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Adriano Aguzzi - Publications

Affiliations: 
Neuropathology University Hospital Zürich, Zürich, Switzerland, Zürich, Zürich, Switzerland 
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349 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Liu Y, Guo J, Matoga M, Korotkova M, Jakobsson PJ, Aguzzi A. NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature Neuroscience. PMID 38802591 DOI: 10.1038/s41593-024-01663-x  0.316
2022 Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 110: 3458-3483. PMID 36327895 DOI: 10.1016/j.neuron.2022.10.020  0.671
2022 Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, et al. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35997131 DOI: 10.1002/mds.29164  0.367
2021 Zhu C, Aguzzi A. Prion protein and prion disease at a glance. Journal of Cell Science. 134. PMID 34472604 DOI: 10.1242/jcs.245605  0.308
2021 Lakkaraju AKK, Frontzek K, Lemes E, Herrmann U, Losa M, Marpakwar R, Aguzzi A. Loss of PIKfyve drives the spongiform degeneration in prion diseases. Embo Molecular Medicine. e14714. PMID 34291577 DOI: 10.15252/emmm.202114714  0.304
2021 Li B, Chen M, Aguzzi A, Zhu C. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). PMID 33758958 DOI: 10.1007/s00109-021-02061-7  0.319
2020 Scheckel C, Imeri M, Schwarz P, Aguzzi A. Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons. Elife. 9. PMID 32960170 DOI: 10.7554/Elife.62911  0.426
2020 Jones E, Hummerich H, Viré E, Uphill J, Dimitriadis A, Speedy H, Campbell T, Norsworthy P, Quinn L, Whitfield J, Linehan J, Jaunmuktane Z, Brandner S, Jat P, Nihat A, ... ... Aguzzi A, et al. Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study. The Lancet. Neurology. 19: 840-848. PMID 32949544 DOI: 10.1016/S1474-4422(20)30273-8  0.31
2020 Senatore A, Frontzek K, Emmenegger M, Chincisan A, Losa M, Reimann R, Horny G, Guo J, Fels S, Sorce S, Zhu C, George N, Ewert S, Pietzonka T, Hornemann S, ... Aguzzi A, et al. Protective anti-prion antibodies in human immunoglobulin repertoires. Embo Molecular Medicine. e12739. PMID 32776637 DOI: 10.15252/Emmm.202012739  0.316
2020 Sorce S, Nuvolone M, Russo G, Chincisan A, Heinzer D, Avar M, Pfammatter M, Schwarz P, Delic M, Müller M, Hornemann S, Sanoudou D, Scheckel C, Aguzzi A. Genome-wide transcriptomics identifies an early preclinical signature of prion infection. Plos Pathogens. 16: e1008653. PMID 32598380 DOI: 10.1371/Journal.Ppat.1008653  0.389
2020 De Cecco E, Celauro L, Vanni S, Grandolfo M, Bistaffa E, Moda F, Aguzzi A, Legname G. The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells. Journal of Neurochemistry. PMID 32394432 DOI: 10.1111/Jnc.15040  0.398
2020 Vanni I, Pirisinu L, Acevedo-Morantes C, Kamali-Jamil R, Rathod V, Di Bari MA, D'Agostino C, Marcon S, Esposito E, Riccardi G, Hornemann S, Senatore A, Aguzzi A, Agrimi U, Wille H, et al. Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease. Brain : a Journal of Neurology. PMID 32303068 DOI: 10.1093/Brain/Awaa078  0.399
2020 Frontzek K, Carta M, Losa M, Epskamp M, Meisl G, Anane A, Brandel JP, Camenisch U, Castilla J, Haïk S, Knowles T, Lindner E, Lutterotti A, Minikel EV, Roiter I, ... ... Aguzzi A, et al. Autoantibodies against the prion protein in individuals with mutations. Neurology. PMID 32098855 DOI: 10.1212/Wnl.0000000000009183  0.353
2019 Baral PK, Yin J, Aguzzi A, James MNG. Transition of the prion protein from a structured cellular form (PrP ) to the infectious scrapie agent (PrP ). Protein Science : a Publication of the Protein Society. PMID 31583788 DOI: 10.1002/Pro.3735  0.339
2019 O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, ... ... Aguzzi A, et al. Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell. 36: 250-267.e9. PMID 31526758 DOI: 10.1016/J.Ccell.2019.08.001  0.351
2019 Liu Y, Aguzzi A. NG2 glia are required for maintaining microglia homeostatic state. Glia. PMID 31518022 DOI: 10.1002/Glia.23721  0.331
2019 Hornemann S, Schwarz P, Rushing EJ, Connolly MD, Zuckermann RN, Yam AY, Aguzzi A. Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads. Plos One. 14: e0216013. PMID 31513666 DOI: 10.1371/Journal.Pone.0216013  0.377
2019 Siberchicot C, Gault N, Déchamps N, Barroca V, Aguzzi A, Roméo PH, Radicella JP, Bravard A, Bernardino-Sgherri J. Prion protein deficiency impairs hematopoietic stem cells determination and sensitizes myeloid progenitors to irradiation. Haematologica. PMID 31371412 DOI: 10.3324/Haematol.2018.205716  0.301
2019 Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P. A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology. Science Translational Medicine. 11. PMID 31167929 DOI: 10.1126/Scitranslmed.Aau6722  0.335
2019 Liu Y, Aguzzi A. Immunotherapy for neurodegeneration? Science (New York, N.Y.). 364: 130-131. PMID 30975878 DOI: 10.1126/Science.Aaw0685  0.403
2019 Zhu C, Li B, Frontzek K, Liu Y, Aguzzi A. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. PMID 30842236 DOI: 10.1084/Jem.20171885  0.385
2019 Zarb Y, Weber-Stadlbauer U, Kirschenbaum D, Kindler DR, Richetto J, Keller D, Rademakers R, Dickson DW, Pasch A, Byzova T, Nahar K, Voigt FF, Helmchen F, Boss A, Aguzzi A, et al. Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response. Brain : a Journal of Neurology. PMID 30805583 DOI: 10.1093/Brain/Awz032  0.305
2019 Zhu C, Li Z, Li B, Pfammatter M, Hornemann S, Aguzzi A. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 76: 208-213. PMID 30743056 DOI: 10.1016/J.Neurobiolaging.2019.01.003  0.457
2019 Klein MA, Aguzzi A. The Neuroimmune Interface in Prion Diseases. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 15: 250-255. PMID 11390920 DOI: 10.1152/Physiologyonline.2000.15.5.250  0.388
2018 Keller A, Nuvolone M, Abakumova I, Chincisan A, Reimann R, Avar M, Heinzer D, Hornemann S, Wagner J, Kirschenbaum D, Voigt FF, Zhu C, Regli L, Helmchen F, Aguzzi A. Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier. Plos Pathogens. 14: e1007424. PMID 30496289 DOI: 10.1371/Journal.Ppat.1007424  0.42
2018 Pease D, Scheckel C, Schaper E, Eckhardt V, Emmenegger M, Xenarios I, Aguzzi A. Genome-Wide Identification of microRNAs Regulating the Human Prion Protein. Brain Pathology (Zurich, Switzerland). PMID 30451334 DOI: 10.1111/Bpa.12679  0.329
2018 Kara E, Marks JD, Aguzzi A. Toxic Protein Spread in Neurodegeneration: Reality versus Fantasy. Trends in Molecular Medicine. PMID 30442495 DOI: 10.1016/J.Molmed.2018.09.004  0.376
2018 Liu Y, Sorce S, Nuvolone M, Domange J, Aguzzi A. Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression. Scientific Reports. 8: 14600. PMID 30279468 DOI: 10.1038/S41598-018-32712-8  0.426
2018 Bardelli M, Frontzek K, Simonelli L, Hornemann S, Pedotti M, Mazzola F, Carta M, Eckhardt V, D'Antuono R, Virgilio T, González SF, Aguzzi A, Varani L. A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity. Plos Pathogens. 14: e1007335. PMID 30273408 DOI: 10.1371/Journal.Ppat.1007335  0.366
2018 Scheckel C, Aguzzi A. Prions, prionoids and protein misfolding disorders. Nature Reviews. Genetics. PMID 29713012 DOI: 10.1038/S41576-018-0011-4  0.416
2018 Baral PK, Swayampakula M, Aguzzi A, James MNG. Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. The Febs Journal. PMID 29569342 DOI: 10.1111/Febs.14438  0.391
2017 Goniotaki D, Lakkaraju AKK, Shrivastava AN, Bakirci P, Sorce S, Senatore A, Marpakwar R, Hornemann S, Gasparini F, Triller A, Aguzzi A. Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. Plos Pathogens. 13: e1006733. PMID 29176838 DOI: 10.1371/Journal.Ppat.1006733  0.371
2017 Aguzzi A, Liu Y. A role for astroglia in prion diseases. The Journal of Experimental Medicine. PMID 29162644 DOI: 10.1084/Jem.20172045  0.34
2017 Aguzzi A, Lakkaraju AKK, Frontzek K. Toward Therapy of Human Prion Diseases. Annual Review of Pharmacology and Toxicology. PMID 28961066 DOI: 10.1146/Annurev-Pharmtox-010617-052745  0.359
2017 Sorce S, Stocker R, Seredenina T, Holmdahl R, Aguzzi A, Chio A, Depaulis A, Heitz F, Olofsson P, Olsson T, Duveau V, Sanoudou D, Skosgater S, Vlahou A, Wasquel D, et al. NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: what is the evidence? Free Radical Biology & Medicine. PMID 28811143 DOI: 10.1016/J.Freeradbiomed.2017.08.006  0.36
2017 Aguzzi A, Zhu C. Microglia in prion diseases. The Journal of Clinical Investigation. PMID 28714865 DOI: 10.1172/Jci90605  0.4
2017 Bethge P, Carta S, Lorenzo DA, Egolf L, Goniotaki D, Madisen L, Voigt FF, Chen JL, Schneider B, Ohkura M, Nakai J, Zeng H, Aguzzi A, Helmchen F. An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator. Plos One. 12: e0179460. PMID 28640817 DOI: 10.1371/Journal.Pone.0179460  0.307
2017 Nuvolone M, Paolucci M, Sorce S, Kana V, Moos R, Matozaki T, Aguzzi A. Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling. Plos One. 12: e0177876. PMID 28545141 DOI: 10.1371/Journal.Pone.0177876  0.461
2017 Wulf MA, Senatore A, Aguzzi A. The biological function of the cellular prion protein: an update. Bmc Biology. 15: 34. PMID 28464931 DOI: 10.1186/S12915-017-0375-5  0.394
2017 Ballmer BA, Moos R, Liberali P, Pelkmans L, Hornemann S, Aguzzi A. Modifiers of prion protein biogenesis and recycling identified by a highly-parallel endocytosis kinetics assay. The Journal of Biological Chemistry. PMID 28341739 DOI: 10.1074/Jbc.M116.773283  0.342
2017 Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A. Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein. Plos One. 12: e0170503. PMID 28207746 DOI: 10.1371/Journal.Pone.0170503  0.385
