| Year |
Citation |
Score |
| 2017 |
Burke RT, Marcus JM, Orth JD. Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells. Oncotarget. PMID 28467801 DOI: 10.18632/oncotarget.17063 |
0.304 |
|
| 2016 |
Burke RT, Orth JD. Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics. Journal of Visualized Experiments : Jove. PMID 27213923 DOI: 10.3791/53994 |
0.357 |
|
| 2015 |
Marcus JM, Burke RT, DeSisto JA, Landesman Y, Orth JD. Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor. Scientific Reports. 5: 14391. PMID 26399741 DOI: 10.1038/srep14391 |
0.371 |
|
| 2015 |
Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ. In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nature Methods. 12: 577-85. PMID 25867850 DOI: 10.1038/Nmeth.3363 |
0.514 |
|
| 2014 |
Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Science Translational Medicine. 6: 261ra152. PMID 25378644 DOI: 10.1126/Scitranslmed.3009318 |
0.462 |
|
| 2012 |
Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Molecular Biology of the Cell. 23: 567-76. PMID 22171325 DOI: 10.1091/Mbc.E11-09-0781 |
0.472 |
|
| 2011 |
Tang Y, Orth JD, Xie T, Mitchison TJ. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Letters. 310: 15-24. PMID 21782324 DOI: 10.1016/J.Canlet.2011.05.024 |
0.549 |
|
| 2011 |
Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Research. 71: 4608-16. PMID 21712408 DOI: 10.1158/0008-5472.Can-11-0412 |
0.502 |
|
| 2010 |
Huang HC, Shi J, Orth JD, Mitchison TJ. Cell death when the SAC is out of commission. Cell Cycle (Georgetown, Tex.). 9: 2049-50. PMID 20559025 DOI: 10.4161/Cc.9.11.11918 |
0.602 |
|
| 2009 |
Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. Plos One. 4: e7339. PMID 19802393 DOI: 10.1371/Journal.Pone.0007339 |
0.489 |
|
| 2009 |
Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 16: 347-58. PMID 19800579 DOI: 10.1016/J.Ccr.2009.08.020 |
0.625 |
|
| 2008 |
Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Molecular Cancer Therapeutics. 7: 3480-9. PMID 18974392 DOI: 10.1158/1535-7163.Mct-08-0684 |
0.554 |
|
| 2008 |
Shi J, Orth JD, Mitchison T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5 Cancer Research. 68: 3269-3276. PMID 18451153 DOI: 10.1158/0008-5472.Can-07-6699 |
0.532 |
|
| 2006 |
Orth JD, McNiven MA. Get off my back! Rapid receptor internalization through circular dorsal ruffles. Cancer Research. 66: 11094-6. PMID 17145849 DOI: 10.1158/0008-5472.CAN-06-3397 |
0.549 |
|
| 2006 |
Orth JD, Krueger EW, Weller SG, McNiven MA. A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Research. 66: 3603-10. PMID 16585185 DOI: 10.1158/0008-5472.CAN-05-2916 |
0.487 |
|
| 2005 |
Cao H, Weller S, Orth JD, Chen J, Huang B, Chen JL, Stamnes M, McNiven MA. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nature Cell Biology. 7: 483-92. PMID 15821732 DOI: 10.1038/ncb1246 |
0.539 |
|
| 2005 |
Yao Q, Chen J, Cao H, Orth JD, McCaffery JM, Stan RV, McNiven MA. Caveolin-1 interacts directly with dynamin-2. Journal of Molecular Biology. 348: 491-501. PMID 15811383 DOI: 10.1016/j.jmb.2005.02.003 |
0.501 |
|
| 2004 |
Buccione R, Orth JD, McNiven MA. Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nature Reviews. Molecular Cell Biology. 5: 647-57. PMID 15366708 DOI: 10.1038/Nrm1436 |
0.54 |
|
| 2004 |
Chen XM, Huang BQ, Splinter PL, Orth JD, Billadeau DD, McNiven MA, LaRusso NF. Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum. Infection and Immunity. 72: 3011-21. PMID 15102814 DOI: 10.1128/Iai.72.5.3011-3021.2004 |
0.54 |
|
| 2003 |
Krueger EW, Orth JD, Cao H, McNiven MA. A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Molecular Biology of the Cell. 14: 1085-96. PMID 12631725 DOI: 10.1091/mbc.E02-08-0466 |
0.538 |
|
| 2003 |
Cao H, Orth JD, Chen J, Weller SG, Heuser JE, McNiven MA. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Molecular and Cellular Biology. 23: 2162-70. PMID 12612086 DOI: 10.1128/MCB.23.6.2162-2170.2003 |
0.552 |
|
| 2003 |
Orth JD, McNiven MA. Dynamin at the actin-membrane interface. Current Opinion in Cell Biology. 15: 31-9. PMID 12517701 DOI: 10.1016/S0955-0674(02)00010-8 |
0.535 |
|
| 2002 |
Orth JD, Krueger EW, Cao H, McNiven MA. The large GTPase dynamin regulates actin comet formation and movement in living cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 167-72. PMID 11782546 DOI: 10.1073/pnas.012607899 |
0.574 |
|
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