Valter Longo - Publications

Affiliations: 
Neuroscience University of Southern California, Los Angeles, CA, United States 
Area:
Neuroscience Biology

45/219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Guevara-Aguirre J, Mishra A, Canepa M, Guevara C, Villacres Á, Guevara A, Peña G, Lescano D, Kopchick JJ, Balasubramanian P, Longo VD. Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. Med (New York, N.Y.). PMID 38677286 DOI: 10.1016/j.medj.2024.03.022  0.501
2022 Di Tano M, Longo VD. Fasting and cancer: from yeast to mammals. International Review of Cell and Molecular Biology. 373: 81-106. PMID 36283768 DOI: 10.1016/bs.ircmb.2022.02.005  0.306
2020 Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, Dietrich J, Fuldner R, Gallicchio L, Green PA, Hurria A, Janelsins MC, Jhappan C, Kirkland JL, Kohanski R, ... Longo V, et al. Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. Journal of the National Cancer Institute. PMID 32348501 DOI: 10.1093/Jnci/Djaa060  0.332
2020 Guevara-Aguirre J, Teran E, Lescano D, Guevara A, Guevara C, Longo V, Gavilanes AWD. Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 51: 58-64. PMID 32145513 DOI: 10.1016/J.Ghir.2020.02.004  0.302
2019 Groot Sd, Lugtenberg R, Welters M, Ehsan I, Vreeswijk M, Smit V, Graaf Hd, Heijns J, Portielje J, Wouw Avd, Imholz A, Kessels L, Vrijaldenhoven S, Baars A, Kranenbarg EM, ... ... Longo V, et al. Abstract P1-15-20: DIetary REstriction as an adjunct to neoadjuvant ChemoTherapy for HER2-negative breast cancer: Final results from the DIRECT trial (BOOG 2013-04) Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P1-15-20  0.324
2018 Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, et al. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Scientific Reports. 8: 14212. PMID 30242290 DOI: 10.1038/S41598-018-32616-7  0.311
2018 Braud Fd, Vernieri C, Huber V, Cova A, Squarcina P, Milano M, Fucà G, Longo V, Rivoltini L. Abstract B022: Metabolic and immunologic effects of the fasting mimicking diet in cancer patients Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B022  0.337
2017 Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. Plos Biology. 15: e1002603. PMID 28459830 DOI: 10.1371/journal.pbio.1002603  0.487
2017 Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. Plos Biology. 15: e2001951. PMID 28358805 DOI: 10.1371/Journal.Pbio.2001951  0.553
2017 Choi IY, Lee C, Longo VD. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Molecular and Cellular Endocrinology. PMID 28137612 DOI: 10.1016/J.Mce.2017.01.042  0.514
2016 Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discovery. PMID 27872127 DOI: 10.1158/2159-8290.Cd-16-0615  0.334
2016 Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 30: 136-46. PMID 27411588 DOI: 10.1016/J.Ccell.2016.06.005  0.525
2016 Lee C, Longo V. Dietary restriction with and without caloric restriction for healthy aging. F1000research. 5. PMID 26918181 DOI: 10.12688/F1000Research.7136.1  0.544
2016 Balasubramanian P, Longo VD. Growth factors, aging and age-related diseases. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. PMID 26883276 DOI: 10.1016/J.Ghir.2016.01.001  0.546
2015 Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. The Journal of Clinical Endocrinology and Metabolism. 100: 2589-96. PMID 25985182 DOI: 10.1210/Jc.2015-1678  0.437
2015 Raffaghello L, Bianchi G, Martella R, Marimpietri D, Petretto A, Inglese E, Amaro A, Pistoia V, Pfeffer U, Longo V. Abstract 1149: Consistency between genomic and proteomic profiles reveals novel molecular mechanisms of fasting antitumor activity Cancer Research. 75: 1149-1149. DOI: 10.1158/1538-7445.Am2015-1149  0.379
2014 Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 13: 958-61. PMID 25040290 DOI: 10.1111/Acel.12243  0.578
2014 Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, ... Longo VD, et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism. 19: 407-17. PMID 24606898 DOI: 10.1016/J.Cmet.2014.02.006  0.497
2014 Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. Plos Genetics. 10: e1004113. PMID 24516402 DOI: 10.1371/Journal.Pgen.1004113  0.345
2014 Biase SD, Brandorst S, Wei M, Longo V. Abstract LB-78: Effects of rapamycin and fasting-cycles therapy on differential stress resistance and sensitization in breast cancer mouse models Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-78  0.416
2013 Balasubramanian P, Longo VD. Aging, nutrient signaling, hematopoietic senescence, and cancer. Critical Reviews in Oncogenesis. 18: 559-71. PMID 24579735 DOI: 10.1615/Critrevoncog.2013010596  0.56
