Rick G. Schnellmann - Publications

Affiliations: 
1986-1994 Pharmacy University of Georgia, Athens, Athens, GA, United States 
 1994-2001 University of Arkansas for Medical Sciences, United States 
 2001-2016 Medical University of South Carolina, Charleston, SC, United States 
 2016- College of Pharmacy University of Arizona, Tucson, AZ 
Area:
Pharmaceutical Sciences
Website:
https://www.pharmacy.arizona.edu/directory/profile/rick-schnellmann-phd

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Santiago Raj PV, Scholpa NE, Hurtado KA, Janda J, Hortareas J, Schnellmann RG. 5-Hydroxytryptamine 1F Receptor Agonist Lasmiditan Differentially Regulates Successful Repair and Failed Repair Genes in a Mouse Model of Acute Kidney Injury. Acs Pharmacology & Translational Science. 7: 3045-3055. PMID 39416968 DOI: 10.1021/acsptsci.4c00246  0.36
2024 Hurtado K, Scholpa NE, Schnellmann JG, Schnellmann RG. Serotonin regulation of mitochondria in kidney diseases. Pharmacological Research. 203: 107154. PMID 38521286 DOI: 10.1016/j.phrs.2024.107154  0.415
2024 Scholpa NE, Simmons EC, Thompson AD, Carroll SS, Schnellmann RG. 5-HT receptor agonism induces mitochondrial biogenesis and increases cellular function in brain microvascular endothelial cells. Frontiers in Cellular Neuroscience. 18: 1365158. PMID 38510106 DOI: 10.3389/fncel.2024.1365158  0.37
2024 Hurtado KA, Schnellmann RG. Mitophagy regulates mitochondrial number following pharmacological induction of mitochondrial biogenesis in renal proximal tubule cells. Frontiers in Pharmacology. 15: 1344075. PMID 38375036 DOI: 10.3389/fphar.2024.1344075  0.473
2023 Hurtado KA, Janda J, Schnellmann RG. Lasmiditan restores mitochondrial quality control mechanisms and accelerates renal recovery after ischemia-reperfusion injury. Biochemical Pharmacology. 218: 115855. PMID 37866804 DOI: 10.1016/j.bcp.2023.115855  0.439
2023 Thompson AD, Janda J, Schnellmann RG. A refined protocol for the isolation and monoculture of primary mouse renal peritubular endothelial cells. Frontiers in Cardiovascular Medicine. 10: 1114726. PMID 36844728 DOI: 10.3389/fcvm.2023.1114726  0.311
2023 Cleveland KH, Schnellmann RG. The β-adrenergic receptor agonist formoterol restores mitochondrial homeostasis in glucose-induced renal proximal tubule injury through separate integrated pathways. Biochemical Pharmacology. 209: 115436. PMID 36720358 DOI: 10.1016/j.bcp.2023.115436  0.422
2022 Cleveland KH, Schnellmann RG. Pharmacological Targeting of Mitochondria in Diabetic Kidney Disease. Pharmacological Reviews. 75: 250-262. PMID 36781216 DOI: 10.1124/pharmrev.122.000560  0.366
2022 Hurtado KA, Janda J, Schnellmann RG. Lasmiditan Promotes Recovery of Renal Function Through Mitochondrial Biogenesis. American Journal of Physiology. Renal Physiology. PMID 36326468 DOI: 10.1152/ajprenal.00249.2022  0.36
2021 Beeson C, Peterson YK, Perron N, Bandyopadhyay M, Nasarre C, Beeson G, Comer RF, Lindsey CC, Schnellmann RG, Rohrer B. Newly Identified Chemicals Preserve Mitochondrial Capacity and Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 33945330 DOI: 10.1089/jop.2020.0140  0.642
2020 Corum DG, Jenkins DP, Heslop JA, Tallent LM, Beeson GC, Barth JL, Schnellmann RG, Muise-Helmericks RC. PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression. The Journal of Biological Chemistry. 295: 18091-18104. PMID 33453819 DOI: 10.1074/jbc.RA120.013716  0.442
2020 Corum DG, Jenkins DP, Heslop JA, Tallent LM, Beeson GC, Barth JL, Schnellmann RG, Muise-Helmericks RC. PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression. The Journal of Biological Chemistry. PMID 33087445 DOI: 10.1074/jbc.RA120.013716  0.442
2020 Cleveland KH, Brosius FC, Schnellmann RG. Regulation of mitochondrial dynamics and energetics in the diabetic renal proximal tubule by the β-adrenergic receptor agonist formoterol. American Journal of Physiology. Renal Physiology. 319: F773-F779. PMID 32954853 DOI: 10.1152/Ajprenal.00427.2020  0.373
2020 Dupre TV, Schnellmann RG, Miller GW. Using the exposome to address gene-environment interactions in kidney disease. Nature Reviews. Nephrology. PMID 32393897 DOI: 10.1038/s41581-020-0302-9  0.361
2020 Vekaria HJ, Hubbard WB, Scholpa NE, Spry ML, Gooch JL, Prince SJ, Schnellmann RG, Sullivan PG. Formoterol, a β-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury. Neurobiology of Disease. 104866. PMID 32289370 DOI: 10.1016/J.Nbd.2020.104866  0.387
