Linda S. Brady - Publications

Affiliations: 
National Institute of Mental Health, Bethesda, MD, United States 
Area:
research administration neuropharmacology
Website:
http://www.nimh.nih.gov/about/organization/dnbbs/index.shtml

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Potter WZ, Brady LS. Current drug development for antidepressants and ideas addressing downstream glutamate: the ketamine example. Cns Spectrums. 19: 112-4. PMID 24565466 DOI: 10.1017/S1092852914000029  1
2014 Brady LS, Potter WZ. Proteomic biomarkers for brain disorders: technical considerations and challenges. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 252. PMID 24317326 DOI: 10.1038/npp.2013.202  1
2014 Brady LS, Potter WZ. Public-private partnerships to revitalize psychiatric drug discovery. Expert Opinion On Drug Discovery. 9: 1-8. PMID 24308355 DOI: 10.1517/17460441.2014.867944  1
2013 Colvis CM, Devaney S, Brady LS, Hudson KL. Partnering for therapeutics discovery. Clinical Pharmacology and Therapeutics. 93: 24-5. PMID 23187876 DOI: 10.1038/clpt.2012.188  1
2012 Brady LS, Insel TR. Translating discoveries into medicine: psychiatric drug development in 2011. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 281-3. PMID 22157856 DOI: 10.1038/npp.2011.106  1
2009 Brady LS, Winsky L, Goodman W, Oliveri ME, Stover E. NIMH initiatives to facilitate collaborations among industry, academia, and government for the discovery and clinical testing of novel models and drugs for psychiatric disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 229-43. PMID 18800066 DOI: 10.1038/npp.2008.125  1
2008 Brady LS, Giffin RB, Woodcock J, Cassell GH, Holmes EW. Grand challenges for psychiatric drug discovery: a perspective. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2047. PMID 18626470 DOI: 10.1038/npp.2008.54  1
2008 Winsky L, Driscoll J, Brady L. Drug discovery and development initiatives at the national institute of mental health: From cell-based systems to proof of concept Animal and Translational Models For Cns Drug Discovery. 1: 59-74. DOI: 10.1016/B978-0-12-373861-5.00002-3  1
2007 Stover EL, Brady L, Marder SR. New paradigms for treatment development. Schizophrenia Bulletin. 33: 1093-9. PMID 17673495 DOI: 10.1093/schbul/sbm085  1
2007 Lazo JS, Brady LS, Dingledine R. Building a pharmacological lexicon: small molecule discovery in academia. Molecular Pharmacology. 72: 1-7. PMID 17405872 DOI: 10.1124/mol.107.035113  1
2005 Winsky L, Brady L. Perspective on the status of preclinical models for psychiatric disorders Drug Discovery Today: Disease Models. 2: 279-283. DOI: 10.1016/j.ddmod.2005.11.007  1
2004 Austin CP, Brady LS, Insel TR, Collins FS. NIH Molecular Libraries Initiative. Science (New York, N.Y.). 306: 1138-9. PMID 15542455 DOI: 10.1126/science.1105511  1
2002 Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM, et al. Developing novel treatments for mood disorders: accelerating discovery. Biological Psychiatry. 52: 589-609. PMID 12361670 DOI: 10.1016/S0006-3223(02)01470-1  1
2001 Brady L. Neuroimaging consortium workshop: development of novel PET and SPECT ligands for brain imaging Journal of Clinical Pharmacology. 116S-117S. PMID 11452718  1
2001 Innis R, Ferguson S, Brady L, Esmond R, Frank RA. Positron-emission tomography tracers as intellectual property Journal of Clinical Pharmacology. 41: 107S-117S. PMID 11452714  1
2000 Devi LA, Brady LS. Dimerization of G-protein coupled receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: S3-4. PMID 11008062 DOI: 10.1016/S0893-133X(00)00154-8  1
2000 Proescholdt MG, Hutto B, Brady LS, Herkenham M. Studies of cerebrospinal fluid flow and penetration into brain following lateral ventricle and cisterna magna injections of the tracer [14C]inulin in rat. Neuroscience. 95: 577-92. PMID 10658638 DOI: 10.1016/S0306-4522(99)00417-0  1
