Frédéric Saudou, PhD

1999-2013 Inserm U1005 Institut Curie, Bures-sur-Yvette, Île-de-France, France 
 2013- Grenoble Institute of Neurosciences Université Grenoble Alpes, INSERM 
Huntington's disease, intracellular dynamics, axonal transport
"Frédéric Saudou"
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Kratter IH, Zahed H, Lau A, et al. (2016) Serine 421 regulates mutant huntingtin toxicity and clearance in mice. The Journal of Clinical Investigation
El-Daher MT, Hangen E, Bruyère J, et al. (2015) Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. The Embo Journal. 34: 2255-71
Ochaba J, Lukacsovich T, Csikos G, et al. (2014) Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America. 111: 16889-94
Drouet V, Ruiz M, Zala D, et al. (2014) Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells. Plos One. 9: e99341
Roux JC, Zala D, Panayotis N, et al. (2012) [Unexpected link between Huntington disease and Rett syndrome]. MéDecine Sciences : M/S. 28: 44-6
Roux JC, Zala D, Panayotis N, et al. (2012) Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway. Neurobiology of Disease. 45: 786-95
Keryer G, Pineda JR, Liot G, et al. (2011) Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. The Journal of Clinical Investigation. 121: 4372-82
Marquer C, Devauges V, Cossec JC, et al. (2011) Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1295-305
Godin JD, Colombo K, Molina-Calavita M, et al. (2010) Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron. 67: 392-406
del Toro D, Xifró X, Pol A, et al. (2010) Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease. Journal of Neurochemistry. 115: 153-67
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