2020 Simmons EC, Scholpa NE, Schnellmann RG. Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases. Experimental Neurology. 329: 113309. PMID 32289315 DOI: 10.1016/j.expneurol.2020.113309  0.432
2019 Collier JB, Schnellmann RG. Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression. Cellular and Molecular Life Sciences : Cmls. PMID 31873757 DOI: 10.1007/s00018-019-03391-z  0.337
2019 Bhargava P, Janda J, Schnellmann RG. Elucidation of cGMP-Dependent Induction of Mitochondrial Biogenesis Through Protein Kinase G and p38 MAPK in the Kidney. American Journal of Physiology. Renal Physiology. PMID 31841384 DOI: 10.1152/ajprenal.00533.2019  0.326
2019 Simmons EC, Scholpa NE, Cleveland KH, Schnellmann RG. 5-HT1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 31776207 DOI: 10.1124/jpet.119.262410  0.322
2019 Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D. Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney International. PMID 31262488 DOI: 10.1016/J.Kint.2019.03.023  0.451
2019 Cameron RB, Peterson YK, Beeson CC, Schnellmann RG. Author Correction: Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol. Scientific Reports. 9: 6790. PMID 31043635 DOI: 10.1038/S41598-019-42463-9  0.618
2019 Cameron RB, Gibbs WS, Miller SR, Dupre TV, Megyesi JK, Beeson CC, Schnellmann RG. Proximal Tubule β2 Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function After Ischemia-Reperfusion Injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 30709866 DOI: 10.1124/Jpet.118.252833  0.477
2018 Scholpa NE, Williams H, Wang W, Corum D, Narang A, Tomlinson S, Sulllivan PG, Rabchevsky AG, Schnellmann RG. Pharmacological stimulation of mitochondrial biogenesis using the FDA-approved β2-adrenoreceptor agonist formoterol for the treatment of spinal cord injury. Journal of Neurotrauma. PMID 30280980 DOI: 10.1089/Neu.2018.5669  0.325
2018 Gibbs WS, Collier JB, Morris M, Beeson CC, Megyesi J, Schnellmann RG. 5-HT1F receptor regulates mitochondrial homeostasis and its loss potentiates acute kidney injury and impairs renal recovery. American Journal of Physiology. Renal Physiology. PMID 29846105 DOI: 10.1152/Ajprenal.00077.2018  0.364
2017 Collier JB, Schnellmann RG. Extracellular Signal-Regulated Kinase 1/2 Regulates Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 29074644 DOI: 10.1124/jpet.117.244152  0.382
2017 Gibbs WS, Garrett SM, Beeson CC, Schnellmann RG. Identification of Dual Mechanisms Mediating 5-hydroxytryptamine Receptor 1F Induced Mitochondrial Biogenesis. American Journal of Physiology. Renal Physiology. ajprenal.00324.2017. PMID 29046298 DOI: 10.1152/Ajprenal.00324.2017  0.761
2017 Scholpa NE, Schnellmann RG. Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target. The Journal of Pharmacology and Experimental Therapeutics. PMID 28935700 DOI: 10.1124/jpet.117.244806  0.385
2017 Cameron RB, Beeson CC, Schnellmann RG. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol. Scientific Reports. 7: 10578. PMID 28874749 DOI: 10.1038/S41598-017-11030-5  0.327
2017 Bhargava P, Schnellmann RG. Mitochondrial energetics in the kidney. Nature Reviews. Nephrology. PMID 28804120 DOI: 10.1038/nrneph.2017.107  0.462
2016 Collier JB, Whitaker RM, Eblen ST, Schnellmann RG. Rapid Renal Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α by Extracellular Regulated Kinase 1/2 in Physiological and Pathological Conditions. The Journal of Biological Chemistry. PMID 27875304 DOI: 10.1074/Jbc.M116.754762  0.453
2016 Cameron RB, Beeson CC, Schnellmann RG. Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases. Journal of Medicinal Chemistry. PMID 27560192 DOI: 10.1021/Acs.Jmedchem.6B00669  0.465
2016 Harmon J, Gibbs W, Whitaker R, Schnellmann R, Adkins DL. Striatal Mitochondrial Disruption Following Severe Traumatic Brain Injury. Journal of Neurotrauma. PMID 27321815 DOI: 10.1089/Neu.2015.4395  0.42
2016 Smith JA, Mayeux PR, Schnellmann RG. Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis. Critical Care Medicine. PMID 27031380 DOI: 10.1097/CCM.0000000000001672  0.301
2016 Harmon JL, Wills LP, McOmish CE, Demireva EY, Gingrich JA, Beeson CC, Schnellmann RG. 5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. The Journal of Pharmacology and Experimental Therapeutics. PMID 26787771 DOI: 10.1124/Jpet.115.228395  0.485
