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Roger F. Butterworth - Publications

Affiliations: 
Université de Montréal, Montréal, Canada 
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Year Citation  Score
2020 Hazell AS, Butterworth RF. Region-selective permeability of the blood-brain barrier to α-aminoisobutyric acid during thiamine deficiency and following its reversal. Metabolic Brain Disease. PMID 33245475 DOI: 10.1007/s11011-020-00644-w  0.675
2020 Butterworth RF. The Role of Liver Disease in Alcohol-Induced Cognitive Defects. Alcohol Health and Research World. 19: 122-129. PMID 31798087  0.329
2019 Butterworth RF. L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle. Canadian Journal of Gastroenterology & Hepatology. 2019: 8182195. PMID 31183339 DOI: 10.1155/2019/8182195  0.329
2019 Butterworth RF. Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology. Drugs. PMID 30706423 DOI: 10.1007/s40265-018-1017-0  0.442
2018 Butterworth RF, Kircheis G, Hilger N, McPhail MJW. Efficacy of l-Ornithine l-Aspartate for the Treatment of Hepatic Encephalopathy and Hyperammonemia in Cirrhosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Clinical and Experimental Hepatology. 8: 301-313. PMID 30302048 DOI: 10.1016/j.jceh.2018.05.004  0.311
2018 Butterworth RF, Canbay A. Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease. Digestive Diseases (Basel, Switzerland). 1-6. PMID 30016770 DOI: 10.1159/000491429  0.316
2015 Butterworth RF. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26589093 DOI: 10.1016/j.jsbmb.2015.11.006  0.464
2015 Butterworth RF. Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited. Metabolic Brain Disease. PMID 26521983 DOI: 10.1007/s11011-015-9746-1  0.504
2015 Butterworth RF. The concept of "the inflamed brain" in acute liver failure: mechanisms and new therapeutic opportunities. Metabolic Brain Disease. PMID 26481639 DOI: 10.1007/s11011-015-9747-0  0.409
2015 Butterworth RF. Etiology of cirrhosis predicts deterioration of "brain reserve" after hepatic encephalopathy or transjugular intrahepatic portosystemic shunt. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. 21: 1115-6. PMID 26073990 DOI: 10.1002/lt.24193  0.4
2015 Butterworth RF. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure. Journal of Clinical and Experimental Hepatology. 5: S96-S103. PMID 26041966 DOI: 10.1016/j.jceh.2014.02.004  0.492
2015 Bémeur C, Butterworth RF. Reprint of: Nutrition in the Management of Cirrhosis and its Neurological Complications. Journal of Clinical and Experimental Hepatology. 5: S131-40. PMID 26041952 DOI: 10.1016/j.jceh.2015.02.004  0.334
2014 Bémeur C, Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications. Journal of Clinical and Experimental Hepatology. 4: 141-50. PMID 25755550 DOI: 10.1016/j.jceh.2013.05.008  0.334
2014 Butterworth RF. Hepatic encephalopathy in alcoholic cirrhosis. Handbook of Clinical Neurology. 125: 589-602. PMID 25307598 DOI: 10.1016/B978-0-444-62619-6.00034-3  0.392
2014 Butterworth RF. Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine. Molecular Genetics and Metabolism. 113: 113-7. PMID 25034052 DOI: 10.1016/j.ymgme.2014.06.003  0.49
2014 Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E. Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. Cns Drugs. 28: 679-97. PMID 24861337 DOI: 10.1007/S40263-014-0174-2  0.311
2014 Thumburu KK, Dhiman RK, Vasishta RK, Chakraborti A, Butterworth RF, Beauchesne E, Desjardins P, Goyal S, Sharma N, Duseja A, Chawla Y. Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure. Journal of Neurochemistry. 128: 617-27. PMID 24164438 DOI: 10.1111/jnc.12511  0.464
2014 Chastre A, Bélanger M, Nguyen BN, Butterworth RF. Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure. Liver International : Official Journal of the International Association For the Study of the Liver. 34: 353-61. PMID 23910048 DOI: 10.1111/Liv.12252  0.816
2013 Butterworth RF. The liver-brain axis in liver failure: neuroinflammation and encephalopathy. Nature Reviews. Gastroenterology & Hepatology. 10: 522-8. PMID 23817325 DOI: 10.1038/nrgastro.2013.99  0.453
2013 Amodio P, Bemeur C, Butterworth R, Cordoba J, Kato A, Montagnese S, Uribe M, Vilstrup H, Morgan MY. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus. Hepatology (Baltimore, Md.). 58: 325-36. PMID 23471642 DOI: 10.1002/Hep.26370  0.303
2013 Bémeur C, Butterworth RF. Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema. Metabolic Brain Disease. 28: 145-50. PMID 23212479 DOI: 10.1007/s11011-012-9361-3  0.462
2013 Butterworth RF. Parkinsonism in cirrhosis: pathogenesis and current therapeutic options. Metabolic Brain Disease. 28: 261-7. PMID 23086199 DOI: 10.1007/s11011-012-9341-7  0.309
2012 Chastre A, Bélanger M, Beauchesne E, Nguyen BN, Desjardins P, Butterworth RF. Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. Plos One. 7: e49670. PMID 23166746 DOI: 10.1371/Journal.Pone.0049670  0.807
2012 Butterworth RF. Reprint of: Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets. Neurochemistry International. 60: 715-22. PMID 22504574 DOI: 10.1016/j.neuint.2012.03.014  0.449
2012 Ahboucha S, Talani G, Fanutza T, Sanna E, Biggio G, Gamrani H, Butterworth RF. Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy. Neurochemistry International. 61: 48-53. PMID 22490610 DOI: 10.1016/J.Neuint.2012.03.020  0.436
2012 Desjardins P, Du T, Jiang W, Peng L, Butterworth RF. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochemistry International. 60: 690-6. PMID 22382077 DOI: 10.1016/j.neuint.2012.02.001  0.481
2012 Butterworth RF. Brain edema and encephalopathy in acute liver failure: a primary neurogliopathy? Neurochemistry International. 60: 661. PMID 22381564 DOI: 10.1016/j.neuint.2012.02.022  0.451
2012 Dhiman R, Thumburu K, Vasishta R, Chakraborti A, Beauchesne É, Desjardins P, Butterworth R, Goyal S, Duseja A, Chawla Y, Sharma N. Increased Expression of Aquaporin-4 in Perivascular Astrocytes End-Feet Contribute to the Development of Brain Edema in Acute Liver Failure American Journal of Gastroenterology. 107: S161. DOI: 10.14309/00000434-201210001-00380  0.471
2012 Thumburu K, Dhiman R, Vasishta R, Chakraborti A, Beauchesne E, Desjardins P, Butterworth R, Goyal S, Duseja A, Chawla Y, Sharma N. 36 INCREASED EXPRESSION OF AQUAPORIN-4 IN PERIVASCULAR ASTROCYTES END-FEET CONTRIBUTE TO THE DEVELOPMENT OF BRAIN EDEMA IN ACUTE LIVER FAILURE Journal of Clinical and Experimental Hepatology. 2: S22. DOI: 10.1016/S0973-6883(12)60037-1  0.366
2011 Butterworth RF. Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets. Neurochemistry International. 59: 830-6. PMID 21864609 DOI: 10.1016/j.neuint.2011.07.014  0.454
2011 Butterworth RF. Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology (Baltimore, Md.). 53: 1372-6. PMID 21480337 DOI: 10.1002/hep.24228  0.476
2011 Bajaj JS, Cordoba J, Mullen KD, Amodio P, Shawcross DL, Butterworth RF, Morgan MY. Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Alimentary Pharmacology & Therapeutics. 33: 739-47. PMID 21306407 DOI: 10.1111/J.1365-2036.2011.04590.X  0.318
2010 Bémeur C, Desjardins P, Butterworth RF. Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure. Journal of Nutrition and Metabolism. 2010: 489823. PMID 21234351 DOI: 10.1155/2010/489823  0.377
2010 Beauchesne E, Desjardins P, Butterworth RF, Hazell AS. Up-regulation of caveolin-1 and blood-brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency. Neurochemistry International. 57: 830-7. PMID 20816907 DOI: 10.1016/J.Neuint.2010.08.022  0.676
2010 Dhiman RK, Saraswat VA, Sharma BK, Sarin SK, Chawla YK, Butterworth R, Duseja A, Aggarwal R, Amarapurkar D, Sharma P, Madan K, Shah S, Seth AK, Gupta RK, Koshy A, et al. Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver. Journal of Gastroenterology and Hepatology. 25: 1029-41. PMID 20594216 DOI: 10.1111/j.1440-1746.2010.06318.x  0.315
2010 Xue Z, Li B, Gu L, Hu X, Li M, Butterworth RF, Peng L. Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo. Neurochemistry International. 57: 395-403. PMID 20447429 DOI: 10.1016/j.neuint.2010.04.014  0.317
2010 Bémeur C, Vaquero J, Desjardins P, Butterworth RF. N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metabolic Brain Disease. 25: 241-9. PMID 20431929 DOI: 10.1007/s11011-010-9201-2  0.443
2010 Butterworth RF. Metal toxicity, liver disease and neurodegeneration. Neurotoxicity Research. 18: 100-5. PMID 20369313 DOI: 10.1007/s12640-010-9185-z  0.356
