Paula Desplats - Publications

Affiliations: 
Neurosciences University of California, San Diego, La Jolla, CA 

32/61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Gutierrez A, Corey-Bloom J, Thomas EA, Desplats P. Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington's Disease Patients. Frontiers in Molecular Neuroscience. 12: 335. PMID 32038165 DOI: 10.3389/Fnmol.2019.00335  0.317
2019 Henderson-Smith A, Fisch KM, Hua J, Liu G, Ricciardelli E, Jepsen K, Huentelman M, Stalberg G, Edland SD, Scherzer CR, Dunckley T, Desplats P. DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood. Epigenetics. 1-18. PMID 30871403 DOI: 10.1080/15592294.2019.1588682  0.355
2018 Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. Journal of Neurochemistry. PMID 30152135 DOI: 10.1111/Jnc.14582  0.365
2017 Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, Rockenstein E, Troncoso JC, Beach TG, Masliah E, Desplats P. MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Frontiers in Molecular Neuroscience. 10: 329. PMID 29089869 DOI: 10.3389/Fnmol.2017.00329  0.313
2017 Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathologica Communications. 5: 2. PMID 28057080 DOI: 10.1186/S40478-016-0409-1  0.363
2016 Cronin P, McCarthy MJ, Lim AS, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27883893 DOI: 10.1016/J.Jalz.2016.10.003  0.314
2016 Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, et al. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain : a Journal of Neurology. PMID 27679481 DOI: 10.1093/Brain/Aww238  0.376
2016 Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. Journal of Neuroinflammation. 13: 120. PMID 27220536 DOI: 10.1186/S12974-016-0585-8  0.327
2016 Spencer B, Kim C, Gonzalez T, Bisquertt A, Patrick C, Rockenstein E, Adame A, Lee SJ, Desplats P, Masliah E. α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy Body disease. Human Molecular Genetics. PMID 26740557 DOI: 10.1093/Hmg/Ddv633  0.374
2015 Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Moessler H, Masliah E. Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson's Disease. Journal of Experimental Neuroscience. 9: 131-40. PMID 27429559 DOI: 10.4137/Jen.S25521  0.389
2015 Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. Journal of Neuroinflammation. 12: 236. PMID 26683203 DOI: 10.1186/S12974-015-0455-9  0.406
2015 Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E. Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease. Stem Cell Research. 15: 54-67. PMID 26209890 DOI: 10.1016/J.Scr.2015.04.008  0.314
2014 Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1753-67. PMID 25008355 DOI: 10.1038/Mt.2014.129  0.403
2014 Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E. A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. The Journal of Biological Chemistry. 289: 17917-31. PMID 24825898 DOI: 10.1074/Jbc.M114.557439  0.355
2014 Rockenstein E, Desplats P, Mante M, Florio J, Anderson S, Meier D, Winter S, Adame A, Moessler H, Masliah E. Neuro-Peptide Treatment With Cerebrolysin Improves The Survival Of Neural Stem Cell Grafts In The App Transgenic Model Of Alzheimer'S Disease Alzheimers & Dementia. 10: 863. DOI: 10.1016/J.Jalz.2014.05.1722  0.302
2013 Masliah E, Dumaop W, Galasko D, Desplats P. Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics : Official Journal of the Dna Methylation Society. 8: 1030-8. PMID 23907097 DOI: 10.4161/Epi.25865  0.36
2013 Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E. TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease. Plos One. 8: e62277. PMID 23626796 DOI: 10.1371/Journal.Pone.0062277  0.37
2012 Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M, Masliah E. Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Molecular Neurodegeneration. 7: 49. PMID 23017109 DOI: 10.1186/1750-1326-7-49  0.364
2012 Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ. Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13454-69. PMID 23015436 DOI: 10.1523/Jneurosci.1292-12.2012  0.401
2012 Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. The Journal of Biological Chemistry. 287: 31691-702. PMID 22833673 DOI: 10.1074/Jbc.M112.354522  0.397
2012 Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9992-8. PMID 22815513 DOI: 10.1523/Jneurosci.1270-12.2012  0.315