1999 Brady LS, Herkenham M, Rothman RB, Partilla JS, König M, Zimmer AM, Zimmer A. Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice. Brain Research. Molecular Brain Research. 68: 193-7. PMID 10320798 DOI: 10.1016/S0169-328X(99)00090-X  1
1999 Rosenthal JP, Beck D, Bhat A, Biswas J, Brady L, Bridbord K, Collins S, Cragg G, Edwards J, Fairfield A, Gottlieb M, Gschwind LA, Hallock Y, Hawks R, Hegyeli R, et al. Combining high risk science with ambitious social and economic goals Pharmaceutical Biology. 37: 6-21.  1
1996 Cizza G, Brady LS, Esclapes ME, Blackman MR, Gold PW, Chrousos GP. Age and gender influence basal and stress-modulated hypothalamic-pituitary-thyroidal function in Fischer 344/N rats. Neuroendocrinology. 64: 440-8. PMID 8990077  1
1996 Voorn P, Brady LS, Berendse HW, Richfield EK. Densitometrical analysis of opioid receptor ligand binding in the human striatum--I. Distribution of mu opioid receptor defines shell and core of the ventral striatum. Neuroscience. 75: 777-92. PMID 8951872 DOI: 10.1016/0306-4522(96)00271-0  1
1996 Vonkeman HE, Voorn P, Brady LS, Berendse HW, Richfield EK. Opioid receptor ligand binding in the human striatum: II. Heterogeneous distribution of kappa opioid receptor labeled with [3H]bremazocine. The Journal of Comparative Neurology. 374: 223-9. PMID 8906495 DOI: 10.1002/(SICI)1096-9861(19961014)374:2<223::AID-CNE5>3.0.CO;2-4  1
1996 Johnson EO, Brady L, Gold PW, Chrousos GP. Distribution of hippocampal mineralocorticoid and glucocorticoid receptor mRNA in a glucocorticoid resistant nonhuman primate Steroids. 61: 69-73. PMID 8750435 DOI: 10.1016/0039-128X(95)00195-V  1
1996 Baker RA, Herkenham M, Brady LS. Effects of long-term treatment with antidepressant drugs on proopiomelanocortin and neuropeptide Y mRNA expression in the hypothalamic arcuate nucleus of rats. Journal of Neuroendocrinology. 8: 337-43. PMID 8736433 DOI: 10.1046/j.1365-2826.1996.04422.x  1
1996 Bramham CR, Southard T, Sarvey JM, Herkenham M, Brady LS. Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: evidence for interhemispheric communication. The Journal of Comparative Neurology. 368: 371-82. PMID 8725345 DOI: 10.1002/(SICI)1096-9861(19960506)368:3<371::AID-CNE4>3.0.CO;2-2  1
1995 Cizza G, Brady LS, Pacak K, Blackman MR, Gold PW, Chrousos GP. Stress-induced inhibition of the hypothalamic-pituitary-thyroid axis is attenuated in the aged Fischer 344/N male rat. Neuroendocrinology. 62: 506-13. PMID 8559282 DOI: 10.1159/000127041  1
1995 Cizza G, Pacak K, Kvetnansky R, Palkovits M, Goldstein DS, Brady LS, Fukuhara K, Bergamini E, Kopin IJ, Blackman MR. Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344/N Fischer rats. The Journal of Clinical Investigation. 95: 1217-24. PMID 7883970 DOI: 10.1172/JCI117771  1
1995 Holmes PV, Blanchard DC, Blanchard RJ, Brady LS, Crawley JN. Chronic social stress increases levels of preprogalanin mRNA in the rat locus coeruleus. Pharmacology, Biochemistry, and Behavior. 50: 655-60. PMID 7542391 DOI: 10.1016/0091-3057(94)00334-3  1
1994 Brady LS, Page SW, Thomas FS, Rader JL, Lynn AB, Misiewicz-Poltorak B, Zelazowski E, Crofford LJ, Zelazowski P, Smith C. 1,1'-Ethylidenebis[L-tryptophan], a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome, suppresses mRNA expression of hypothalamic corticotropin-releasing hormone in Lewis (LEW/N) rat brain. Neuroimmunomodulation. 1: 59-65. PMID 8528886 DOI: 10.1159/000097091  1
1994 Cizza G, Calogero AE, Brady LS, Bagdy G, Bergamini E, Blackman MR, Chrousos GP, Gold PW. Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age. Endocrinology. 134: 1611-20. PMID 8137722 DOI: 10.1210/endo.134.4.8137722  1
1994 Young JK, McKenzie JC, Brady LS, Herkenham M. Hypothalamic lesions increase levels of neuropeptide Y mRNA in the arcuate nucleus of mice. Neuroscience Letters. 165: 13-7. PMID 8015714 DOI: 10.1016/0304-3940(94)90698-X  1