2015 Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, et al. Suramin protects from cisplatin-induced acute kidney injury. American Journal of Physiology. Renal Physiology. ajprenal.00433.2015. PMID 26661653 DOI: 10.1152/ajprenal.00433.2015  0.388
2015 Whitaker RM, Corum D, Beeson CC, Schnellmann RG. Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases. Annual Review of Pharmacology and Toxicology. PMID 26566156 DOI: 10.1146/Annurev-Pharmtox-010715-103155  0.503
2015 Liu Q, Krishnasamy Y, Rehman H, Lemasters JJ, Schnellmann RG, Zhong Z. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. Plos One. 10: e0140906. PMID 26480480 DOI: 10.1371/Journal.Pone.0140906  0.519
2015 Alhasson F, Dattaroy D, Das S, Chandrashekaran V, Seth RK, Schnellmann RG, Chatterjee S. NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity. American Journal of Physiology. Renal Physiology. ajprenal.00243.2015. PMID 26447219 DOI: 10.1152/ajprenal.00243.2015  0.376
2015 Whitaker RM, Stallons LJ, Kneff JE, Alge JL, Harmon JL, Rahn JJ, Arthur JM, Beeson CC, Chan SL, Schnellmann RG. Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury. Kidney International. PMID 26287315 DOI: 10.1038/Ki.2015.240  0.494
2015 Subathra M, Korrapati M, Howell LA, Arthur JM, Shayman JA, Schnellmann RG, Siskind LJ. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American Journal of Physiology. Renal Physiology. 309: F204-15. PMID 26041445 DOI: 10.1152/Ajprenal.00150.2015  0.327
2015 Wills LP, Beeson GC, Hoover DB, Schnellmann RG, Beeson CC. Assessment of ToxCast Phase II for mitochondrial liabilities using a high-throughput respirometric assay. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 25926417 DOI: 10.1093/Toxsci/Kfv085  0.503
2015 Seremwe M, Schnellmann RG, Bollag WB. Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model. Endocrinology. 156: 2138-49. PMID 25836666 DOI: 10.1210/En.2014-1866  0.357
2015 Liu Q, Rehman H, Krishnasamy Y, Schnellmann RG, Lemasters JJ, Zhong Z. Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice. Journal of Hepatology. 63: 68-74. PMID 25703084 DOI: 10.1016/J.Jhep.2015.02.017  0.302
2015 Whitaker RM, Korrapati MC, Stallons LJ, Jesinkey SR, Arthur JM, Beeson CC, Zhong Z, Schnellmann RG. Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 145: 108-17. PMID 25666834 DOI: 10.1093/Toxsci/Kfv038  0.49
2015 Smith JA, Stallons LJ, Collier JB, Chavin KD, Schnellmann RG. Suppression of mitochondrial biogenesis through toll-like receptor 4-dependent mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling in endotoxin-induced acute kidney injury. The Journal of Pharmacology and Experimental Therapeutics. 352: 346-57. PMID 25503387 DOI: 10.1124/Jpet.114.221085  0.433
2015 Leonard AP, Cameron RB, Speiser JL, Wolf BJ, Peterson YK, Schnellmann RG, Beeson CC, Rohrer B. Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning. Biochimica Et Biophysica Acta. 1853: 348-60. PMID 25447550 DOI: 10.1016/J.Bbamcr.2014.11.002  0.723
2015 Whitaker RM, Stallons LJ, Kneff JE, Alge JL, Harmon JL, Rahn JJ, Arthur JM, Beeson CC, Chan SL, Schnellmann RG. Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury Kidney International. DOI: 10.1038/ki.2015.240  0.401
2014 Jesinkey SR, Korrapati MC, Rasbach KA, Beeson CC, Schnellmann RG. Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice. The Journal of Pharmacology and Experimental Therapeutics. 351: 663-73. PMID 25292181 DOI: 10.1124/Jpet.114.217380  0.769
2014 Smith JA, Stallons LJ, Schnellmann RG. Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury. American Journal of Physiology. Renal Physiology. 307: F435-44. PMID 24990892 DOI: 10.1152/ajprenal.00271.2014  0.414
2014 Garrett SM, Whitaker RM, Beeson CC, Schnellmann RG. Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. The Journal of Pharmacology and Experimental Therapeutics. 350: 257-64. PMID 24849926 DOI: 10.1124/Jpet.114.214700  0.809
2014 Jesinkey SR, Funk JA, Stallons LJ, Wills LP, Megyesi JK, Beeson CC, Schnellmann RG. Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury. Journal of the American Society of Nephrology : Jasn. 25: 1157-62. PMID 24511124 DOI: 10.1681/Asn.2013090952  0.751
2014 Stallons LJ, Whitaker RM, Schnellmann RG. Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis. Toxicology Letters. 224: 326-32. PMID 24275386 DOI: 10.1016/j.toxlet.2013.11.014  0.498