2017 Nuvolone M, Schmid N, Miele G, Sorce S, Moos R, Schori C, Beerli RR, Bauer M, Saudan P, Dietmeier K, Lachmann I, Linnebank M, Martin R, Kallweit U, Kana V, ... ... Aguzzi A, et al. Cystatin F is a biomarker of prion pathogenesis in mice. Plos One. 12: e0171923. PMID 28178353 DOI: 10.1371/Journal.Pone.0171923  0.411
2016 Frontzek K, Pfammatter M, Sorce S, Senatore A, Schwarz P, Moos R, Frauenknecht K, Hornemann S, Aguzzi A. Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication. Plos One. 11: e0163601. PMID 27684562 DOI: 10.1371/Journal.Pone.0163601  0.43
2016 Sherman MA, LaCroix M, Amar F, Larson ME, Forster C, Aguzzi A, Bennett DA, Ramsden M, Lesné SE. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9647-58. PMID 27629715 DOI: 10.1523/Jneurosci.1899-16.2016  0.341
2016 Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, ... ... Aguzzi A, et al. The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. PMID 27501152 DOI: 10.1038/Nature19312  0.388
2016 Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, et al. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radical Biology & Medicine. PMID 27212019 DOI: 10.1016/J.Freeradbiomed.2016.05.016  0.309
2016 Zhu C, Herrmann US, Falsig J, Abakumova I, Nuvolone M, Schwarz P, Frauenknecht K, Rushing EJ, Aguzzi A. A neuroprotective role for microglia in prion diseases. The Journal of Experimental Medicine. PMID 27185853 DOI: 10.1084/Jem.20151000  0.45
2016 Nuvolone M, Hermann M, Sorce S, Russo G, Tiberi C, Schwarz P, Minikel E, Sanoudou D, Pelczar P, Aguzzi A. Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science. The Journal of Experimental Medicine. 213: 313-27. PMID 26926995 DOI: 10.1084/Jem.20151610  0.395
2016 Haybaeck J, Heikenwalder M, Klevenz B, Schwarz P, Margalith I, Bridel C, Mertz K, Zirdum E, Petsch B, Fuchs TJ, Stitz L, Aguzzi A. Correction: Aerosols transmit prions to immunocompetent and immunodeficient mice. Plos Pathogens. 12: e1005463. PMID 26872256 DOI: 10.1371/Journal.Ppat.1005463  0.331
2016 Frontzek K, Lutz MI, Aguzzi A, Kovacs GG, Budka H. Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting. Swiss Medical Weekly. 146: w14287. PMID 26812492 DOI: 10.4414/Smw.2016.14287  0.313
2016 Aguzzi A, Lakkaraju AK. Cell Biology of Prions and Prionoids: A Status Report. Trends in Cell Biology. 26: 40-51. PMID 26455408 DOI: 10.1016/J.Tcb.2015.08.007  0.382
2015 Zhu C, Schwarz P, Abakumova I, Aguzzi A. Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance. Plos One. 10: e0144983. PMID 26658276 DOI: 10.1371/Journal.Pone.0144983  0.336
2015 Frontzek K, Moos R, Schaper E, Jann L, Herfs G, Zimmermann DR, Aguzzi A, Budka H. Iatrogenic and sporadic Creutzfeldt-Jakob disease in 2 sisters without mutation in the prion protein gene. Prion. 9: 444-8. PMID 26634863 DOI: 10.1080/19336896.2015.1121356  0.39
2015 Nuvolone M, Aguzzi A. Altered Monoaminergic Systems and Depressive-like Behavior in Congenic Prion Protein Knock-out Mice. The Journal of Biological Chemistry. 290: 26350. PMID 26500295 DOI: 10.1074/Jbc.L115.689117  0.347
2015 Baral PK, Swayampakula M, Aguzzi A, James MN. X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. Journal of Structural Biology. 192: 37-47. PMID 26320075 DOI: 10.1016/J.Jsb.2015.08.014  0.348
2015 Schreiner B, Romanelli E, Liberski P, Ingold-Heppner B, Sobottka-Brillout B, Hartwig T, Chandrasekar V, Johannssen H, Zeilhofer HU, Aguzzi A, Heppner F, Kerschensteiner M, Becher B. Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS. Cell Reports. 12: 1377-84. PMID 26299968 DOI: 10.1016/J.Celrep.2015.07.051  0.649
2015 Herrmann US, Schütz AK, Shirani H, Huang D, Saban D, Nuvolone M, Li B, Ballmer B, Åslund AK, Mason JJ, Rushing E, Budka H, Nyström S, Hammarström P, Böckmann A, ... ... Aguzzi A, et al. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 7: 299ra123. PMID 26246168 DOI: 10.1126/Scitranslmed.Aab1923  0.405
2015 Cudalbu C, Craveiro M, Mlynárik V, Bremer J, Aguzzi A, Gruetter R. In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T. Neurochemical Research. PMID 26202424 DOI: 10.1007/S11064-015-1643-9  0.385
2015 Zhu C, Herrmann US, Li B, Abakumova I, Moos R, Schwarz P, Rushing EJ, Colonna M, Aguzzi A. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 36: 1994-2003. PMID 25816748 DOI: 10.1016/J.Neurobiolaging.2015.02.019  0.418
2015 Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. Plos Pathogens. 11: e1004662. PMID 25710374 DOI: 10.1371/Journal.Ppat.1004662  0.356
2015 Nuvolone M, Sorce S, Schwarz P, Aguzzi A. Prion pathogenesis in the absence of NLRP3/ASC inflammasomes. Plos One. 10: e0117208. PMID 25671600 DOI: 10.1371/Journal.Pone.0117208  0.411
2015 Dametto P, Lakkaraju AK, Bridel C, Villiger L, O'Connor T, Herrmann US, Pelczar P, Rülicke T, McHugh D, Adili A, Aguzzi A. Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP. Plos One. 10: e0117412. PMID 25658480 DOI: 10.1371/Journal.Pone.0117412  0.396
2014 Sorce S, Nuvolone M, Keller A, Falsig J, Varol A, Schwarz P, Bieri M, Budka H, Aguzzi A. The role of the NADPH oxidase NOX2 in prion pathogenesis. Plos Pathogens. 10: e1004531. PMID 25502554 DOI: 10.1371/Journal.Ppat.1004531  0.417
2014 Ganzinger KA, Narayan P, Qamar SS, Weimann L, Ranasinghe RT, Aguzzi A, Dobson CM, McColl J, St George-Hyslop P, Klenerman D. Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)). Chembiochem : a European Journal of Chemical Biology. 15: 2515-21. PMID 25294384 DOI: 10.1002/Cbic.201402377  0.345
2014 Aguzzi A. Neurodegeneration: Alzheimer's disease under strain. Nature. 512: 32-4. PMID 25100477 DOI: 10.1038/512032A  0.354
2014 Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ. Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1022-7. PMID 24431459 DOI: 10.1523/Jneurosci.4636-13.2014  0.406
2014 Baral PK, Swayampakula M, Rout MK, Kav NN, Spyracopoulos L, Aguzzi A, James MN. Structural basis of prion inhibition by phenothiazine compounds. Structure (London, England : 1993). 22: 291-303. PMID 24373770 DOI: 10.1016/J.Str.2013.11.009  0.326
2014 Baral P, Swayampakula M, Rout M, Spyracopoulos L, Aguzzi A, James M. Structural Basis of Prion Protein Conformation Conversion Inhibition Acta Crystallographica Section a Foundations and Advances. 70: C812-C812. DOI: 10.1107/S2053273314091876  0.367
2014 Aguzzi A. Toxicity of prions and prionoids: implications in neurodegenerative diseases Neurobiology of Aging. 35: S1. DOI: 10.1016/J.Neurobiolaging.2014.01.031  0.378
2013 Aguzzi A, Nuvolone M, Zhu C. The immunobiology of prion diseases. Nature Reviews. Immunology. 13: 888-902. PMID 24189576 DOI: 10.1038/Nri3553  0.366
2013 Nuvolone M, Kana V, Hutter G, Sakata D, Mortin-Toth SM, Russo G, Danska JS, Aguzzi A. SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. The Journal of Experimental Medicine. 210: 2539-52. PMID 24145514 DOI: 10.1084/Jem.20131274  0.422
2013 Aguzzi A, Gitler AD. A template for new drugs against Alzheimer's disease. Cell. 154: 1182-4. PMID 24034239 DOI: 10.1016/J.Cell.2013.08.049  0.31
2013 Keller A, Westenberger A, Sobrido MJ, García-Murias M, Domingo A, Sears RL, Lemos RR, Ordoñez-Ugalde A, Nicolas G, da Cunha JE, Rushing EJ, Hugelshofer M, Wurnig MC, Kaech A, Reimann R, ... ... Aguzzi A, et al. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nature Genetics. 45: 1077-82. PMID 23913003 DOI: 10.1038/Ng.2723  0.307
2013 Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, ... ... Aguzzi A, et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 501: 102-6. PMID 23903654 DOI: 10.1038/Nature12402  0.367
2013 Krasemann S, Mearini G, Krämer E, Wagenführ K, Schulz-Schaeffer W, Neumann M, Bodemer W, Kaup FJ, Beekes M, Carrier L, Aguzzi A, Glatzel M. BSE-associated prion-amyloid cardiomyopathy in primates. Emerging Infectious Diseases. 19: 985-8. PMID 23735198 DOI: 10.3201/Eid1906.120906  0.343
2013 Swayampakula M, Baral PK, Aguzzi A, Kav NN, James MN. The crystal structure of an octapeptide repeat of the prion protein in complex with a Fab fragment of the POM2 antibody. Protein Science : a Publication of the Protein Society. 22: 893-903. PMID 23629842 DOI: 10.1002/Pro.2270  0.307
2013 Sponarova J, Nuvolone M, Whicher C, Frei N, Kana V, Schwarz P, Westermark GT, Aguzzi A. Efficient amyloid A clearance in the absence of immunoglobulins and complement factors. The American Journal of Pathology. 182: 1297-307. PMID 23454183 DOI: 10.1016/J.Ajpath.2012.12.035  0.363
2013 Aguzzi A, Barres BA, Bennett ML. Microglia: scapegoat, saboteur, or something else? Science (New York, N.Y.). 339: 156-61. PMID 23307732 DOI: 10.1126/Science.1227901  0.337
2013 Ashe KH, Aguzzi A. Prions, prionoids and pathogenic proteins in Alzheimer disease. Prion. 7: 55-9. PMID 23208281 DOI: 10.4161/Pri.23061  0.419
2012 Larson M, Sherman MA, Amar F, Nuvolone M, Schneider JA, Bennett DA, Aguzzi A, Lesné SE. The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16857-71a. PMID 23175838 DOI: 10.1523/Jneurosci.1858-12.2012  0.367
2012 Falsig J, Sonati T, Herrmann US, Saban D, Li B, Arroyo K, Ballmer B, Liberski PP, Aguzzi A. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. Plos Pathogens. 8: e1002985. PMID 23133383 DOI: 10.1371/Journal.Ppat.1002985  0.407
2012 Baral PK, Wieland B, Swayampakula M, Polymenidou M, Rahman MH, Kav NN, Aguzzi A, James MN. Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta Crystallographica. Section D, Biological Crystallography. 68: 1501-12. PMID 23090399 DOI: 10.1107/S0907444912037328  0.342
2012 Varvel NH, Grathwohl SA, Baumann F, Liebig C, Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M. Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 18150-5. PMID 23071306 DOI: 10.1073/Pnas.1210150109  0.683