1994 Patchev VK, Brady LS, Karl M, Chrousos GP. Regulation of HSP90 and corticosteroid receptor mRNA by corticosterone levels in vivo. Molecular and Cellular Endocrinology. 103: 57-64. PMID 7958398 DOI: 10.1016/0303-7207(94)90069-8  1
1994 Brady LS, Lynn AB, Glowa JR, Le DQ, Herkenham M. Repeated electroconvulsive shock produces long-lasting increases in messenger RNA expression of corticotropin-releasing hormone and tyrosine hydroxylase in rat brain. Therapeutic implications. The Journal of Clinical Investigation. 94: 1263-8. PMID 7916018 DOI: 10.1172/JCI117444  1
1994 Brady LS, Lynn AB, Herkenham M, Gottesfeld Z. Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4951-64. PMID 7913957  1
1994 Brady LS. Stress, antidepressant drugs, and the locus coeruleus. Brain Research Bulletin. 35: 545-56. PMID 7859112 DOI: 10.1016/0361-9230(94)90168-6  1
1994 Voorn P, Brady LS, Schotte A, Berendse HW, Richfield EK. Evidence for two neurochemical divisions in the human nucleus accumbens. The European Journal of Neuroscience. 6: 1913-6. PMID 7704301 DOI: 10.1111/j.1460-9568.1994.tb00582.x  1
1993 Patchev VK, Mastorakos G, Brady LS, Redwine J, Wilder RL, Chrousos GP. Increased arginine vasopressin secretion may participate in the enhanced susceptibility of Lewis rats to inflammatory disease. Neuroendocrinology. 58: 106-10. PMID 8264843 DOI: 10.1159/000126519  1
1993 Rothman RB, Brady LS, Xu H, Long JB. Chronic intracerebroventricular infusion of the antiopioid peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), downregulates mu opioid binding sites in rat brain. Peptides. 14: 1271-7. PMID 8134310 DOI: 10.1016/0196-9781(93)90187-L  1
1992 Mamalaki E, Kvetnansky R, Brady LS, Gold PW, Herkenham M. Repeated immobilization stress alters tyrosine hydroxylase, corticotropin-releasing hormone and corticosteroid receptor messenger ribonucleic Acid levels in rat brain. Journal of Neuroendocrinology. 4: 689-99. PMID 21554656 DOI: 10.1111/j.1365-2826.1992.tb00220.x  1
1992 Cizza G, Brady LS, Calogero AE, Bagdy G, Lynn AB, Kling MA, Blackman MR, Chrousos GP, Gold PW. Central hypothyroidism is associated with advanced age in male Fischer 344/N rats: in vivo and in vitro studies. Endocrinology. 131: 2672-80. PMID 1446609 DOI: 10.1210/endo.131.6.1446609  1
1992 Brady LS, Gold PW, Herkenham M, Lynn AB, Whitfield HJ. The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain Research. 572: 117-25. PMID 1351783 DOI: 10.1016/0006-8993(92)90459-M  1
1992 Rothman RB, Bykov V, Xue BG, Xu H, De Costa BR, Jacobson AE, Rice KC, Kleinman JE, Brady LS. Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences. Peptides. 13: 977-87. PMID 1336192 DOI: 10.1016/0196-9781(92)90059-C  1
1992 Brady LS, Lynn AB, Whitfield HJ, Kim H, Herkenham M. Intrahippocampal colchicine alters hypothalamic corticotropin-releasing hormone and hippocampal steroid receptor mRNA in rat brain. Neuroendocrinology. 55: 121-33. PMID 1320216  1
1991 Smith MA, Brady LS, Glowa J, Gold PW, Herkenham M. Effects of stress and adrenalectomy on tyrosine hydroxylase mRNA levels in the locus ceruleus by in situ hybridization. Brain Research. 544: 26-32. PMID 1677301 DOI: 10.1016/0006-8993(91)90881-U  1
1991 Brady LS, Whitfield HJ, Fox RJ, Gold PW, Herkenham M. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. The Journal of Clinical Investigation. 87: 831-7. PMID 1671867 DOI: 10.1172/JCI115086  1
1990 Whitfield HJ, Brady LS, Smith MA, Mamalaki E, Fox RJ, Herkenham M. Optimization of cRNA probe in situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: a detailed protocol. Cellular and Molecular Neurobiology. 10: 145-57. PMID 2334945 DOI: 10.1007/BF00733641  1