2014 Rehman H, Krishnasamy Y, Haque K, Thurman RG, Lemasters JJ, Schnellmann RG, Zhong Z. Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats. Plos One. 8: e65029. PMID 23755172 DOI: 10.1371/Journal.Pone.0065029  0.423
2013 Stallons LJ, Funk JA, Schnellmann RG. Mitochondrial Homeostasis in Acute Organ Failure. Current Pathobiology Reports. 1. PMID 24386614 DOI: 10.1007/S40139-013-0023-X  0.753
2013 Funk JA, Schnellmann RG. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury. Toxicology and Applied Pharmacology. 273: 345-54. PMID 24096033 DOI: 10.1016/J.Taap.2013.09.026  0.726
2013 Whitaker RM, Wills LP, Stallons LJ, Schnellmann RG. cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury. The Journal of Pharmacology and Experimental Therapeutics. 347: 626-34. PMID 24042162 DOI: 10.1124/jpet.113.208017  0.576
2013 Peterson YK, Cameron RB, Wills LP, Trager RE, Lindsey CC, Beeson CC, Schnellmann RG. β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis. Bioorganic & Medicinal Chemistry Letters. 23: 5376-81. PMID 23954364 DOI: 10.1016/J.Bmcl.2013.07.052  0.786
2013 Wills LP, Beeson GC, Trager RE, Lindsey CC, Beeson CC, Peterson YK, Schnellmann RG. High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury. Toxicology and Applied Pharmacology. 272: 490-502. PMID 23811330 DOI: 10.1016/J.Taap.2013.06.014  0.808
2013 Saunders JE, Beeson CC, Schnellmann RG. Characterization of functionally distinct mitochondrial subpopulations. Journal of Bioenergetics and Biomembranes. 45: 87-99. PMID 23080405 DOI: 10.1007/S10863-012-9478-4  0.498
2012 Smith MA, McInnes C, Whitaker RM, Lindsey CC, Comer RF, Beeson CC, Schnellmann RG. Calpain 10 homology modeling with CYGAK and increased lipophilicity leads to greater potency and efficacy in cells. Acs Chemical Biology. 7: 1410-9. PMID 22612451 DOI: 10.1021/Cb300219H  0.404
2012 Liu Q, Rehman H, Krishnasamy Y, Ramshesh VK, Theruvath TP, Chavin KD, Schnellmann RG, Lemasters JJ, Zhong Z. Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers. Free Radical Biology & Medicine. 53: 250-9. PMID 22609250 DOI: 10.1016/J.Freeradbiomed.2012.05.012  0.397
2012 Eaddy AC, Cummings BS, McHowat J, Schnellmann RG. The role of endoplasmic reticulum Ca2+-independent phospholipase a2γ in oxidant-induced lipid peroxidation, Ca2+ release, and renal cell death. Toxicological Sciences : An Official Journal of the Society of Toxicology. 128: 544-52. PMID 22584685 DOI: 10.1093/Toxsci/Kfs175  0.79
2012 Smith MA, Schnellmann RG. Calpains, mitochondria, and apoptosis. Cardiovascular Research. 96: 32-7. PMID 22581845 DOI: 10.1093/cvr/cvs163  0.54
2012 Smith MA, Covington MD, Schnellmann RG. Loss of calpain 10 causes mitochondrial dysfunction during chronic hyperglycemia. Archives of Biochemistry and Biophysics. 523: 161-8. PMID 22568896 DOI: 10.1016/j.abb.2012.04.020  0.52
2012 Wills LP, Trager RE, Beeson GC, Lindsey CC, Peterson YK, Beeson CC, Schnellmann RG. The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis. The Journal of Pharmacology and Experimental Therapeutics. 342: 106-18. PMID 22490378 DOI: 10.1124/Jpet.112.191528  0.822
2012 Smith MA, Schnellmann RG. Mitochondrial calpain 10 is degraded by Lon protease after oxidant injury. Archives of Biochemistry and Biophysics. 517: 144-52. PMID 22179018 DOI: 10.1016/j.abb.2011.11.023  0.569
2012 Funk JA, Schnellmann RG. Persistent disruption of mitochondrial homeostasis after acute kidney injury. American Journal of Physiology. Renal Physiology. 302: F853-64. PMID 22160772 DOI: 10.1152/Ajprenal.00035.2011  0.743
2012 Evans ZP, Palanisamy AP, Sutter AG, Ellett JD, Ramshesh VK, Attaway H, Schmidt MG, Schnellmann RG, Chavin KD. Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G336-42. PMID 22094601 DOI: 10.1152/Ajpgi.00049.2011  0.434
2012 Covington MD, Schnellmann RG. Chronic high glucose downregulates mitochondrial calpain 10 and contributes to renal cell death and diabetes-induced renal injury. Kidney International. 81: 391-400. PMID 22012129 DOI: 10.1038/ki.2011.356  0.475
2011 Ellett JD, Atkinson C, Evans ZP, Amani Z, Balish E, Schmidt MG, Schnellmann RG, Chavin KD. Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. 17: 1089-98. PMID 21563297 DOI: 10.1002/Lt.22333  0.316