2012 Lee SJ, Desplats P, Lee HJ, Spencer B, Masliah E. Cell-to-cell transmission of α-synuclein aggregates. Methods in Molecular Biology (Clifton, N.J.). 849: 347-59. PMID 22528101 DOI: 10.1007/978-1-61779-551-0_23  0.395
2012 Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. Increased Calcium Influx and Decreased Buffering Capacity of Intracellular Stores Underlie Neuropathology Induced by Over-Expression of α-Synuclein Biophysical Journal. 102: 424a-425a. DOI: 10.1016/J.Bpj.2011.11.2321  0.331
2011 Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. The American Journal of Pathology. 178: 1646-61. PMID 21435449 DOI: 10.1016/J.Ajpath.2010.12.033  0.319
2011 Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. The Journal of Biological Chemistry. 286: 9031-7. PMID 21296890 DOI: 10.1074/Jbc.C110.212589  0.41
2010 Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E. Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. Plos One. 5: e14020. PMID 21103359 DOI: 10.1371/Journal.Pone.0014020  0.369
2010 Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nature Reviews. Neurology. 6: 702-6. PMID 21045796 DOI: 10.1038/Nrneurol.2010.145  0.351
2010 Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. Plos One. 5: e9313. PMID 20174468 DOI: 10.1371/Journal.Pone.0009313  0.407
2009 Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 106: 13010-5. PMID 19651612 DOI: 10.1073/Pnas.0903691106  0.399
2009 Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, Buerger E, Winkler J. Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Experimental Neurology. 219: 543-52. PMID 19619535 DOI: 10.1016/J.Expneurol.2009.07.013  0.313
2008 Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. Plos One. 3: e3135. PMID 18769546 DOI: 10.1371/Journal.Pone.0003135  0.388
2008 Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4250-60. PMID 18417705 DOI: 10.1523/Jneurosci.0066-08.2008  0.381
Low-probability matches (unlikely to be authored by this person)
2014 Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, Smith D, Masliah E, Grant I. Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. Plos One. 9: e102555. PMID 25054922 DOI: 10.1371/Journal.Pone.0102555  0.299
2016 Wiswell R, Guerrero-Preston R, Cronin P, Mott J, Desplats P. Alterations In Dna Methylation Contribute To Neuroinflammation In Alzheimer’S Disease Alzheimers & Dementia. 12: 860. DOI: 10.1016/J.Jalz.2016.06.1765  0.293
2016 Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7971-84. PMID 27466341 DOI: 10.1523/Jneurosci.0775-16.2016  0.289
2011 Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, et al. In vivo demonstration that alpha-synuclein oligomers are toxic. Proceedings of the National Academy of Sciences of the United States of America. 108: 4194-9. PMID 21325059 DOI: 10.1073/Pnas.1100976108  0.286
2014 Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. Journal of Alzheimer's Disease : Jad. 39: 583-600. PMID 24240640 DOI: 10.3233/Jad-131589  0.285
2011 LS-, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Correction: Cell-to-cell transmission of non-prion protein aggregates Nature Reviews Neurology. 7: 5-5. DOI: 10.1038/Nrneurol.2010.191  0.27
2019 Kim T, Valera E, Desplats P. Alterations in Striatal microRNA-mRNA Networks Contribute to Neuroinflammation in Multiple System Atrophy. Molecular Neurobiology. PMID 30968343 DOI: 10.1007/S12035-019-1577-3  0.269
2013 Desplats P, Dumaop W, Smith D, Adame A, Everall I, Letendre S, Ellis R, Cherner M, Grant I, Masliah E. Molecular and pathologic insights from latent HIV-1 infection in the human brain. Neurology. 80: 1415-23. PMID 23486877 DOI: 10.1212/Wnl.0B013E31828C2E9E  0.263
2005 Desplats P, Folco E, Salerno GL. Sucrose may play an additional role to that of an osmolyte in Synechocystis sp. PCC 6803 salt-shocked cells. Plant Physiology and Biochemistry : Ppb / SociéTé FrançAise De Physiologie VéGéTale. 43: 133-8. PMID 15820660 DOI: 10.1016/J.Plaphy.2005.01.008  0.258
2018 Frasch MG, Lobmaier S, Stampalija T, Desplats P, Pallarés ME, Pastor V, Brocco M, Wu HT, Schulkin J, Herry C, Seely A, Metz GAS, Louzoun Y, Antonelli M. Non-invasive biomarkers of fetal brain development reflecting prenatal stress: an integrative multi-scale multi-species perspective on data collection and analysis. Neuroscience and Biobehavioral Reviews. PMID 29859198 DOI: 10.1016/J.Neubiorev.2018.05.026  0.256