2013 Bartke A, Sun LY, Longo V. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiological Reviews. 93: 571-98. PMID 23589828 DOI: 10.1152/Physrev.00006.2012  0.437
2013 Gonidakis S, Longo VD. Assessing chronological aging in bacteria. Methods in Molecular Biology (Clifton, N.J.). 965: 421-37. PMID 23296675 DOI: 10.1007/978-1-62703-239-1_28  0.7
2013 Quinn DI, Groshen SG, Shah M, Tsao-Wei DD, Garcia AA, Pham H, Lin YG, Ketchens C, Massopust K, Wei M, Longo V, Dorff TB. Final results of a phase I trial of fasting prior to platinum-based chemotherapy. Journal of Clinical Oncology. 31: 9632-9632. DOI: 10.1200/Jco.2013.31.15_Suppl.9632  0.312
2013 Groot Sd, Vreeswijk M, Smit V, Heijns J, Imholz A, Kessels L, Jager A, Los M, Weijl N, Smorenburg C, Portielje J, Liefers G, Velde Cvd, Meershoek E, Leeuwen Ev, ... ... Longo V, et al. Abstract OT3-1-03: DIRECT: A phase II/III randomized trial with dietary restriction as an adjunct to neoadjuvant chemotherapy for HER2-negative breast cancer Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-Ot3-1-03  0.324
2012 Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. Fasting enhances the response of glioma to chemo- and radiotherapy. Plos One. 7: e44603. PMID 22984531 DOI: 10.1371/Journal.Pone.0044603  0.534
2012 Lee C, Raffaghello L, Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 114-22. PMID 22391012 DOI: 10.1016/J.Drup.2012.01.004  0.55
2012 Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Science Translational Medicine. 4: 124ra27. PMID 22323820 DOI: 10.1126/Scitranslmed.3003293  0.56
2011 Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 30: 3305-16. PMID 21516129 DOI: 10.1038/Onc.2011.91  0.578
2011 Gonidakis S, Finkel SE, Longo VD. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging. 3: 291-303. PMID 21464517  0.729
2011 Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Science Translational Medicine. 3: 70ra13. PMID 21325617 DOI: 10.1126/scitranslmed.3001845  0.56
2011 Longo V, Lee C, Raffaghello L, Safdie F, Bianchi G. 166 INVITED Starvation and Differential Stress Resistance in Cancer Treatment European Journal of Cancer. 47: S40. DOI: 10.1016/S0959-8049(11)70381-1  0.343
2010 Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo VD. Fasting and differential chemotherapy protection in patients. Cell Cycle (Georgetown, Tex.). 9: 4474-6. PMID 21088487  0.306
2010 Balasubramanian P, Longo VD. Linking Klotho, Nrf2, MAP kinases and aging. Aging. 2: 632-3. PMID 21076180  0.45
2010 Gonidakis S, Finkel SE, Longo VD. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. 9: 868-81. PMID 20707865 DOI: 10.1111/J.1474-9726.2010.00618.X  0.726
2010 Gonidakis S, Finkel SE, Longo VD. E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biological Chemistry. 391: 1139-47. PMID 20707605 DOI: 10.1515/Bc.2010.120  0.727
2010 Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Research. 70: 1564-72. PMID 20145127 DOI: 10.1158/0008-5472.Can-09-3228  0.553
2010 Lee C, Safdie F, Raffaghello L, Wei M, Longo V. Abstract 3223: Severe dietary restriction enhances cancer treatment: Protecting normal cells and sensitizing malignant cells to chemotherapy by fasting Cancer Research. 70: 3223-3223. DOI: 10.1158/1538-7445.Am10-3223  0.61
2009 Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. Fasting and cancer treatment in humans: A case series report. Aging. 1: 988-1007. PMID 20157582  0.529
2009 Longo VD. Linking sirtuins, IGF-I signaling, and starvation. Experimental Gerontology. 44: 70-4. PMID 18638538 DOI: 10.1016/j.exger.2008.06.005  0.337
2008 Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 105: 8215-20. PMID 18378900 DOI: 10.1073/Pnas.0708100105  0.56
2008 Longo VD. The race to control aging and diseases: Sir2/SirT1 against Ras, TOR and Akt/S6K The Biochemist. 30: 8-13. DOI: 10.1042/bio03005008  0.333
2005 Fabrizio P, Li L, Longo VD. Analysis of gene expression profile in yeast aging chronologically. Mechanisms of Ageing and Development. 126: 11-6. PMID 15610757 DOI: 10.1016/j.mad.2004.09.015  0.323
2003 Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. 163: 35-46. PMID 12586694  0.307
2002 Longo VD, Fabrizio P. Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cellular and Molecular Life Sciences : Cmls. 59: 903-8. PMID 12169020 DOI: 10.1007/s00018-002-8477-8  0.324
Low-probability matches (unlikely to be authored by this person)
2022 Mirisola MG, Longo VD. Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms. Cells. 11. PMID 35626750 DOI: 10.3390/cells11101714  0.299
2003 Fabrizio P, Longo VD. The chronological life span of Saccharomyces cerevisiae. Aging Cell. 2: 73-81. PMID 12882320  0.297