2010 Butterworth RF. Altered glial-neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy. Neurochemistry International. 57: 383-8. PMID 20350577 DOI: 10.1016/j.neuint.2010.03.012  0.501
2010 Chastre A, Jiang W, Desjardins P, Butterworth RF. Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. Metabolic Brain Disease. 25: 17-21. PMID 20217200 DOI: 10.1007/S11011-010-9185-Y  0.814
2010 Bémeur C, Desjardins P, Butterworth RF. Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse. Metabolic Brain Disease. 25: 23-9. PMID 20198438 DOI: 10.1007/s11011-010-9186-x  0.421
2010 Bemeur C, Desjardins P, Butterworth RF. Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease. 25: 3-9. PMID 20195724 DOI: 10.1007/s11011-010-9177-y  0.344
2010 Bémeur C, Qu H, Desjardins P, Butterworth RF. IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochemistry International. 56: 213-5. PMID 19931338 DOI: 10.1016/j.neuint.2009.11.010  0.435
2010 Bémeur C, Chastre A, Desjardins P, Butterworth RF. No changes in expression of tight junction proteins or blood-brain barrier permeability in azoxymethane-induced experimental acute liver failure Neurochemistry International. 56: 205-207. DOI: 10.1016/J.Neuint.2009.11.012  0.815
2009 Beauchesne E, Desjardins P, Hazell AS, Butterworth RF. eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain. Journal of Neurochemistry. 111: 452-9. PMID 19686244 DOI: 10.1111/J.1471-4159.2009.06338.X  0.682
2009 Butterworth RF, Norenberg MD, Felipo V, Ferenci P, Albrecht J, Blei AT. Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver International : Official Journal of the International Association For the Study of the Liver. 29: 783-8. PMID 19638106 DOI: 10.1111/J.1478-3231.2009.02034.X  0.408
2009 Butterworth RF, Lalonde R, Power C, Baker GB, Gamrani H, Ahboucha S. Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated rats. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 1319-25. PMID 19594690 DOI: 10.1111/j.1365-2982.2009.01356.x  0.37
2009 Beauchesne E, Desjardins P, Hazell AS, Butterworth RF. Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain. Neurochemistry International. 55: 275-81. PMID 19576514 DOI: 10.1016/J.Neuint.2009.03.014  0.679
2009 Jiang W, Desjardins P, Butterworth RF. Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats. Neurochemistry International. 55: 601-5. PMID 19524003 DOI: 10.1016/j.neuint.2009.06.001  0.473
2009 Jiang W, Desjardins P, Butterworth RF. Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. Neurochemistry International. 55: 124-8. PMID 19428816 DOI: 10.1016/j.neuint.2009.02.007  0.451
2009 Sawara K, Desjardins P, Chatauret N, Kato A, Suzuki K, Butterworth RF. Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure. Neurochemistry International. 55: 119-23. PMID 19428815 DOI: 10.1016/j.neuint.2009.01.023  0.483
2009 Tshala-Katumbay D, Desjardins P, Sabri M, Butterworth R, Spencer P. New insights into mechanisms of gamma-diketone-induced axonopathy. Neurochemical Research. 34: 1919-23. PMID 19404740 DOI: 10.1007/S11064-009-9977-9  0.307
2009 Jiang W, Desjardins P, Butterworth RF. Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 944-52. PMID 19259110 DOI: 10.1038/jcbfm.2009.18  0.443
2009 Jiang W, Desjardins P, Butterworth RF. Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. Journal of Neurochemistry. 109: 485-93. PMID 19220703 DOI: 10.1111/j.1471-4159.2009.05981.x  0.467
2009 Hazell AS, Butterworth RF. Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol and Alcoholism (Oxford, Oxfordshire). 44: 141-7. PMID 19151161 DOI: 10.1093/Alcalc/Agn120  0.65
2009 Butterworth RF. Thiamine deficiency-related brain dysfunction in chronic liver failure. Metabolic Brain Disease. 24: 189-96. PMID 19067139 DOI: 10.1007/s11011-008-9129-y  0.473
2008 Butterworth RF. Pathophysiology of hepatic encephalopathy: The concept of synergism. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 38: S116-21. PMID 19125942 DOI: 10.1111/j.1872-034X.2008.00436.x  0.456
2008 Navarro D, Zwingmann C, Butterworth RF. Impaired oxidation of branched-chain amino acids in the medial thalamus of thiamine-deficient rats. Metabolic Brain Disease. 23: 445-55. PMID 18773288 DOI: 10.1007/s11011-008-9105-6  0.439
2008 Watanabe Y, Kato A, Sawara K, Butterworth RF, Sasaki T, Terasaki K, Sera K, Suzuki K. Selective alterations of brain dopamine D(2) receptor binding in cirrhotic patients: results of a (11)C-N-methylspiperone PET study. Metabolic Brain Disease. 23: 265-74. PMID 18686022 DOI: 10.1007/s11011-008-9092-7  0.378
2008 Ahboucha S, Jiang W, Chatauret N, Mamer O, Baker GB, Butterworth RF. Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 20: 949-57. PMID 18482252 DOI: 10.1111/j.1365-2982.2008.01132.x  0.445
2008 Gu B, Desjardins P, Butterworth RF. Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. Metabolic Brain Disease. 23: 175-87. PMID 18481165 DOI: 10.1007/s11011-008-9089-2  0.382
2008 Navarro D, Zwingmann C, Butterworth RF. Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy. Journal of Neurochemistry. 106: 603-12. PMID 18410518 DOI: 10.1111/j.1471-4159.2008.05410.x  0.386
2008 Navarro D, Zwingmann C, Chatauret N, Butterworth RF. Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats. Metabolic Brain Disease. 23: 115-22. PMID 18034292 DOI: 10.1007/s11011-007-9076-z  0.415
2008 Ahboucha S, Butterworth RF. The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy. Neurochemistry International. 52: 575-87. PMID 17610999 DOI: 10.1016/j.neuint.2007.05.004  0.45
2008 Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF. NMR study of 13C-glucose and 13C-acetate metabolism in the brain of rats with acute liver failure Journal of Neurochemistry. 81: 9-13. DOI: 10.1046/j.1471-4159.81.s1.3_20.x  0.435
2008 Navarro D, Zwingmann C, Hazell AS, Leibfritz D, Butterworth RF. Poster Sessions BP01: Energy Metabolism Journal of Neurochemistry. 81: 45-45. DOI: 10.1046/J.1471-4159.81.S1.14_1.X  0.658
2007 Vaquero J, Butterworth RF. Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions. Neurological Research. 29: 683-90. PMID 18173908 DOI: 10.1179/016164107X240099  0.49
2007 Vaquero J, Butterworth RF. Mild hypothermia for the treatment of acute liver failure--what are we waiting for? Nature Clinical Practice. Gastroenterology & Hepatology. 4: 528-9. PMID 17909531 DOI: 10.1038/ncpgasthep0927  0.36
2007 Butterworth R. Neuronal cell death in hepatic encephalopathy. Metabolic Brain Disease. 22: 309-20. PMID 17851742 DOI: 10.1007/s11011-007-9072-3  0.391
2007 Ahboucha S, Butterworth RF. The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy. Metabolic Brain Disease. 22: 291-308. PMID 17823858 DOI: 10.1007/s11011-007-9065-2  0.473
2007 Vaquero J, Bélanger M, James L, Herrero R, Desjardins P, Côté J, Blei AT, Butterworth RF. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology. 132: 372-83. PMID 17241886 DOI: 10.1053/j.gastro.2006.11.025  0.376
2006 Vaquero J, Butterworth RF. The brain glutamate system in liver failure. Journal of Neurochemistry. 98: 661-9. PMID 16771837 DOI: 10.1111/j.1471-4159.2006.03918.x  0.493
2006 Bélanger M, Côté J, Butterworth RF. Neurobiological characterization of an azoxymethane mouse model of acute liver failure. Neurochemistry International. 48: 434-40. PMID 16563565 DOI: 10.1016/j.neuint.2005.11.022  0.439
2006 Ahboucha S, Pomier-Layrargues G, Mamer O, Butterworth RF. Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Neurochemistry International. 49: 372-8. PMID 16563564 DOI: 10.1016/j.neuint.2006.02.002  0.46
2006 Chatauret N, Desjardins P, Zwingmann C, Rose C, Rao KV, Butterworth RF. Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. Journal of Hepatology. 44: 1083-8. PMID 16530878 DOI: 10.1016/J.Jhep.2005.11.048  0.607
2006 Ahboucha S, Coyne L, Hirakawa R, Butterworth RF, Halliwell RF. An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons. Neurochemistry International. 48: 703-7. PMID 16487630 DOI: 10.1016/J.Neuint.2005.12.006  0.303
2006 Bélanger M, Desjardins P, Chatauret N, Butterworth RF. Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure. Glia. 53: 557-62. PMID 16374780 DOI: 10.1002/glia.20310  0.439
2006 Sen S, Rose C, Ytrebø LM, Davies NA, Nedredal GI, Drevland SS, Kjønnø M, Prinzen FW, Hodges SJ, Deutz NE, Williams R, Butterworth RF, Revhaug A, Jalan R. Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Critical Care Medicine. 34: 158-64. PMID 16374170 DOI: 10.1097/01.Ccm.0000196203.39832.3C  0.611
2005 Ahboucha S, Butterworth RF. Role of endogenous benzodiazepine ligands and their GABA-A--associated receptors in hepatic encephalopathy. Metabolic Brain Disease. 20: 425-37. PMID 16382352 DOI: 10.1007/s11011-005-7928-y  0.352
