Patrick Aebischer - Publications

Affiliations: 
1984-1992 Medical Sciences Brown University, Providence, RI 
 1999- École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 

190 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lei H, Dirren E, Poitry-Yamate C, Schneider BL, Gruetter R, Aebischer P. Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18756499. PMID 29400109 DOI: 10.1177/0271678X18756499  0.64
2016 Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. PMID 27400265 DOI: 10.1038/nm.4132  0.68
2016 Lathuilière A, Laversenne V, Astolfo A, Kopetzki E, Jacobsen H, Stampanoni M, Bohrmann B, Schneider BL, Aebischer P. A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies. Brain : a Journal of Neurology. PMID 26956423 DOI: 10.1093/brain/aww036  0.68
2016 Brys I, Bobela W, Schneider BL, Aebischer P, Fuentes R. Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease. The International Journal of Neuroscience. 1-9. PMID 26856727 DOI: 10.3109/00207454.2016.1138296  0.68
2015 Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, et al. In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons. Cell Metabolism. PMID 26698914 DOI: 10.1016/j.cmet.2015.10.010  0.68
2015 Sotelo-Hitschfeld T, Niemeyer MI, Mächler P, Ruminot I, Lerchundi R, Wyss MT, Stobart J, Fernández-Moncada I, Valdebenito R, Garrido-Gerter P, Contreras-Baeza Y, Schneider BL, Aebischer P, Lengacher S, San Martín A, et al. Channel-mediated lactate release by K⁺-stimulated astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4168-78. PMID 25762664 DOI: 10.1523/JNEUROSCI.5036-14.2015  0.68
2015 Dirren E, Aebischer J, Rochat C, Towne C, Schneider BL, Aebischer P. SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice. Annals of Clinical and Translational Neurology. 2: 167-84. PMID 25750921 DOI: 10.1002/acn3.162  0.64
2015 Yang S, Cacquevel M, Saksida LM, Bussey TJ, Schneider BL, Aebischer P, Melani R, Pizzorusso T, Fawcett JW, Spillantini MG. Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology. Experimental Neurology. 265: 48-58. PMID 25483398 DOI: 10.1016/j.expneurol.2014.11.013  0.68
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab1996  0.68
2014 Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, et al. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Human Molecular Genetics. 23: 4887-905. PMID 24794857 DOI: 10.1093/hmg/ddu202  0.68
2014 Kaplan A, Spiller KJ, Towne C, Kanning KC, Choe GT, Geber A, Akay T, Aebischer P, Henderson CE. Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration. Neuron. 81: 333-48. PMID 24462097 DOI: 10.1016/j.neuron.2013.12.009  0.68
2014 Lathuilière A, Bohrmann B, Kopetzki E, Schweitzer C, Jacobsen H, Moniatte M, Aebischer P, Schneider BL. Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation. Biomaterials. 35: 792-802. PMID 24344356 DOI: 10.1016/j.biomaterials.2013.10.026  0.68
2014 Dirren E, Towne CL, Setola V, Redmond DE, Schneider BL, Aebischer P. Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cord. Human Gene Therapy. 25: 109-20. PMID 24191919 DOI: 10.1089/hum.2013.021  0.68
2014 Lathuilière A, Cosson S, Lutolf MP, Schneider BL, Aebischer P. A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells. Biomaterials. 35: 779-91. PMID 24103654 DOI: 10.1016/j.biomaterials.2013.09.071  0.68
2014 Aebischer P. Forword Industrial Scale Suspension Culture of Living Cells. v-vi.  0.68
2013 Oueslati A, Schneider BL, Aebischer P, Lashuel HA. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: E3945-54. PMID 23983262 DOI: 10.1073/pnas.1309991110  0.68
2013 Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1602-10. PMID 23712039 DOI: 10.1038/mt.2013.108  0.68
2013 Kunze A, Lengacher S, Dirren E, Aebischer P, Magistretti PJ, Renaud P. Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 964-75. PMID 23695230 DOI: 10.1039/c3ib40022k  0.68
2013 Löw K, Aebischer P, Schneider BL. Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Human Gene Therapy. 24: 613-29. PMID 23600720 DOI: 10.1089/hum.2012.174  0.68
2013 Dassie E, Andrews MR, Bensadoun JC, Cacquevel M, Schneider BL, Aebischer P, Wouters FS, Richardson JC, Hussain I, Howlett DR, Spillantini MG, Fawcett JW. Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. Neurobiology of Aging. 34: 1355-68. PMID 23273572 DOI: 10.1016/j.neurobiolaging.2012.11.011  0.68
2013 Coune PG, Craveiro M, Gaugler MN, Mlynárik V, Schneider BL, Aebischer P, Gruetter R. An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker. Nmr in Biomedicine. 26: 43-50. PMID 22711560 DOI: 10.1002/nbm.2817  0.68
2012 Coune PG, Schneider BL, Aebischer P. Parkinson's disease: gene therapies. Cold Spring Harbor Perspectives in Medicine. 2: a009431. PMID 22474617 DOI: 10.1101/cshperspect.a009431  0.68
2012 Mlynárik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R. Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: S87-99. PMID 22451319 DOI: 10.3233/JAD-2012-112072  0.68
