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Brandon K. Hadland, Ph.D. - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Notch
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ishida T, Heck AM, Varnum-Finney B, Dozono S, Nourigat-McKay C, Kraskouskas K, Wellington R, Waltner O, Jackson DL, Delaney C, Rafii S, Bernstein ID, Hadland B. Differentiation latency and dormancy signatures define fetal liver HSCs at single cell resolution. Biorxiv : the Preprint Server For Biology. PMID 37333272 DOI: 10.1101/2023.06.01.543314  0.345
2023 Itkin T, Houghton S, Schreiner R, Lin Y, Badwe CR, Voisin V, Murison A, Seyedhassantehrani N, Kaufmann KB, Garcia-Prat L, Booth GT, Geng F, Liu Y, Gomez-Salinero JM, Shieh JH, ... ... Hadland B, et al. Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing. Biorxiv : the Preprint Server For Biology. PMID 37034724 DOI: 10.1101/2023.03.27.534417  0.367
2022 Hadland B, Varnum-Finney B, Dozono S, Dignum T, Nourigat-McKay C, Heck AM, Ishida T, Jackson DL, Itkin T, Butler JM, Rafii S, Trapnell C, Bernstein ID. Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics. Nature Communications. 13: 1584. PMID 35332125 DOI: 10.1038/s41467-022-28781-z  0.409
2021 Dignum T, Varnum-Finney B, Srivatsan SR, Dozono S, Waltner O, Heck AM, Ishida T, Nourigat-McKay C, Jackson DL, Rafii S, Trapnell C, Bernstein ID, Hadland B. Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo. Cell Reports. 36: 109675. PMID 34525376 DOI: 10.1016/j.celrep.2021.109675  0.359
2021 Choi YJ, Heck AM, Hayes BJ, Lih D, Rayner SG, Hadland B, Zheng Y. WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis. Stem Cell Research & Therapy. 12: 321. PMID 34090485 DOI: 10.1186/s13287-021-02380-z  0.313
2020 Heck AM, Ishida T, Hadland B. Location, Location, Location: How Vascular Specialization Influences Hematopoietic Fates During Development. Frontiers in Cell and Developmental Biology. 8: 602617. PMID 33282876 DOI: 10.3389/fcell.2020.602617  0.36
2019 Kobayashi M, Tarnawsky SP, Wei H, Mishra A, Azevedo Portilho N, Wenzel P, Davis B, Wu J, Hadland B, Yoshimoto M. Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo. Stem Cell Reports. PMID 31231025 DOI: 10.1016/j.stemcr.2019.05.025  0.31
2019 Itkin T, Badwe CR, Houghton S, Lin Y, Liu Y, Guo P, Gomez-Salinero JM, Geng F, Shieh J, Redmond D, Hsu YS, Hadland B, Rafii S. Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing By Self-Renewing Hematopoietic Stem and Progenitor Cells Blood. 134: 725-725. DOI: 10.1182/Blood-2019-126190  0.44
2019 Hadland B, Varnum-Finney B, Dozono S, Dignum T, Nourigat-Mckay C, Jackson D, Rafii S, Trapnell C, Bernstein ID. Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo Blood. 134: 3699-3699. DOI: 10.1182/Blood-2019-126109  0.435
2018 Hadland BK, Varnum-Finney B, Nourigat-Mckay C, Flowers D, Bernstein ID. Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture. Journal of Visualized Experiments : Jove. PMID 29806841 DOI: 10.3791/56973  0.341
2018 Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, et al. NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nature Communications. 9: 1828. PMID 29739946 DOI: 10.1038/S41467-018-04134-7  0.406
2018 Hadland B, Varnum-Finney B, Dozono S, Jackson D, Rafii S, Bernstein ID, Trapnell C. Single Cell Transcriptomics Maps the Embryonic Emergence of HSC and Identifies Intercellular Interactions Regulating HSC Genesis Blood. 132: 5086-5086. DOI: 10.1182/Blood-2018-99-118772  0.481
2017 Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis. Cell Reports. 20: 1597-1608. PMID 28813672 DOI: 10.1016/J.Celrep.2017.07.067  0.394
2017 Li Y, Gao L, Hadland B, Tan K, Speck NA. CD27 marks murine embryonic hematopoietic stem cells and type II pre-hematopoietic stem cells. Blood. PMID 28588017 DOI: 10.1182/Blood-2017-03-776849  0.358
2017 Palpant NJ, Pabon L, Friedman CE, Roberts M, Hadland B, Zaunbrecher RJ, Bernstein I, Zheng Y, Murry CE. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nature Protocols. 12: 15-31. PMID 27906170 DOI: 10.1038/Nprot.2016.153  0.348
2016 Le Q, Meshinchi S, Hadland BK, Walter RB, Bernstein ID. The Role of Notch in Vascular Endothelial Cell-Mediated Protection of AML Precursors from Targeted Therapy Blood. 128: 2750-2750. DOI: 10.1182/blood.v128.22.2750.2750  0.314
2016 Uenishi G, McLeod E, Jung HS, Hadland B, Bernstein I, Slukvin I. Regulation of hematoendothelial transition by notch signaling in human pluripotent stem cell cultures Experimental Hematology. 44: S104. DOI: 10.1016/J.Exphem.2016.06.230  0.372
2016 Hadland B, Varnum-Finney B, Bernstein I. Clonal analysis of hematopoietic stem cell precursors reveals developmental evolution of phenotypic and functional properties Experimental Hematology. 44: S78. DOI: 10.1016/j.exphem.2016.06.151  0.31
2015 Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE. Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes. Development (Cambridge, England). PMID 26153229 DOI: 10.1242/Jcs.180588  0.441
2015 Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. The Journal of Clinical Investigation. 125: 2032-45. PMID 25866967 DOI: 10.1172/Jci80137  0.422
2015 Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE. Inhibition of  -catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes Journal of Cell Science. 128: e1.2-e1.2. DOI: 10.1242/jcs.180588  0.302
2014 Hadland BK, Varnum-Finney B, Moon RT, Poulos MG, Butler JM, Rafii S, Bernstein ID. Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro Blood. 124: 2897-2897. DOI: 10.1182/Blood.V124.21.2897.2897  0.457
2013 Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 13: 459-70. PMID 24094326 DOI: 10.1016/J.Stem.2013.09.002  0.392
2013 Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development (Cambridge, England). 140: 3799-808. PMID 23924634 DOI: 10.1242/Dev.094789  0.439
2012 Hadland BK, Varnum-Finney B, Bernstein ID. Activation of Notch Signaling Mediates Ex Vivo Expansion of Multilineage, Engrafting Murine Hematopoietic Progenitors From Embryonic Sources. Blood. 120: 2321-2321. DOI: 10.1182/blood.v120.21.2321.2321  0.428
2007 Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England). 134: 535-44. PMID 17215306 DOI: 10.1242/Dev.02733  0.612
2004 Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000). 40: 40-4. PMID 15354292 DOI: 10.1002/Gene.20061  0.593
2004 Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood. 104: 3097-105. PMID 15251982 DOI: 10.1182/Blood-2004-03-1224  0.598
2001 Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R. Gamma -secretase inhibitors repress thymocyte development. Proceedings of the National Academy of Sciences of the United States of America. 98: 7487-91. PMID 11416218 DOI: 10.1073/Pnas.131202798  0.499
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