2005 Bélanger M, Butterworth RF. Acute liver failure: a critical appraisal of available animal models. Metabolic Brain Disease. 20: 409-23. PMID 16382351 DOI: 10.1007/s11011-005-7927-z  0.343
2005 Vaquero J, Rose C, Butterworth RF. Keeping cool in acute liver failure: rationale for the use of mild hypothermia. Journal of Hepatology. 43: 1067-77. PMID 16246452 DOI: 10.1016/J.Jhep.2005.05.039  0.657
2005 Shawcross DL, Olde Damink SW, Butterworth RF, Jalan R. Ammonia and hepatic encephalopathy: the more things change, the more they remain the same. Metabolic Brain Disease. 20: 169-79. PMID 16167195 DOI: 10.1007/s11011-005-7205-0  0.389
2005 Ahboucha S, Layrargues GP, Mamer O, Butterworth RF. Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy. Annals of Neurology. 58: 169-70. PMID 15984019 DOI: 10.1002/ana.20534  0.413
2005 Desjardins P, Butterworth RF. Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy. Molecular Neurobiology. 31: 17-25. PMID 15953809 DOI: 10.1385/MN:31:1-3:017  0.352
2005 Zwingmann C, Butterworth R. An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: Further studies using NMR spectroscopy Neurochemistry International. 47: 19-30. PMID 15916833 DOI: 10.1016/j.neuint.2005.04.003  0.476
2005 Ahboucha S, Araqi F, Layrargues GP, Butterworth RF. Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain. Neurochemistry International. 47: 58-63. PMID 15913842 DOI: 10.1016/j.neuint.2005.04.007  0.405
2005 Bélanger M, Desjardins P, Chatauret N, Rose C, Butterworth RF. Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. Journal of Hepatology. 42: 694-9. PMID 15826719 DOI: 10.1016/J.Jhep.2004.12.029  0.694
2005 Chan TS, Shangari N, Wilson JX, Chan H, Butterworth RF, O'Brien PJ. The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress. Free Radical Biology & Medicine. 38: 867-73. PMID 15749382 DOI: 10.1016/j.freeradbiomed.2004.12.006  0.329
2005 Bémeur C, Ste-Marie L, Desjardins P, Vachon L, Butterworth RF, Hazell AS, Montgomery J. Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. Neurochemistry International. 46: 399-407. PMID 15737438 DOI: 10.1016/J.Neuint.2004.11.007  0.648
2005 Navarro D, Zwingmann C, Hazell AS, Butterworth RF. Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy. Journal of Neuroscience Research. 79: 33-41. PMID 15573405 DOI: 10.1002/Jnr.20290  0.698
2004 Ahboucha S, Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint. Metabolic Brain Disease. 19: 331-43. PMID 15554425 DOI: 10.1023/B:MEBR.0000043979.58915.41  0.408
2004 Ahboucha S, Pomier-Layrargues G, Butterworth RF. Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy. Metabolic Brain Disease. 19: 241-51. PMID 15554420 DOI: 10.1023/B:MEBR.0000043974.89820.22  0.403
2004 Bémeur C, Ste-Marie L, Desjardins P, Butterworth RF, Vachon L, Montgomery J, Hazell AS. Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat. Neurochemistry International. 45: 1167-74. PMID 15380626 DOI: 10.1016/J.Neuint.2004.06.010  0.675
2004 Rodrigo R, Montoliu C, Chatauret N, Butterworth R, Behrends S, Del Olmo JA, Serra MA, Rodrigo JM, Erceg S, Felipo V. Alterations in soluble guanylate cyclase content and modulation by nitric oxide in liver disease. Neurochemistry International. 45: 947-53. PMID 15312989 DOI: 10.1016/j.neuint.2004.03.025  0.484
2004 Chan H, Butterworth RF, Hazell AS. Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels. Neuroscience Letters. 366: 231-4. PMID 15288424 DOI: 10.1016/J.Neulet.2004.04.095  0.665
2004 Lozeva V, Montgomery JA, Tuomisto L, Rocheleau B, Pannunzio M, Huet PM, Butterworth RF. Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis. Journal of Hepatology. 40: 742-8. PMID 15094220 DOI: 10.1016/j.jhep.2004.01.003  0.466
2004 Kruse M, Navarro D, Desjardins P, Butterworth RF. Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability. Neurochemistry International. 45: 49-56. PMID 15082221 DOI: 10.1016/j.neuint.2003.12.007  0.415
2004 Lozeva-Thomas V, Ahonen P, Chatauret N, Tuomisto L, Butterworth RF. Brain histamine in experimental acute liver failure: effects of L-histidine loading. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 53: S55-6. PMID 15054617 DOI: 10.1007/s00011-003-0326-1  0.415
2004 Normandin L, Ann Beaupré L, Salehi F, St -Pierre A, Kennedy G, Mergler D, Butterworth RF, Philippe S, Zayed J. Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology. 25: 433-41. PMID 15019306 DOI: 10.1016/J.Neuro.2003.10.001  0.372
2004 Bémeur C, Ste-Marie L, Desjardins P, Hazell AS, Vachon L, Butterworth R, Montgomery J. Decreased beta-actin mRNA expression in hyperglycemic focal cerebral ischemia in the rat. Neuroscience Letters. 357: 211-4. PMID 15003287 DOI: 10.1016/J.Neulet.2003.12.081  0.636
2004 Zwingmann C, Chatauret N, Rose C, Leibfritz D, Butterworth RF. Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia. Brain Research. 999: 118-23. PMID 14746928 DOI: 10.1016/J.Brainres.2003.11.048  0.687
2004 CHATAURET N, BUTTERWORTH RF. Effects of liver failure on inter-organ trafficking of ammonia: implications for the treatment of hepatic encephalopathy Journal of Gastroenterology and Hepatology. 19: S219-S223. DOI: 10.1111/j.1440-1746.2004.03648.x  0.419
2004 Rose C, Chatauret N, Belanger M, Desjardins P, Butterworth R. 161 Chronic liver failure attenuates the CNS consequences of subsequent acute liver failure by ‘priming’ of muscle glutamine synthetase capacity Journal of Hepatology. 40: 54. DOI: 10.1016/S0168-8278(04)90161-4  0.606
2003 Butterworth RF. Brain edema in acute liver failure. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology. 22: S59-61. PMID 15025258 DOI: 10.1016/B978-0-12-803196-4.00015-1  0.505
2003 Butterworth RF. Pathogenesis of hepatic encephalopathy: update on molecular mechanisms. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology. 22: S11-6. PMID 15025246  0.362
2003 Butterworth RF. Molecular neurobiology of acute liver failure. Seminars in Liver Disease. 23: 251-8. PMID 14523678 DOI: 10.1055/s-2003-42643  0.492
2003 Lozeva V, Tuomisto L, Tarhanen J, Butterworth RF. Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Journal of Hepatology. 39: 522-7. PMID 12971961 DOI: 10.1016/S0168-8278(03)00353-2  0.404
2003 Butterworth RF. Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices. Liver International : Official Journal of the International Association For the Study of the Liver. 23: 5-9. PMID 12950954 DOI: 10.1034/J.1478-3231.23.S.3.1.X  0.471
2003 Chatauret N, Zwingmann C, Rose C, Leibfritz D, Butterworth RF. Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Gastroenterology. 125: 815-24. PMID 12949727 DOI: 10.1016/S0016-5085(03)01054-0  0.683
2003 Butterworth RF. Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. Journal of Hepatology. 39: 278-85. PMID 12873828 DOI: 10.1016/S0168-8278(03)00267-8  0.303
2003 Ahboucha S, Desjardins P, Chatauret N, Pomier-Layrargues G, Butterworth RF. Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy. Neurochemistry International. 43: 551-6. PMID 12820983 DOI: 10.1016/S0197-0186(03)00065-2  0.348
2003 Chan H, Butterworth RF. Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain. Neurochemistry International. 43: 525-32. PMID 12742100 DOI: 10.1016/S0197-0186(03)00043-3  0.348
2003 Harper C, Garrick T, Matsumoto I, Pfefferbaum A, Adalsteinsson E, Sullivan E, Dodd P, Lewohl J, Butterworth R. How important are brain banks for alcohol research? Alcoholism, Clinical and Experimental Research. 27: 310-23. PMID 12605081 DOI: 10.1097/01.Alc.0000052585.81056.Ca  0.357
2003 Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF. Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. Hepatology (Baltimore, Md.). 37: 420-8. PMID 12540793 DOI: 10.1053/jhep.2003.50052  0.452
2003 Desjardins P, Sauvageau A, Bouthillier A, Navarro D, Hazell AS, Rose C, Butterworth RF. Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. Neurochemistry International. 42: 299-303. PMID 12470703 DOI: 10.1016/S0197-0186(02)00101-8  0.718
2003 Bélanger M, Ahboucha S, Desjardins P, Butterworth RF. Upregulation of peripheral-type (mitochondrial) benzodiazepine receptors in hyperammonemic syndromes: consequences for neuronal excitability Advances in Molecular and Cell Biology. 31: 983-997. DOI: 10.1016/S1569-2558(03)31044-6  0.444
2003 ROSE C, SEN S, YTREBO L, DAVIES N, NEDREDAL G, WILLIAMS R, BUTTERWORTH R, REVHAUG A, JALAN R. 809 Improvement in cerebral lactate, glutamate and energy metabolism with albumin dialysis in a large animal model of acute liver failure: a microdialysis study Hepatology. 38: 552-552. DOI: 10.1016/S0270-9139(03)80851-0  0.617