2012 Pinzer BR, Cacquevel M, Modregger P, McDonald SA, Bensadoun JC, Thuering T, Aebischer P, Stampanoni M. Imaging brain amyloid deposition using grating-based differential phase contrast tomography. Neuroimage. 61: 1336-46. PMID 22450300 DOI: 10.1016/j.neuroimage.2012.03.029  0.68
2012 Gaugler MN, Genc O, Bobela W, Mohanna S, Ardah MT, El-Agnaf OM, Cantoni M, Bensadoun JC, Schneggenburger R, Knott GW, Aebischer P, Schneider BL. Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta Neuropathologica. 123: 653-69. PMID 22361813 DOI: 10.1007/s00401-012-0963-y  0.68
2012 Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of Biological Chemistry. 287: 15345-64. PMID 22315227 DOI: 10.1074/jbc.M111.318949  0.68
2012 Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA. Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1536-44. PMID 22302797 DOI: 10.1523/JNEUROSCI.3784-11.2012  0.68
2012 Aebischer P. Philanthropy: The price of charity. Nature. 481: 260. PMID 22258589 DOI: 10.1038/481260a  0.68
2012 Ciron C, Lengacher S, Dusonchet J, Aebischer P, Schneider BL. Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function. Human Molecular Genetics. 21: 1861-76. PMID 22246294 DOI: 10.1093/hmg/ddr618  0.68
2012 Löw K, Aebischer P. Use of viral vectors to create animal models for Parkinson's disease. Neurobiology of Disease. 48: 189-201. PMID 22227451 DOI: 10.1016/j.nbd.2011.12.038  0.68
2011 Coune PG, Bensadoun JC, Aebischer P, Schneider BL. Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. Journal of Parkinson's Disease. 1: 373-87. PMID 23939344 DOI: 10.3233/JPD-2011-11058  0.68
2011 Marroquin Belaunzaran O, Cordero MI, Setola V, Bianchi S, Galli C, Bouche N, Mlynarik V, Gruetter R, Sandi C, Bensadoun JC, Molinari M, Aebischer P. Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool. Plos One. 6: e18268. PMID 21533130 DOI: 10.1371/journal.pone.0018268  0.68
2011 Dusonchet J, Kochubey O, Stafa K, Young SM, Zufferey R, Moore DJ, Schneider BL, Aebischer P. A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 907-12. PMID 21248115 DOI: 10.1523/JNEUROSCI.5092-10.2011  0.68
2011 Towne C, Setola V, Schneider BL, Aebischer P. Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 274-83. PMID 21102563 DOI: 10.1038/mt.2010.260  0.68
2010 Langou K, Moumen A, Pellegrino C, Aebischer J, Medina I, Aebischer P, Raoul C. AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway. Journal of Neurochemistry. 114: 795-809. PMID 20477942 DOI: 10.1111/j.1471-4159.2010.06806.x  0.68
2010 Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3184-98. PMID 20203178 DOI: 10.1523/JNEUROSCI.5922-09.2010  0.68
2010 Duplan L, Bernard N, Casseron W, Dudley K, Thouvenot E, Honnorat J, Rogemond V, De Bovis B, Aebischer P, Marin P, Raoul C, Henderson CE, Pettmann B. Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 785-96. PMID 20071543 DOI: 10.1523/JNEUROSCI.5411-09.2010  0.68
2010 Towne C, Schneider BL, Kieran D, Redmond DE, Aebischer P. Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6. Gene Therapy. 17: 141-6. PMID 19727139 DOI: 10.1038/gt.2009.119  0.68
2009 Towne C, Pertin M, Beggah AT, Aebischer P, Decosterd I. Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery. Molecular Pain. 5: 52. PMID 19737386 DOI: 10.1186/1744-8069-5-52  0.68
2009 Mastroeni R, Bensadoun JC, Charvin D, Aebischer P, Pujol A, Raoul C. Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model. Annals of Neurology. 66: 117-22. PMID 19670442 DOI: 10.1002/ana.21677  0.68
2009 Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P. Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. Neurobiology of Disease. 36: 303-11. PMID 19660547 DOI: 10.1016/j.nbd.2009.07.022  0.68
2009 Ulusoy A, Sahin G, Björklund T, Aebischer P, Kirik D. Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1574-84. PMID 19584816 DOI: 10.1038/mt.2009.142  0.68
2009 Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiology of Disease. 35: 385-98. PMID 19505575 DOI: 10.1016/j.nbd.2009.05.023  0.68
2009 Towne C, Aebischer P. Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi. Methods in Molecular Biology (Clifton, N.J.). 555: 87-108. PMID 19495690 DOI: 10.1007/978-1-60327-295-7_7  0.68
2009 Redmond DE, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR. Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF. The Journal of Comparative Neurology. 515: 31-40. PMID 19399891 DOI: 10.1002/cne.22028  0.68
2009 Dusonchet J, Bensadoun JC, Schneider BL, Aebischer P. Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease. Neurobiology of Disease. 35: 32-41. PMID 19348945 DOI: 10.1016/j.nbd.2009.03.013  0.68
2009 Barde I, Laurenti E, Verp S, Groner AC, Towne C, Padrun V, Aebischer P, Trumpp A, Trono D. Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications. Journal of Virology. 83: 5574-80. PMID 19279087 DOI: 10.1128/JVI.00001-09  0.68
2009 Blockeel C, Mock P, Verheyen G, Bouche N, Le Goff P, Heyman Y, Wrenzycki C, Höffmann K, Niemann H, Haentjens P, de Los Santos MJ, Fernandez-Sanchez M, Velasco M, Aebischer P, Devroey P, et al. An in vivo culture system for human embryos using an encapsulation technology: a pilot study. Human Reproduction (Oxford, England). 24: 790-6. PMID 19273881 DOI: 10.1093/humrep/dep005  0.68
