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Al La Spada, MD PhD

1993-2009 University of Washington, Seattle, Seattle, WA 
 2009- Pediatrics University of California, San Diego, La Jolla, CA 
Polyglutamine disease mechanisms
"Al La Spada"
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Mean distance: 16.6 (cluster 11)


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Scott A. Wilke research assistant UCSD
Stephan J. Guyenet grad student 2009 University of Washington
Jamie Ann Johansen post-doc 2008-2010 UCSD
Stevan N. Djakovic post-doc 2010-2011 UCSD
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Badders NM, Korff A, Miranda HC, et al. (2018) Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy. Nature Medicine
Polanco MJ, Parodi S, Piol D, et al. (2016) Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy. Science Translational Medicine. 8: 370ra181
Guyenet SJ, Mookerjee SS, Lin A, et al. (2015) Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Human Molecular Genetics. 24: 3908-17
Cortes CJ, La Spada AR. (2015) Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? Molecular and Cellular Neurosciences. 66: 53-61
Ward JM, La Spada AR. (2015) Ataxin-3, DNA damage repair, and SCA3 cerebellar degeneration: on the path to parsimony? Plos Genetics. 11: e1004937
Eschbach J, von Einem B, Müller K, et al. (2015) Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization. Annals of Neurology. 77: 15-32
Dubinsky AN, Dastidar SG, Hsu CL, et al. (2014) Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metabolism. 20: 626-38
Ward JM, La Spada AR. (2014) Identification of the SCA21 disease gene: remaining challenges and promising opportunities. Brain : a Journal of Neurology. 137: 2626-8
Cortes CJ, Miranda HC, Frankowski H, et al. (2014) Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nature Neuroscience. 17: 1180-9
La Spada AR. (2014) Something wicked this way comes: huntingtin. Nature Neuroscience. 17: 1014-5
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