2003 SEN S, ROSE C, YTREBO L, DAVIES N, NEDREDAL G, DREVLAND S, KJONNO M, WILLIAMS R, BUTTERWORTH R, REVHAUG A. 786 Albumin dialysis reduces brain water and intracranial pressure in acute liver failure: a randomised controlled study in a pig model Hepatology. 38: 540-540. DOI: 10.1016/S0270-9139(03)80828-5  0.629
2003 ZWINGMANN C, CHATAURET N, BUTTERWORTH R. 222 Inter-organ trafficking of ammonia and its metabolites in acute liver failure: results of a C-nuclear magnetic resonance study Hepatology. 38: 263-263. DOI: 10.1016/S0270-9139(03)80265-3  0.312
2003 BELANGER M, DESJARDINS P, BUTTERWORTH R. 120 Neurological characterization of a novel mouse model of acute liver failure Hepatology. 38: 214-214. DOI: 10.1016/S0270-9139(03)80163-5  0.368
2002 Chatauret N, Rose C, Butterworth RF. Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects. Metabolic Brain Disease. 17: 445-51. PMID 12602520 DOI: 10.1023/A:1021982523691  0.672
2002 Zwingmann C, Desjardins P, Hazell A, Chatauret N, Michalak A, Butterworth RF. Reduced expression of astrocytic glycine transporter (Glyt-1) in acute liver failure. Metabolic Brain Disease. 17: 263-73. PMID 12602503 DOI: 10.1023/A:1021997532352  0.701
2002 Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metabolic Brain Disease. 17: 221-7. PMID 12602499 DOI: 10.1023/A:1021989230535  0.51
2002 Corbalán R, Chatauret N, Behrends S, Butterworth RF, Felipo V. Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients. Hepatology (Baltimore, Md.). 36: 1155-62. PMID 12395325 DOI: 10.1053/jhep.2002.36365  0.453
2002 Normandin L, Carrier G, Gardiner PF, Kennedy G, Hazell AS, Mergler D, Butterworth RF, Philippe S, Zayed J. Assessment of bioaccumulation, neuropathology, and neurobehavior following subchronic (90 days) inhalation in Sprague-Dawley rats exposed to manganese phosphate. Toxicology and Applied Pharmacology. 183: 135-45. PMID 12387753 DOI: 10.1006/Taap.2002.9464  0.665
2002 Felipo V, Butterworth RF. Neurobiology of ammonia. Progress in Neurobiology. 67: 259-79. PMID 12207972 DOI: 10.1016/S0301-0082(02)00019-9  0.481
2002 Dirson G, Desjardins P, Tannenberg T, Dodd P, Butterworth RF. Selective loss of expression of glutamate GluR2/R3 receptor subunits in cerebellar tissue from a patient with olivopontocerebellar atrophy. Metabolic Brain Disease. 17: 77-82. PMID 12083339 DOI: 10.1023/A:1015412027708  0.335
2002 Bélanger M, Desjardins P, Chatauret N, Butterworth RF. Loss of expression of glial fibrillary acidic protein in acute hyperammonemia. Neurochemistry International. 41: 155-60. PMID 12020615 DOI: 10.1016/S0197-0186(02)00037-2  0.453
2002 Desjardins P, Butterworth RF. The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders. Neurochemistry International. 41: 109-14. PMID 12020611 DOI: 10.1016/S0197-0186(02)00031-1  0.49
2002 Butterworth RF. Glutamate transporters in hyperammonemia. Neurochemistry International. 41: 81-5. PMID 12020607 DOI: 10.1016/S0197-0186(02)00027-X  0.437
2002 Schliess F, Görg B, Fischer R, Desjardins P, Bidmon HJ, Herrmann A, Butterworth RF, Zilles K, Häussinger D. Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 739-41. PMID 11923223 DOI: 10.1096/Fj.01-0862Fje  0.364
2002 Felipo V, Butterworth RF. Mitochondrial dysfunction in acute hyperammonemia. Neurochemistry International. 40: 487-91. PMID 11850105 DOI: 10.1016/S0197-0186(01)00119-X  0.342
2001 Butterworth RF. Glutamate transporter and receptor function in disorders of ammonia metabolism. Mental Retardation and Developmental Disabilities Research Reviews. 7: 276-9. PMID 11754522 DOI: 10.1002/mrdd.1038  0.308
2001 Desjardins P, Bélanger M, Butterworth RF. Alterations in expression of genes coding for key astrocytic proteins in acute liver failure. Journal of Neuroscience Research. 66: 967-71. PMID 11746425 DOI: 10.1002/jnr.10045  0.509
2001 Chatauret N, Rose C, Therrien G, Butterworth RF. Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure. Metabolic Brain Disease. 16: 95-102. PMID 11726093 DOI: 10.1023/A:1011622830569  0.687
2001 Butterworth RF. Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings. Metabolic Brain Disease. 16: 55-65. PMID 11726089 DOI: 10.1023/A:1011614528751  0.516
2001 Salehi F, Carrier G, Normandin L, Kennedy G, Butterworth RF, Hazell A, Therrien G, Mergler D, Philippe S, Zayed J. Assessment of bioaccumulation and neurotoxicity in rats with portacaval anastomosis and exposed to manganese phosphate: a pilot study. Inhalation Toxicology. 13: 1151-63. PMID 11696878 DOI: 10.1080/08958370152647654  0.646
2001 Butterworth RF. Images of the brain in chronic liver failure. Journal of Hepatology. 35: 661-2. PMID 11690714 DOI: 10.1016/S0168-8278(01)00225-2  0.414
2001 Ste-Marie L, Hazell AS, Bémeur C, Butterworth R, Montgomery J. Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia. Brain Research. 918: 10-9. PMID 11684037 DOI: 10.1016/S0006-8993(01)02903-1  0.665
2001 Hazell AS, Rao KV, Danbolt NC, Pow DV, Butterworth RF. Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. Journal of Neurochemistry. 78: 560-8. PMID 11483659 DOI: 10.1046/J.1471-4159.2001.00436.X  0.675
2001 St-Pierre A, Normandin L, Carrier G, Kennedy G, Butterworth R, Zayed J. Bioaccumulation and locomotor effect of manganese dust in rats. Inhalation Toxicology. 13: 623-32. PMID 11452358 DOI: 10.1080/08958370117066  0.31
2001 Lozeva V, Tuomisto L, Sola D, Plumed C, Hippeläinen M, Butterworth R. Increased density of brain histamine H1 receptors in rats with portacaval anastomosis and in cirrhotic patients with chronic hepatic encephalopathy Hepatology. 33: 1370-1376. PMID 11391525 DOI: 10.1053/Jhep.2001.25090  0.422
2001 Butterworth RF. Mild hypothermia prevents cerebral edema in acute liver failure. Journal of Hepato-Biliary-Pancreatic Surgery. 8: 16-9. PMID 11294286 DOI: 10.1007/s005340170046  0.377
2001 Todd KG, Butterworth RF. In vivo microdialysis in an animal model of neurological disease: thiamine deficiency (Wernicke) encephalopathy. Methods (San Diego, Calif.). 23: 55-61. PMID 11162149 DOI: 10.1006/meth.2000.1105  0.387
2001 Michalak A, Chatauret N, Butterworth RF. Evidence for a serotonin transporter deficit in experimental acute liver failure. Neurochemistry International. 38: 163-68. PMID 11137885 DOI: 10.1016/S0197-0186(00)00062-0  0.46
2001 Michalak A, Rose C, Butterworth RF. Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure. Neurochemistry International. 38: 25-30. PMID 10913685 DOI: 10.1016/S0197-0186(00)00048-6  0.673
2001 Rose C, Chatauret N, Pannunzio M, Butterworth R. Mild hypothermia prevents cerebral edema and improves both oxidative metabolism and excitatory amino acid distribution in brain in fulminant hepatic failure (FHF) Journal of Hepatology. 34: 43. DOI: 10.1016/S0168-8278(01)81018-7  0.635
2000 Pannunzio P, Hazell AS, Pannunzio M, Rao KV, Butterworth RF. Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy. Journal of Neuroscience Research. 62: 286-92. PMID 11020221 DOI: 10.1002/1097-4547(20001015)62:2<286::Aid-Jnr13>3.0.Co;2-0  0.644
2000 Butterworth RF. Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency. Metabolic Brain Disease. 15: 83-91. PMID 10885542 DOI: 10.1023/A:1011165819480  0.363
2000 Chan H, Hazell AS, Desjardins P, Butterworth RF. Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes. Neurochemistry International. 37: 243-8. PMID 10812209 DOI: 10.1016/S0197-0186(00)00026-7  0.698
2000 Rose C, Michalak A, Pannunzio M, Chatauret N, Rambaldi A, Butterworth RF. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology (Baltimore, Md.). 31: 872-7. PMID 10733542 DOI: 10.1053/He.2000.5923  0.667
2000 Butterworth RF. The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy. Neurochemistry International. 36: 411-6. PMID 10733008 DOI: 10.1016/S0197-0186(99)00132-1  0.484
2000 Butterworth RF. Complications of cirrhosis III. Hepatic encephalopathy. Journal of Hepatology. 32: 171-80. PMID 10728803 DOI: 10.1016/S0168-8278(00)80424-9  0.475
2000 Rose C, Butterworth R, Michalak A, Quack G, Kircheis G. L-ornithine L-aspartate lowers blood ammonia in acute and chronicliver failure by distinct mechanisms Journal of Hepatology. 32: 53. DOI: 10.1016/S0168-8278(00)80534-6  0.556
2000 Rose C, Michalak A, Pannunzio M, Chatauret N, Rambaldi A, Butterworth R. Beneficial effect of hypothermia in acute liver failure: Delayed onsetof brain edema and alterations of brain amino acid profiles Journal of Hepatology. 32: 49. DOI: 10.1016/S0168-8278(00)80521-8  0.663