2017 Vernieri C, Milano M, Mennitto A, Fucà G, Rinaldi L, Ferrari B, Capri G, Mariani G, Bianchi GV, Longo V, Braud Fd. T11Safety and metabolic effects of the fasting mimicking diet in cancer patients Annals of Oncology. 28. DOI: 10.1093/Annonc/Mdx436.010  0.294
2010 Finch CE, Morgan TE, Longo VD, de Magalhaes JP. Cell resilience in species life spans: a link to inflammation? Aging Cell. 9: 519-26. PMID 20415721 DOI: 10.1111/J.1474-9726.2010.00578.X  0.293
2010 Parrella E, Longo VD. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. Thescientificworldjournal. 10: 161-77. PMID 20098959 DOI: 10.1100/tsw.2010.8  0.291
2014 Nencioni A, Caffa I, Raffaghello L, Montecucco F, Cea M, Monacelli F, Grossi F, Patrone F, Odetti P, Ballestrero A, Longo V. Potentiation of crizotinib activity by fasting cycles in an ALK+ lung cancer model. Journal of Clinical Oncology. 32: e13511-e13511. DOI: 10.1200/Jco.2014.32.15_Suppl.E13511  0.291
2010 Lee C, Safdie F, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Longo V. OR13,75 Role of IGF-I and IGFBPs in the fasting-induced protection of mice versus malignant cells against chemotherapy Growth Hormone & Igf Research. 20: S33-S34. DOI: 10.1016/S1096-6374(10)70091-5  0.29
2003 Longo VD. The Ras and Sch9 pathways regulate stress resistance and longevity. Experimental Gerontology. 38: 807-11. PMID 12855292  0.289
2021 Salvadori G, Mirisola MG, Longo VD. Intermittent and Periodic Fasting, Hormones, and Cancer Prevention. Cancers. 13. PMID 34572814 DOI: 10.3390/cancers13184587  0.289
2016 Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. Safety and feasibility of fasting in combination with platinum-based chemotherapy. Bmc Cancer. 16: 360. PMID 27282289 DOI: 10.1186/S12885-016-2370-6  0.286
2018 Guidi N, Morselli M, Pellegrini M, Wei M, Longo V. Fasting Mimicking Diet-Induced Pluripotency and Epigenetic Reprogramming in Hematopoietic Stem Cells during Aging Experimental Hematology. 64: S69. DOI: 10.1016/J.Exphem.2018.06.237  0.286
2009 Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. Plos Genetics. 5: e1000467. PMID 19424415 DOI: 10.1371/Journal.Pgen.1000467  0.285
2015 Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, ... ... Longo VD, et al. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism. PMID 26094889 DOI: 10.1016/J.Cmet.2015.05.012  0.285
2001 Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. Regulation of longevity and stress resistance by Sch9 in yeast. Science (New York, N.Y.). 292: 288-90. PMID 11292860 DOI: 10.1126/science.1059497  0.284
2015 Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget. 6: 11806-19. PMID 25909219  0.283
2017 Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, ... ... Longo V, et al. A review of the biomedical innovations for healthy longevity. Aging. PMID 28132958 DOI: 10.18632/Aging.101163  0.282
2002 Longo VD. Oxygen? No thanks, I'm on a diet. Science of Aging Knowledge Environment : Sage Ke. 2002: pe10. PMID 14602992 DOI: 10.1126/sageke.2002.24.pe10  0.282
2000 Longo VD. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiology of Aging. 20: 479-86. PMID 10638521 DOI: 10.1016/S0197-4580(99)00089-5  0.281
2017 Raffaghello L, Longo V. Metabolic Alterations at the Crossroad of Aging and Oncogenesis. International Review of Cell and Molecular Biology. 332: 1-42. PMID 28526131 DOI: 10.1016/bs.ircmb.2017.01.003  0.28
2018 Buono R, Longo VD. Starvation, Stress Resistance, and Cancer. Trends in Endocrinology and Metabolism: Tem. PMID 29463451 DOI: 10.1016/j.tem.2018.01.008  0.279
2004 Fabrizio P, Pletcher SD, Minois N, Vaupel JW, Longo VD. Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. Febs Letters. 557: 136-42. PMID 14741356 DOI: 10.1016/S0014-5793(03)01462-5  0.279
2014 Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 13: 457-67. PMID 24649827 DOI: 10.1111/Acel.12202  0.276
2008 Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. Plos Genetics. 4: e13. PMID 18225956 DOI: 10.1371/Journal.Pgen.0040013  0.275
2008 Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. The Journal of Cell Biology. 180: 67-81. PMID 18195102 DOI: 10.1083/Jcb.200707154  0.274
2018 De Braud FG, Milano M, Fucà G, Mariani G, Capri G, Bianchi GV, Corsetto P, Longo V, Rivoltini L, Vernieri C. Safety and metabolic effects of cyclic fasting mimicking diet (FMD) in cancer patients. Journal of Clinical Oncology. 36: e14549-e14549. DOI: 10.1200/Jco.2018.36.15_Suppl.E14549  0.273
2023 Blaževitš O, Di Tano M, Longo VD. Fasting and fasting mimicking diets in cancer prevention and therapy. Trends in Cancer. 9: 212-222. PMID 36646607 DOI: 10.1016/j.trecan.2022.12.006  0.273