2011 Blum JL, Kinsey GR, Monian P, Sun B, Cummings BS, McHowat J, Schnellmann RG. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. Toxicology in Vitro : An International Journal Published in Association With Bibra. 25: 1001-6. PMID 21443943 DOI: 10.1016/J.Tiv.2011.03.014  0.766
2011 Eaddy AC, Schnellmann RG. Visualization and quantification of endoplasmic reticulum Ca2+ in renal cells using confocal microscopy and Fluo5F. Biochemical and Biophysical Research Communications. 404: 424-7. PMID 21130732 DOI: 10.1016/J.Bbrc.2010.11.137  0.785
2011 Rehman H, Liu Q, Krishnasamy Y, Shi Y, Schnellmann RG, Zhong Z. Daidzein Improves Mitochondrial Biogenesis After Ischemia/Reperfusion and Partial Hepatectomy Gastroenterology. 140: S-950-S-951. DOI: 10.1016/S0016-5085(11)63938-3  0.373
2010 Beeson CC, Beeson GC, Schnellmann RG. A high-throughput respirometric assay for mitochondrial biogenesis and toxicity. Analytical Biochemistry. 404: 75-81. PMID 20465991 DOI: 10.1016/J.Ab.2010.04.040  0.531
2010 Funk JA, Odejinmi S, Schnellmann RG. SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. The Journal of Pharmacology and Experimental Therapeutics. 333: 593-601. PMID 20103585 DOI: 10.1124/Jpet.109.161992  0.754
2010 Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG. 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. The Journal of Pharmacology and Experimental Therapeutics. 332: 632-9. PMID 19875674 DOI: 10.1124/Jpet.109.159947  0.817
2009 Covington MD, Arrington DD, Schnellmann RG. Calpain 10 is required for cell viability and is decreased in the aging kidney. American Journal of Physiology. Renal Physiology. 296: F478-86. PMID 19144693 DOI: 10.1152/Ajprenal.90477.2008  0.797
2009 Rasbach KA, Arrington DD, Odejinmi S, Giguere C, Beeson CC, Schnellmann RG. Identification and optimization of a novel inhibitor of mitochondrial calpain 10. Journal of Medicinal Chemistry. 52: 181-8. PMID 19072163 DOI: 10.1021/Jm800735D  0.802
2009 Zhuang S, Lu B, Daubert RA, Chavin KD, Wang L, Schnellmann RG. Suramin promotes recovery from renal ischemia/reperfusion injury in mice. Kidney International. 75: 304-11. PMID 18843260 DOI: 10.1038/Ki.2008.506  0.38
2008 Rasbach KA, Green PT, Schnellmann RG. Oxidants and Ca+2 induce PGC-1alpha degradation through calpain. Archives of Biochemistry and Biophysics. 478: 130-5. PMID 18718443 DOI: 10.1016/J.Abb.2008.08.003  0.785
2008 Giguere CJ, Schnellmann RG. Limitations of SLLVY-AMC in calpain and proteasome measurements. Biochemical and Biophysical Research Communications. 371: 578-81. PMID 18457661 DOI: 10.1016/j.bbrc.2008.04.133  0.367
2008 Kinsey GR, Blum JL, Covington MD, Cummings BS, McHowat J, Schnellmann RG. Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. Journal of Lipid Research. 49: 1477-87. PMID 18398221 DOI: 10.1194/Jlr.M800030-Jlr200  0.761
2008 Zhuang S, Kinsey GR, Yan Y, Han J, Schnellmann RG. Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells. The Journal of Pharmacology and Experimental Therapeutics. 325: 732-40. PMID 18339970 DOI: 10.1124/Jpet.108.136358  0.779
2008 Hallman MA, Zhuang S, Schnellmann RG. Regulation of dedifferentiation and redifferentiation in renal proximal tubular cells by the epidermal growth factor receptor. The Journal of Pharmacology and Experimental Therapeutics. 325: 520-8. PMID 18270318 DOI: 10.1124/Jpet.107.134031  0.72
2008 Rasbach KA, Schnellmann RG. Isoflavones promote mitochondrial biogenesis. The Journal of Pharmacology and Experimental Therapeutics. 325: 536-43. PMID 18267976 DOI: 10.1124/Jpet.107.134882  0.834
2008 Zhuang S, Kinsey GR, Rasbach K, Schnellmann RG. Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells. American Journal of Physiology. Renal Physiology. 294: F459-68. PMID 18171996 DOI: 10.1152/Ajprenal.00473.2007  0.778
2008 Arrington DD, Schnellmann RG. Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress. American Journal of Physiology. Cell Physiology. 294: C641-50. PMID 18094145 DOI: 10.1152/Ajpcell.00400.2007  0.837
2008 Giguere CJ, Covington MD, Schnellmann RG. Mitochondrial calpain 10 activity and expression in the kidney of multiple species. Biochemical and Biophysical Research Communications. 366: 258-62. PMID 18054326 DOI: 10.1016/j.bbrc.2007.11.133  0.523