2009 Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P. Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease. Human Molecular Genetics. 18: 872-87. PMID 19074459 DOI: 10.1093/hmg/ddn417  0.68
2009 Perrin V, Dufour N, Raoul C, Hassig R, Brouillet E, Aebischer P, Luthi-Carter R, Déglon N. Implication of the JNK pathway in a rat model of Huntington's disease. Experimental Neurology. 215: 191-200. PMID 19022249 DOI: 10.1016/j.expneurol.2008.10.008  0.68
2009 McDonald A, Marone F, Hintermüller C, J-C Bensadoun, Aebischer P, Stampanoni M. High-throughput, high-resolution X-ray phase contrast tomographic microscopy for visualisation of soft tissue Journal of Physics: Conference Series. 186. DOI: 10.1088/1742-6596/186/1/012043  0.68
2008 Runne H, Régulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Déglon N, Luthi-Carter R. Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9723-31. PMID 18815258 DOI: 10.1523/JNEUROSCI.3044-08.2008  0.68
2008 Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 2002-10. PMID 18797452 DOI: 10.1038/mt.2008.197  0.68
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/JCI35781  0.68
2008 Schneider B, Zufferey R, Aebischer P. Viral vectors, animal models and new therapies for Parkinson's disease. Parkinsonism & Related Disorders. 14: S169-71. PMID 18585946 DOI: 10.1016/j.parkreldis.2008.04.024  0.68
2008 Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN. GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. Cell Transplantation. 17: 383-95. PMID 18522241  0.68
2008 Szulc J, Aebischer P. Conditional gene expression and knockdown using lentivirus vectors encoding shRNA. Methods in Molecular Biology (Clifton, N.J.). 434: 291-309. PMID 18470652 DOI: 10.1007/978-1-60327-248-3_18  0.68
2008 Towne C, Raoul C, Schneider BL, Aebischer P. Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1018-25. PMID 18414477 DOI: 10.1038/mt.2008.73  0.68
2008 Bauer M, Szulc J, Meyer M, Jensen CH, Terki TA, Meixner A, Kinkl N, Gasser T, Aebischer P, Ueffing M. Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons. Journal of Neurochemistry. 104: 1101-15. PMID 17986227 DOI: 10.1111/j.1471-4159.2007.05037.x  0.68
2008 Schneider BL, Gaugler MN, Aebischer P. Viral Vectors. A Potent Approach to Generate Genetic Models of Parkinson's Disease Parkinson's Disease. 269-284. DOI: 10.1016/B978-0-12-374028-1.00020-8  0.68
2007 Aebischer P, Kato AC. Playng defense against Lou Gehrig's disease. Scientific American. 297: 86-93. PMID 17990828  0.68
2007 Wiznerowicz M, Jakobsson J, Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P, Trono D. The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis. The Journal of Biological Chemistry. 282: 34535-41. PMID 17893143 DOI: 10.1074/jbc.M705898200  0.68
2007 Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. Plos One. 2: e689. PMID 17668067 DOI: 10.1371/journal.pone.0000689  0.68
2007 Palfi S, Brouillet E, Jarraya B, Bloch J, Jan C, Shin M, Condé F, Li XJ, Aebischer P, Hantraye P, Déglon N. Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1444-51. PMID 17505477 DOI: 10.1038/sj.mt.6300185  0.68
2007 Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN. Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. Journal of Neuroscience Methods. 163: 338-49. PMID 17397931 DOI: 10.1016/j.jneumeth.2007.02.022  0.68
2007 Perrin V, Régulier E, Abbas-Terki T, Hassig R, Brouillet E, Aebischer P, Luthi-Carter R, Déglon N. Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 903-11. PMID 17375066 DOI: 10.1038/mt.sj.6300141  0.68
2007 Consiglio A, Martino S, Dolcetta D, Cusella G, Conese M, Marchesini S, Benaglia G, Wrabetz L, Orlacchio A, Déglon N, Aebischer P, Severini GM, Bordignon C. Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts. Journal of the Neurological Sciences. 255: 7-16. PMID 17341424 DOI: 10.1016/j.jns.2007.01.010  0.68
2007 Schneider BL, Seehus CR, Capowski EE, Aebischer P, Zhang SC, Svendsen CN. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Human Molecular Genetics. 16: 651-66. PMID 17309880 DOI: 10.1093/hmg/ddm008  0.68
2006 Bensadoun JC, Aebischer P. Viral vectors as a tool to model and treat Parkinson's disease. Wiener Klinische Wochenschrift. 118: 568-70. PMID 17136329 DOI: 10.1007/s00508-006-0736-5  0.68
2006 Arango M, Holbert S, Zala D, Brouillet E, Pearson J, Régulier E, Thakur AK, Aebischer P, Wetzel R, Déglon N, Néri C. CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4649-59. PMID 16641246 DOI: 10.1523/JNEUROSCI.5409-05.2006  0.68
2006 Raoul C, Buhler E, Sadeghi C, Jacquier A, Aebischer P, Pettmann B, Henderson CE, Haase G. Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Proceedings of the National Academy of Sciences of the United States of America. 103: 6007-12. PMID 16581901 DOI: 10.1073/pnas.0508774103  0.48