1999 Todd KG, Hazell AS, Butterworth RF. Alcohol-thiamine interactions: an update on the pathogenesis of Wernicke encephalopathy. Addiction Biology. 4: 261-72. PMID 20575793 DOI: 10.1080/13556219971470  0.639
1999 Desjardins P, Rao KV, Michalak A, Rose C, Butterworth RF. Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle. Metabolic Brain Disease. 14: 273-80. PMID 10850554 DOI: 10.1023/A:1020741226752  0.658
1999 Todd K, Butterworth RF. Mechanisms of selective neuronal cell death due to thiamine deficiency. Annals of the New York Academy of Sciences. 893: 404-11. PMID 10672278 DOI: 10.1111/J.1749-6632.1999.Tb07866.X  0.382
1999 Hazell AS, Butterworth RF. Hepatic encephalopathy: An update of pathophysiologic mechanisms. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 222: 99-112. PMID 10564534 DOI: 10.1046/J.1525-1373.1999.D01-120.X  0.713
1999 Chan H, Butterworth RF. Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy. Neurochemical Research. 24: 1397-401. PMID 10555780 DOI: 10.1023/A:1022532623281  0.514
1999 Desjardins P, Todd KG, Hazell AS, Butterworth RF. Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats. Neurochemistry International. 35: 363-9. PMID 10517697 DOI: 10.1016/S0197-0186(99)00082-0  0.675
1999 Desjardins P, Bandeira P, Rao VL, Butterworth RF. Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues. Neurochemistry International. 35: 293-9. PMID 10482349 DOI: 10.1016/S0197-0186(99)00075-3  0.479
1999 Hazell AS, Desjardins P, Butterworth RF. Chronic exposure of rat primary astrocyte cultures to manganese results in increased binding sites for the 'peripheral-type' benzodiazepine receptor ligand 3H-PK 11195. Neuroscience Letters. 271: 5-8. PMID 10471200 DOI: 10.1016/S0304-3940(99)00489-9  0.689
1999 Rose C, Butterworth RF, Zayed J, Normandin L, Todd K, Michalak A, Spahr L, Huet PM, Pomier-Layrargues G. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology. 117: 640-4. PMID 10464140 DOI: 10.1016/S0016-5085(99)70457-9  0.668
1999 Rose C, Michalak A, Rao KV, Quack G, Kircheis G, Butterworth RF. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology (Baltimore, Md.). 30: 636-40. PMID 10462368 DOI: 10.1002/Hep.510300311  0.686
1999 Hazell AS, Desjardins P, Butterworth RF. Increased expression of glyceraldehyde-3-phosphate dehydrogenase in cultured astrocytes following exposure to manganese. Neurochemistry International. 35: 11-7. PMID 10403426 DOI: 10.1016/S0197-0186(99)00024-8  0.649
1999 Todd KG, Butterworth RF. Early microglial response in experimental thiamine deficiency: an immunohistochemical analysis. Glia. 25: 190-8. PMID 9890633 DOI: 10.1002/(SICI)1098-1136(19990115)25:2<190::AID-GLIA9>3.0.CO;2-B  0.366
1999 Butterworth RF. Change of 'editor-in-chief' of metabolic brain disease Metabolic Brain Disease. 14: i. DOI: 10.1023/A:1020749528569  0.346
1998 Butterworth RF. Alterations of neurotransmitter-related gene expression in human and experimental portal-systemic encephalopathy. Metabolic Brain Disease. 13: 337-49. PMID 10206825 DOI: 10.1023/A:1020641009971  0.469
1998 Layrargues GP, Rose C, Spahr L, Zayed J, Normandin L, Butterworth RF. Role of manganese in the pathogenesis of portal-systemic encephalopathy. Metabolic Brain Disease. 13: 311-7. PMID 10206823 DOI: 10.1023/A:1020636809063  0.619
1998 Perney P, Butterworth RF, Mousseau DD, Lavoie J, Fabbro-Peray P, Blanc F, Layrargues GP. Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake. Metabolic Brain Disease. 13: 201-10. PMID 9804365 DOI: 10.1023/A:1023271908568  0.343
1998 Rao VL, Butterworth RF. Neuronal nitric oxide synthase and Hepatic Encephalopathy. Metabolic Brain Disease. 13: 175-89. PMID 9804363 DOI: 10.1023/A:1023281307660  0.374
1998 Butterworth RF. Evidence for a central cholinergic deficit in congenital ornithine transcarbamylase deficiency. Developmental Neuroscience. 20: 478-84. PMID 9778587 DOI: 10.1159/000017346  0.389
1998 Butterworth RF. Pathogenesis of acute hepatic encephalopathy. Digestion. 59: 16-21. PMID 9718413 DOI: 10.1159/000051414  0.364
1998 Rose C, Michalak A, Pannunzio P, Therrien G, Quack G, Kircheis G, Butterworth RF. L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metabolic Brain Disease. 13: 147-57. PMID 9699922 DOI: 10.1016/S0168-8278(98)80479-0  0.604
1998 Hazell AS, Todd KG, Butterworth RF. Mechanisms of neuronal cell death in Wernicke's encephalopathy. Metabolic Brain Disease. 13: 97-122. PMID 9699919 DOI: 10.1023/A:1020657129593  0.705
1998 Butterworth RF. Effects of hyperammonaemia on brain function. Journal of Inherited Metabolic Disease. 21: 6-20. PMID 9686341  0.341
1998 Todd KG, Butterworth RF. Increased neuronal cell survival after L-deprenyl treatment in experimental thiamine deficiency. Journal of Neuroscience Research. 52: 240-6. PMID 9579414 DOI: 10.1002/(SICI)1097-4547(19980415)52:2<240::AID-JNR12>3.0.CO;2-B  0.403
1998 Audet RM, Butterworth RF. Portacaval anastomosis results in more widespread alterations of cerebral metabolism in old versus young adult rats: implications for post-shunt encephalopathy. Metabolic Brain Disease. 13: 69-78. PMID 9570641 DOI: 10.1023/A:1020683013238  0.796
1998 Michalak A, Rose C, Buu PN, Butterworth RF. Evidence for altered central noradrenergic function in experimental acute liver failure in the rat. Hepatology (Baltimore, Md.). 27: 362-8. PMID 9462632 DOI: 10.1002/Hep.510270208  0.667
1998 Butterworth R, Desjardins P, Bandeira P, Hazell A. Altered “peripheral-type” benzodiazepine receptor (PTBR) gene expression in brain and testis following end-to-side portacaval anastomosis Journal of Hepatology. 28: 73. DOI: 10.1016/S0168-8278(98)80490-X  0.666
1998 Butterworth R, Rose C, Quack G, Kircheis G. L-Ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action Journal of Hepatology. 28: 70. DOI: 10.1016/S0168-8278(98)80479-0  0.483
1997 Michalak A, Butterworth RF. Selective increases of extracellular brain concentrations of aromatic and branched-chain amino acids in relation to deterioration of neurological status in acute (ischemic) liver failure. Metabolic Brain Disease. 12: 259-69. PMID 9475499 DOI: 10.1023/A:1022369908162  0.504
1997 Michalak A, Butterworth RF. Ornithine transcarbamylase deficiency: pathogenesis of the cerebral disorder and new prospects for therapy. Metabolic Brain Disease. 12: 171-82. PMID 9346466 DOI: 10.1023/B:MEBR.0000007098.80372.68  0.373
1997 Kril JJ, Flowers D, Butterworth RF. Distinctive pattern of Bergmann glial pathology in human hepatic encephalopathy. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 31: 279-87. PMID 9336769 DOI: 10.1007/Bf02815130  0.385
1997 Rao VL, Audet RM, Butterworth RF. Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis. Brain Research. 765: 169-72. PMID 9310409 DOI: 10.1016/S0006-8993(97)00652-5  0.818
1997 Michalak A, Knecht K, Butterworth RF. Hepatic encephalopathy in acute liver failure: role of the glutamate system. Advances in Experimental Medicine and Biology. 420: 35-43. PMID 9286424 DOI: 10.1007/978-1-4615-5945-0_2  0.441
1997 Knecht K, Michalak A, Rose C, Rothstein JD, Butterworth RF. Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neuroscience Letters. 229: 201-3. PMID 9237493 DOI: 10.1016/S0304-3940(97)00444-8  0.678
1997 Desjardins P, Bandeira P, Raghavendra Rao VL, Ledoux S, Butterworth RF. Increased expression of the peripheral-type benzodiazepine receptor-isoquinoline carboxamide binding protein mRNA in brain following portacaval anastomosis. Brain Research. 758: 255-8. PMID 9203558 DOI: 10.1016/S0006-8993(97)00339-9  0.426
1997 de Waele JP, Audet RM, Rose C, Butterworth RF. The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference? Alcoholism, Clinical and Experimental Research. 21: 305-10. PMID 9113268 DOI: 10.1111/J.1530-0277.1997.Tb03765.X  0.767
1997 Butterworth RF. Hepatic encephalopathy and brain edema in acute hepatic failure: does glutamate play a role? Hepatology (Baltimore, Md.). 25: 1032-4. PMID 9096616 DOI: 10.1002/hep.510250440  0.441
1997 Michalak A, Butterworth RF. Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure. Hepatology (Baltimore, Md.). 25: 631-5. PMID 9049210 DOI: 10.1002/hep.510250323  0.43
1997 Therrien G, Rose C, Butterworth J, Butterworth RF. Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat. Hepatology (Baltimore, Md.). 25: 551-6. PMID 9049197 DOI: 10.1002/Hep.510250310  0.603
