Charles Askew, PhD

2008-2015 Neuroscience University of Virginia, Charlottesville, VA 
 2011-2015 Otolaryngology Harvard - Boston Children's Hospital 
 2015- Gene Therapy Center University of North Carolina, Chapel Hill, Chapel Hill, NC 
Sensory Neuroscience
"Charles Askew"
Mean distance: 16.03 (cluster 6)


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Michael Anne Gratton research assistant 2003-2008 Penn
James C. Saunders research assistant 2005-2008 Penn
Jeffrey R. Holt grad student 2008-2015 University of Virginia, Harvard
Richard J. Samulski post-doc 2015- UNC Chapel Hill
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Pan B, Askew C, Galvin A, et al. (2017) Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nature Biotechnology
Landegger LD, Pan B, Askew C, et al. (2017) A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nature Biotechnology
Askew C, Rochat C, Pan B, et al. (2015) Tmc gene therapy restores auditory function in deaf mice. Science Translational Medicine. 7: 295ra108
Zou J, Zheng T, Ren C, et al. (2014) Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Human Molecular Genetics. 23: 2374-90
Geng R, Melki S, Chen DH, et al. (2012) The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9485-98
Collado MS, Thiede BR, Baker W, et al. (2011) The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11855-66
Zallocchi M, Meehan DT, Delimont D, et al. (2009) Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors. Hearing Research. 255: 109-20
Gratton MA, Rao VH, Meehan DT, et al. (2005) Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology. The American Journal of Pathology. 166: 1465-74
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