2006 Madia F, Gattazzo C, Fabrizio P, Longo VD. A simple model system for age-dependent DNA damage and cancer. Mechanisms of Ageing and Development. 128: 45-9. PMID 17118426 DOI: 10.1016/j.mad.2006.11.009  0.272
2007 Cheng C, Fabrizio P, Ge H, Longo VD, Li LM. Inference of transcription modification in long-live yeast strains from their expression profiles. Bmc Genomics. 8: 219. PMID 17617911 DOI: 10.1186/1471-2164-8-219  0.272
2024 Brandhorst S, Longo VD. Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 78: 101182. PMID 39665873 DOI: 10.1016/j.drup.2024.101182  0.271
2010 Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. Plos Genetics. 6: e1001024. PMID 20657825 DOI: 10.1371/Journal.Pgen.1001024  0.271
2009 Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, Goodman MF, Longo VD. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. The Journal of Cell Biology. 186: 509-23. PMID 19687253 DOI: 10.1083/Jcb.200906011  0.264
2018 Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and cancer: molecular mechanisms and clinical application. Nature Reviews. Cancer. 18: 707-719. PMID 30327499 DOI: 10.1038/s41568-018-0061-0  0.263
2024 Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nature Communications. 15: 1309. PMID 38378685 DOI: 10.1038/s41467-024-45260-9  0.263
2010 Fontana L, Partridge L, Longo VD. Extending healthy life span--from yeast to humans. Science (New York, N.Y.). 328: 321-6. PMID 20395504 DOI: 10.1126/science.1172539  0.262
2015 Di Biase S, Longo VD. Fasting-induced differential stress sensitization in cancer treatment. Molecular & Cellular Oncology. 3: e1117701. PMID 27314084 DOI: 10.1080/23723556.2015.1117701  0.26
2018 Dorff TB, Shelechi M, Kang I, Morgan TE, Groshen SG, Yennu S, Garcia AA, Quinn DI, Longo V. A randomized phase II clinical trial of a fasting-mimic diet prior to chemotherapy to evaluate the impact on toxicity and efficacy. Journal of Clinical Oncology. 36: TPS10132-TPS10132. DOI: 10.1200/Jco.2018.36.15_Suppl.Tps10132  0.26
1996 Longo VD, Gralla EB, Valentine JS. Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. The Journal of Biological Chemistry. 271: 12275-80. PMID 8647826 DOI: 10.1074/Jbc.271.21.12275  0.259
2008 Longo VD, Lieber MR, Vijg J. Turning anti-ageing genes against cancer. Nature Reviews. Molecular Cell Biology. 9: 903-10. PMID 18946478 DOI: 10.1038/nrm2526  0.257
2024 Fanti M, Longo V. Nutrition, GH/IGF-I signaling, and cancer. Endocrine-Related Cancer. PMID 39166749 DOI: 10.1530/ERC-23-0048  0.255
2003 Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science (New York, N.Y.). 299: 1342-6. PMID 12610293 DOI: 10.1126/science.1077991  0.253
2017 Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Scientific Reports. 7: 40919. PMID 28145503 DOI: 10.1038/Srep40919  0.251
2004 Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo VD. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. The Journal of Cell Biology. 166: 1055-67. PMID 15452146 DOI: 10.1083/Jcb.200404002  0.249
2024 Giuliani G, Longo VD. Ketone Bodies in Cell Physiology and Cancer. American Journal of Physiology. Cell Physiology. PMID 38189128 DOI: 10.1152/ajpcell.00441.2023  0.249
2020 Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nature Communications. 11: 2332. PMID 32393788 DOI: 10.1038/s41467-020-16243-3  0.248
2013 Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Experimental Gerontology. 48: 1120-8. PMID 23454633 DOI: 10.1016/J.Exger.2013.02.016  0.247
2022 Salvadori G, Zanardi F, Iannelli F, Lobefaro R, Vernieri C, Longo VD. Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape. Cell Metabolism. 33: 2247-2259.e6. PMID 34731655 DOI: 10.1016/j.cmet.2021.10.008  0.245
2016 Brandhorst S, Longo VD. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 241-66. PMID 27557543 DOI: 10.1007/978-3-319-42118-6_12  0.245
2013 Hu J, Wei M, Mirisola MG, Longo VD. Assessing chronological aging in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 965: 463-72. PMID 23296677 DOI: 10.1007/978-1-62703-239-1_30  0.245
2016 Cheng C, Adams G, Perin L, Wei M, Zhou X, Lam B, Sacco SD, Mirisola M, Quinn D, Dorff T, Kopchick J, Longo V. Erratum: Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression (Cell Stem Cell (2014) 14 (810-823)) Cell Stem Cell. 18: 291-292. DOI: 10.1016/J.Stem.2016.01.018  0.245
2012 Fontana L, Vinciguerra M, Longo VD. Growth factors, nutrient signaling, and cardiovascular aging. Circulation Research. 110: 1139-50. PMID 22499903 DOI: 10.1161/CIRCRESAHA.111.246470  0.243