2012 Stoeck K, Sanchez-Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M, Sanchez-Valle R, Mitrova E, Sklaviadis T, Kulczycki J, Slivarichova D, Saiz A, Calero M, Knight R, Aguzzi A, et al. Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. Brain : a Journal of Neurology. 135: 3051-61. PMID 23012332 DOI: 10.1093/Brain/Aws238  0.301
2012 Michel B, Ferguson A, Johnson T, Bender H, Meyerett-Reid C, Pulford B, von Teichman A, Seelig D, Weis JH, Telling GC, Aguzzi A, Zabel MD. Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease. Journal of Immunology (Baltimore, Md. : 1950). 189: 4520-7. PMID 23002439 DOI: 10.4049/Jimmunol.1201579  0.397
2012 Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, ... ... Aguzzi A, et al. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 150: 194-206. PMID 22770220 DOI: 10.1016/J.Cell.2012.05.032  0.35
2012 Aguzzi A, Falsig J. Prion propagation, toxicity and degradation. Nature Neuroscience. 15: 936-9. PMID 22735515 DOI: 10.1038/Nn.3120  0.39
2012 Nyström S, Mishra R, Hornemann S, Aguzzi A, Nilsson KP, Hammarström P. Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. The Journal of Biological Chemistry. 287: 25975-84. PMID 22669942 DOI: 10.1074/Jbc.M112.372136  0.32
2012 Aguzzi A, Zhu C. Five questions on prion diseases. Plos Pathogens. 8: e1002651. PMID 22570608 DOI: 10.1371/Journal.Ppat.1002651  0.419
2012 Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, Falsig J, Nyström S, Hammarström P, Aslund A, Nilsson KP, Yam A, Whitters E, Hornemann S, Aguzzi A. Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates. The Journal of Biological Chemistry. 287: 18872-87. PMID 22493452 DOI: 10.1074/Jbc.M112.355958  0.388
2012 Jung HH, Bremer J, Streffer J, Virdee K, Spillantini MG, Crowther RA, Brugger P, Van Broeckhoven C, Aguzzi A, Tolnay M. Phenotypic variation of autosomal-dominant corticobasal degeneration. European Neurology. 67: 142-50. PMID 22261560 DOI: 10.1159/000334731  0.318
2011 Baral PK, Wieland B, Swayampakula M, Polymenidou M, Aguzzi A, Kav NN, James MN. Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1211-3. PMID 22102029 DOI: 10.1107/S1744309111026273  0.346
2011 Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A. Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13840-7. PMID 21957246 DOI: 10.1523/Jneurosci.3504-11.2011  0.38
2011 Stitz L, Aguzzi A. Aerosols: an underestimated vehicle for transmission of prion diseases? Prion. 5: 138-41. PMID 21778819 DOI: 10.4161/Pri.5.3.16851  0.364
2011 Ayers JI, Schutt CR, Shikiya RA, Aguzzi A, Kincaid AE, Bartz JC. The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. Plos Pathogens. 7: e1001317. PMID 21437239 DOI: 10.1371/Journal.Ppat.1001317  0.34
2011 Hafner-Bratkovic I, Bester R, Pristovsek P, Gaedtke L, Veranic P, Gaspersic J, Mancek-Keber M, Avbelj M, Polymenidou M, Julius C, Aguzzi A, Vorberg I, Jerala R. Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. The Journal of Biological Chemistry. 286: 12149-56. PMID 21324909 DOI: 10.1074/Jbc.M110.213926  0.343
2011 Haybaeck J, Heikenwalder M, Klevenz B, Schwarz P, Margalith I, Bridel C, Mertz K, Zirdum E, Petsch B, Fuchs TJ, Stitz L, Aguzzi A. Aerosols transmit prions to immunocompetent and immunodeficient mice. Plos Pathogens. 7: e1001257. PMID 21249178 DOI: 10.1371/Journal.Ppat.1001257  0.431
2011 Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A, Sigurdson CJ. Sheep with scrapie and mastitis transmit infectious prions through the milk. Journal of Virology. 85: 1136-9. PMID 21084475 DOI: 10.1128/Jvi.02022-10  0.365
2011 Polymenidou M, Prokop S, Jung HH, Hewer E, Peretz D, Moos R, Tolnay M, Aguzzi A. Atypical prion protein conformation in familial prion disease with PRNP P105T mutation. Brain Pathology (Zurich, Switzerland). 21: 209-14. PMID 20875062 DOI: 10.1111/J.1750-3639.2010.00439.X  0.67
2010 Krasemann S, Neumann M, Geissen M, Bodemer W, Kaup FJ, Schulz-Schaeffer W, Morel N, Aguzzi A, Glatzel M. Preclinical deposition of pathological prion protein in muscle of experimentally infected primates. Plos One. 5: e13906. PMID 21085647 DOI: 10.1371/Journal.Pone.0013906  0.392
2010 Kranich J, Krautler NJ, Falsig J, Ballmer B, Li S, Hutter G, Schwarz P, Moos R, Julius C, Miele G, Aguzzi A. Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner. The Journal of Experimental Medicine. 207: 2271-81. PMID 20837697 DOI: 10.1084/Jem.20092401  0.437
2010 Calella AM, Farinelli M, Nuvolone M, Mirante O, Moos R, Falsig J, Mansuy IM, Aguzzi A. Prion protein and Abeta-related synaptic toxicity impairment. Embo Molecular Medicine. 2: 306-14. PMID 20665634 DOI: 10.1002/Emmm.201000082  0.323
2010 Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A. A molecular switch controls interspecies prion disease transmission in mice. The Journal of Clinical Investigation. 120: 2590-9. PMID 20551516 DOI: 10.1172/Jci42051  0.325
2010 Mirrione MM, Konomos DK, Gravanis I, Dewey SL, Aguzzi A, Heppner FL, Tsirka SE. Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice Neurobiology of Disease. 39: 85-97. PMID 20382223 DOI: 10.1016/J.Nbd.2010.04.001  0.635
2010 Aguzzi A, O'Connor T. Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nature Reviews. Drug Discovery. 9: 237-48. PMID 20190788 DOI: 10.1038/Nrd3050  0.395
2010 Bremer J, Baumann F, Tiberi C, Wessig C, Fischer H, Schwarz P, Steele AD, Toyka KV, Nave KA, Weis J, Aguzzi A. Axonal prion protein is required for peripheral myelin maintenance. Nature Neuroscience. 13: 310-8. PMID 20098419 DOI: 10.1038/Nn.2483  0.322
2010 Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T. Experimental verification of a traceback phenomenon in prion infection. Journal of Virology. 84: 3230-8. PMID 20089646 DOI: 10.1128/Jvi.02387-09  0.362
2010 Hornemann S, Sponarova J, Zhu C, Finder V, Glockshuber R, Nilsson PK, Aguzzi A. Mechanistic and structural aspects of the interaction of luminescent conjugated polymers with amyloid oligomers Amyloid. 17: 98-99. DOI: 10.3109/13506121003737419  0.344
2009 Aguzzi A, Rajendran L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron. 64: 783-90. PMID 20064386 DOI: 10.1016/J.Neuron.2009.12.016  0.388
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1515/Nf-2010-0107  0.767
2009 Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiological Reviews. 89: 1105-52. PMID 19789378 DOI: 10.1152/Physrev.00006.2009  0.437
2009 Bremer J, Heikenwalder M, Haybaeck J, Tiberi C, Krautler NJ, Kurrer MO, Aguzzi A. Repetitive immunization enhances the susceptibility of mice to peripherally administered prions. Plos One. 4: e7160. PMID 19779609 DOI: 10.1371/Journal.Pone.0007160  0.385
2009 Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A. Functionally relevant domains of the prion protein identified in vivo. Plos One. 4: e6707. PMID 19738901 DOI: 10.1371/Journal.Pone.0006707  0.405
2009 Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, ... Aguzzi A, et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. Acs Chemical Biology. 4: 673-84. PMID 19624097 DOI: 10.1021/Cb900112V  0.771
2009 Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M. Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proceedings of the National Academy of Sciences of the United States of America. 106: 12926-31. PMID 19622727 DOI: 10.1073/Pnas.0903200106  0.318
2009 Aguzzi A. Cell biology: Beyond the prion principle. Nature. 459: 924-5. PMID 19536253 DOI: 10.1038/459924A  0.411
2009 Nuvolone M, Aguzzi A, Heikenwalder M. Cells and prions: a license to replicate. Febs Letters. 583: 2674-84. PMID 19527722 DOI: 10.1016/J.Febslet.2009.06.014  0.415
2009 Aguzzi A, Steele AD. Prion topology and toxicity. Cell. 137: 994-6. PMID 19524502 DOI: 10.1016/J.Cell.2009.05.041  0.391
2009 Ladogana A, Sanchez-Juan P, Mitrová E, Green A, Cuadrado-Corrales N, Sánchez-Valle R, Koscova S, Aguzzi A, Sklaviadis T, Kulczycki J, Gawinecka J, Saiz A, Calero M, van Duijn CM, Pocchiari M, et al. Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies. Journal of Neurology. 256: 1620-8. PMID 19444528 DOI: 10.1007/S00415-009-5163-X  0.32
2009 Weller M, Aguzzi A. Movement disorders reveal Creutzfeldt-Jakob disease. Nature Reviews. Neurology. 5: 185-6. PMID 19347022 DOI: 10.1038/Nrneurol.2009.32  0.314
2009 Race B, Meade-White K, Race R, Baumann F, Aguzzi A, Chesebro B. Prion protein on astrocytes or in extracellular fluid impedes neurodegeneration induced by truncated prion protein. Experimental Neurology. 217: 347-52. PMID 19332059 DOI: 10.1016/J.Expneurol.2009.03.017  0.441
2009 Nazabal A, Hornemann S, Aguzzi A, Zenobi R. Hydrogen/deuterium exchange mass spectrometry identifies two highly protected regions in recombinant full-length prion protein amyloid fibrils. Journal of Mass Spectrometry. 44: 965-977. PMID 19283723 DOI: 10.1002/Jms.1572  0.349
2009 Rutishauser D, Mertz KD, Moos R, Brunner E, Rülicke T, Calella AM, Aguzzi A. The comprehensive native interactome of a fully functional tagged prion protein. Plos One. 4: e4446. PMID 19209230 DOI: 10.1371/Journal.Pone.0004446  0.391
2009 Le Pichon CE, Valley MT, Polymenidou M, Chesler AT, Sagdullaev BT, Aguzzi A, Firestein S. Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nature Neuroscience. 12: 60-9. PMID 19098904 DOI: 10.1038/Nn.2238  0.353
2009 Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 304-9. PMID 19073920 DOI: 10.1073/Pnas.0810680105  0.449
2009 Sigurdson CJ, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. Bacterial colitis increases susceptibility to oral prion disease. The Journal of Infectious Diseases. 199: 243-52. PMID 19072552 DOI: 10.1086/595791  0.417
2008 Falsig J, Nilsson KP, Knowles TP, Aguzzi A. Chemical and biophysical insights into the propagation of prion strains. Hfsp Journal. 2: 332-41. PMID 19436493 DOI: 10.2976/1.2990786  0.374
2008 Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 29: 998-1008. PMID 19100703 DOI: 10.1016/J.Immuni.2008.10.014  0.412