1990 Crofford LJ, Rader JI, Dalakas MC, Hill RH, Page SW, Needham LL, Brady LS, Heyes MP, Wilder RL, Gold PW. L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat. The Journal of Clinical Investigation. 86: 1757-63. PMID 2243145 DOI: 10.1172/JCI114902  1
1990 Brady LS, Smith MA, Gold PW, Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology. 52: 441-7. PMID 2177853 DOI: 10.1159/000125626  1
1990 Rothman RB, Bykov V, de Costa BR, Jacobson AE, Rice KC, Brady LS. Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain. Peptides. 11: 311-31. PMID 2162533 DOI: 10.1016/0196-9781(90)90088-M  1
1990 Rothman RB, Bykov V, de Costa BR, Jacobson AE, Rice KC, Brady LS. Evidence for four opioid kappa binding sites in guinea pig brain. Progress in Clinical and Biological Research. 328: 9-12. PMID 2154826  1
1989 Calogero AE, Bernardini R, Margioris AN, Bagdy G, Gallucci WT, Munson PJ, Tamarkin L, Tomai TP, Brady L, Gold PW, Chrousos GP. Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami Peptides. 10: 189-200. PMID 2787501 DOI: 10.1016/0196-9781(89)90096-X  1
1989 Bondy CA, Jensen RT, Brady LS, Gainer H. Cholecystokinin evokes secretion of oxytocin and vasopressin from rat neural lobe independent of external calcium. Proceedings of the National Academy of Sciences of the United States of America. 86: 5198-201. PMID 2740351  1
1989 Bondy CA, Whitnall MH, Brady LS. Regulation of carboxypeptidase H gene expression in magnocellular neurons: response to osmotic stimulation. Molecular Endocrinology (Baltimore, Md.). 3: 2086-92. PMID 2628743 DOI: 10.1210/mend-3-12-2086  1
1989 Bondy CA, Whitnall MH, Brady LS, Gainer H. Coexisting peptides in hypothalamic neuroendocrine systems: some functional implications. Cellular and Molecular Neurobiology. 9: 427-46. PMID 2575930 DOI: 10.1007/BF00712791  1
1989 Rothman RB, Bykov V, Long JB, Brady LS, Jacobson AE, Rice KC, Holaday JW. Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites. European Journal of Pharmacology. 160: 71-82. PMID 2540993 DOI: 10.1016/0014-2999(89)90655-9  1
1989 Brady LS, Herkenham M, Long JB, Rothman RB. Chronic morphine increases mu-opiate receptor binding in rat brain: a quantitative autoradiographic study. Brain Research. 477: 382-6. PMID 2539233 DOI: 10.1016/0006-8993(89)91432-7  1
1988 Witkin JM, Brady LS, Barrett JE. Antagonism by ketanserin of the behavioral effects of quipazine but not l-5-hydroxytryptophan in squirrel monkeys. Psychopharmacology. 94: 302-5. PMID 3128804 DOI: 10.1007/BF00174679  1
1988 Iadarola MJ, Brady LS, Draisci G, Dubner R. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain. 35: 313-26. PMID 2906426 DOI: 10.1016/0304-3959(88)90141-8  1
1988 Brady LS, Rothman RB, Herkenham M. Physiological regulation of neurohypophyseal kappa-opiate receptors. Brain Research. 443: 398-402. PMID 2896058 DOI: 10.1016/0006-8993(88)91641-1  1
1987 Brady LS, Herkenham M. Dehydration reduces kappa-opiate receptor binding in the neurohypophysis of the rat. Brain Research. 425: 212-7. PMID 2827842 DOI: 10.1016/0006-8993(87)90503-8  1
1986 Brady LS, Barrett JE. Drug-behavior interaction history: modification of the effects of morphine on punished behavior. Journal of the Experimental Analysis of Behavior. 45: 221-8. PMID 3958667 DOI: 10.1901/jeab.1986.45-221  1
1986 Barrett JE, Brady LS, Stanley JA, Mansbach RS, Witkin JM. Behavioral studies with anxiolytic drugs. II. Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 236: 313-9. PMID 2868115  1
1985 Brady LS, Barrett JE. Effects of serotonin receptor antagonists on punished responding maintained by stimulus-shock termination or food presentation in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 234: 106-12. PMID 4009495  1
1985 Barrett JE, Brady LS, Witkin JM, Cook JM, Larscheid P. Interactions between the benzodiazepine receptor antagonist Ro 15-1788 (flumazepil) and the inverse agonist beta-CCE: behavioral studies with squirrel monkeys. Life Sciences. 36: 1407-14. PMID 3920465 DOI: 10.1016/0024-3205(85)90047-5  1