2023 Buono R, Tucci J, Cutri R, Guidi N, Mangul S, Raucci F, Pellegrini M, Mittelman SD, Longo VD. Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival. Cancers. 15. PMID 38136414 DOI: 10.3390/cancers15245870  0.243
2011 Sehati S, Clement MH, Martins J, Xu L, Longo VD, Valentine JS, Gralla EB. Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radical Biology & Medicine. 50: 1591-8. PMID 21397007 DOI: 10.1016/J.Freeradbiomed.2011.03.004  0.243
2008 Fabrizio P, Longo VD. Chronological aging-induced apoptosis in yeast. Biochimica Et Biophysica Acta. 1783: 1280-5. PMID 18445486 DOI: 10.1016/j.bbamcr.2008.03.017  0.242
2012 Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metabolism. 16: 18-31. PMID 22768836 DOI: 10.1016/J.Cmet.2012.06.002  0.239
2012 Longo VD, Fabrizio P. Chronological aging in Saccharomyces cerevisiae. Sub-Cellular Biochemistry. 57: 101-21. PMID 22094419 DOI: 10.1007/978-94-007-2561-4_5  0.239
2019 Brandhorst S, Longo VD. Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity. Advances in Nutrition (Bethesda, Md.). 10: S340-S350. PMID 31728501 DOI: 10.1093/advances/nmz079  0.237
2007 Cheng C, Fabrizio P, Ge H, Wei M, Longo VD, Li LM. Significant and systematic expression differentiation in long-lived yeast strains. Plos One. 2: e1095. PMID 17971858 DOI: 10.1371/Journal.Pone.0001095  0.236
2010 Longo VD, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends in Pharmacological Sciences. 31: 89-98. PMID 20097433 DOI: 10.1016/j.tips.2009.11.004  0.236
2004 Longo VD. Search for methuselah genes heats up. Science of Aging Knowledge Environment : Sage Ke. 2004: pe6. PMID 14960761 DOI: 10.1126/sageke.2004.6.pe6  0.236
2013 Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 12: 257-68. PMID 23362919 DOI: 10.1111/Acel.12049  0.236
2012 Longo V. LONGEVITY REGULATION BY NUTRIENT SIGNALING PATHWAYS: RADICAL PROBLEMS WITHOUT ANTI-RADICAL SOLUTIONS Free Radical Biology and Medicine. 53: S10. DOI: 10.1016/J.Freeradbiomed.2012.10.020  0.233
2014 Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metabolism. 19: 181-92. PMID 24440038 DOI: 10.1016/J.Cmet.2013.12.008  0.23
2024 Raucci F, Vernieri C, Di Tano M, Ligorio F, Blaževitš O, Lazzeri S, Shmahala A, Fragale G, Salvadori G, Varano G, Casola S, Buono R, Visco E, de Braud F, Longo VD. Cyclic fasting-mimicking diet plus bortezomib and rituximab is an effective treatment for chronic lymphocytic leukemia. Cancer Research. PMID 38241703 DOI: 10.1158/0008-5472.CAN-23-0295  0.23
1997 Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. The Journal of Cell Biology. 137: 1581-8. PMID 9199172 DOI: 10.1083/Jcb.137.7.1581  0.229
2021 Pomatto-Watson LCD, Bodogai M, Bosompra O, Kato J, Wong S, Carpenter M, Duregon E, Chowdhury D, Krishna P, Ng S, Ragonnaud E, Salgado R, Gonzalez Ericsson P, Diaz-Ruiz A, Bernier M, ... ... Longo VD, et al. Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition. Nature Communications. 12: 6201. PMID 34707136 DOI: 10.1038/s41467-021-26431-4  0.227
2014 Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 14: 810-23. PMID 24905167 DOI: 10.1016/J.Stem.2014.04.014  0.226
2006 Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell. 126: 257-68. PMID 16873059 DOI: 10.1016/J.Cell.2006.07.002  0.226
2007 Fabrizio P, Longo VD. The chronological life span of Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 371: 89-95. PMID 17634576 DOI: 10.1007/978-1-59745-361-5_8  0.225
2020 Di Tano M, Longo VD. A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer. Molecular & Cellular Oncology. 7: 1791671. PMID 32944646 DOI: 10.1080/23723556.2020.1791671  0.225
2005 Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. Sir2 blocks extreme life-span extension. Cell. 123: 655-67. PMID 16286010 DOI: 10.1016/J.Cell.2005.08.042  0.224
2014 Mirzaei H, Suarez JA, Longo VD. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends in Endocrinology and Metabolism: Tem. 25: 558-66. PMID 25153840 DOI: 10.1016/j.tem.2014.07.002  0.223
2004 Longo VD. Ras: the other pro-aging pathway. Science of Aging Knowledge Environment : Sage Ke. 2004: pe36. PMID 15456908 DOI: 10.1126/sageke.2004.39.pe36  0.222
2011 Wei M, Madia F, Longo VD. Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. Journal of Visualized Experiments : Jove. PMID 21989366 DOI: 10.3791/3030  0.22
2010 Longo VD, Nislow C, Fabrizio P. Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy. 6: 1227-8. PMID 20953148 DOI: 10.4161/Auto.6.8.13850  0.22
2015 Shim HS, Wei M, Brandhorst S, Longo VD. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Research. 75: 1056-67. PMID 25614517 DOI: 10.1158/0008-5472.Can-14-2249  0.217
