Al La Spada, MD PhD

Affiliations: 
1993-2009 University of Washington, Seattle, Seattle, WA 
 2009- Pediatrics University of California, San Diego, La Jolla, CA 
Area:
Polyglutamine disease mechanisms
Website:
https://profiles.ucsd.edu/albert.laspada
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"Al La Spada"
Bio:

https://medschool.ucsd.edu/education/neurograd/faculty/Pages/albert-spada.aspx
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Mean distance: 16.6 (cluster 11)
 
SNBCP

Children

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Scott A. Wilke research assistant UCSD
Stephan J. Guyenet grad student 2009 University of Washington
Jamie Ann Johansen post-doc 2008-2010 UCSD
Stevan N. Djakovic post-doc 2010-2011 UCSD
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Publications

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Guyenet SJ, Mookerjee SS, Lin A, et al. (2015) Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Human Molecular Genetics. 24: 3908-17
Cortes CJ, La Spada AR. (2015) Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? Molecular and Cellular Neurosciences. 66: 53-61
Ward JM, La Spada AR. (2015) Ataxin-3, DNA damage repair, and SCA3 cerebellar degeneration: on the path to parsimony? Plos Genetics. 11: e1004937
Eschbach J, von Einem B, Müller K, et al. (2015) Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Annals of Neurology. 77: 15-32
Dubinsky AN, Dastidar SG, Hsu CL, et al. (2014) Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metabolism. 20: 626-38
Ward JM, La Spada AR. (2014) Identification of the SCA21 disease gene: remaining challenges and promising opportunities. Brain : a Journal of Neurology. 137: 2626-8
Cortes CJ, Miranda HC, Frankowski H, et al. (2014) Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nature Neuroscience. 17: 1180-9
La Spada AR. (2014) Something wicked this way comes: huntingtin. Nature Neuroscience. 17: 1014-5
Ramachandran PS, Boudreau RL, Schaefer KA, et al. (2014) Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1635-42
Montague K, Malik B, Gray AL, et al. (2014) Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy. Brain : a Journal of Neurology. 137: 1894-906
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