/jbc.M408273200 |
0.443 |
|
| 2004 |
Qiao M, Shapiro P, Kumar R, Passaniti A. Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway. The Journal of Biological Chemistry. 279: 42709-18. PMID 15304489 DOI: 10.1074/Jbc.M404480200 |
0.433 |
|
| 2004 |
Cha H, Smith BL, Gallo K, Machamer CE, Shapiro P. Phosphorylation of golgin-160 by mixed lineage kinase 3. Journal of Cell Science. 117: 751-60. PMID 14734651 DOI: 10.1242/Jcs.00897 |
0.606 |
|
| 2004 |
Cha H, Hancock C, Dangi S, Maiguel D, Carrier F, Shapiro P. Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies. The Biochemical Journal. 378: 857-65. PMID 14670079 DOI: 10.1042/BJ20031173 |
0.63 |
|
| 2004 |
Dangi S, Cha H, Shapiro P. Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis. Cellular Signalling. 15: 667-75. PMID 12742227 DOI: 10.1016/s0898-6568(03)00002-0 |
0.604 |
|
| 2003 |
Lee EK, Regenold WT, Shapiro P. Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-Cancer Drugs. 13: 859-68. PMID 12394272 DOI: 10.1097/00001813-200209000-00012 |
0.413 |
|
| 2003 |
Shapiro P. Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy. Critical Reviews in Clinical Laboratory Sciences. 39: 285-330. PMID 12385501 DOI: 10.1080/10408360290795538 |
0.52 |
|
| 2002 |
Roberts EC, Shapiro PS, Nahreini TS, Pages G, Pouyssegur J, Ahn NG. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Molecular and Cellular Biology. 22: 7226-41. PMID 12242299 DOI: 10.1128/Mcb.22.20.7226-7241.2002 |
0.675 |
|
| 2002 |
Reddy SP, Adiseshaiah P, Shapiro P, Vuong H. BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells. American Journal of Respiratory Cell and Molecular Biology. 27: 64-70. PMID 12091247 DOI: 10.1165/ajrcmb.27.1.20020003oc |
0.552 |
|
| 2002 |
Roy SK, Hu J, Meng Q, Xia Y, Shapiro PS, Reddy SP, Platanias LC, Lindner DJ, Johnson PF, Pritchard C, Pagés G, Pouyssegur J, Kalvakolanu DV. MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America. 99: 7945-50. PMID 12048245 DOI: 10.1073/Pnas.122075799 |
0.381 |
|
| 2002 |
Vuong H, Patterson T, Adiseshaiah P, Shapiro P, Kalvakolanu DV, Reddy SP. JNK1 and AP-1 regulate PMA-inducible squamous differentiation marker expression in Clara-like H441 cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L215-25. PMID 11792626 DOI: 10.1152/ajplung.00125.2001 |
0.376 |
|
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