2007 Kinsey GR, McHowat J, Patrick KS, Schnellmann RG. Role of Ca2+-independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition. The Journal of Pharmacology and Experimental Therapeutics. 321: 707-15. PMID 17312185 DOI: 10.1124/Jpet.107.119545  0.761
2007 Rasbach KA, Schnellmann RG. PGC-1alpha over-expression promotes recovery from mitochondrial dysfunction and cell injury. Biochemical and Biophysical Research Communications. 355: 734-9. PMID 17307137 DOI: 10.1016/J.Bbrc.2007.02.023  0.84
2007 Rasbach KA, Schnellmann RG. Signaling of mitochondrial biogenesis following oxidant injury. The Journal of Biological Chemistry. 282: 2355-62. PMID 17116659 DOI: 10.1074/Jbc.M608009200  0.828
2007 Lock EA, Reed CJ, Kinsey GR, Schnellmann RG. Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells. Toxicology. 229: 79-90. PMID 17097791 DOI: 10.1016/J.Tox.2006.10.003  0.741
2007 Kinsey GR, McHowat J, Beckett CS, Schnellmann RG. Identification of calcium-independent phospholipase A2gamma in mitochondria and its role in mitochondrial oxidative stress. American Journal of Physiology. Renal Physiology. 292: F853-60. PMID 17047165 DOI: 10.1152/Ajprenal.00318.2006  0.78
2006 Lock EA, Barth JL, Argraves SW, Schnellmann RG. Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene. Toxicology and Applied Pharmacology. 216: 319-30. PMID 16844155 DOI: 10.1016/j.taap.2006.06.002  0.356
2006 Zhuang S, Schnellmann RG. A death-promoting role for extracellular signal-regulated kinase. The Journal of Pharmacology and Experimental Therapeutics. 319: 991-7. PMID 16801453 DOI: 10.1124/jpet.106.107367  0.45
2006 Arrington DD, Van Vleet TR, Schnellmann RG. Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction. American Journal of Physiology. Cell Physiology. 291: C1159-71. PMID 16790502 DOI: 10.1152/Ajpcell.00207.2006  0.833
2005 Zhuang S, Schnellmann RG. Suramin promotes proliferation and scattering of renal epithelial cells. The Journal of Pharmacology and Experimental Therapeutics. 314: 383-90. PMID 15833899 DOI: 10.1124/jpet.104.080648  0.359
2005 Zhuang S, Yan Y, Han J, Schnellmann RG. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. The Journal of Biological Chemistry. 280: 21036-42. PMID 15797859 DOI: 10.1074/jbc.M413300200  0.414
2005 Kinsey GR, Cummings BS, Beckett CS, Saavedra G, Zhang W, McHowat J, Schnellmann RG. Identification and distribution of endoplasmic reticulum iPLA2. Biochemical and Biophysical Research Communications. 327: 287-93. PMID 15629460 DOI: 10.1016/J.Bbrc.2004.12.016  0.741
2004 Cummings BS, Schnellmann RG. Measurement of cell death in mammalian cells. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit 12.8. PMID 22294120 DOI: 10.1002/0471141755.Ph1208S25  0.301
2004 Zhuang S, Dang Y, Schnellmann RG. Requirement of the epidermal growth factor receptor in renal epithelial cell proliferation and migration. American Journal of Physiology. Renal Physiology. 287: F365-72. PMID 15213065 DOI: 10.1152/ajprenal.00035.2004  0.37
2004 Cummings BS, Gelasco AK, Kinsey GR, McHowat J, Schnellmann RG. Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress. Journal of the American Society of Nephrology : Jasn. 15: 1441-51. PMID 15153555 DOI: 10.1097/01.Asn.0000127923.57438.Ec  0.731
2004 Zhuang S, Schnellmann RG, Zhougang S. H2O2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells. American Journal of Physiology. Renal Physiology. 286: F858-65. PMID 15075181 DOI: 10.1152/ajprenal.00282.2003  0.355
2004 Cummings BS, Kinsey GR, Bolchoz LJ, Schnellmann RG. Identification of caspase-independent apoptosis in epithelial and cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 310: 126-34. PMID 15028782 DOI: 10.1124/Jpet.104.065862  0.715
2004 Liu X, Van Vleet T, Schnellmann RG. The role of calpain in oncotic cell death. Annual Review of Pharmacology and Toxicology. 44: 349-70. PMID 14744250 DOI: 10.1146/annurev.pharmtox.44.101802.121804  0.425
2004 Cummings BS, McHowat J, Schnellmann RG. Role of an endoplasmic reticulum Ca2+-independent phospholipase A2 in cisplatin-induced renal cell apoptosis. The Journal of Pharmacology and Experimental Therapeutics. 308: 921-8. PMID 14634037 DOI: 10.1124/Jpet.103.060541  0.319
2003 Van Vleet TR, Schnellmann RG. Toxic nephropathy: environmental chemicals. Seminars in Nephrology. 23: 500-8. PMID 13680539 DOI: 10.1016/S0270-9295(03)00094-9  0.361