2008 Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, ... Aguzzi A, et al. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. Plos One. 3: e3872. PMID 19060956 DOI: 10.1371/Journal.Pone.0003872  0.363
2008 Miele G, Seeger H, Marino D, Eberhard R, Heikenwalder M, Stoeck K, Basagni M, Knight R, Green A, Chianini F, Wüthrich RP, Hock C, Zerr I, Aguzzi A. Urinary alpha1-antichymotrypsin: a biomarker of prion infection. Plos One. 3: e3870. PMID 19057641 DOI: 10.1371/Journal.Pone.0003870  0.35
2008 Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Experimental Gerontology. 43: 1086-93. PMID 18799131 DOI: 10.1016/J.Exger.2008.08.050  0.425
2008 Seeger H, Julius C, Cozzari C, Calella AM, Dattilo M, Aguzzi A. Prion depletion and preservation of biological activity by preparative chaotrope ultracentrifugation. Biologicals. 36: 403-411. PMID 18760936 DOI: 10.1016/J.Biologicals.2008.07.004  0.304
2008 Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 13626-31. PMID 18757733 DOI: 10.1073/Pnas.0806319105  0.719
2008 Ott D, Taraborrelli C, Aguzzi A. Novel dominant-negative prion protein mutants identified from a randomized library. Protein Engineering, Design & Selection : Peds. 21: 623-9. PMID 18676974 DOI: 10.1093/Protein/Gzn042  0.398
2008 Aguzzi A, Baumann F, Bremer J. The prion's elusive reason for being. Annual Review of Neuroscience. 31: 439-77. PMID 18558863 DOI: 10.1146/Annurev.Neuro.31.060407.125620  0.402
2008 Kranich J, Krautler NJ, Heinen E, Polymenidou M, Bridel C, Schildknecht A, Huber C, Kosco-Vilbois MH, Zinkernagel R, Miele G, Aguzzi A. Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8 Journal of Experimental Medicine. 205: 1293-1302. PMID 18490487 DOI: 10.1084/Jem.20071019  0.348
2008 Heikenwalder M, Prinz M, Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rülicke T, Macpherson AJ, Holländer GA, Nedospasov SA, Aguzzi A. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. The American Journal of Pathology. 172: 1555-70. PMID 18483211 DOI: 10.2353/Ajpath.2008.070572  0.338
2008 Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A. Prion propagation in mice lacking central nervous system NF-kappaB signalling. The Journal of General Virology. 89: 1545-50. PMID 18474572 DOI: 10.1099/Vir.0.83622-0  0.326
2008 Polymenidou M, Trusheim H, Stallmach L, Moos R, Julius C, Miele G, Lenz-Bauer C, Aguzzi A. Canine MDCK cell lines are refractory to infection with human and mouse prions. Vaccine. 26: 2601-14. PMID 18423803 DOI: 10.1016/J.Vaccine.2008.03.035  0.386
2008 Falsig J, Aguzzi A. The prion organotypic slice culture assay--POSCA. Nature Protocols. 3: 555-62. PMID 18388937 DOI: 10.1038/Nprot.2008.13  0.329
2008 Gavín R, Ureña J, Rangel A, Pastrana MA, Requena JR, Soriano E, Aguzzi A, Del Río JA. Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons. Neurobiology of Disease. 30: 243-54. PMID 18374587 DOI: 10.1016/J.Nbd.2008.02.001  0.354
2008 Genoud N, Ott D, Braun N, Prinz M, Schwarz P, Suter U, Trono D, Aguzzi A. Antiprion prophylaxis by gene transfer of a soluble prion antagonist. The American Journal of Pathology. 172: 1287-96. PMID 18372425 DOI: 10.2353/Ajpath.2008.070836  0.435
2008 Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M. Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease. Neuro-Degenerative Diseases. 5: 347-54. PMID 18349519 DOI: 10.1159/000121389  0.359
2008 Aguzzi A, Sigurdson C, Heikenwaelder M. Molecular mechanisms of prion pathogenesis. Annual Review of Pathology. 3: 11-40. PMID 18233951 DOI: 10.1146/Annurev.Pathmechdis.3.121806.154326  0.457
2008 Von Poser-Klein C, Flechsig E, Hoffmann T, Schwarz P, Harms H, Bujdoso R, Aguzzi A, Klein MA. Alteration of B-cell subsets enhances neuroinvasion in mouse scrapie infection Journal of Virology. 82: 3791-3795. PMID 18199638 DOI: 10.1128/Jvi.02036-07  0.369
2008 Aguzzi A. Unraveling prion strains with cell biology and organic chemistry. Proceedings of the National Academy of Sciences of the United States of America. 105: 11-2. PMID 18172195 DOI: 10.1073/Pnas.0710824105  0.401
2008 Julius C, Hutter G, Wagner U, Seeger H, Kana V, Kranich J, Klöhn PC, Klöhn P, Weissmann C, Miele G, Aguzzi A. Transcriptional stability of cultured cells upon prion infection. Journal of Molecular Biology. 375: 1222-33. PMID 18082765 DOI: 10.1016/J.Jmb.2007.11.003  0.329
2008 Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, Aguzzi A. A versatile prion replication assay in organotypic brain slices. Nature Neuroscience. 11: 109-17. PMID 18066056 DOI: 10.1038/Nn2028  0.715
2008 Heikenwalder M, Julius C, Aguzzi A. Prions and peripheral nerves: a deadly rendezvous. Journal of Neuroscience Research. 85: 2714-25. PMID 17393538 DOI: 10.1002/Jnr.21246  0.409
2007 Steele AD, Lindquist S, Aguzzi A. The prion protein knockout mouse: a phenotype under challenge. Prion. 1: 83-93. PMID 19164918 DOI: 10.4161/Pri.1.2.4346  0.435
2007 Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Prion strain discrimination using luminescent conjugated polymers. Nature Methods. 4: 1023-30. PMID 18026110 DOI: 10.1038/Nmeth1131  0.383
2007 Heikenwalder M, Federau C, Boehmer Lv, Schwarz P, Wagner M, Zeller N, Haybaeck J, Prinz M, Becher B, Aguzzi A. Germinal center B cells are dispensable in prion transport and neuroinvasion. Journal of Neuroimmunology. 192: 113-23. PMID 17964667 DOI: 10.1016/J.Jneuroim.2007.09.022  0.393
2007 Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, von Teichman A, Haas KM, Zeller N, Tedder TF, Weis JH, Aguzzi A. Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. Journal of Immunology (Baltimore, Md. : 1950). 179: 6144-52. PMID 17947689 DOI: 10.4049/Jimmunol.179.9.6144  0.322
2007 Aguzzi A. Prion biology: the quest for the test. Nature Methods. 4: 614-6. PMID 17664944 DOI: 10.1038/Nmeth0807-614  0.309
2007 Aguzzi A, Heikenwalder M, Polymenidou M. Insights into prion strains and neurotoxicity. Nature Reviews. Molecular Cell Biology. 8: 552-61. PMID 17585315 DOI: 10.1038/Nrm2204  0.37
2007 Nicolas O, Gavín R, Braun N, Ureña JM, Fontana X, Soriano E, Aguzzi A, del Río JA. Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3107-17. PMID 17494993 DOI: 10.1096/Fj.06-7827Com  0.347
2007 Rangel A, Burgaya F, Gavín R, Soriano E, Aguzzi A, Del Río JA. Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptors. Journal of Neuroscience Research. 85: 2741-55. PMID 17304577 DOI: 10.1002/Jnr.21215  0.37
2007 Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, Heikenwalder M, Rülicke T, Bürkle A, Aguzzi A. Lethal recessive myelin toxicity of prion protein lacking its central domain. The Embo Journal. 26: 538-47. PMID 17245436 DOI: 10.1038/Sj.Emboj.7601510  0.367
2007 Sigurdson CJ, Aguzzi A. Chronic wasting disease. Biochimica Et Biophysica Acta. 1772: 610-8. PMID 17223321 DOI: 10.1016/J.Bbadis.2006.10.010  0.371
2007 Aguzzi A, Heppner FL, Westner IM, Glatzel M. Prion diseases Neurobiology of Disease. 473-483. DOI: 10.1016/B978-012088592-3/50044-X  0.708
2006 Priller J, Prinz M, Heikenwalder M, Zeller N, Schwarz P, Heppner FL, Aguzzi A. Early and rapid engraftment of bone marrow-derived microglia in scrapie. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11753-62. PMID 17093096 DOI: 10.1523/Jneurosci.2275-06.2006  0.703
2006 Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF. Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 15951-6. PMID 17038503 DOI: 10.1073/Pnas.0604493103  0.301
2006 Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. Strain fidelity of chronic wasting disease upon murine adaptation. Journal of Virology. 80: 12303-11. PMID 17020952 DOI: 10.1128/Jvi.01120-06  0.43
2006 Aguzzi A, Heikenwalder M. Pathogenesis of prion diseases: current status and future outlook. Nature Reviews. Microbiology. 4: 765-75. PMID 16980938 DOI: 10.1038/Nrmicro1492  0.406
2006 Aguzzi A, Glatzel M. Prion infections, blood and transfusions. Nature Clinical Practice. Neurology. 2: 321-9. PMID 16932576 DOI: 10.1038/Ncpneuro0214  0.346
2006 Sigurdson C, Polymenidou M, Aguzzi A. Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neuro-Degenerative Diseases. 2: 1-5. PMID 16908997 DOI: 10.1159/000086425  0.416
2006 Junt T, Tumanov AV, Harris N, Heikenwalder M, Zeller N, Kuprash DV, Aguzzi A, Ludewig B, Nedospasov SA, Zinkernagel RM. Expression of lymphotoxin beta governs immunity at two distinct levels. European Journal of Immunology. 36: 2061-75. PMID 16841297 DOI: 10.1002/Eji.200626255  0.325
2006 Aguzzi A. Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis. Journal of Neurochemistry. 97: 1726-39. PMID 16805779 DOI: 10.1111/J.1471-4159.2006.03909.X  0.435
2006 Vogelgesang S, Glatzel M, Walker LC, Kroemer HK, Aguzzi A, Warzok RW. Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease. Acta Neuropathologica. 111: 436-43. PMID 16523342 DOI: 10.1007/S00401-006-0042-3  0.352
2006 Schoch G, Seeger H, Bogousslavsky J, Tolnay M, Janzer RC, Aguzzi A, Glatzel M. Analysis of prion strains by PrPSc profiling in sporadic Creutzfeldt-Jakob disease. Plos Medicine. 3: e14. PMID 16354106 DOI: 10.1371/Journal.Pmed.0030014  0.413
2005 Polymenidou M, Stoeck K, Glatzel M, Vey M, Bellon A, Aguzzi A. Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease. The Lancet. Neurology. 4: 805-14. PMID 16297838 DOI: 10.1016/S1474-4422(05)70225-8  0.344
2005 Seeger H, Heikenwalder M, Zeller N, Kranich J, Schwarz P, Gaspert A, Seifert B, Miele G, Aguzzi A. Coincident scrapie infection and nephritis lead to urinary prion excretion. Science (New York, N.Y.). 310: 324-6. PMID 16224026 DOI: 10.1126/Science.1118829  0.377
