Frédéric Saudou, PhD

Affiliations: 
1999-2013 Inserm U1005 Institut Curie, Bures-sur-Yvette, Île-de-France, France 
 2013- Grenoble Institute of Neurosciences Université Grenoble Alpes, INSERM 
Area:
Huntington's disease, intracellular dynamics, axonal transport
Website:
https://neurosciences.ujf-grenoble.fr/search/team-saudou-intracellular-dynamics-neurodegeneration?language=en
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"Frédéric Saudou"
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Publications

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Migazzi A, Scaramuzzino C, Anderson EN, et al. (2021) Huntingtin-mediated axonal transport requires arginine methylation by PRMT6. Cell Reports. 35: 108980
Virlogeux A, Scaramuzzino C, Lenoir S, et al. (2021) Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice. Science Advances. 7
Vitet H, Brandt V, Saudou F. (2020) Traffic signaling: new functions of huntingtin and axonal transport in neurological disease. Current Opinion in Neurobiology. 63: 122-130
Kacher R, Lamazière A, Heck N, et al. (2019) CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease. Brain : a Journal of Neurology
Kacher R, Kappes V, Lamazière A, et al. (2018) I13 Striatal regulation of cholesterol metabolism by CYP46A1 is associated with multiple benefits in huntington’s disease knock-in mice models Journal of Neurology, Neurosurgery, and Psychiatry. 89
Migazzi A, Tripathy D, Scaramuzzino C, et al. (2018) A14 Arginine methylation of huntingtin is a novel post-translational modification that impacts huntington’s disease pathogenesis Journal of Neurology, Neurosurgery, and Psychiatry. 89
Kratter IH, Zahed H, Lau A, et al. (2016) Serine 421 regulates mutant huntingtin toxicity and clearance in mice. The Journal of Clinical Investigation
Saudou F, Humbert S. (2016) The Biology of Huntingtin. Neuron. 89: 910-26
Ochaba J, Lukacsovich T, Csikos G, et al. (2014) Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America. 111: 16889-94
Drouet V, Ruiz M, Zala D, et al. (2014) Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells. Plos One. 9: e99341
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