2002 Cummings BS, McHowat J, Schnellmann RG. Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death. American Journal of Physiology. Renal Physiology. 283: F492-8. PMID 12167600 DOI: 10.1152/Ajprenal.00022.2002  0.444
2002 Liu X, Harriman JF, Schnellmann RG. Cytoprotective properties of novel nonpeptide calpain inhibitors in renal cells. The Journal of Pharmacology and Experimental Therapeutics. 302: 88-94. PMID 12065704 DOI: 10.1124/jpet.302.1.88  0.353
2002 Cummings BS, Schnellmann RG. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. The Journal of Pharmacology and Experimental Therapeutics. 302: 8-17. PMID 12065694 DOI: 10.1124/Jpet.302.1.8  0.338
2001 Liu X, Rainey JJ, Harriman JF, Schnellmann RG. Calpains mediate acute renal cell death: role of autolysis and translocation. American Journal of Physiology. Renal Physiology. 281: F728-38. PMID 11553520  0.343
2000 Nowak G, Carter CA, Schnellmann RG. Ascorbic acid promotes recovery of cellular functions following toxicant-induced injury. Toxicology and Applied Pharmacology. 167: 37-45. PMID 10936077 DOI: 10.1006/taap.2000.8986  0.301
1999 Sarang SS, Miller GW, Grant DF, Schnellmann RG. Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys. Nephron. 82: 254-60. PMID 10395998 DOI: 10.1159/000045410  0.429
1998 Schnellmann RG, Williams SW. Proteases in renal cell death: calpains mediate cell death produced by diverse toxicants. Renal Failure. 20: 679-86. PMID 9768434 DOI: 10.3109/08860229809045162  0.339
1998 Waters SL, Schnellmann RG. Examination of the mechanisms of action of diverse cytoprotectants in renal cell death. Toxicologic Pathology. 26: 58-63. PMID 9502388  0.369
1997 Waters SL, Miller GW, Aleo MD, Schnellmann RG. Neurosteroid inhibition of cell death. American Journal of Physiology. Renal Physiology. 273: F869-F876. PMID 29586117 DOI: 10.1152/ajprenal.1997.273.6.F869  0.511
1997 Waters SL, Miller GW, Aleo MD, Schnellmann RG. Neurosteroid inhibition of cell death. The American Journal of Physiology. 273: F869-76. PMID 9435674 DOI: 10.1152/Ajprenal.1997.273.6.F869  0.546
1997 Waters SL, Sarang SS, Wang KK, Schnellmann RG. Calpains mediate calcium and chloride influx during the late phase of cell injury. The Journal of Pharmacology and Experimental Therapeutics. 283: 1177-84. PMID 9399991  0.305
1997 Waters SL, Wong JK, Schnellmann RG. Depletion of endoplasmic reticulum calcium stores protects against hypoxia- and mitochondrial inhibitor-induced cellular injury and death. Biochemical and Biophysical Research Communications. 240: 57-60. PMID 9367881 DOI: 10.1006/bbrc.1997.7606  0.327
1997 Moran JH, Weise R, Schnellmann RG, Freeman JP, Grant DF. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. Toxicology and Applied Pharmacology. 146: 53-9. PMID 9299596 DOI: 10.1006/Taap.1997.8197  0.331
1995 Miller GW, Schnellmann RG. Inhibitors of renal chloride transport do not block toxicant-induced chloride influx in the proximal tubule. Toxicology Letters. 76: 179-84. PMID 7725349 DOI: 10.1016/0378-4274(94)03224-U  0.546
1994 Miller GW, Lock EA, Schnellmann RG. Strychnine and glycine protect renal proximal tubules from various nephrotoxicants and act in the late phase of necrotic cell injury. Toxicology and Applied Pharmacology. 125: 192-7. PMID 8171427 DOI: 10.1006/taap.1994.1064  0.467
1994 Miller GW, Schnellmann RG. A putative cytoprotective receptor in the kidney: relation to the neuronal strychnine-sensitive glycine receptor. Life Sciences. 55: 27-34. PMID 8015346 DOI: 10.1016/0024-3205(94)90078-7  0.496
1994 Schnellmann RG, Yang X, Carrick JB. Arachidonic acid release in renal proximal tubule cell injuries and death. Journal of Biochemical Toxicology. 9: 211-7. PMID 7853355  0.321
1993 Rodeheaver DP, Schnellmann RG. Extracellular acidosis ameliorates metabolic-inhibitor-induced and potentiates oxidant-induced cell death in renal proximal tubules. The Journal of Pharmacology and Experimental Therapeutics. 265: 1355-60. PMID 8510014  0.417
1993 Miller GW, Schnellmann RG. Cytoprotection by inhibition of chloride channels: the mechanism of action of glycine and strychnine. Life Sciences. 53: 1211-5. PMID 8412478 DOI: 10.1016/0024-3205(93)90539-F  0.481
1993 Miller GW, Schnellmann RG. A novel low-affinity strychnine binding site on renal proximal tubules: role in toxic cell death. Life Sciences. 53: 1203-9. PMID 8412477 DOI: 10.1016/0024-3205(93)90538-E  0.454