1997 Mousseau DD, Baker GB, Butterworth RF. Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy. Journal of Neurochemistry. 68: 1200-8. PMID 9048767 DOI: 10.1046/J.1471-4159.1997.68031200.X  0.405
1997 Rao VL, Audet RM, Butterworth RF. Portacaval shunting and hyperammonemia stimulate the uptake of L-[3H] arginine but not of L-[3H]nitroarginine into rat brain synaptosomes. Journal of Neurochemistry. 68: 337-43. PMID 8978744 DOI: 10.1046/J.1471-4159.1997.68010337.X  0.794
1996 Rao VL, Butterworth RF. Regional distribution of binding sites for the nitric oxide synthase inhibitor L-[3H]nitroarginine in rat brain. Neurochemical Research. 21: 355-9. PMID 9139242 DOI: 10.1007/Bf02531652  0.342
1996 Mousseau DD, Rao VL, Butterworth RF. Vesicular dysfunction during experimental thiamine deficiency is indicated by alterations in dopamine metabolism. European Journal of Pharmacology. 317: 263-7. PMID 8997609 DOI: 10.1016/S0014-2999(96)00842-4  0.338
1996 Butterworth RF. The neurobiology of hepatic encephalopathy. Seminars in Liver Disease. 16: 235-44. PMID 8989809 DOI: 10.1055/s-2007-1007236  0.328
1996 Bergqvist PB, Hjorth S, Audet RM, Apelqvist G, Bengtsson F, Butterworth RF. Ammonium acetate challenge in experimental chronic hepatic encephalopathy induces a transient increase of brain 5-HT release in vivo. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 6: 317-22. PMID 8985716 DOI: 10.1016/S0924-977X(96)00037-5  0.777
1996 Butterworth RF. Taurine in hepatic encephalopathy. Advances in Experimental Medicine and Biology. 403: 601-6. PMID 8915400 DOI: 10.1007/978-1-4899-0182-8_66  0.474
1996 Spahr L, Butterworth RF, Fontaine S, Bui L, Therrien G, Milette PC, Lebrun LH, Zayed J, Leblanc A, Pomier-Layrargues G. Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology (Baltimore, Md.). 24: 1116-20. PMID 8903385 DOI: 10.1002/Hep.510240523  0.315
1996 Ratnakumari L, Qureshi IA, Butterworth RF, Marescau B, De Deyn PP. Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: effect of metabolic arginine deficiency. Neuroscience Letters. 215: 153-6. PMID 8899736 DOI: 10.1016/0304-3940(96)12975-X  0.38
1996 Bergqvist PB, Heyes MP, Apelqvist G, Butterworth RF, Bengtsson F. Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 382-9. PMID 8887992 DOI: 10.1016/0893-133X(95)00256-D  0.46
1996 Sonnewald U, Therrien G, Butterworth RF. Portacaval anastomosis results in altered neuron--astrocytic metabolic trafficking of amino acids: evidence from 13C-NMR studies. Journal of Neurochemistry. 67: 1711-7. PMID 8858957 DOI: 10.1046/J.1471-4159.1996.67041711.X  0.337
1996 Michalak A, Rose C, Butterworth J, Butterworth RF. Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology (Baltimore, Md.). 24: 908-13. PMID 8855196 DOI: 10.1002/Hep.510240425  0.66
1996 de Waele JP, Audet RM, Leong DK, Butterworth RF. Portacaval anastomosis induces region-selective alterations of the endogenous opioid system in the rat brain. Hepatology (Baltimore, Md.). 24: 895-901. PMID 8855194 DOI: 10.1002/Hep.510240423  0.794
1996 Héroux M, Raghavendra Rao VL, Lavoie J, Richardson JS, Butterworth RF. Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. Metabolic Brain Disease. 11: 81-8. PMID 8815392 DOI: 10.1007/Bf02080933  0.335
1996 Leong DK, Butterworth RF. Neuronal cell death in Wernicke's encephalopathy: pathophysiologic mechanisms and implications for PET imaging. Metabolic Brain Disease. 11: 71-9. PMID 8815391 DOI: 10.1007/Bf02080932  0.405
1996 Ratnakumari L, Qureshi IA, Butterworth RF. Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency. Pediatric Research. 40: 25-8. PMID 8798241 DOI: 10.1203/00006450-199607000-00005  0.328
1996 Butterworth RF. Neuroactive amino acids in hepatic encephalopathy. Metabolic Brain Disease. 11: 165-73. PMID 8776718 DOI: 10.1007/Bf02069503  0.471
1996 Mousseau DD, Rao VL, Butterworth RF. Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms. Journal of Neurochemistry. 67: 1113-23. PMID 8752118 DOI: 10.1046/J.1471-4159.1996.67031113.X  0.333
1996 Mousseau DD, Rao VL, Butterworth RF. Na+,K(+)-ATPase activity is selectively increased in thalamus in thiamine deficiency prior to the appearance of neurological symptoms. European Journal of Pharmacology. 300: 191-6. PMID 8739207 DOI: 10.1016/0014-2999(95)00865-9  0.332
1996 Rao VL, Mousseau DD, Butterworth RF. Nitric oxide synthase activities are selectively decreased in vulnerable brain regions in thiamine deficiency. Neuroscience Letters. 208: 17-20. PMID 8731164 DOI: 10.1016/0304-3940(96)12541-6  0.416
1996 Leong DK, Oliva L, Butterworth RF. Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging. Alcoholism, Clinical and Experimental Research. 20: 601-5. PMID 8727262 DOI: 10.1111/J.1530-0277.1996.Tb01101.X  0.35
1995 Layrargues GP, Shapcott D, Spahr L, Butterworth RF. Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy? Metabolic Brain Disease. 10: 353-6. PMID 8847998 DOI: 10.1007/Bf02109365  0.374
1995 Butterworth RF, Spahr L, Fontaine S, Layrargues GP. Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy. Metabolic Brain Disease. 10: 259-67. PMID 8847990 DOI: 10.1007/Bf02109357  0.353
1995 Ratnakumari L, Qureshi IA, Butterworth RF. Loss of [3H]MK801 binding sites in brain in congenital ornithine transcarbamylase deficiency. Metabolic Brain Disease. 10: 249-55. PMID 8830285 DOI: 10.1007/Bf02081030  0.419
1995 Peterson C, Héroux M, Lavoie J, Butterworth RF. Loss of [3H]kainate and of NMDA-displaceable [3H]glutamate binding sites in brain in thiamine deficiency: results of a quantitative autoradiographic study. Neurochemical Research. 20: 1155-60. PMID 8746800 DOI: 10.1007/Bf00995378  0.405
1995 Bergeron M, Swain MS, Molina-Holgado E, Reader TA, Butterworth RF. Effect of probenecid on 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid of rats with portacaval anastomosis. Neurochemical Research. 20: 963-7. PMID 8587655 DOI: 10.1007/Bf00970743  0.423
1995 Rao VL, Mousseau DD, Butterworth RF. A quantitative autoradiographic study of muscarinic cholinergic receptor subtypes in the brains of pyrithiamine-treated rats. Neurochemical Research. 20: 907-14. PMID 8587648 DOI: 10.1007/Bf00970736  0.382
1995 Mousseau DD, Butterworth RF. A high-affinity [3H]tryptamine binding site in human brain. Progress in Brain Research. 106: 285-91. PMID 8584665 DOI: 10.1016/S0079-6123(08)61225-X  0.378
1995 Mousseau DD, Butterworth RF. Trace amines in hepatic encephalopathy. Progress in Brain Research. 106: 277-84. PMID 8584664 DOI: 10.1016/S0079-6123(08)61224-8  0.447
1995 Ratnakumari L, Audet R, Qureshi IA, Butterworth RF. Na+,K(+)-ATPase activities are increased in brain in both congenital and acquired hyperammonemic syndromes. Neuroscience Letters. 197: 89-92. PMID 8552287 DOI: 10.1016/0304-3940(95)11906-D  0.311
1995 Héroux M, Butterworth RF. Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy. Neurochemical Research. 20: 87-93. PMID 7739764 DOI: 10.1007/Bf00995157  0.444
1995 Bergeron M, Swain MS, Reader TA, Butterworth RF. Regional alterations of dopamine and its metabolites in rat brain following portacaval anastomosis. Neurochemical Research. 20: 79-86. PMID 7739763 DOI: 10.1007/BF00995156  0.394
1995 Rao VL, Audet RM, Butterworth RF. Selective alterations of extracellular brain amino acids in relation to function in experimental portal-systemic encephalopathy: results of an in vivo microdialysis study. Journal of Neurochemistry. 65: 1221-8. PMID 7643101 DOI: 10.1046/J.1471-4159.1995.65031221.X  0.807
1995 Rao VL, Butterworth RF. Thiamine phosphatases in human brain: regional alterations in patients with alcoholic cirrhosis. Alcoholism, Clinical and Experimental Research. 19: 523-6. PMID 7625592 DOI: 10.1111/J.1530-0277.1995.Tb01541.X  0.406
1995 Butterworth RF. Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Metabolic Brain Disease. 10: 1-8. PMID 7596324 DOI: 10.1007/Bf01991777  0.354
1995 Rao VL, Audet RM, Butterworth RF. Increased nitric oxide synthase activities and L-[3H]arginine uptake in brain following portacaval anastomosis. Journal of Neurochemistry. 65: 677-8. PMID 7542313 DOI: 10.1046/J.1471-4159.1995.65020677.X  0.813
1995 Lavoie J, Butterworth RF. Reduced activities of thiamine-dependent enzymes in brains of alcoholics in the absence of Wernicke's encephalopathy. Alcoholism, Clinical and Experimental Research. 19: 1073-7. PMID 7485819 DOI: 10.1111/J.1530-0277.1995.Tb00991.X  0.39
1994 Mousseau DD, Layrargues GP, Butterworth RF. Region-selective decreases in densities of [3H]tryptamine binding sites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Journal of Neurochemistry. 62: 621-5. PMID 8294925 DOI: 10.1046/J.1471-4159.1994.62020621.X  0.411
