Gideon Dreyfuss
Affiliations: | Biochemistry and Biophysics | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Spinal Muscular Atrophy, RNA binding proteins, Splicing, High-Throughput ScreeningWebsite:
http://www.med.upenn.edu/biocbiop/faculty/dreyfuss/Google:
"Gideon Dreyfuss"Bio:
http://www.nasonline.org/member-directory/members/20027261.html
http://www.med.upenn.edu/apps/faculty/index.php/p17458
http://www.med.upenn.edu/dreyfusslab/
http://www.hhmi.org/scientists/gideon-dreyfuss
Dr. Gideon Dreyfuss is currently the Isaac Norris Professor Biochemistry and Biophysics at the University of Pennsylvania School of Medicine and a principal investigator of the Howard Hughes Medical Institute.
Dr. Dreyfuss's research is concentrated on Spinal Muscular Atrophy (SMA)/neurogeneration, the survival of motor neuron (SMN) complex, RNA-binding protein, Ribonucleoproteins (RNP), and high throughput screening.
He received his Ph.D. in biological chemistry in 1978 from Harvard University. Dr. Dreyfuss is a fellow of the American Academy of Arts and Sciences.
Mean distance: 15.39 (cluster 11) | S | N | B | C | P |
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Elkan Rogers Blout | grad student | 1978 | Harvard (Chemistry Tree) | |
| (On cyclic AMP-dependent protein kinases) | ||||
| David Baltimore | post-doc | MIT (Chemistry Tree) | ||
Children
Sign in to add trainee| Christopher G. Dengler | research assistant | 2004-2009 | Penn |
| Yang Do Choi | grad student | Seoul National University | |
| Doug Portman | grad student | 1989-1995 | Penn |
| Lili Wan | grad student | 2001 | Penn |
| Jeongsik Yong | grad student | 2002 | Penn |
| Chia C. Chan | grad student | 2004 | Penn |
| Tracey G. Polsky | grad student | 2005 | Penn |
| Michael D. Diem | grad student | 2006 | Penn |
| Daniel J. Battle | post-doc | 2003 | Penn (Chemistry Tree) |
Publications
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| Cai Z, So BR, Dreyfuss G. (2021) Comprehensive RNP profiling in cells identifies U1 snRNP complexes with cleavage and polyadenylation factors active in telescripting. Methods in Enzymology. 655: 325-347 |
| So BR, Dreyfuss G. (2020) Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies. Cold Spring Harbor Symposia On Quantitative Biology |
| Di C, So BR, Cai Z, et al. (2020) U1 snRNP Telescripting Roles in Transcription and Its Mechanism. Cold Spring Harbor Symposia On Quantitative Biology |
| Oh JM, Venters CC, Di C, et al. (2020) U1 snRNP regulates cancer cell migration and invasion in vitro. Nature Communications. 11: 1 |
| So BR, Di C, Cai Z, et al. (2019) A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells. Molecular Cell |
| Venters CC, Oh JM, Di C, et al. (2019) U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation. Cold Spring Harbor Perspectives in Biology. 11 |
| Oh JM, Di C, Venters CC, et al. (2017) U1 snRNP telescripting regulates a size-function-stratified human genome. Nature Structural & Molecular Biology |
| Wan L, Dreyfuss G. (2017) Splicing-Correcting Therapy for SMA. Cell. 170: 5 |
| So BR, Wan L, Zhang Z, et al. (2016) A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange. Nature Structural & Molecular Biology |
| Dreyfuss G. (2015) On the occasion of the 20th anniversary of the RNA journal. Rna (New York, N.Y.). 21: 603-4 |