1993 Schnellmann RG, Swagler AR, Compton MM. Absence of endonuclease activation during acute cell death in renal proximal tubules. The American Journal of Physiology. 265: C485-90. PMID 8396329  0.385
1992 Aleo MD, Schnellmann RG. The neurotoxicants strychnine and bicuculline protect renal proximal tubules from mitochondrial inhibitor-induced cell death. Life Sciences. 51: 1783-7. PMID 1331642 DOI: 10.1016/0024-3205(92)90048-T  0.304
1991 Aleo MD, Rankin GO, Cross TJ, Schnellmann RG. Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria. Chemico-Biological Interactions. 78: 109-21. PMID 2009578 DOI: 10.1016/0009-2797(91)90107-I  0.359
1991 Aleo MD, Wyatt RD, Schnellmann RG. Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat renal proximal tubules. Toxicology and Applied Pharmacology. 107: 73-80. PMID 1987662 DOI: 10.1016/0041-008X(91)90332-9  0.35
1991 Schnellmann RG. Renal mitochondrial glutathione transport. Life Sciences. 49: 393-8. PMID 1857187 DOI: 10.1016/0024-3205(91)90447-J  0.39
1991 Aleo MD, Wyatt RD, Schnellmann RG. The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. Toxicology and Applied Pharmacology. 109: 455-63. PMID 1853344 DOI: 10.1016/0041-008X(91)90008-3  0.37
1991 Groves CE, Schnellmann RG, Sokol PP, Steffens TG, Lock EA. Pentachlorobutadienyl-L-cysteine (PCBC) toxicity: the importance of mitochondrial dysfunction. Journal of Biochemical Toxicology. 6: 253-60. PMID 1774769  0.45
1990 Schnellmann RG. The cellular effects of a unique pesticide sulfluramid (N-ethylperfluorooctane sulphonamide) on rabbit renal proximal tubules. Toxicology in Vitro : An International Journal Published in Association With Bibra. 4: 71-4. PMID 20702287 DOI: 10.1016/0887-2333(90)90012-I  0.319
1990 Lock EA, Schnellmann RG. The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. Toxicology and Applied Pharmacology. 104: 180-90. PMID 2360207 DOI: 10.1016/0041-008X(90)90293-4  0.325
1989 Schnellmann RG. 2-Bromohydroquinone-induced toxicity to rabbit renal proximal tubules: evidence against oxidative stress. Toxicology and Applied Pharmacology. 99: 11-8. PMID 2727993 DOI: 10.1016/0041-008X(89)90106-3  0.366
1989 Schnellmann RG, Monks TJ, Mandel LJ, Lau SS. 2-Bromohydroquinone-induced toxicity to rabbit renal proximal tubules: the role of biotransformation, glutathione, and covalent binding. Toxicology and Applied Pharmacology. 99: 19-27. PMID 2567073 DOI: 10.1016/0041-008X(89)90107-5  0.376
1989 Schnellmann RG, Cross TJ, Lock EA. Pentachlorobutadienyl-L-cysteine uncouples oxidative phosphorylation by dissipating the proton gradient. Toxicology and Applied Pharmacology. 100: 498-505. PMID 2551076 DOI: 10.1016/0041-008X(89)90297-4  0.379
1988 Schnellmann RG. Mechanisms of t-butyl hydroperoxide-induced toxicity to rabbit renal proximal tubules. The American Journal of Physiology. 255: C28-33. PMID 3389399  0.356
1988 Schnellmann RG, Gilchrist SM, Mandel LJ. Intracellular distribution and depletion of glutathione in rabbit renal proximal tubules. Kidney International. 34: 229-33. PMID 3184599 DOI: 10.1038/Ki.1988.169  0.443
1987 Schnellmann RG, Lock EA, Mandel LJ. A mechanism of S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine toxicity to rabbit renal proximal tubules. Toxicology and Applied Pharmacology. 90: 513-21. PMID 3660416 DOI: 10.1016/0041-008X(87)90143-8  0.435
1987 Schnellmann RG, Ewell FP, Sgambati M, Mandel LJ. Mitochondrial toxicity of 2-bromohydroquinone in rabbit renal proximal tubules. Toxicology and Applied Pharmacology. 90: 420-6. PMID 3660411 DOI: 10.1016/0041-008X(87)90134-7  0.438
1986 Wiersma DA, Schnellmann RG, Sipes IG. The in vitro metabolism and bioactivation of 1,2-dibromoethane (ethylene dibromide) by human liver. Journal of Biochemical Toxicology. 1: 1-11. PMID 3271877 DOI: 10.1002/Jbt.2570010302  0.311
1986 Schnellmann RG, Mandel LJ. Cellular toxicity of bromobenzene and bromobenzene metabolites to rabbit proximal tubules: the role and mechanism of 2-bromohydroquinone. The Journal of Pharmacology and Experimental Therapeutics. 237: 456-61. PMID 3009785  0.31
1985 Schnellmann RG, Mandel LJ. Intracellular compartmentation of glutathione in rabbit renal proximal tubules. Biochemical and Biophysical Research Communications. 133: 1001-5. PMID 4084299 DOI: 10.1016/0006-291X(85)91235-5  0.414
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