1994 Pomier-Layrargues G, Giguère JF, Lavoie J, Perney P, Gagnon S, D'Amour M, Wells J, Butterworth RF. Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial. Hepatology (Baltimore, Md.). 19: 32-7. PMID 8276366 DOI: 10.1002/Hep.1840190107  0.332
1994 Leong DK, Le O, Oliva L, Butterworth RF. Increased densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand [3H]PK11195 in vulnerable regions of the rat brain in thiamine deficiency encephalopathy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 100-5. PMID 8263044 DOI: 10.1038/jcbfm.1994.14  0.416
1994 Blei AT, Olafsson S, Therrien G, Butterworth RF. Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis. Hepatology (Baltimore, Md.). 19: 1437-44. PMID 8188174 DOI: 10.1016/0270-9139(94)90240-2  0.48
1994 Rao VL, Audet R, Therrien G, Butterworth RF. Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis. Digestive Diseases and Sciences. 39: 1055-63. PMID 8174418 DOI: 10.1007/Bf02087558  0.785
1994 Mousseau DD, Butterworth RF. The [3H]tryptamine receptor in human brain: kinetics, distribution, and pharmacologic profile. Journal of Neurochemistry. 63: 1052-9. PMID 8051546 DOI: 10.1046/J.1471-4159.1994.63031052.X  0.344
1994 Rao VL, Qureshi IA, Butterworth RF. Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice. Neuroscience Letters. 170: 27-30. PMID 8041507 DOI: 10.1016/0304-3940(94)90230-5  0.325
1994 Butterworth RF. Portal-systemic encephalopathy: a disorder of multiple neurotransmitter systems. Revista De Gastroenterologã­a De Mã©Xico. 59: 79-84. PMID 7916475 DOI: 10.1007/978-1-4615-1989-8_8  0.309
1994 Mousseau DD, Butterworth RF. Current theories on the pathogenesis of hepatic encephalopathy. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 206: 329-44. PMID 7915420 DOI: 10.3181/00379727-206-43770  0.485
1994 Ratnakumari L, Qureshi IA, Butterworth RF. Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency. Metabolic Brain Disease. 9: 43-51. PMID 7914668 DOI: 10.1007/Bf01996073  0.414
1994 Rao VL, Therrien G, Butterworth RF. Choline acetyltransferase and acetylcholinesterase activities are unchanged in brain in human and experimental portal-systemic encephalopathy. Metabolic Brain Disease. 9: 401-7. PMID 7898405 DOI: 10.1007/Bf02098886  0.423
1994 Rao VL, Butterworth RF. Alterations of [3H]8-OH-DPAT and [3H]ketanserin binding sites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Neuroscience Letters. 182: 69-72. PMID 7891891 DOI: 10.1016/0304-3940(94)90208-9  0.342
1994 Leong DK, Therrien G, Swain MS, Butterworth RF. Densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand 3H-PK11195 are increased in brain 24 hours following portacaval anastomosis. Metabolic Brain Disease. 9: 267-73. PMID 7838068 DOI: 10.1007/Bf01991200  0.383
1994 Therrien G, Sarhan S, Knödgen B, Butterworth RF, Seiler N. Effects of ornithine aminotransferase inactivation by 5-fluoromethylornithine in rats following portacaval anastomosis. Metabolic Brain Disease. 9: 211-24. PMID 7838064 DOI: 10.1007/Bf01991195  0.399
1994 Ratnakumari L, Qureshi IA, Butterworth RF. Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency. Neuroscience Letters. 178: 63-5. PMID 7816342 DOI: 10.1016/0304-3940(94)90290-9  0.361
1993 Ratnakumari L, Qureshi IA, Butterworth RF. Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia. Biochemical Pharmacology. 45: 137-46. PMID 8424807 DOI: 10.1016/0006-2952(93)90386-B  0.408
1993 Butterworth RF, Kril JJ, Harper CG. Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. Alcoholism, Clinical and Experimental Research. 17: 1084-8. PMID 8279670 DOI: 10.1111/J.1530-0277.1993.Tb05668.X  0.332
1993 Rao VL, Giguère JF, Layrargues GP, Butterworth RF. Increased activities of MAOA and MAOB in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Brain Research. 621: 349-52. PMID 8242348 DOI: 10.1016/0006-8993(93)90126-8  0.456
1993 Rao VL, Qureshi IA, Butterworth RF. Increased densities of binding sites for the peripheral-type benzodiazepine receptor ligand [3H]PK 11195 in congenital ornithine transcarbamylase-deficient sparse fur mouse. Pediatric Research. 34: 777-80. PMID 8108192 DOI: 10.1203/00006450-199312000-00016  0.363
1993 Hazell AS, Butterworth RF, Hakim AM. Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency. Journal of Neurochemistry. 61: 1155-8. PMID 8103080 DOI: 10.1111/J.1471-4159.1993.Tb03635.X  0.685
1993 Ratnakumari L, Qureshi IA, Butterworth RF. Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy. Metabolism: Clinical and Experimental. 42: 1039-46. PMID 8102193 DOI: 10.1016/0026-0495(93)90020-O  0.356
1993 Girard G, Giguère JF, Butterworth RF. Region-selective reductions in activities of glutamine synthetase in rat brain following portacaval anastomosis. Metabolic Brain Disease. 8: 207-15. PMID 7910653 DOI: 10.1007/BF01001062  0.49
1993 Butterworth RF. Portal-systemic encephalopathy: a disorder of neuron-astrocytic metabolic trafficking. Developmental Neuroscience. 15: 313-9. PMID 7805584 DOI: 10.1159/000111350  0.408
1993 Butterworth RF. Hepatic Encephalopathy and Cerebral Edema in Fulminant Liver Failure Canadian Journal of Gastroenterology. 7: 547-549. DOI: 10.1155/1993/728683  0.388
1992 Ratnakumari L, Qureshi IA, Butterworth RF. Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice. Biochemical and Biophysical Research Communications. 184: 746-51. PMID 1575747 DOI: 10.1016/0006-291X(92)90653-3  0.384
1992 Swain M, Butterworth RF, Blei AT. Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats. Hepatology (Baltimore, Md.). 15: 449-53. PMID 1544626 DOI: 10.1002/Hep.1840150316  0.517
1992 Swain MS, Bergeron M, Audet R, Blei AT, Butterworth RF. Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter: a comparison of two rodent models of fulminant liver failure. Hepatology (Baltimore, Md.). 16: 1028-35. PMID 1356903 DOI: 10.1002/Hep.1840160428  0.823
1992 Szerb JC, Butterworth RF. Effect of ammonium ions on synaptic transmission in the mammalian central nervous system. Progress in Neurobiology. 39: 135-53. PMID 1354386 DOI: 10.1016/0301-0082(92)90008-3  0.385
1992 Girard G, Butterworth RF. Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle. Digestive Diseases and Sciences. 37: 1121-6. PMID 1352200 DOI: 10.1007/Bf01300297  0.417
1992 Giguère JF, Hamel E, Butterworth RF. Increased densities of binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 in rat brain following portacaval anastomosis. Brain Research. 585: 295-8. PMID 1324770 DOI: 10.1016/0006-8993(92)91222-Z  0.363
1991 Therrien G, Giguère JF, Butterworth RF. Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy. Metabolic Brain Disease. 6: 225-31. PMID 1812395 DOI: 10.1007/BF00996922  0.455
1991 Therrien G, Butterworth RF. Cerebrospinal fluid amino acids in relation to neurological status in experimental portal-systemic encephalopathy. Metabolic Brain Disease. 6: 65-74. PMID 1749365 DOI: 10.1007/Bf00999904  0.382
1991 Bengtsson F, Bugge M, Johansen KH, Butterworth RF. Brain tryptophan hydroxylation in the portacaval shunted rat: a hypothesis for the regulation of serotonin turnover in vivo. Journal of Neurochemistry. 56: 1069-74. PMID 1704417 DOI: 10.1111/J.1471-4159.1991.Tb02030.X  0.441
1991 Lê O, Héroux M, Butterworth RF. Pyrithiamine-induced thiamine deficiency results in decreased Ca(2+)-dependent release of glutamate from rat hippocampal slices. Metabolic Brain Disease. 6: 125-32. PMID 1685763 DOI: 10.1007/Bf00996904  0.409
1991 Butterworth RF, Le O, Lavoie J, Szerb JC. Effect of portacaval anastomosis on electrically stimulated release of glutamate from rat hippocampal slices. Journal of Neurochemistry. 56: 1481-4. PMID 1672881 DOI: 10.1111/J.1471-4159.1991.Tb02041.X  0.374
1991 Butterworth RF, Tonon MC, Désy L, Giguère JF, Vaudry H, Pelletier G. Increased brain content of the endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), following portacaval anastomosis in the rat. Peptides. 12: 119-25. PMID 1646996 DOI: 10.1016/0196-9781(91)90177-Q  0.469
1991 Pomier-Layrargues G, Nguyen NH, Faucher C, Giguère J, Butterworth RF. Subclinical Hepatic Encephalopathy in Cirrhotic Patients: Prevalence and Relationship to Liver Function Canadian Journal of Gastroenterology. 5: 121-125. DOI: 10.1155/1991/680528  0.309
1990 Fournier H, Butterworth RF. Effects of thiamine deficiency on thiamine-dependent enzymes in regions of the brain of pregnant rats and their offspring. Metabolic Brain Disease. 5: 77-84. PMID 2385216 DOI: 10.1007/Bf01001048  0.421