2006 Pardo R, Colin E, Régulier E, Aebischer P, Déglon N, Humbert S, Saudou F. Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1635-45. PMID 16452687 DOI: 10.1523/JNEUROSCI.3706-05.2006  0.68
2006 Szulc J, Wiznerowicz M, Sauvain MO, Trono D, Aebischer P. A versatile tool for conditional gene expression and knockdown. Nature Methods. 3: 109-16. PMID 16432520 DOI: 10.1038/nmeth846  0.68
2006 Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Therapy. 13: 379-88. PMID 16355116 DOI: 10.1038/sj.gt.3302679  0.48
2006 Raoul C, Barker SD, Aebischer P. Viral-based modelling and correction of neurodegenerative diseases by RNA interference. Gene Therapy. 13: 487-95. PMID 16319945 DOI: 10.1038/sj.gt.3302690  0.68
2006 Sajadi A, Bensadoun JC, Schneider BL, Lo Bianco C, Aebischer P. Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease. Neurobiology of Disease. 22: 119-29. PMID 16300956 DOI: 10.1016/j.nbd.2005.10.006  0.68
2006 Blanco-Bose WE, Schneider BL, Aebischer P. Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 447-56. PMID 16209937 DOI: 10.1016/j.ymthe.2005.08.010  0.68
2006 Ridet JL, Bensadoun JC, Déglon N, Aebischer P, Zurn AD. Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease. Neurobiology of Disease. 21: 29-34. PMID 16023352 DOI: 10.1016/j.nbd.2005.06.003  0.68
2006 Aebischer P, Wahlberg L, Tresco PA, Winn SR. Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution1 The Biomaterials: Silver Jubilee Compendium. 61-67. DOI: 10.1016/B978-008045154-1.50009-5  0.68
2005 Zala D, Benchoua A, Brouillet E, Perrin V, Gaillard MC, Zurn AD, Aebischer P, Déglon N. Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiology of Disease. 20: 785-98. PMID 16006135 DOI: 10.1016/j.nbd.2005.05.017  0.68
2005 Ahn YH, Bensadoun JC, Aebischer P, Zurn AD, Seiger A, Björklund A, Lindvall O, Wahlberg L, Brundin P, Kaminski Schierle GS. Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor. Brain Research Bulletin. 66: 135-42. PMID 15982530 DOI: 10.1016/j.brainresbull.2005.04.009  0.68
2005 Sajadi A, Bauer M, Thöny B, Aebischer P. Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Journal of Neurochemistry. 93: 1482-6. PMID 15935064 DOI: 10.1111/j.1471-4159.2005.03139.x  0.68
2005 Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, Aebischer P, Svendsen CN. GDNF delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy. 16: 509-21. PMID 15871682 DOI: 10.1089/hum.2005.16.509  0.68
2005 Colin E, Régulier E, Perrin V, Dürr A, Brice A, Aebischer P, Déglon N, Humbert S, Saudou F. Akt is altered in an animal model of Huntington's disease and in patients. The European Journal of Neuroscience. 21: 1478-88. PMID 15845076 DOI: 10.1111/j.1460-9568.2005.03985.x  0.68
2005 Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, Henderson CE, Aebischer P. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nature Medicine. 11: 423-8. PMID 15768028 DOI: 10.1038/nm1207  0.68
2004 Bloch J, Bachoud-Lévi AC, Déglon N, Lefaucheur JP, Winkel L, Palfi S, Nguyen JP, Bourdet C, Gaura V, Remy P, Brugières P, Boisse MF, Baudic S, Cesaro P, Hantraye P, ... Aebischer P, et al. Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study. Human Gene Therapy. 15: 968-75. PMID 15585112 DOI: 10.1089/hum.2004.15.968  0.68
2004 Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 17510-5. PMID 15576511 DOI: 10.1073/pnas.0405313101  0.68
2004 Lo Bianco C, Déglon N, Pralong W, Aebischer P. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiology of Disease. 17: 283-9. PMID 15474365 DOI: 10.1016/j.nbd.2004.06.008  0.68
2004 Zufferey R, Aebischer P. Salivary glands and gene therapy: the mouth waters. Gene Therapy. 11: 1425-6. PMID 15269715 DOI: 10.1038/sj.gt.3302321  0.68
2004 Schwenter F, Schneider BL, Pralong WF, Déglon N, Aebischer P. Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions. Human Gene Therapy. 15: 669-80. PMID 15242527 DOI: 10.1089/1043034041361172  0.68
2004 Guillot S, Azzouz M, Déglon N, Zurn A, Aebischer P. Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice. Neurobiology of Disease. 16: 139-49. PMID 15207271 DOI: 10.1016/j.nbd.2004.01.017  0.68
2004 Régulier E, Zala D, Aebischer P, Déglon N. Lentiviral-mediated gene transfer to model triplet repeat disorders. Methods in Molecular Biology (Clifton, N.J.). 277: 199-213. PMID 15201458 DOI: 10.1385/1-59259-804-8:199  0.68
2004 Kishima H, Poyot T, Bloch J, Dauguet J, Condé F, Dollé F, Hinnen F, Pralong W, Palfi S, Déglon N, Aebischer P, Hantraye P. Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons. Neurobiology of Disease. 16: 428-39. PMID 15193299 DOI: 10.1016/j.nbd.2004.03.012  0.68
2004 Schwenter F, Bouche N, Pralong WF, Aebischer P. In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices. Biomaterials. 25: 3861-8. PMID 15020162 DOI: 10.1016/j.biomaterials.2003.10.030  0.68
2004 Sajadi A, Schneider BL, Aebischer P. Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease. Current Biology : Cb. 14: 326-30. PMID 14972684 DOI: 10.1016/j.cub.2004.01.053  0.68