2023 Maragkakis M, Malla S, Hatzoglou M, Trifunovic A, Glick AB, Finkel T, Longo VD, Kaushik S, Muñoz-Cánoves P, Lithgow GJ, Naidoo N, Booth LN, Payea MJ, Herman AB, de Cabo R, et al. Biology of Stress Responses in Aging. Aging Biology. 1. PMID 38500537 DOI: 10.59368/agingbio.20230001  0.216
2013 Nencioni A, Cea M, Montecucco F, Longo VD, Patrone F, Carella AM, Holyoake TL, Helgason GV. Autophagy in blood cancers: biological role and therapeutic implications. Haematologica. 98: 1335-43. PMID 24006406 DOI: 10.3324/haematol.2012.079061  0.216
2020 Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, ... ... Longo VD, et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 583: 620-624. PMID 32669709 DOI: 10.1038/S41586-020-2502-7  0.214
2003 Gendron CM, Minois N, Fabrizio P, Longo VD, Pletcher SD, Vaupel JW. Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mechanisms of Ageing and Development. 124: 1059-63. PMID 14659594 DOI: 10.1016/j.mad.2003.08.003  0.214
2020 Maniaci G, La Cascia C, Giammanco A, Ferraro L, Chianetta R, Di Peri R, Sardella Z, Citarrella R, Mannella Y, Larcan S, Montana S, Mirisola MG, Longo V, Rizzo M, La Barbera D. Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial. Journal of Clinical Psychology. PMID 32394438 DOI: 10.1002/Jclp.22971  0.211
2010 Ge H, Wei M, Fabrizio P, Hu J, Cheng C, Longo VD, Li LM. Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Research. 38: 143-58. PMID 19880387 DOI: 10.1093/Nar/Gkp849  0.211
2022 Longo VD, Anderson RM. Nutrition, longevity and disease: From molecular mechanisms to interventions. Cell. 185: 1455-1470. PMID 35487190 DOI: 10.1016/j.cell.2022.04.002  0.211
2008 Li Y, Xu W, McBurney MW, Longo VD. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metabolism. 8: 38-48. PMID 18590691 DOI: 10.1016/J.Cmet.2008.05.004  0.209
2021 Longo VD, Di Tano M, Mattson MP, Guidi N. Intermittent and periodic fasting, longevity and disease. Nature Aging. 1: 47-59. PMID 35310455 DOI: 10.1038/s43587-020-00013-3  0.209
2008 Parrella E, Longo VD. The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods (San Diego, Calif.). 46: 256-62. PMID 18930829 DOI: 10.1016/j.ymeth.2008.10.004  0.208
2017 Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Research Reviews. PMID 28216454 DOI: 10.1016/j.arr.2017.02.001  0.208
2015 Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget. 6: 11820-32. PMID 25909220 DOI: 10.18632/oncotarget.3689  0.207
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, ... ... Longo V, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  0.207
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  0.204
2012 Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. Journal of Cellular Physiology. 227: 3803-11. PMID 22422508 DOI: 10.1002/jcp.24090  0.202
2015 Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 14: 497-510. PMID 25902704 DOI: 10.1111/Acel.12338  0.201
2020 Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, ... ... Longo V, et al. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging. 12. PMID 32575074 DOI: 10.18632/aging.103534  0.201
1998 Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, Holm NV, Iachine IA, Kannisto V, Khazaeli AA, Liedo P, Longo VD, Zeng Y, Manton KG, Curtsinger JW. Biodemographic trajectories of longevity. Science (New York, N.Y.). 280: 855-60. PMID 9599158 DOI: 10.1126/Science.280.5365.855  0.198
2020 de Groot S, Lugtenberg RT, Cohen D, Welters MJP, Ehsan I, Vreeswijk MPG, Smit VTHBM, de Graaf H, Heijns JB, Portielje JEA, van de Wouw AJ, Imholz ALT, Kessels LW, Vrijaldenhoven S, Baars A, ... ... Longo VD, et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature Communications. 11: 3083. PMID 32576828 DOI: 10.1038/s41467-020-16138-3  0.197
2017 Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, ... ... Longo VD, et al. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine. 9. PMID 28202779 DOI: 10.1126/Scitranslmed.Aai8700  0.197
2016 Mattson MP, Longo VD, Harvie M. Impact of Intermittent Fasting on Health and Disease Processes. Ageing Research Reviews. PMID 27810402 DOI: 10.1016/J.Arr.2016.10.005  0.196
2018 Guidi N, Longo VD. Periodic fasting starves cisplatin-resistant cancers to death. The Embo Journal. PMID 29875131 DOI: 10.15252/embj.201899815  0.196
2015 Mirzaei H, Raynes R, Longo VD. The conserved role of protein restriction in aging and disease. Current Opinion in Clinical Nutrition and Metabolic Care. PMID 26560522 DOI: 10.1097/Mco.0000000000000239  0.195
2021 Vernieri C, Fuca G, Ligorio F, Huber V, Vingiani A, Iannelli F, Raimondi A, Rinchai D, Frige G, Belfiore A, Lalli L, Chiodoni C, Cancila V, Zanardi F, Ajazi A, ... ... Longo VD, et al. Fasting-mimicking diet is safe and reshapes metabolism and antitumor immunity in cancer patients. Cancer Discovery. PMID 34789537 DOI: 10.1158/2159-8290.CD-21-0030  0.194