1985 Barrett JE, Brady LS, Witkin JM. Behavioral studies with anxiolytic drugs. I. Interactions of the benzodiazepine antagonist Ro 15-1788 with chlordiazepoxide, pentobarbital and ethanol. The Journal of Pharmacology and Experimental Therapeutics. 233: 554-9. PMID 2989486  1
1985 Brady LS, Barrett JE. Effects of serotonin receptor agonists and antagonists on schedule-controlled behavior of squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 235: 436-41. PMID 2932546  1
1985 Barrett JE, Brady LS. Neuropeptide modulation of the behavioral effects of drugs. Progress in Clinical and Biological Research. 192: 37-50. PMID 2417253  1
1985 Brady LS, Coen CH, Barrett JE. Behavioral and neurochemical effects of buspirone and haloperidol in squirrel monkeys Federation Proceedings. 44: No. 1821.  1
1984 Brady LS, Barrett JE. Effects of thyrotropin-releasing hormone (TRH) and MK-771 on behavior of squirrel monkeys controlled by noxious stimuli. Peptides. 5: 783-7. PMID 6436798 DOI: 10.1016/0196-9781(84)90022-6  1
1984 Brady LS, Valentine JO, Barrett JE. Effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, MK-771, on punished responding of squirrel monkeys. Psychopharmacology. 83: 151-4. PMID 6431464 DOI: 10.1007/BF00429724  1
1984 Brady LS, Mansbach RS, Skurdal DN, Muldoon SM, Barrett JE. Reversal of the antinociceptive effects of centrally-administered morphine by the benzodiazepine receptor antagonist Ro 15-1788. Life Sciences. 35: 2593-600. PMID 6096663 DOI: 10.1016/0024-3205(84)90026-2  1
1984 Weissman BA, Barret JE, Brady LS. Behavioral and neurochemical studies on the anticonflict actions of buspirone Drug Development Research. 4: 83-93.  1
1983 Brady LS, Barrett JE. Modulation of the behavioral effects of chlordiazepoxide (CDAP) by substance P (SP) in squirrel monkeys Federation Proceedings. 42: No. 6265.  1
1982 Brady LS, Holtzman SG. Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats. The Journal of Pharmacology and Experimental Therapeutics. 222: 190-7. PMID 7201020  1
1982 Brady LS, Valentine JO, Barrett JE. Effects of thyrotropin releasing hormone (TRH) on punished responding in squirrel monkeys Federation Proceedings. 41: No. 7374.  1
1982 Barrett JE, Brady LS. Interactions of the benzodiazepine antagonist Ro 15-1788 with chlordiazepoxide and pentobarbital: Effects on schedule-controlled behavior of squirrel monkeys Federation Proceedings. 41: No. 7397.  1
1981 Brady LS, Holtzman SG. Effects of intraventricular morphine and enkephalins on schedule-controlled behavior in nondependent, morphine-dependent and postdependent rats. The Journal of Pharmacology and Experimental Therapeutics. 219: 344-51. PMID 7197301  1
1981 Brady LS, Holtzman SG. Locomotor activity in morphine-dependent and post-dependent rats. Pharmacology, Biochemistry, and Behavior. 14: 361-70. PMID 7195032 DOI: 10.1016/0091-3057(81)90403-2  1
1981 Brady LS, Holtzman SG. Effects of intraventricular morphine and enkephalins on locomotor activity in nondependent, morphine-dependent and postdependent rats. The Journal of Pharmacology and Experimental Therapeutics. 218: 613-20. PMID 7021799  1
1981 Brady LS, Holtzman SG. Effects of intraventricular (IVT) morphine and enkephalins on schedule-controlled responding in morphine-dependent and non-dependent rats Federation Proceedings. 40: 411.  1
1980 Brady LS, Holtzman SG. Schedule-controlled behavior in the morphine-dependent and post-dependent rat. Psychopharmacology. 70: 11-8. PMID 6775328 DOI: 10.1007/BF00432364  1
1979 Brady LS, Holtzman SG. Locomotor activity (LA) in morphine (M) tolerant and nontolerant rats Federation Proceedings. 38: No. 1899.  1
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