2004 Zala D, Bensadoun JC, Pereira de Almeida L, Leavitt BR, Gutekunst CA, Aebischer P, Hayden MR, Déglon N. Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. Experimental Neurology. 185: 26-35. PMID 14697316 DOI: 10.1016/j.expneurol.2003.09.002  0.68
2004 Raoul C, Aebischer P. ALS, IGF-1 and gene therapy: 'It's never too late to mend' Gene Therapy. 11: 429-430. DOI: 10.1038/sj.gt.3302204  0.68
2003 Bjerkvig R, Read TA, Vajkoczy P, Aebischer P, Pralong W, Platt S, Melvik JE, Hagen A, Dornish M. Cell therapy using encapsulated cells producing endostatin. Acta Neurochirurgica. Supplement. 88: 137-41. PMID 14531571  0.68
2003 Régulier E, Trottier Y, Perrin V, Aebischer P, Déglon N. Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. Human Molecular Genetics. 12: 2827-36. PMID 12952868 DOI: 10.1093/hmg/ddg305  0.68
2003 Schneider BL, Schwenter F, Pralong WF, Aebischer P. Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 506-14. PMID 12727114 DOI: 10.1016/S1525-0016(03)00055-8  0.68
2003 Kostic C, Chiodini F, Salmon P, Wiznerowicz M, Deglon N, Hornfeld D, Trono D, Aebischer P, Schorderet DF, Munier FL, Arsenijevic Y. Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina. Gene Therapy. 10: 818-21. PMID 12704422 DOI: 10.1038/sj.gt.3301948  0.68
2003 Déglon N, Aubert V, Spertini F, Winkel L, Aebischer P. Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology. Xenotransplantation. 10: 204-13. PMID 12694540 DOI: 10.1034/j.1399-3089.2003.00110.x  0.68
2003 Schwenter F, Déglon N, Aebischer P. Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy. The Journal of Gene Medicine. 5: 246-57. PMID 12666190 DOI: 10.1002/jgm.338  0.68
2003 Bensadoun JC, Pereira de Almeida L, Fine EG, Tseng JL, Déglon N, Aebischer P. Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors. Journal of Controlled Release : Official Journal of the Controlled Release Society. 87: 107-15. PMID 12618027 DOI: 10.1016/S0168-3659(02)00353-X  0.68
2003 Schneider BL, Aebischer P. Cellular implants: pioneers in xenotransplantation? Xenotransplantation. 10: 96-7. PMID 12588642 DOI: 10.1034/j.1399-3089.2003.02086.x  0.68
2002 Abbas-Terki T, Blanco-Bose W, Déglon N, Pralong W, Aebischer P. Lentiviral-mediated RNA interference. Human Gene Therapy. 13: 2197-201. PMID 12542850 DOI: 10.1089/104303402320987888  0.68
2002 Barras FM, Pasche P, Bouche N, Aebischer P, Zurn AD. Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat. Journal of Neuroscience Research. 70: 746-55. PMID 12444596 DOI: 10.1002/jnr.10434  0.68
2002 Régulier E, Pereira de Almeida L, Sommer B, Aebischer P, Déglon N. Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease. Human Gene Therapy. 13: 1981-90. PMID 12427308 DOI: 10.1089/10430340260355383  0.68
2002 Rinsch C, Dupraz P, Schneider BL, Déglon N, Maxwell PH, Ratcliffe PJ, Aebischer P. Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia. Kidney International. 62: 1395-401. PMID 12234311 DOI: 10.1111/j.1523-1755.2002.kid574.x  0.68
2002 Ostenfeld T, Tai YT, Martin P, Déglon N, Aebischer P, Svendsen CN. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. Journal of Neuroscience Research. 69: 955-65. PMID 12205689 DOI: 10.1002/jnr.10396  0.68
2002 Aszmann OC, Korak KJ, Kropf N, Fine E, Aebischer P, Frey M. Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions. Plastic and Reconstructive Surgery. 110: 1066-72. PMID 12198419 DOI: 10.1097/01.PRS.0000020990.82332.43  0.68
2002 Boison D, Huber A, Padrun V, Déglon N, Aebischer P, Möhler H. Seizure suppression by adenosine-releasing cells is independent of seizure frequency. Epilepsia. 43: 788-96. PMID 12180995 DOI: 10.1046/j.1528-1157.2002.33001.x  0.68
2002 Sommer B, Rinsch C, Payen E, Dalle B, Schneider B, Déglon N, Henri A, Beuzard Y, Aebischer P. Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts Molecular Therapy. 6: 155-161. PMID 12161181 DOI: 10.1006/mthe.2002.0646  0.68
2002 Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P. alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 10813-8. PMID 12122208 DOI: 10.1073/pnas.152339799  0.68
2002 Palfi S, Leventhal L, Chu Y, Ma SY, Emborg M, Bakay R, Déglon N, Hantraye P, Aebischer P, Kordower JH. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4942-54. PMID 12077191  0.68
2002 Pericin M, Althage A, Freigang S, Hengartner H, Rolland E, Dupraz P, Thorens B, Aebischer P, Zinkernagel RM. Allogeneic beta-islet cells correct diabetes and resist immune rejection. Proceedings of the National Academy of Sciences of the United States of America. 99: 8203-6. PMID 12060765 DOI: 10.1073/pnas.122241299  0.68
2002 de Almeida LP, Ross CA, Zala D, Aebischer P, Déglon N. Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3473-83. PMID 11978824  0.68
2002 Déglon N, Aebischer P. Lentiviruses as vectors for CNS diseases Current Topics in Microbiology and Immunology. 261: 191-209. PMID 11892248  0.48
2002 Fine EG, Decosterd I, Papaloïzos M, Zurn AD, Aebischer P. GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. The European Journal of Neuroscience. 15: 589-601. PMID 11886440 DOI: 10.1046/j.1460-9568.2002.01892.x  0.68