2021 Mishra A, Mirzaei H, Guidi N, Vinciguerra M, Mouton A, Linardic M, Rappa F, Barone R, Navarrete G, Wei M, Brandhorst S, Di Biase S, Morgan TE, Ram Kumar S, Conti PS, ... ... Longo VD, et al. Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan. Nature Metabolism. PMID 34650272 DOI: 10.1038/s42255-021-00469-6  0.194
2012 Mirisola MG, Longo VD. Acetic acid and acidification accelerate chronological and replicative aging in yeast. Cell Cycle (Georgetown, Tex.). 11: 3532-3. PMID 22951542 DOI: 10.4161/cc.22042  0.192
2005 Longo VD, Mitteldorf J, Skulachev VP. Programmed and altruistic ageing. Nature Reviews. Genetics. 6: 866-72. PMID 16304601 DOI: 10.1038/Nrg1706  0.192
2024 Vernieri C, Ligorio F, Tripathy D, Longo VD. Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence. Cell Metabolism. PMID 39059383 DOI: 10.1016/j.cmet.2024.06.014  0.192
2022 Cortellino S, Raveane A, Chiodoni C, Delfanti G, Pisati F, Spagnolo V, Visco E, Fragale G, Ferrante F, Magni S, Iannelli F, Zanardi F, Casorati G, Bertolini F, Dellabona P, ... ... Longo VD, et al. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects. Cell Reports. 40: 111256. PMID 36001966 DOI: 10.1016/j.celrep.2022.111256  0.192
2014 Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell. 13: 193-6. PMID 23941528 DOI: 10.1111/Acel.12151  0.19
2017 Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 168: 775-788.e12. PMID 28235195 DOI: 10.1016/J.Cell.2017.01.040  0.188
2024 Brandhorst S, Longo VD. Exploring juventology: unlocking the secrets of youthspan and longevity programs. Frontiers in Aging. 5: 1379289. PMID 38638872 DOI: 10.3389/fragi.2024.1379289  0.181
2013 Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 4: 2451-61. PMID 24353195 DOI: 10.18632/Oncotarget.1586  0.179
2013 Mirisola MG, Longo VD. A radical signal activates the epigenetic regulation of longevity. Cell Metabolism. 17: 812-3. PMID 23747240 DOI: 10.1016/j.cmet.2013.05.015  0.179
2021 Valdemarin F, Caffa I, Persia A, Cremonini AL, Ferrando L, Tagliafico L, Tagliafico A, Guijarro A, Carbone F, Ministrini S, Bertolotto M, Becherini P, Bonfiglio T, Giannotti C, Khalifa A, ... ... Longo VD, et al. Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment. Cancers. 13. PMID 34439167 DOI: 10.3390/cancers13164013  0.178
2004 Gendron CM, Minois N, Fabrizio P, Longo VD, Pletcher SD, Vaupel JW. Corrigendum to “Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic” Mechanisms of Ageing and Development. 125: 251. DOI: 10.1016/j.mad.2004.02.003  0.178
2023 Mishra A, Giuliani G, Longo VD. Nutrition and dietary restrictions in cancer prevention. Biochimica Et Biophysica Acta. Reviews On Cancer. 1879: 189063. PMID 38147966 DOI: 10.1016/j.bbcan.2023.189063  0.178
2014 Mirzaei H, Longo VD. Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metabolism. 19: 555-7. PMID 24703691 DOI: 10.1016/j.cmet.2014.03.021  0.175
2017 Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. Brain structure and function associated with younger adults in growth hormone receptor deficient humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28073935 DOI: 10.1523/Jneurosci.1929-16.2016  0.171
2011 Mirisola MG, Longo VD. Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging. 3: 340-3. PMID 21732566  0.17
2023 Cortellino S, Longo VD. Metabolites and Immune Response in Tumor Microenvironments. Cancers. 15. PMID 37568713 DOI: 10.3390/cancers15153898  0.167
2017 Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, ... ... Longo VD, et al. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metabolism. 25: 1320-1333.e5. PMID 28591635 DOI: 10.1016/J.Cmet.2017.05.003  0.167
2019 Buono R, Longo VD. When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die. Cell. 178: 1038-1040. PMID 31442398 DOI: 10.1016/j.cell.2019.07.052  0.165
2022 Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, ... ... Longo VD, et al. Meeting Report: Aging Research and Drug Discovery. Aging. 14. PMID 35089871 DOI: 10.18632/aging.203859  0.161
2019 Brandhorst S, Longo VD. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circulation Research. 124: 952-965. PMID 30870119 DOI: 10.1161/CIRCRESAHA.118.313352  0.16
2022 Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, ... ... Longo VD, et al. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Reports. 40: 111417. PMID 36170815 DOI: 10.1016/j.celrep.2022.111417  0.16