1990 Lavoie J, Layrargues GP, Butterworth RF. Increased densities of peripheral-type benzodiazepine receptors in brain autopsy samples from cirrhotic patients with hepatic encephalopathy. Hepatology (Baltimore, Md.). 11: 874-8. PMID 2161396 DOI: 10.1002/Hep.1840110524  0.393
1990 Butterworth RF. Increased endogenous neuropeptide ligand for benzodiazepine receptors in hepatic encephalopathy. Hepatology (Baltimore, Md.). 11: 708-9. PMID 2158481 DOI: 10.1002/Hep.1840110431  0.385
1990 Butterworth RF, Pomier Layrargues G. Benzodiazepine receptors and hepatic encephalopathy. Hepatology (Baltimore, Md.). 11: 499-501. PMID 2155867 DOI: 10.1002/Hep.1840110323  0.312
1990 Butterworth RF, Besnard AM. Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metabolic Brain Disease. 5: 179-84. PMID 2087217 DOI: 10.1007/Bf00997071  0.347
1990 Peterson C, Giguere JF, Cotman CW, Butterworth RF. Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis. Journal of Neurochemistry. 55: 386-90. PMID 1973453 DOI: 10.1111/j.1471-4159.1990.tb04149.x  0.412
1990 Bergeron M, Swain MS, Reader TA, Grondin L, Butterworth RF. Effect of ammonia on brain serotonin metabolism in relation to function in the portacaval shunted rat. Journal of Neurochemistry. 55: 222-9. PMID 1693945 DOI: 10.1111/J.1471-4159.1990.Tb08842.X  0.393
1989 Fournier H, Butterworth RF. Effects of maternal thiamine deficiency on the development of thiamine-dependent enzymes in regions of the rat brain. Neurochemistry International. 15: 439-44. PMID 20504518 DOI: 10.1016/0197-0186(89)90162-9  0.394
1989 Ganz R, Swain M, Traber P, DalCanto M, Butterworth RF, Blei AT. Ammonia-induced swelling of rat cerebral cortical slices: implications for the pathogenesis of brain edema in acute hepatic failure. Metabolic Brain Disease. 4: 213-23. PMID 2796874 DOI: 10.1007/Bf01000297  0.478
1989 Bergeron M, Layrargues GP, Butterworth RF. Aromatic and branched-chain amino acids in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Metabolic Brain Disease. 4: 169-76. PMID 2796871 DOI: 10.1007/Bf01000293  0.44
1989 Butterworth RF. Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome. Alcohol and Alcoholism (Oxford, Oxfordshire). 24: 271-9. PMID 2675860 DOI: 10.1093/Oxfordjournals.Alcalc.A044913  0.443
1989 Butterworth RF, Héroux M. Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes. Journal of Neurochemistry. 52: 1079-84. PMID 2564421 DOI: 10.1111/J.1471-4159.1989.Tb01850.X  0.412
1989 Pomier-Layrargues G, Giguère JF, Lavoie J, Willems B, Butterworth RF. Pharmacokinetics of benzodiazepine antagonist Ro 15-1788 in cirrhotic patients with moderate or severe liver dysfunction. Hepatology (Baltimore, Md.). 10: 969-72. PMID 2511137 DOI: 10.1002/Hep.1840100613  0.307
1989 Bergeron M, Reader TA, Layrargues GP, Butterworth RF. Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Neurochemical Research. 14: 853-9. PMID 2480534 DOI: 10.1007/Bf00964814  0.422
1988 Héroux M, Butterworth RF. Reversible alterations of cerebral gamma-aminobutyric acid in pyrithiamine-treated rats: implications for the pathogenesis of Wernicke's encephalopathy. Journal of Neurochemistry. 51: 1221-6. PMID 3418348 DOI: 10.1111/J.1471-4159.1988.Tb03090.X  0.349
1988 Butterworth RF, Girard G, Giguère JF. Regional differences in the capacity for ammonia removal by brain following portocaval anastomosis. Journal of Neurochemistry. 51: 486-90. PMID 3392540 DOI: 10.1111/J.1471-4159.1988.Tb01064.X  0.474
1988 Butterworth RF, Lavoie J, Giguère JF, Pomier-Layrargues G. Affinities and densities of high-affinity [3H]muscimol (GABA-A) binding sites and of central benzodiazepine receptors are unchanged in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Hepatology (Baltimore, Md.). 8: 1084-8. PMID 2843451 DOI: 10.1002/Hep.1840080517  0.341
1988 Roy S, Pomier-Layrargues G, Butterworth RF, Huet PM. Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors. Hepatology (Baltimore, Md.). 8: 845-9. PMID 2839406 DOI: 10.1002/Hep.1840080424  0.454
1987 Giguère JF, Butterworth RF. Activities of thiamine-dependent enzymes in two experimental models of thiamine deficiency encephalopathy: 3. Transketolase. Neurochemical Research. 12: 305-10. PMID 3587500 DOI: 10.1007/BF00972141  0.38
1987 Butterworth RF, Giguère JF, Michaud J, Lavoie J, Layrargues GP. Ammonia: key factor in the pathogenesis of hepatic encephalopathy. Neurochemical Pathology. 6: 1-12. PMID 3306479 DOI: 10.1007/Bf02833598  0.494
1987 Lavoie J, Giguère JF, Layrargues GP, Butterworth RF. Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy. Metabolic Brain Disease. 2: 283-90. PMID 2905419 DOI: 10.1007/Bf00999698  0.445
1987 Butterworth RF, Lavoie J, Giguère JF, Layrargues GP, Bergeron M. Cerebral GABA-ergic and glutamatergic function in hepatic encephalopathy. Neurochemical Pathology. 6: 131-44. PMID 2888065 DOI: 10.1007/Bf02833603  0.472
1987 Lavoie J, Giguère JF, Layrargues GP, Butterworth RF. Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Journal of Neurochemistry. 49: 692-7. PMID 2886551 DOI: 10.1111/J.1471-4159.1987.Tb00949.X  0.458
1986 Butterworth RF, Giguère JF, Besnard AM. Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase. Neurochemical Research. 11: 567-77. PMID 3724963 DOI: 10.1007/BF00965326  0.439
1986 Butterworth RF, Giguère JF. Cerebral aminoacids in portal-systemic encephalopathy: lack of evidence for altered gamma-aminobutyric acid (GABA) function. Metabolic Brain Disease. 1: 221-8. PMID 3508243 DOI: 10.1007/BF01001783  0.417
1985 Butterworth RF, Giguere JF, Besnard AM. Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex. Neurochemical Research. 10: 1417-28. PMID 4069311 DOI: 10.1007/BF00964982  0.404
1984 Butterworth RF, Giguère JF. Pyruvate dehydrogenase activity in regions of the rat brain during postnatal development. Journal of Neurochemistry. 43: 280-2. PMID 6726253 DOI: 10.1111/J.1471-4159.1984.Tb06710.X  0.397
1984 Giguère JF, Butterworth RF. Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy. Neurochemical Research. 9: 1309-21. PMID 6150451 DOI: 10.1007/BF00973042  0.441
1982 Butterworth RF. Neurotransmitter function in thiamine-deficiency encephalopathy. Neurochemistry International. 4: 449-64. PMID 20487899 DOI: 10.1016/0197-0186(82)90033-X  0.364
1982 Butterworth RF, Merkel AD, Landreville F. Regional amino acid distribution in relation to function in insulin hypoglycaemia. Journal of Neurochemistry. 38: 1483-9. PMID 6121012 DOI: 10.1111/J.1471-4159.1982.Tb07929.X  0.39
1980 de Michele G, Jolicoeur FB, Rondeau DB, Butterworth RF, Barbeau A. Effects of Glutamate and Aspartate on Ataxic Gait Induced by 3-Acetyl Pyridine in Rats Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 7: 451-454. PMID 6163516 DOI: 10.1017/S0317167100023052  0.33
1980 Butterworth RF, Landreville F, Hamel E, Merkel A, Giguere F, Barbeau A. Effect of Asparagine, Glutamine and Insulin on Cerebral Amino Acid Neurotransmitters Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 7: 447-450. PMID 6111388 DOI: 10.1017/S0317167100023040  0.388
1979 Davidson DL, Butterworth RF, Bélanger F, Barbeau A. Ouabain induced stereotyped behavior in rats. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 5: 401-4. PMID 570449 DOI: 10.1017/S0317167100024173  0.302
1979 Butterworth RF, Hamel E, Landreville F, Barbeau A. Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 6: 217-22. PMID 487314 DOI: 10.1017/S0317167100119675  0.337
1979 Butterworth RF, Gonce M, Barbeau A. Accumulation and removal of Hg203 in different regions of the rat brain. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 5: 397-400. PMID 217517 DOI: 10.1017/S0317167100024161  0.411
1979 Hamel E, Butterworth RF, Barbeau A. Effect of thiamine deficiency on levels of putative amino acid transmitters in affected regions of the rat brain. Journal of Neurochemistry. 33: 575-7. PMID 38303 DOI: 10.1111/J.1471-4159.1979.Tb05191.X  0.402
1978 Butterworth RF, Bélanger F, Barbeau A. Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs. Pharmacology, Biochemistry, and Behavior. 8: 41-5. PMID 625480 DOI: 10.1016/0091-3057(78)90121-1  0.324
1978 Butterworth RF, Hamel E, Landreville F, Barbeau A. Cerebellar Ataxia Produced by 3-Acetyl Pyridine in Rat Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 5: 131-133. DOI: 10.1017/S0317167100024914  0.349
1975 Butterworth RF, Barbeau A. Apomorphine: sterotyped behavior and regional distribution in rat brain. Canadian Journal of Biochemistry. 53: 308-11. PMID 1168528 DOI: 10.1139/O75-043  0.388
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