2005 Kovács GG, Puopolo M, Ladogana A, Pocchiari M, Budka H, van Duijn C, Collins SJ, Boyd A, Giulivi A, Coulthart M, Delasnerie-Laupretre N, Brandel JP, Zerr I, Kretzschmar HA, de Pedro-Cuesta J, ... ... Aguzzi A, et al. Genetic prion disease: the EUROCJD experience. Human Genetics. 118: 166-74. PMID 16187142 DOI: 10.1007/S00439-005-0020-1  0.315
2005 Gavín R, Braun N, Nicolas O, Parra B, Ureña JM, Mingorance A, Soriano E, Torres JM, Aguzzi A, del Río JA. PrP(106-126) activates neuronal intracellular kinases and Egr1 synthesis through activation of NADPH-oxidase independently of PrPc. Febs Letters. 579: 4099-106. PMID 16023105 DOI: 10.1016/J.Febslet.2005.06.037  0.335
2005 Donofrio G, Heppner FL, Polymenidou M, Musahl C, Aguzzi A. Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies. Journal of Virology. 79: 8330-8. PMID 15956578 DOI: 10.1128/Jvi.79.13.8330-8338.2005  0.701
2005 Aguzzi A. Prion Toxicity: All Sail and No Anchor Science. 308: 1420-1421. PMID 15933188 DOI: 10.1126/Science.1114168  0.445
2005 Glatzel M, Mohajeri MH, Poirier R, Nitsch RM, Schwarz P, Lu B, Aguzzi A. No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis. The Journal of General Virology. 86: 1861-7. PMID 15914866 DOI: 10.1099/Vir.0.80811-0  0.428
2005 Radovanovic I, Braun N, Giger OT, Mertz K, Miele G, Prinz M, Navarro B, Aguzzi A. Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC Journal of Neuroscience. 25: 4879-4888. PMID 15888663 DOI: 10.1523/Jneurosci.0328-05.2005  0.4
2005 Glatzel M, Stoeck K, Seeger H, Lührs T, Aguzzi A. Human prion diseases: molecular and clinical aspects. Archives of Neurology. 62: 545-52. PMID 15824251 DOI: 10.1001/Archneur.62.4.545  0.411
2005 Nikles D, Bach P, Boller K, Merten CA, Montrasio F, Heppner FL, Aguzzi A, Cichutek K, Kalinke U, Buchholz CJ. Circumventing tolerance to the prion protein (PrP): vaccination with PrP-displaying retrovirus particles induces humoral immune responses against the native form of cellular PrP. Journal of Virology. 79: 4033-42. PMID 15767405 DOI: 10.1128/Jvi.79.7.4033-4042.2005  0.706
2005 Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, Aitken A, Wiltfang J, Aguzzi A, Bahn E, Baxter HC, Brose N, Otto M. Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein. Molecular and Cellular Biology. 25: 1339-46. PMID 15684385 DOI: 10.1128/Mcb.25.4.1339-1346.2005  0.413
2005 Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, Becher B, Aguzzi A. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nature Medicine. 11: 146-52. PMID 15665833 DOI: 10.1038/Nm1177  0.686
2005 Heikenwalder M, Zeller N, Seeger H, Prinz M, Klöhn PC, Schwarz P, Ruddle NH, Weissmann C, Aguzzi A. Chronic lymphocytic inflammation specifies the organ tropism of prions. Science (New York, N.Y.). 307: 1107-10. PMID 15661974 DOI: 10.1126/Science.1106460  0.386
2005 Weissmann C, Aguzzi A. Approaches to therapy of prion diseases. Annual Review of Medicine. 56: 321-44. PMID 15660515 DOI: 10.1146/Annurev.Med.56.062404.172936  0.355
2005 Masel J, Genoud N, Aguzzi A. Efficient inhibition of prion replication by PrP-Fc(2) suggests that the prion is a PrP(Sc) oligomer. Journal of Molecular Biology. 345: 1243-51. PMID 15644218 DOI: 10.1016/J.Jmb.2004.10.088  0.389
2005 Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C. A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. The Journal of Biological Chemistry. 280: 5137-40. PMID 15615717 DOI: 10.1074/Jbc.C400560200  0.531
2005 Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, Becher B, Aguzzi A. Erratum: CORRIGENDUM: Experimental autoimmune encephalomyelitis repressed by microglial paralysis Nature Medicine. 11: 455-455. DOI: 10.1038/Nm0405-455  0.628
2004 Pocchiari M, Puopolo M, Croes EA, Budka H, Gelpi E, Collins S, Lewis V, Sutcliffe T, Guilivi A, Delasnerie-Laupretre N, Brandel JP, Alperovitch A, Zerr I, Poser S, Kretzschmar HA, ... ... Aguzzi A, et al. Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Brain : a Journal of Neurology. 127: 2348-59. PMID 15361416 DOI: 10.1093/Brain/Awh249  0.316
2004 Glatzel M, Giger O, Braun N, Aguzzi A. The peripheral nervous system and the pathogenesis of prion diseases. Current Molecular Medicine. 4: 355-9. PMID 15354866 DOI: 10.2174/1566524043360618  0.405
2004 Aguzzi A, Sigurdson CJ. Antiprion immunotherapy: to suppress or to stimulate? Nature Reviews. Immunology. 4: 725-36. PMID 15343371 DOI: 10.1038/Nri1437  0.386
2004 Heppner FL, Aguzzi A. Recent developments in prion immunotherapy. Current Opinion in Immunology. 16: 594-8. PMID 15342005 DOI: 10.1016/J.Coi.2004.07.008  0.695
2004 Polymenidou M, Heppner FL, Pellicioli EC, Urich E, Miele G, Braun N, Wopfner F, Schätzl HM, Becher B, Aguzzi A. Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection. Proceedings of the National Academy of Sciences of the United States of America. 101: 14670-6. PMID 15292505 DOI: 10.1073/Pnas.0404772101  0.716
2004 Aguzzi A, Heikenwalder M, Miele G. Progress and problems in the biology, diagnostics, and therapeutics of prion diseases. The Journal of Clinical Investigation. 114: 153-60. PMID 15254579 DOI: 10.1172/Jci22438  0.389
2004 Prinz M, Montrasio F, Furukawa H, van der Haar ME, Schwarz P, Rülicke T, Giger OT, Häusler KG, Perez D, Glatzel M, Aguzzi A. Intrinsic resistance of oligodendrocytes to prion infection. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5974-81. PMID 15229245 DOI: 10.1523/Jneurosci.0122-04.2004  0.42
2004 Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Disease and Associated Disorders. 18: 44-6. PMID 15195463 DOI: 10.1097/00002093-200401000-00009  0.644
2004 Aguzzi A, Miele G. Recent advances in prion biology. Current Opinion in Neurology. 17: 337-42. PMID 15167069 DOI: 10.1097/00019052-200406000-00015  0.397
2004 Heikenwalder M, Prinz M, Heppner FL, Aguzzi A. Current concepts and controversies in prion immunopathology. Journal of Molecular Neuroscience : Mn. 23: 3-12. PMID 15126687 DOI: 10.1385/Jmn:23:1-2:003  0.694
2004 Aguzzi A. Understanding the diversity of prions. Nature Cell Biology. 6: 290-2. PMID 15057242 DOI: 10.1038/Ncb0404-290  0.332
2004 Genoud N, Behrens A, Arrighi I, Aguzzi A. Prion proteins and infertility: insight from mouse models. Cytogenetic and Genome Research. 103: 285-9. PMID 15051949 DOI: 10.1159/000076814  0.316
2004 Glatzel M, Giger O, Seeger H, Aguzzi A. Variant Creutzfeldt-jakob disease: between lymphoid organs and brain. Trends in Microbiology. 12: 51-3. PMID 15040321 DOI: 10.1016/J.Tim.2003.12.001  0.421
2004 Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development. 125: 149-51. PMID 15037022 DOI: 10.1016/J.Mad.2003.12.002  0.651
2004 Rossetti AO, Bogousslavsky J, Glatzel M, Aguzzi A. Mimicry of variant Creutzfeldt-Jakob disease by sporadic Creutzfeldt-Jakob disease: importance of the pulvinar sign. Archives of Neurology. 61: 445-6. PMID 15023826 DOI: 10.1001/Archneur.61.3.445  0.355
2004 Genoud N, Behrens A, Miele G, Robay D, Heppner FL, Freigang S, Aguzzi A. Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proceedings of the National Academy of Sciences of the United States of America. 101: 4198-203. PMID 15007175 DOI: 10.1073/Pnas.0400131101  0.686
2004 Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration Nature Medicine. 10: 187-192. PMID 14745443 DOI: 10.1038/Nm987  0.314
2004 Aguzzi A, Polymenidou M. Mammalian prion biology: one century of evolving concepts. Cell. 116: 313-27. PMID 14744440 DOI: 10.1016/S0092-8674(03)01031-6  0.38
2004 Aguzzi A. Prions and the immune system: a journey through gut, spleen, and nerves. Advances in Immunology. 81: 123-71. PMID 14711055 DOI: 10.1016/S0065-2776(03)81004-0  0.383
2004 Kovacs GG, Lindeck-Pozza E, Chimelli L, Araújo AQ, Gabbai AA, Ströbel T, Glatzel M, Aguzzi A, Budka H. Creutzfeldt-Jakob disease and inclusion body myositis: abundant disease-associated prion protein in muscle. Annals of Neurology. 55: 121-5. PMID 14705121 DOI: 10.1002/Ana.10813  0.377
2004 Aguzzi A. The immune component of brain disease: The surprising renaissance of neuroimmunology Current Opinion in Immunology. 16: 584-586. DOI: 10.1016/J.Coi.2004.07.019  0.316
2003 Glatzel M, Ott PM, Linder T, Gebbers JO, Gmür A, Wüst W, Huber G, Moch H, Podvinec M, Stamm B, Aguzzi A. Human prion diseases: epidemiology and integrated risk assessment. The Lancet. Neurology. 2: 757-63. PMID 14636781 DOI: 10.1016/S1474-4422(03)00588-X  0.328
2003 Glatzel M, Abela E, Maissen M, Aguzzi A. Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. The New England Journal of Medicine. 349: 1812-20. PMID 14602879 DOI: 10.1056/Nejmoa030351  0.363
2003 Aguzzi A, Haass C. Games played by rogue proteins in prion disorders and Alzheimer's disease. Science (New York, N.Y.). 302: 814-8. PMID 14593165 DOI: 10.1126/Science.1087348  0.533
2003 Prinz M, Heikenwalder M, Junt T, Schwarz P, Glatzel M, Heppner FL, Fu YX, Lipp M, Aguzzi A. Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature. 425: 957-62. PMID 14562059 DOI: 10.1038/Nature02072  0.695
2003 Aguzzi A, Heppner FL, Heikenwalder M, Prinz M, Mertz K, Seeger H, Glatzel M. Immune system and peripheral nerves in propagation of prions to CNS. British Medical Bulletin. 66: 141-59. PMID 14522856 DOI: 10.1093/Bmb/66.1.141  0.7
2003 Hutter G, Heppner FL, Aguzzi A. No superoxide dismutase activity of cellular prion protein in vivo. Biological Chemistry. 384: 1279-85. PMID 14515989 DOI: 10.1515/Bc.2003.142  0.714
2003 Flechsig E, Hegyi I, Leimeroth R, Zuniga A, Rossi D, Cozzio A, Schwarz P, Rülicke T, Götz J, Aguzzi A, Weissmann C. Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. The Embo Journal. 22: 3095-101. PMID 12805223 DOI: 10.1093/Emboj/Cdg285  0.402
2003 Aguzzi A, Heikenwalder M. Prion diseases: Cannibals and garbage piles. Nature. 423: 127-9. PMID 12736665 DOI: 10.1038/423127A  0.38
