Gideon Dreyfuss

Biochemistry and Biophysics University of Pennsylvania, Philadelphia, PA, United States 
Spinal Muscular Atrophy, RNA binding proteins, Splicing, High-Throughput Screening
"Gideon Dreyfuss"
Dr. Gideon Dreyfuss is currently the Isaac Norris Professor Biochemistry and Biophysics at the University of Pennsylvania School of Medicine and a principal investigator of the Howard Hughes Medical Institute.

Dr. Dreyfuss's research is concentrated on Spinal Muscular Atrophy (SMA)/neurogeneration, the survival of motor neuron (SMN) complex, RNA-binding protein, Ribonucleoproteins (RNP), and high throughput screening.
He received his Ph.D. in biological chemistry in 1978 from Harvard University. Dr. Dreyfuss is a fellow of the American Academy of Arts and Sciences.

Mean distance: 15.39 (cluster 11)
Cross-listing: Chemistry Tree


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Elkan Rogers Blout grad student 1978 Harvard (Chemistry Tree)
 (On cyclic AMP-dependent protein kinases)
David Baltimore post-doc MIT (Chemistry Tree)


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Christopher G. Dengler research assistant 2004-2009 Penn
Doug Portman grad student 1989-1995 Penn
Lili Wan grad student 2001 Penn
Jeongsik Yong grad student 2002 Penn
Chia C. Chan grad student 2004 Penn
Tracey G. Polsky grad student 2005 Penn
Michael D. Diem grad student 2006 Penn
Daniel J. Battle post-doc 2003 Penn (Chemistry Tree)
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Venters CC, Oh JM, Di C, et al. (2019) U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation. Cold Spring Harbor Perspectives in Biology. 11
Wan L, Dreyfuss G. (2017) Splicing-Correcting Therapy for SMA. Cell. 170: 5
So BR, Wan L, Zhang Z, et al. (2016) A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange. Nature Structural & Molecular Biology
Dreyfuss G. (2015) On the occasion of the 20th anniversary of the RNA journal. Rna (New York, N.Y.). 21: 603-4
Zhang Z, Pinto AM, Wan L, et al. (2013) Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America. 110: 19348-53
Younis I, Dittmar K, Wang W, et al. (2013) Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA. Elife. 2: e00780
Liu X, Biswas S, Berg MG, et al. (2013) Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. Journal of Natural Products. 76: 685-93
Berg MG, Singh LN, Younis I, et al. (2012) U1 snRNP determines mRNA length and regulates isoform expression. Cell. 150: 53-64
Berg MG, Wan L, Younis I, et al. (2012) A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Molecular and Cellular Biology. 32: 1271-83
Gruber JJ, Olejniczak SH, Yong J, et al. (2012) Ars2 promotes proper replication-dependent histone mRNA 3' end formation. Molecular Cell. 45: 87-98
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