2001 Bensadoun JC, Pereira de Almeida L, Dréano M, Aebischer P, Déglon N. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome European Journal of Neuroscience. 14: 1753-1761. PMID 11860469 DOI: 10.1046/j.0953-816X.2001.01802.x  0.68
2001 Bloch J, Fine EG, Bouche N, Zurn AD, Aebischer P. Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root Experimental Neurology. 172: 425-432. PMID 11716566 DOI: 10.1006/exnr.2001.7778  0.68
2001 Zurn AD, Widmer HR, Aebischer P. Sustained delivery of GDNF: Towards a treatment for Parkinson's disease Brain Research Reviews. 36: 222-229. PMID 11690619 DOI: 10.1016/S0165-0173(01)00098-4  0.68
2001 Arsenijevic Y, Weiss S, Schneider B, Aebischer P. Insulin-like growth factor-1 is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2 Journal of Neuroscience. 21: 7194-7202. PMID 11549730  0.48
2001 Aebischer P, Ridet JL. Recombinant proteins for neurodegenerative diseases: The delivery issue Trends in Neurosciences. 24: 533-540. PMID 11506887 DOI: 10.1016/S0166-2236(00)01899-3  0.68
2001 De Almeida LP, Zala D, Aebischer P, Déglon N. Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease Neurobiology of Disease. 8: 433-446. PMID 11442352 DOI: 10.1006/nbdi.2001.0388  0.48
2001 Arsenijevic Y, Villemure JG, Brunet JF, Bloch JJ, Déglon N, Kostic C, Zurn A, Aebischer P. Isolation of multipotent neural precursors residing in the cortex of the adult human brain. Experimental Neurology. 170: 48-62. PMID 11421583 DOI: 10.1006/exnr.2001.7691  0.68
2001 Huber A, Padrun V, Déglon N, Aebischer P, Möhler H, Boison D. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy Proceedings of the National Academy of Sciences of the United States of America. 98: 7611-7616. PMID 11404469 DOI: 10.1073/pnas.131102898  0.68
2001 Schneider BL, Peduto G, Aebischer P. A self-immunomodulating myoblast cell line for erythropoietin delivery. Gene Therapy. 8: 58-66. PMID 11402302 DOI: 10.1038/sj.gt.3301356  0.68
2001 Rinsch C, Quinodoz P, Pittet B, Alizadeh N, Baetens D, Montandon D, Aebischer P, Pepper MS. Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia Gene Therapy. 8: 523-533. PMID 11319619 DOI: 10.1038/sj.gt.3301436  0.68
2001 Kordower JH, Aebischer P. Gene therapy to the rescue in Parkinson's disease: Response from Kordower and Aebischer Trends in Pharmacological Sciences. 22: 105-106. PMID 11239562 DOI: 10.1016/S0165-6147(00)01637-0  0.68
2001 Rinsch C, Peduto G, Schneider BL, Aebischer P. Inducing host acceptance to encapsulated xenogeneic myoblasts. Transplantation. 71: 345-51. PMID 11233892  0.68
2001 Bamber NI, Li H, Lu X, Oudega M, Aebischer P, Xu XM. Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels European Journal of Neuroscience. 13: 257-268. PMID 11168530 DOI: 10.1046/j.1460-9568.2001.01387.x  0.68
2001 Emborg ME, Deglon N, Leventhal L, Aebischer P, Kordower JH. Viral vector-mediated gene therapy for Parkinson's disease Clinical Neuroscience Research. 1: 496-506. DOI: 10.1016/S1566-2772(01)00027-5  0.68
2000 Tseng JL, Aebischer P. Encapsulated neural transplants Progress in Brain Research. 127: 189-202. PMID 11142028 DOI: 10.1016/S0079-6123(00)27010-6  0.68
2000 Ridet JL, Déglon N, Aebischer P. Gene transfer techniques for the delivery of GDNF in Parkinson's disease Novartis Foundation Symposium. 231: 202-215. PMID 11131539  0.68
2000 Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen EY, Palfi S, Roitberg BZ, Brown WD, Holden JE, Pyzalski R, Taylor MD, Carvey P, ... ... Aebischer P, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (New York, N.Y.). 290: 767-73. PMID 11052933 DOI: 10.1126/science.290.5492.767  0.68
2000 Zurn AD, Henry H, Schluep M, Aubert V, Winkel L, Eilers B, Bachmann C, Aebischer P. Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells Cell Transplantation. 9: 471-484. PMID 11038064  0.48
2000 Bachoud-Lévi AC, Déglon N, Nguyen JP, Bloch J, Bourdet C, Winkel L, Rémy P, Goddard M, Lefaucheur JP, Brugières P, Baudic S, Cesaro P, Peschanski M, Aebischer P. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Human Gene Therapy. 11: 1723-9. PMID 10954906 DOI: 10.1089/10430340050111377  0.68
2000 Peduto G, Rinsch C, Schneider BL, Rolland E, Aebischer P. Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. Transplantation. 70: 78-85. PMID 10919579  0.68
2000 Hottinger AF, Azzouz M, Deglon N, Aebischer P, Zurn AD. Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus Journal of Neuroscience. 20: 5587-5593. PMID 10908595  0.68
2000 Bensadoun JC, Déglon N, Tseng JL, Ridet JL, Zurn AD, Aebischer P. Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF Experimental Neurology. 164: 15-24. PMID 10877911 DOI: 10.1006/exnr.2000.7409  0.68
2000 Mittoux V, Joseph JM, Conde F, Palfi S, Dautry C, Poyot T, Bloch J, Deglon N, Ouary S, Nimchinsky EA, Brouillet E, Hof PR, Peschanski M, Aebischer P, Hantraye P. Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. Human Gene Therapy. 11: 1177-87. PMID 10834619 DOI: 10.1089/10430340050015220  0.68