2003 Meier P, Genoud N, Prinz M, Maissen M, Rülicke T, Zurbriggen A, Raeber AJ, Aguzzi A. Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease. Cell. 113: 49-60. PMID 12679034 DOI: 10.1016/S0092-8674(03)00201-0  0.439
2003 Prinz M, Huber G, Macpherson AJ, Heppner FL, Glatzel M, Eugster HP, Wagner N, Aguzzi A. Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes. The American Journal of Pathology. 162: 1103-11. PMID 12651603 DOI: 10.1016/S0002-9440(10)63907-7  0.688
2003 Prinz M, Heikenwalder M, Schwarz P, Takeda K, Akira S, Aguzzi A. Prion pathogenesis in the absence of Toll-like receptor signalling. Embo Reports. 4: 195-9. PMID 12612611 DOI: 10.1038/Sj.Embor.Embor731  0.365
2003 Praus M, Kettelgerdes G, Baier M, Holzhütter H, Jungblut PR, Maissen M, Epple G, Schleuning W, Kottgen E, Aguzzi A, Gessner R. Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110. Thrombosis and Haemostasis. 89: 812-819. DOI: 10.1267/Thro03050812  0.353
2002 Rogivue C, Gottwein J, Aguzzi A, Glatzel M. [Transmissible spongiform encephalopathies in humans]. Schweizer Archiv Fã¼R Tierheilkunde. 144: 685-90. PMID 12585209 DOI: 10.1024/0036-7281.144.12.685  0.339
2002 Glatzel M, Gottwein J, Aguzzi A. [Prions as the driving force in transmissible spongiform encephalopathies]. Schweizer Archiv Fã¼R Tierheilkunde. 144: 633-8. PMID 12585203 DOI: 10.1024/0036-7281.144.12.633  0.409
2002 Glatzel M, Pekarik V, Lührs T, Dittami J, Aguzzi A. Analysis of the prion protein in primates reveals a new polymorphism in codon 226 (Y226F). Biological Chemistry. 383: 1021-5. PMID 12222676 DOI: 10.1515/Bc.2002.109  0.327
2002 Künzi V, Glatzel M, Nakano MY, Greber UF, Van Leuven F, Aguzzi A. Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7471-7. PMID 12196569 DOI: 10.1523/Jneurosci.22-17-07471.2002  0.356
2002 Glatzel M, Rogivue C, Ghani A, Streffer JR, Amsler L, Aguzzi A. Incidence of Creutzfeldt-Jakob disease in Switzerland. Lancet. 360: 139-41. PMID 12126826 DOI: 10.1016/S0140-6736(02)09384-4  0.361
2002 Behrens A, Genoud N, Naumann H, Rülicke T, Janett F, Heppner FL, Ledermann B, Aguzzi A. Absence of the prion protein homologue Doppel causes male sterility. The Embo Journal. 21: 3652-8. PMID 12110578 DOI: 10.1093/Emboj/Cdf386  0.703
2002 Sisó S, Puig B, Varea R, Vidal E, Acín C, Prinz M, Montrasio F, Badiola J, Aguzzi A, Pumarola M, Ferrer I. Abnormal synaptic protein expression and cell death in murine scrapie. Acta Neuropathologica. 103: 615-626. PMID 12012094 DOI: 10.1007/S00401-001-0512-6  0.342
2002 Glatzel M, Brandner S, Klein MA, Horstmann S, Aguzzi A. Prions--role of the peripheral nervous system. Virus Research. 82: 53. PMID 11885950 DOI: 10.1016/S0168-1702(01)00434-8  0.302
2002 Behrens A, Aguzzi A. Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl. Trends in Neurosciences. 25: 150-4. PMID 11852147 DOI: 10.1016/S0166-2236(00)02089-0  0.398
2002 Thackray AM, Klein MA, Aguzzi A, Bujdoso R. Chronic subclinical prion disease induced by low-dose inoculum Journal of Virology. 76: 2510-2517. PMID 11836429 DOI: 10.1128/Jvi.76.5.2510-2517.2002  0.427
2002 Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, Odermatt B, Pfeffer K, Aguzzi A. Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells Proceedings of the National Academy of Sciences of the United States of America. 99: 919-924. PMID 11792852 DOI: 10.1073/Pnas.022626399  0.364
2002 Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, Kleinert R, Prinz M, Aguzzi A, Denk H. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. The American Journal of Pathology. 160: 255-63. PMID 11786419 DOI: 10.1016/S0002-9440(10)64369-6  0.343
2002 Heppner FL, Arrighi I, Kalinke U, Aguzzi A. Immunity against prions? Trends in Molecular Medicine. 7: 477-9. PMID 11689311 DOI: 10.1016/S1471-4914(01)02182-7  0.704
2001 Raeber AJ, Montrasio F, Hegyi I, Frigg R, Klein MA, Aguzzi A, Weissmann C. Studies on prion replication in spleen. Developmental Immunology. 8: 291-304. PMID 11785678 DOI: 10.1155/2001/95404  0.399
2001 Glatzel M, Aguzzi A. The shifting biology of prions. Brain Research. Brain Research Reviews. 36: 241-8. PMID 11690621 DOI: 10.1016/S0165-0173(01)00100-X  0.405
2001 Aguzzi A, Glatzel M, Montrasio F, Prinz M, Heppner FL. Interventional strategies against prion diseases. Nature Reviews. Neuroscience. 2: 745-9. PMID 11584312 DOI: 10.1038/35094590  0.677
2001 Parizek P, Roeckl C, Weber J, Flechsig E, Aguzzi A, Raeber AJ. Similar turnover and shedding of the cellular prion protein in primary lymphoid and neuronal cells. The Journal of Biological Chemistry. 276: 44627-32. PMID 11571302 DOI: 10.1074/Jbc.M107458200  0.407
2001 Heppner FL, Musahl C, Arrighi I, Klein MA, Rülicke T, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science (New York, N.Y.). 294: 178-82. PMID 11546838 DOI: 10.1126/Science.1063093  0.727
2001 Heppner FL, Prinz M, Aguzzi A. Pathogenesis of prion diseases: possible implications of microglial cells. Progress in Brain Research. 132: 737-50. PMID 11545032 DOI: 10.1016/S0079-6123(01)32114-3  0.705
2001 Aguzzi A. Peripheral prion pursuit. The Journal of Clinical Investigation. 108: 661-2. PMID 11544269 DOI: 10.1172/Jci13919  0.39
2001 Heppner FL, Christ AD, Klein MA, Prinz M, Fried M, Kraenhenbuhl JP, Aguzzi A. Transepithelial prion transport by M cells [1] Nature Medicine. 7: 976-977. PMID 11533681 DOI: 10.1038/Nm0901-976  0.632
2001 Afanasieva TA, Pekarik V, Grazia D'Angelo M, Klein MA, Voigtländer T, Stocking C, Aguzzi A. Insertional mutagenesis of preneoplastic astrocytes by Moloney murine leukemia virus. Journal of Neurovirology. 7: 169-81. PMID 11517390 DOI: 10.1080/13550280152058834  0.328
2001 Glatzel M, Heppner FL, Albers KM, Aguzzi A. Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron. 31: 25-34. PMID 11498048 DOI: 10.1016/S0896-6273(01)00331-2  0.677
2001 Steinbach JP, Kozmik Z, Pfeffer P, Aguzzi A. Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. International Journal of Cancer. 93: 459-67. PMID 11477548 DOI: 10.1002/Ijc.1371  0.346
2001 Aguzzi A, Brandner S, Fischer MB, Furukawa H, Glatzel M, Hawkins C, Heppner FL, Montrasio F, Navarro B, Parizek P, Pekarik V, Prinz M, Raeber AJ, Röckl C, Klein MA. Spongiform encephalopathies: insights from transgenic models. Advances in Virus Research. 56: 313-52. PMID 11450305 DOI: 10.1016/S0065-3527(01)56032-7  0.72
2001 Maissen M, Roeckl C, Glatzel M, Goldmann W, Aguzzi A. Plasminogen binds to disease-associated prion protein of multiple species. Lancet. 357: 2026-8. PMID 11438139 DOI: 10.1016/S0140-6736(00)05110-2  0.422
2001 Kaeser PS, Klein MA, Schwarz P, Aguzzi A. Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells. Journal of Virology. 75: 7097-106. PMID 11435590 DOI: 10.1128/Jvi.75.15.7097-7106.2001  0.401
2001 Hainfellner JA, Voigtländer T, Ströbel T, Mazal PR, Maddalena AS, Aguzzi A, Budka H. Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo. Journal of Neuropathology and Experimental Neurology. 60: 449-61. PMID 11379820 DOI: 10.1093/Jnen/60.5.449  0.349
2001 Behrens A, Brandner S, Genoud N, Aguzzi A. Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel. Embo Reports. 2: 347-52. PMID 11306558 DOI: 10.1093/Embo-Reports/Kve088  0.413
2001 Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A. Complement facilitates early prion pathogenesis. Nature Medicine. 7: 488-92. PMID 11283678 DOI: 10.1038/86567  0.363
2001 Aguzzi A, Heppner FL. Pathogenesis of prion diseases: a progress report. Cell Death and Differentiation. 7: 889-902. PMID 11279534 DOI: 10.1038/Sj.Cdd.4400737  0.396
2001 Montrasio F, Cozzio A, Flechsig E, Rossi D, Klein MA, Rülicke T, Raeber AJ, Vosshenrich CA, Proft J, Aguzzi A, Weissmann C. B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 4034-7. PMID 11274428 DOI: 10.1073/Pnas.051609398  0.39
2001 Weissmann C, Raeber AJ, Montrasio F, Hegyi I, Frigg R, Klein MA, Aguzzi A. Prions and the lymphoreticular system. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356: 177-84. PMID 11260798 DOI: 10.1098/Rstb.2000.0763  0.399
2001 Aguzzi A, Montrasio F, Kaeser PS. Prions: health scare and biological challenge. Nature Reviews. Molecular Cell Biology. 2: 118-26. PMID 11252953 DOI: 10.1038/35052063  0.381
2001 D' Angelo MG, Afanasieva T, Aguzzi A. Angiogenesis in transgenic models of multistep carcinogenesis. Journal of Neuro-Oncology. 50: 89-98. PMID 11245284 DOI: 10.1023/A:1006418723103  0.326
2001 Aguzzi A. Blood simple prion diagnostics. Nature Medicine. 7: 289-90. PMID 11231622 DOI: 10.1038/85423  0.327
2001 Rossi D, Cozzio A, Flechsig E, Klein MA, Rülicke T, Aguzzi A, Weissmann C. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. The Embo Journal. 20: 694-702. PMID 11179214 DOI: 10.1093/Emboj/20.4.694  0.351
2000 Glatzel M, Klein MA, Brandner S, Aguzzi A. Prions: from neurografts to neuroinvasion. Archives of Virology. Supplementum. 3-12. PMID 11214933 DOI: 10.1007/978-3-7091-6308-5_1  0.395
2000 Aguzzi A, Klein MA, Montrasio F, Pekarik V, Brandner S, Furukawa H, Käser P, Röckl C, Glatzel M. Prions: pathogenesis and reverse genetics. Annals of the New York Academy of Sciences. 920: 140-57. PMID 11193143 DOI: 10.1111/J.1749-6632.2000.Tb06916.X  0.453
2000 Brandner S, Klein MA, Frigg R, Pekarik V, Parizek P, Raeber A, Glatzel M, Schwarz P, Rülicke T, Weissmann C, Aguzzi A. Neuroinvasion of prions: insights from mouse models. Experimental Physiology. 85: 705-12. PMID 11187965 DOI: 10.1111/J.1469-445X.2000.02091.X  0.459
2000 Klein MA, Rüedi D, Nozaki M, Dell EW, Diserens AC, Seelentag W, Janzer RC, Aguzzi A, Hegi ME. Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant Oncogene. 19: 5329-5337. PMID 11103934 DOI: 10.1038/Sj.Onc.1203941  0.312