2019 Desplats P, Gutierrez AM, Antonelli MC, Frasch MG. Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood. Neuroscience and Biobehavioral Reviews. PMID 31703966 DOI: 10.1016/J.Neubiorev.2019.10.013  0.254
2018 Spencer B, Rank L, Metcalf J, Desplats P. Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples. Scientific Reports. 8: 4070. PMID 29511314 DOI: 10.1038/S41598-018-22434-2  0.252
2018 Kim T, Metcalf J, Mott J, Desplats P. P2-195: Amyloid Beta Induces Aberrant Dna Methylation Transitions That Activate Microglia Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.882  0.249
2014 Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Molecular Neurodegeneration. 9: 18. PMID 24885390 DOI: 10.1186/1750-1326-9-18  0.245
2004 Miller TR, Hnilicka K, Dziedzic A, Desplats P, Belas R. Chemotaxis of Silicibacter sp. strain TM1040 toward dinoflagellate products. Applied and Environmental Microbiology. 70: 4692-701. PMID 15294804 DOI: 10.1128/Aem.70.8.4692-4701.2004  0.237
2012 Tang B, Becanovic K, Desplats PA, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR, Thomas EA. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Human Molecular Genetics. 21: 3097-111. PMID 22492998 DOI: 10.1093/Hmg/Dds132  0.231
2012 Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. The Febs Journal. 279: 1000-13. PMID 22251432 DOI: 10.1111/J.1742-4658.2012.08489.X  0.231
2022 Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, et al. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35997131 DOI: 10.1002/mds.29164  0.225
1998 Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G. Sucrose-Phosphate Synthase from Synechocystis sp. Strain PCC 6803: Identification of the spsA Gene and Characterization of the Enzyme Expressed in Escherichia coli Journal of Bacteriology. 180: 6776-6779. PMID 9852031 DOI: 10.1128/Jb.180.24.6776-6779.1998  0.217
2008 Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 15564-9. PMID 18829438 DOI: 10.1073/Pnas.0804249105  0.214
2023 Whittaker DS, Akhmetova L, Carlin D, Romero H, Welsh DK, Colwell CS, Desplats P. Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer's disease. Cell Metabolism. PMID 37607543 DOI: 10.1016/j.cmet.2023.07.014  0.214
2007 Desplats PA, Denny CA, Kass KE, Gilmartin T, Head SR, Sutcliffe JG, Seyfried TN, Thomas EA. Glycolipid and ganglioside metabolism imbalances in Huntington's disease. Neurobiology of Disease. 27: 265-77. PMID 17600724 DOI: 10.1016/J.Nbd.2007.05.003  0.21
2020 Haspel JA, Anafi R, Brown MK, Cermakian N, Depner C, Desplats P, Gelman AE, Haack M, Jelic S, Kim BS, Laposky AD, Lee YC, Mongodin E, Prather AA, Prendergast B, et al. Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary. Jci Insight. 5. PMID 31941836 DOI: 10.1172/Jci.Insight.131487  0.195
2006 Desplats PA, Kass KE, Gilmartin T, Stanwood GD, Woodward EL, Head SR, Sutcliffe JG, Thomas EA. Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease. Journal of Neurochemistry. 96: 743-57. PMID 16405510 DOI: 10.1111/J.1471-4159.2005.03588.X  0.191
2021 Nasamran CA, Sachan ANS, Mott J, Kuras YI, Scherzer CR, Study HB, Ricciardelli E, Jepsen K, Edland SD, Fisch KM, Desplats P. Differential blood DNA methylation across Lewy body dementias. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12156. PMID 33665346 DOI: 10.1002/dad2.12156  0.183
2022 Caldwell AB, Anantharaman BG, Ramachandran S, Nguyen P, Liu Q, Trinh I, Galasko DR, Desplats PA, Wagner SL, Subramaniam S. Transcriptomic profiling of sporadic Alzheimer's disease patients. Molecular Brain. 15: 83. PMID 36224601 DOI: 10.1186/s13041-022-00963-2  0.156
2010 Denny CA, Desplats PA, Thomas EA, Seyfried TN. Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease. Journal of Neurochemistry. 115: 748-58. PMID 20731757 DOI: 10.1111/j.1471-4159.2010.06964.x  0.144
2008 Desplats PA, Lambert JR, Thomas EA. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiology of Disease. 31: 298-308. PMID 18595722 DOI: 10.1016/j.nbd.2008.05.005  0.141
2015 Desplats PA. Perinatal programming of neurodevelopment: epigenetic mechanisms and the prenatal shaping of the brain. Advances in Neurobiology. 10: 335-61. PMID 25287548 DOI: 10.1007/978-1-4939-1372-5_16  0.108
Hide low-probability matches.