2000 Cisterni C, Henderson CE, Aebischer P, Pettmann B, Déglon N. Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors. Journal of Neurochemistry. 74: 1820-8. PMID 10800924 DOI: 10.1046/j.1471-4159.2000.0741820.x  0.68
2000 Azzouz M, Hottinger A, Paterna JC, Zurn AD, Aebischer P, Büeler H. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2 Human Molecular Genetics. 9: 803-811. PMID 10749988  0.68
2000 Schense JC, Bloch J, Aebischer P, Hubbell JA. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension Nature Biotechnology. 18: 415-419. PMID 10748522 DOI: 10.1038/74473  0.68
2000 Déglon N, Tseng JL, Bensadoun JC, Zurn AD, Arsenijevic Y, De Almeida LP, Zufferey R, Trono D, Aebischer P. Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease Human Gene Therapy. 11: 179-190. PMID 10646649 DOI: 10.1089/10430340050016256  0.68
2000 Aebischer P. The contribution of encapsulation to cell therapy European Cytokine Network. 11: 327-328.  0.68
1999 Rinsch C, Schneider BL, Aebischer P. Highlights of the cell transplantation meeting at Montreux, March 1999. Cell Transplantation. 8: 571-6. PMID 10701484  0.68
1999 Boison D, Scheurer L, Tseng JL, Aebischer P, Mohler H. Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer Experimental Neurology. 160: 164-174. PMID 10630201 DOI: 10.1006/exnr.1999.7209  0.68
1999 Kordower JH, Bloch J, Ma SY, Chu Y, Palfi S, Roitberg BZ, Emborg M, Hantraye P, Déglon N, Aebischer P. Lentiviral gene transfer to the nonhuman primate brain. Experimental Neurology. 160: 1-16. PMID 10630186 DOI: 10.1006/exnr.1999.7178  0.48
1999 Fitting JW, Paillex R, Hirt L, Aebischer P, Schluep M. Sniff nasal pressure: A sensitive respiratory test to assess progression of amyotrophic lateral sclerosis Annals of Neurology. 46: 887-893. PMID 10589541 DOI: 10.1002/1531-8249(199912)46:6<887::AID-ANA11>3.0.CO;2-L  0.48
1999 Dalle B, Payen E, Regulier E, Deglon N, Rouyer-Fessard P, Beuzard Y, Aebischer P. Improvement of mouse β-thalassemia upon erythropoietin delivery by encapsulated myoblasts Gene Therapy. 6: 157-161. PMID 10435099 DOI: 10.1038/sj.gt.3300812  0.48
1999 Aebischer P, Hottinger AF, Deglon N. Cellular xenotransplantation [1] Nature Medicine. 5: 852. PMID 10426290  0.68
1999 Hottinger AF, Aebischer P. Treatment of diseases of the central nervous system using encapsulated cells Advances and Technical Standards in Neurosurgery. 25: 3-20. PMID 10370715  0.68
1999 Bamber NI, Li H, Aebischer P, Xu XM. Fetal spinal cord tissue in mini-guidance channels promotes longitudinal axonal growth after grafting into hemisected adult rat spinal cords Neural Plasticity. 6: 103-121. DOI: 10.1155/NP.1999.103  0.68
1999 Makohliso SA, Léonard D, Giovangrandi L, Mathieu HJ, Ilegems M, Aebischer P. Surface characterization of a biochip prototype for cell-based biosensor applications Langmuir. 15: 2940-2946. DOI: 10.1021/la980688h  0.68
1998 Régulier E, Schneider BL, Déglon N, Beuzard Y, Aebischer P. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts Gene Therapy. 5: 1014-1022. PMID 10326023  0.48
1998 Borkenhagen M, Stoll RC, Neuenschwander P, Suter UW, Aebischer P. In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel. Biomaterials. 19: 2155-65. PMID 9884056  0.48
1998 Makohliso SA, Giovangrandi L, Léonard D, Mathieu HJ, Ilegems M, Aebischer P. Application of Teflon-AF® thin films for bio-patterning of neural cell adhesion Biosensors and Bioelectronics. 13: 1227-1235. PMID 9871978 DOI: 10.1016/S0956-5663(98)00036-0  0.48
1998 Décosterd I, Buchser E, Gilliard N, Saydoff J, Zurn AD, Aebischer P. Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain Pain. 76: 159-166. PMID 9696469 DOI: 10.1016/S0304-3959(98)00044-X  0.48
1998 Tseng JL, Bruhn SL, Zurn AD, Aebischer P. Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy. Neuroreport. 9: 1817-22. PMID 9665607  0.68
1998 Borkenhagen M, Clémence JF, Sigrist H, Aebischer P. Three-dimensional extracellular matrix engineering in the nervous system Journal of Biomedical Materials Research. 40: 392-400. PMID 9570070 DOI: 10.1002/(SICI)1097-4636(19980603)40:3<392::AID-JBM8>3.0.CO;2-C  0.48
1998 Vejsada R, Tseng JL, Lindsay RM, Acheson A, Aebischer P, Kato AC. Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons. Neuroscience. 84: 129-39. PMID 9522368 DOI: 10.1016/S0306-4522(97)00497-1  0.48
1998 Sautter J, Tseng JL, Braguglia D, Aebischer P, Spenger C, Seiler RW, Widmer HR, Zurn AD. Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts Experimental Neurology. 149: 230-236. PMID 9454632 DOI: 10.1006/exnr.1997.6718  0.48
1998 Zurn AD, Tseng JL, Déglon N, Joseph JM, Aebischer P. A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease Advances in Pharmacology (San Diego, Calif.). 42: 929-931. PMID 9328050 DOI: 10.1016/S1054-3589(08)60899-6  0.48
1997 Rinsch C, Régulier E, Déglon N, Dalle B, Beuzard Y, Aebischer P. A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension Human Gene Therapy. 8: 1881-1889. PMID 9382954  0.68