2000 Fischer MB, Roeckl C, Parizek P, Schwarz HP, Aguzzi A. Binding of disease-associated prion protein to plasminogen. Nature. 408: 479-83. PMID 11100730 DOI: 10.1038/35044100  0.365
2000 Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, Kretzschmar H, Von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Muller U. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members Journal of Neuroscience. 20: 7951-7963. PMID 11050115 DOI: 10.1523/Jneurosci.20-21-07951.2000  0.386
2000 Glatzel M, Aguzzi A. PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion. The Journal of General Virology. 81: 2813-21. PMID 11038396 DOI: 10.1099/0022-1317-81-11-2813  0.405
2000 Flechsig E, Shmerling D, Hegyi I, Raeber AJ, Fischer M, Cozzio A, von Mering C, Aguzzi A, Weissmann C. Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron. 27: 399-408. PMID 10985358 DOI: 10.1016/S0896-6273(00)00046-5  0.417
2000 Chrast R, Scott HS, Madani R, Huber L, Wolfer DP, Prinz M, Aguzzi A, Lipp HP, Antonarakis SE. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Human Molecular Genetics. 9: 1853-64. PMID 10915774 DOI: 10.1093/Hmg/9.12.1853  0.302
2000 Glatzel M, Aguzzi A. Peripheral pathogenesis of prion diseases. Microbes and Infection / Institut Pasteur. 2: 613-9. PMID 10884612 DOI: 10.1016/S1286-4579(00)00364-6  0.423
2000 Montrasio F, Frigg R, Glatzel M, Klein MA, Mackay F, Aguzzi A, Weissmann C. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science (New York, N.Y.). 288: 1257-9. PMID 10818004 DOI: 10.1126/Science.288.5469.1257  0.362
2000 Brandner S, Klein MA, Aguzzi A. [Mechanisms of neuroinvasion by prions: molecular principles and present state of research]. Schweizerische Medizinische Wochenschrift. 130: 435-42. PMID 10780058 DOI: 10.5167/Uzh-1919  0.441
2000 Raeber AJ, Aguzzi A. Engulfment of prions in the germinal centre. Immunology Today. 21: 66-7. PMID 10712000 DOI: 10.1016/S0167-5699(99)01562-5  0.364
2000 Glatzel M, Flechsig E, Navarro B, Klein MA, Paterna JC, Büeler H, Aguzzi A. Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system. Proceedings of the National Academy of Sciences of the United States of America. 97: 442-7. PMID 10618437 DOI: 10.1073/Pnas.97.1.442  0.306
2000 Aguzzi A, Montrasio F, Brandner S, Frigg R, Röckl C, Fischer M, Pekarik V, Furukawa H. Molecular pathology of prion diseases Neurobiology of Aging. 21: 1. DOI: 10.1016/S0197-4580(00)82679-2  0.359
1999 Weissmann C, Aguzzi A. Perspectives: neurobiology. PrP's double causes trouble. Science (New York, N.Y.). 286: 914-5. PMID 10577243 DOI: 10.1126/Science.286.5441.914  0.424
1999 Maddalena AS, Hainfellner JA, Hegi ME, Glatzel M, Aguzzi A. No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice. Brain Pathology (Zurich, Switzerland). 9: 627-37. PMID 10517501 DOI: 10.1111/J.1750-3639.1999.Tb00544.X  0.32
1999 Frigg R, Klein MA, Hegyi I, Zinkernagel RM, Aguzzi A. Scrapie pathogenesis in subclinically infected B-cell-deficient mice. Journal of Virology. 73: 9584-8. PMID 10516067 DOI: 10.1128/Jvi.73.11.9584-9588.1999  0.411
1999 Pohl U, Wick W, Weissenberger J, Steinbach JP, Dichgans J, Aguzzi A, Weller M. Characterization of Tu-2449, a glioma cell line derived from a spontaneous tumor in GFAP-v-src-transgenic mice: comparison with established murine glioma cell lines. International Journal of Oncology. 15: 829-34. PMID 10493969 DOI: 10.3892/Ijo.15.4.829  0.358
1999 Aguzzi A, Brandner S. The genetics of prions--a contradiction in terms? Lancet. 354: SI22-5. PMID 10437852 DOI: 10.1016/S0140-6736(99)90245-3  0.431
1999 Sancho S, Magyar JP, Aguzzi A, Suter1 U. Distal axonopathy in peripheral nerves of PMP22-mutant mice. Brain : a Journal of Neurology. 1563-77. PMID 10430839 DOI: 10.1093/Brain/122.8.1563  0.331
1999 Lichtlen P, Georgiev O, Schaffner W, Aguzzi A, Brandner S. The heavy metal-responsive transcription factor-1 (MTF-1) is not required for neural differentiation. Biological Chemistry. 380: 711-5. PMID 10430037 DOI: 10.1515/Bc.1999.089  0.308
1999 Hefti HP, Frese M, Landis H, Di Paolo C, Aguzzi A, Haller O, Pavlovic J. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. Journal of Virology. 73: 6984-91. PMID 10400797 DOI: 10.1128/Jvi.73.8.6984-6991.1999  0.342
1999 Calogero S, Grassi F, Aguzzi A, Voigtländer T, Ferrier P, Ferrari S, Bianchi ME. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nature Genetics. 22: 276-80. PMID 10391216 DOI: 10.1038/10338  0.33
1999 Raeber AJ, Klein MA, Frigg R, Flechsig E, Aguzzi A, Weissmann C. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. The Embo Journal. 18: 2702-6. PMID 10329617 DOI: 10.1093/Emboj/18.10.2702  0.377
1999 Aguzzi A, Brandner S. Shrinking prions: new folds to old questions. Nature Medicine. 5: 486-7. PMID 10229220 DOI: 10.1038/8366  0.38
1999 Brandner S, Klein MA, Aguzzi A. A crucial role for B cells in neuroinvasive scrapie. Transfusion Clinique Et Biologique : Journal De La Sociã©Tã© Franã§Aise De Transfusion Sanguine. 6: 17-23. PMID 10188209 DOI: 10.1016/S1246-7820(99)80007-X  0.319
1999 Raeber AJ, Sailer A, Hegyi I, Klein MA, Rülicke T, Fischer M, Brandner S, Aguzzi A, Weissmann C. Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. Proceedings of the National Academy of Sciences of the United States of America. 96: 3987-92. PMID 10097150 DOI: 10.1073/Pnas.96.7.3987  0.41
1999 Aguzzi A, Raeber AJ. Transgenic models of neurodegeneration. Neurodegeneration: of (transgenic) mice and men. Brain Pathology (Zurich, Switzerland). 8: 695-7. PMID 9804378 DOI: 10.1111/J.1750-3639.1998.Tb00195.X  0.318
1998 Aguzzi A, Klein MA, Musahl C, Raeber AJ, Blättler T, Hegyi I, Frigg R, Brandner S. Use of brain grafts to study the pathogenesis of prion diseases. Essays in Biochemistry. 33: 133-47. PMID 10488447 DOI: 10.1042/Bse0330133  0.359
1998 Steinbach JP, Müller U, Leist M, Li Z, Nicotera P, Aguzzi A. Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. Cell Death & Differentiation. 5: 858-866. PMID 10203685 DOI: 10.1038/Sj.Cdd.4400391  0.342
1998 Klein MA, Frigg R, Raeber AJ, Flechsig E, Hegyi I, Zinkernagel RM, Weissmann C, Aguzzi A. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Medicine. 4: 1429-33. PMID 9846583 DOI: 10.1038/4022  0.431
1998 Raeber AJ, Brandner S, Klein MA, Benninger Y, Musahl C, Frigg R, Roeckl C, Fischer MB, Weissmann C, Aguzzi A. Transgenic and knockout mice in research on prion diseases. Brain Pathology (Zurich, Switzerland). 8: 715-33. PMID 9804380 DOI: 10.1111/J.1750-3639.1998.Tb00197.X  0.432
1998 Vingerhoets FJ, Hegyi I, Aguzzi A, Myers P, Pizzolato G, Landis T. An unusual case of Creutzfeldt-Jakob disease. Neurology. 51: 617-9. PMID 9710052 DOI: 10.1212/Wnl.51.2.617  0.311
1998 Mrkic B, Pavlovic J, Rülicke T, Volpe P, Buchholz CJ, Hourcade D, Atkinson JP, Aguzzi A, Cattaneo R. Measles virus spread and pathogenesis in genetically modified mice. Journal of Virology. 72: 7420-7. PMID 9696838 DOI: 10.1128/Jvi.72.9.7420-7427.1998  0.342
1998 Zanusso G, Liu D, Ferrari S, Hegyi I, Yin X, Aguzzi A, Hornemann S, Liemann S, Glockshuber R, Manson JC, Brown P, Petersen RB, Gambetti P, Sy MS. Prion protein expression in different species: analysis with a panel of new mAbs. Proceedings of the National Academy of Sciences of the United States of America. 95: 8812-6. PMID 9671761 DOI: 10.1073/Pnas.95.15.8812  0.411
1998 Cathomen T, Mrkic B, Spehner D, Drillien R, Naef R, Pavlovic J, Aguzzi A, Billeter MA, Cattaneo R. A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain. The Embo Journal. 17: 3899-908. PMID 9670007 DOI: 10.1093/Emboj/17.14.3899  0.327
1998 Weissmann C, Fischer M, Raeber A, Büeler H, Sailer A, Shmerling D, Rülicke T, Brandner S, Aguzzi A. The use of transgenic mice in the investigation of transmissible spongiform encephalopathies. Revue Scientifique Et Technique (International Office of Epizootics). 17: 278-90. PMID 9638817 DOI: 10.1007/978-1-4899-1896-3_7  0.417
1998 Rovigatti U, Afanasyeva T, Brandner S, Hainfellner JA, Kiess M, Maddalena A, Malin G, Rülicke T, Steinbach J, Weissenberger J, Aguzzi A. Transgenic mice as research tools in neurocarcinogenesis. Journal of Neurovirology. 4: 159-74. PMID 9584953 DOI: 10.3109/13550289809114516  0.325
1998 Aguzzi A, Weissmann C. Spongiform encephalopathies. The prion's perplexing persistence. Nature. 392: 763-4. PMID 9572134 DOI: 10.1038/33812  0.391
1998 Shmerling D, Hegyi I, Fischer M, Blättler T, Brandner S, Götz J, Rülicke T, Flechsig E, Cozzio A, von Mering C, Hangartner C, Aguzzi A, Weissmann C. Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell. 93: 203-14. PMID 9568713 DOI: 10.1016/S0092-8674(00)81572-X  0.422
1998 Lampe JB, Marino S, Rethwilm A, Aguzzi A. Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus Neuropathology and Applied Neurobiology. 24: 36-43. PMID 9549727 DOI: 10.1046/J.1365-2990.1998.00086.X  0.372
1998 Brandner S, Isenmann S, Kühne G, Aguzzi A. Identification of the end stage of scrapie using infected neural grafts. Brain Pathology (Zurich, Switzerland). 8: 19-27. PMID 9458163 DOI: 10.1111/J.1750-3639.1998.Tb00130.X  0.363
1998 Sibilia M, Steinbach JP, Stingl L, Aguzzi A, Wagner EF. A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. The Embo Journal. 17: 719-31. PMID 9450997 DOI: 10.1093/Emboj/17.3.719  0.319
1998 Weber T, Aguzzi A. The spectrum of transmissible spongiform encephalopathies. Intervirology. 40: 198-212. PMID 9450236 DOI: 10.1159/000150546  0.43
1998 Aguzzi A. Prion Diseases: an Update Current Opinion in Psychiatry. 11: 155-162. DOI: 10.1007/978-3-662-04033-1_12  0.388
1997 Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, Bootz F, Suter M, Zinkernagel RM, Aguzzi A. A crucial role for B cells in neuroinvasive scrapie. Nature. 390: 687-90. PMID 9414161 DOI: 10.1038/37789  0.408