1997 Pizzorusso T, Porciatti V, Tseng JL, Aebischer P, Maffei L. Transplant of polymer-encapsulated cells genetically engineered to release nerve growth factor allows a normal functional development of the visual cortex in dark-reared rats. Neuroscience. 80: 307-11. PMID 9284336 DOI: 10.1016/S0306-4522(97)00182-6  0.48
1997 Hottinger AF, Fine EG, Gurney ME, Zurn AD, Aebischer P. The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis. The European Journal of Neuroscience. 9: 1548-51. PMID 9240414 DOI: 10.1111/j.1460-9568.1997.tb01511.x  0.68
1997 Pochon NAM, Menoud A, Tseng JL, Zurn AD, Aebischer P. Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization European Journal of Neuroscience. 9: 463-471. PMID 9104588 DOI: 10.1111/j.1460-9568.1997.tb01623.x  0.68
1997 Tseng JL, Baetge EE, Zurn AD, Aebischer P. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine Journal of Neuroscience. 17: 325-333. PMID 8987758  0.68
1997 Kato AC, Aebischer P. Gene therapies fob the central nervous system | Thérapies géniques pour le système nerveux central Medecine Et Hygiene. 55: 1536-1538.  0.68
1996 Zurn AD, Tseng J, Aebischer P. Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps European Neurology. 36: 405-408. PMID 8954314  0.48
1996 Tan SA, Aebischer P. The problems of delivering neuroactive molecules to the CNS Ciba Foundation Symposia. 211-239. PMID 8866136  0.68
1996 Zum AD, Tseng J, Aebischer P. Symptomatic cell therapies cells as biological minipumps European Neurology. 36: 405-408.  0.68
1996 Borkenhagen M, Clemence JF, Aebischer P. Development of a bioartificial synthetic extracellular matrix-equivalent for nerve regeneration Transactions of the Annual Meeting of the Society For Biomaterials in Conjunction With the International Biomaterials Symposium. 2: 229.  0.68
1996 Makohliso SA, Aebischer P, Giovangrandi L, Buhlmann HJ, Dutoit M. Biomimetic materials approach towards the development of a neural cell-based biosensor Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 81-82.  0.68
1993 Sagen J, Wang H, Tresco PA, Aebischer P. Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2415-23. PMID 7684773  0.68
1992 Tresco PA, Winn SR, Tan S, Jaeger CB, Greene LA, Aebischer P. POLYMER-ENCAPSULATED PC12 CELLS: LONG-TERM SURVIVAL AND ASSOCIATED REDUCTION IN LESION-INDUCED ROTATIONAL BEHAVIOR. Cell Transplantation. 1: 255-264. PMID 28153072  0.68
1992 Winn SR, Tresco PA, Zielinski B, Sagen J, Aebischer P. Microencapsulated bovine chromaffin cells in vitro: effect of density and coseeding with a NGF-releasing cell line. Journal of Neural Transplantation & Plasticity. 3: 115-24. PMID 1515479 DOI: 10.1155/NP.1992.115  0.48
1992 Jaeger CB, Aebischer P, Tresco PA, Winn SR, Greene LA. Growth of tumour cell lines in polymer capsules: ultrastructure of encapsulated PC12 cells. Journal of Neurocytology. 21: 469-80. PMID 1500946 DOI: 10.1007/BF01186951  0.48
1992 Tresco PA, Winn SR, Aebischer P. Polymer encapsulated neurotransmitter secreting cells. Potential treatment for Parkinson's disease. Asaio Journal (American Society For Artificial Internal Organs : 1992). 38: 17-23. PMID 1348191  0.68
1992 Tresco PA, Winn SR, Tan S, Jaeger CB, Greene LA, Aebischer P. Polymer-encapsulated PC12 cells: long-term survival and associated reduction in lesion-induced rotational behavior. Cell Transplantation. 1: 255-64. PMID 1344297  0.68
1991 Aebischer P, Wahlberg L, Tresco PA, Winn SR. Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution. Biomaterials. 12: 50-6. PMID 2009346 DOI: 10.1016/0142-9612(91)90132-T  0.68
1991 Aebischer P, Tresco PA, Winn SR, Greene LA, Jaeger CB. Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line. Experimental Neurology. 111: 269-75. PMID 1999230 DOI: 10.1016/0014-4886(91)90093-R  0.68
1991 Winn SR, Tresco PA, Zielinski B, Greene LA, Jaeger CB, Aebischer P. Behavioral recovery following intrastriatal implantation of microencapsulated PC12 cells. Experimental Neurology. 113: 322-9. PMID 1915723 DOI: 10.1016/0014-4886(91)90022-5  0.68
1991 Jaeger CB, Winn SR, Tresco PA, Aebischer P. Repair of the blood-brain barrier following implantation of polymer capsules. Brain Research. 551: 163-70. PMID 1913150 DOI: 10.1016/0006-8993(91)90929-P  0.68
1991 Aebischer P, Winn SR, Tresco PA, Jaeger CB, Greene LA. Transplantation of polymer encapsulated neurotransmitter secreting cells: effect of the encapsulation technique. Journal of Biomechanical Engineering. 113: 178-83. PMID 1875690  0.48
1991 Aebischer P, Tresco PA, Sagen J, Winn SR. Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats. Brain Research. 560: 43-9. PMID 1760745 DOI: 10.1016/0006-8993(91)91212-J  0.68
1990 Jaeger CB, Greene LA, Tresco PA, Winn SR, Aebischer P. Polymer encapsulated dopaminergic cell lines as "alternative neural grafts". Progress in Brain Research. 82: 41-6. PMID 2290954  0.68
1989 Winn SR, Wahlberg L, Tresco PA, Aebischer P. An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats. Experimental Neurology. 105: 244-50. PMID 2504616 DOI: 10.1016/0014-4886(89)90126-X  0.68
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