1997 Aguzzi A, Collinge J. Post-exposure prophylaxis after accidental prion inoculation. Lancet. 350: 1519-20. PMID 9388404 DOI: 10.1016/S0140-6736(05)63941-4  0.334
1997 Weissmann C, Aguzzi A. Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease. Current Opinion in Neurobiology. 7: 695-700. PMID 9384548 DOI: 10.1016/S0959-4388(97)80091-8  0.331
1997 Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. The Embo Journal. 16: 6057-65. PMID 9321385 DOI: 10.1093/Emboj/16.20.6057  0.453
1997 Blättler T, Brandner S, Raeber AJ, Klein MA, Voigtländer T, Weissmann C, Aguzzi A. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature. 389: 69-73. PMID 9288968 DOI: 10.1038/37981  0.392
1997 Schmidt M, Niewiesk S, Heeney J, Aguzzi A, Rethwilm A. Mouse model to study the replication of primate foamy viruses. The Journal of General Virology. 1929-33. PMID 9266990 DOI: 10.1099/0022-1317-78-8-1929  0.338
1997 Aguzzi A, Blättler T, Klein MA, Räber AJ, Hegyi I, Frigg R, Brandner S, Weissmann C. Tracking prions: the neurografting approach. Cellular and Molecular Life Sciences : Cmls. 53: 485-95. PMID 9230924 DOI: 10.1007/S000180050060  0.408
1997 Weissenberger J, Steinbach JP, Malin G, Spada S, Rülicke T, Aguzzi A. Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice. Oncogene. 14: 2005-13. PMID 9160879 DOI: 10.1038/Sj.Onc.1201168  0.314
1997 Aguzzi A. Prions and antiprions. Biological Chemistry. 378: 1393-1395. DOI: 10.5167/Uzh-2018  0.376
1996 Weissmann C, Fischer M, Raeber A, Büeler H, Sailer A, Shmerling D, Rülicke T, Brandner S, Aguzzi A. The role of PrP in pathogenesis of experimental scrapie. Cold Spring Harbor Symposia On Quantitative Biology. 61: 511-22. PMID 9246477 DOI: 10.1101/Sqb.1996.061.01.051  0.352
1996 Brandner S, Raeber A, Sailer A, Blättler T, Fischer M, Weissmann C, Aguzzi A. Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 93: 13148-51. PMID 8917559 DOI: 10.1073/Pnas.93.23.13148  0.428
1996 Aguzzi A, Brandner S, Marino S, Steinbach JP. Transgenic and knockout mice in the study of neurodegenerative diseases. Journal of Molecular Medicine (Berlin, Germany). 74: 111-26. PMID 8846161 DOI: 10.1007/Bf01575443  0.397
1996 Magyar JP, Martini R, Ruelicke T, Aguzzi A, Adlkofer K, Dembic Z, Zielasek J, Toyka KV, Suter U. Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5351-60. PMID 8757248 DOI: 10.1523/Jneurosci.16-17-05351.1996  0.342
1996 Aguzzi A. Pathogenesis of spongiform encephalopathies: an update. International Archives of Allergy and Immunology. 110: 99-106. PMID 8646000 DOI: 10.1159/000237273  0.38
1996 Fischer M, Rülicke T, Raeber A, Sailer A, Moser M, Oesch B, Brandner S, Aguzzi A, Weissmann C. Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. The Embo Journal. 15: 1255-64. PMID 8635458 DOI: 10.1002/J.1460-2075.1996.Tb00467.X  0.431
1996 Müller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rülicke T, Brandner S, Aguzzi A, Weissman C. Mice homozygous for a modified beta-amyloid precursor protein (beta APP) gene show impaired behavior and high incidence of agenesis of the corpus callosum. Annals of the New York Academy of Sciences. 777: 65-73. PMID 8624128 DOI: 10.1111/J.1749-6632.1996.Tb34402.X  0.32
1996 Aguzzi A, Marino S, Tschopp R, Rethwilm A. Regulation of expression and pathogenic potential of human foamy virus in vitro and in transgenic mice. Current Topics in Microbiology and Immunology. 206: 243-73. PMID 8608720 DOI: 10.1007/978-3-642-85208-4_13  0.314
1996 Tschopp RR, Brandner S, Marino S, Bothe K, Horak I, Rethwilm A, Aguzzi A. Analysis of the determinants of neurotropism and neurotoxicity of HFV in transgenic mice. Virology. 216: 338-46. PMID 8607263 DOI: 10.1006/Viro.1996.0069  0.363
1996 Fritschy JM, Brandner S, Aguzzi A, Koedood M, Luscher B, Mitchell PJ. Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2275-82. PMID 8601807 DOI: 10.1523/Jneurosci.16-07-02275.1996  0.351
1996 Lindberg RL, Porcher C, Grandchamp B, Ledermann B, Bürki K, Brandner S, Aguzzi A, Meyer UA. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Nature Genetics. 12: 195-9. PMID 8563760 DOI: 10.1038/Ng0296-195  0.313
1996 Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, Marino S, Weissmann C, Aguzzi A. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature. 379: 339-43. PMID 8552188 DOI: 10.1038/379339A0  0.378
1996 Aguzzi A, Brandner S. Molekulare Mechanismen der Prion-Toxizität E-Neuroforum. 2. DOI: 10.1515/Nf-1996-0302  0.352
1995 Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Jellinger K. Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathology (Zurich, Switzerland). 5: 459-66. PMID 8974629 DOI: 10.1111/J.1750-3639.1995.Tb00625.X  0.362
1995 Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schäfer R, Kumar A, Williams BR, Aguet M, Weissmann C. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. The Embo Journal. 14: 6095-106. PMID 8557029 DOI: 10.1002/J.1460-2075.1995.Tb00300.X  0.308
1995 Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ. Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases) Brain Pathology (Zurich, Switzerland). 5: 319-22. PMID 8520732 DOI: 10.1111/J.1750-3639.1995.Tb00609.X  0.342
1995 Hergersberg M, Matsuo K, Gassmann M, Schaffner W, Lüscher B, Rülicke T, Aguzzi A. Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice. Human Molecular Genetics. 4: 359-66. PMID 7795588 DOI: 10.1093/Hmg/4.3.359  0.316
1995 Adlkofer K, Martini R, Aguzzi A, Zielasek J, Toyka KV, Suter U. Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Nature Genetics. 11: 274-80. PMID 7581450 DOI: 10.1038/Ng1195-274  0.311
1994 Büeler H, Raeber A, Sailer A, Fischer M, Aguzzi A, Weissmann C. High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Molecular Medicine (Cambridge, Mass.). 1: 19-30. PMID 8790598 DOI: 10.1007/Bf03403528  0.406
1994 Hummler E, Cole TJ, Blendy JA, Ganss R, Aguzzi A, Schmid W, Beermann F, Schütz G. Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 91: 5647-51. PMID 8202542 DOI: 10.1073/Pnas.91.12.5647  0.309
1994 Aberdam D, Aguzzi A, Baudoin C, Galliano M, Ortonne J, Meneguzzi G. Developmental Expression of Nicein Adhesion Protein (Laminin-5) Subunits Suggests Multiple Morphogenic Roles Cell Adhesion and Communication. 2: 115-129. PMID 8081888 DOI: 10.3109/15419069409004431  0.328
1994 Wiestler OD, Brüstle O, Eibl RH, Radner H, Aguzzi A, Kleihues P. Oncogene transfer into the brain. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 135: 55-66. PMID 8047697 DOI: 10.1007/978-3-642-85039-4_7  0.335
1994 Weissmann C, Büeler H, Fischer M, Sailer A, Aguzzi A, Aguet M. PrP-deficient mice are resistant to scrapie. Annals of the New York Academy of Sciences. 724: 235-40. PMID 8030944 DOI: 10.1111/J.1749-6632.1994.Tb38913.X  0.409
1994 Aguzzi A, Brandner S, Sure U, Rüedi D, Isenmann S. Transgenic and knock-out mice: models of neurological disease. Brain Pathology (Zurich, Switzerland). 4: 3-20. PMID 8025701 DOI: 10.1111/J.1750-3639.1994.Tb00806.X  0.418
1994 Müller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rülicke T, Brandner S, Aguzzi A, Weissmann C. Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell. 79: 755-65. PMID 8001115 DOI: 10.1016/0092-8674(94)90066-3  0.329
1994 Kiefer F, Anhauser I, Soriano P, Aguzzi A, Courtneidge SA, Wagner EF. Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases Current Biology. 4: 100-109. PMID 7953508 DOI: 10.1016/S0960-9822(94)00025-4  0.307
1994 Sailer A, Büeler H, Fischer M, Aguzzi A, Weissmann C. No propagation of prions in mice devoid of PrP. Cell. 77: 967-8. PMID 7912659 DOI: 10.1016/0092-8674(94)90436-7  0.369
1993 Wick G, Trieb K, Aguzzi A, Recheis H, Anderl H, Grubeck-Loebenstein B. Possible role of human foamy virus in Graves' disease. Intervirology. 35: 101-7. PMID 8407236 DOI: 10.1159/000150300  0.336
1993 Aguzzi A. The foamy virus family: molecular biology, epidemiology and neuropathology. Biochimica Et Biophysica Acta. 1155: 1-24. PMID 8389200 DOI: 10.1016/0304-419X(93)90019-9  0.349
1993 Hilberg F, Aguzzi A, Howells N, Wagner EF. c-jun is essential for normal mouse development and hepatogenesis. Nature. 365: 179-81. PMID 8371760 DOI: 10.1038/365179A0  0.323
1993 Weissmann C, Büeler H, Sailer A, Fischer M, Aguet M, Aguzzi A. Role of PrP in prion diseases. British Medical Bulletin. 49: 995-1011. PMID 8137140 DOI: 10.1093/Oxfordjournals.Bmb.A072658  0.307
1993 Büeler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C. Mice devoid of PrP are resistant to scrapie. Cell. 73: 1339-47. PMID 8100741 DOI: 10.1016/0092-8674(93)90360-3  0.405
1993 Wick G, Grubeck-Loebenstein B, Trieb K, Kalischnig G, Aguzzi A. Human foamy virus antigens in thyroid tissue of Graves' disease patients. International Archives of Allergy and Immunology. 99: 153-6. PMID 1336420 DOI: 10.1159/000236350  0.323
1992 Boulter CA, Aguzzi A, Evans MJ, Affara N. A chimaeric mouse model for autosomal-dominant polycystic kidney disease. Contributions to Nephrology. 97: 60-70. PMID 1633717 DOI: 10.1159/000421645  0.324
1992 Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. The Embo Journal. 11: 2563-2571. DOI: 10.1002/J.1460-2075.1992.Tb05321.X  0.313
1991 Bothe K, Aguzzi A, Lassmann H, Rethwilm A, Horak I. Progressive encephalopathy and myopathy in transgenic mice expressing human foamy virus genes. Science (New York, N.Y.). 253: 555-7. PMID 1650034 DOI: 10.1126/Science.1650034  0.38
1989 Williams RL, Risau W, Zerwes HG, Drexler H, Aguzzi A, Wagner EF. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell. 57: 1053-63. PMID 2736622 DOI: 10.1016/0092-8674(89)90343-7  0.329
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