2015 Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Longo VD, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/J.Semcancer.2015.09.007  0.16
2016 Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metabolism. 23: 1048-59. PMID 27304506 DOI: 10.1016/J.Cmet.2016.06.001  0.159
2021 Diaz-Ruiz A, Rhinesmith T, Pomatto-Watson LCD, Price NL, Eshaghi F, Ehrlich MR, Moats JM, Carpenter M, Rudderow A, Brandhorst S, Mattison JA, Aon MA, Bernier M, Longo VD, de Cabo R. Diet composition influences the metabolic benefits of short cycles of very low caloric intake. Nature Communications. 12: 6463. PMID 34753921 DOI: 10.1038/s41467-021-26654-5  0.157
2004 Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. The Journal of Biological Chemistry. 279: 32055-62. PMID 15166213 DOI: 10.1074/Jbc.M403590200  0.154
2005 Skulachev VP, Longo VD. Aging as a mitochondria-mediated atavistic program: can aging be switched off? Annals of the New York Academy of Sciences. 1057: 145-64. PMID 16399892 DOI: 10.1196/Annals.1356.009  0.153
1999 Longo VD, Liou LL, Valentine JS, Gralla EB. Mitochondrial superoxide decreases yeast survival in stationary phase. Archives of Biochemistry and Biophysics. 365: 131-42. PMID 10222047 DOI: 10.1006/Abbi.1999.1158  0.149
2020 van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle ME, Willems van Dijk K, Longo VD, Lamb HJ, Numans ME, Pijl H. Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. Bmc Endocrine Disorders. 20: 94. PMID 32580710 DOI: 10.1186/s12902-020-00576-7  0.146
2024 Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, ... ... Longo VD, et al. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging. 16. PMID 39418098 DOI: 10.18632/aging.206135  0.142
2016 Mirzaei H, Di Biase S, Longo VD. Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circulation Research. 118: 1612-25. PMID 27174953 DOI: 10.1161/CIRCRESAHA.116.307473  0.138
2019 Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Reports. 26: 2704-2719.e6. PMID 30840892 DOI: 10.1016/J.Celrep.2019.02.019  0.135
2020 Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, ... ... Longo VD, et al. Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. PMID 33273708 DOI: 10.1038/s41586-020-2957-6  0.133
2020 Lugtenberg RT, de Groot S, Kaptein AA, Fischer MJ, Kranenbarg EM, Carpentier MD, Cohen D, de Graaf H, Heijns JB, Portielje JEA, van de Wouw AJ, Imholz ALT, Kessels LW, Vrijaldenhoven S, Baars A, ... ... Longo VD, et al. Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial. Breast Cancer Research and Treatment. PMID 33179154 DOI: 10.1007/s10549-020-05991-x  0.128
2022 Gregor A, Huber L, Auernigg-Haselmaier S, Sternberg F, Billerhart M, Dunkel A, Somoza V, Ogris M, Kofler B, Longo VD, König J, Duszka K. A Comparison of the Impact of Restrictive Diets on the Gastrointestinal Tract of Mice. Nutrients. 14. PMID 35956298 DOI: 10.3390/nu14153120  0.128
2020 Crupi AN, Haase J, Brandhorst S, Longo VD. Periodic and Intermittent Fasting in Diabetes and Cardiovascular Disease. Current Diabetes Reports. 20: 83. PMID 33301104 DOI: 10.1007/s11892-020-01362-4  0.124
2014 Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proceedings of the National Academy of Sciences of the United States of America. 111: 16647-53. PMID 25404320 DOI: 10.1073/Pnas.1413965111  0.123
2024 Villani V, Frank CN, Cravedi P, Hou X, Bin S, Kamitakahara A, Barbati C, Buono R, Da Sacco S, Lemley KV, De Filippo RE, Lai S, Laviano A, Longo VD, Perin L. A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy. Science Translational Medicine. 16: eadl5514. PMID 39475573 DOI: 10.1126/scitranslmed.adl5514  0.123
2022 Mishra A, Longo VD. Fasting and Fasting Mimicking Diets in Obesity and Cardiometabolic Disease Prevention and Treatment. Physical Medicine and Rehabilitation Clinics of North America. 33: 699-717. PMID 35989059 DOI: 10.1016/j.pmr.2022.04.009  0.121
2016 Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Reports. PMID 27239035 DOI: 10.1016/J.Celrep.2016.05.009  0.121
2025 Micarelli A, Mrakic-Sposta S, Vezzoli A, Malacrida S, Caputo S, Micarelli B, Misici I, Carbini V, Iennaco I, Granito I, Longo VD, Alessandrini M. Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial. Cell Reports. Medicine. 6: 101971. PMID 39970875 DOI: 10.1016/j.xcrm.2025.101971  0.12
2010 Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, ... ... Longo VD, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9695-707. PMID 20660252 DOI: 10.1523/Jneurosci.0027-10.2010  0.118
2002 Longo VD, Finch CE. Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Archives of Neurology. 59: 1706-8. PMID 12433254 DOI: 10.1001/archneur.59.11.1706  0.117
2023 Hadžić K, Gregor A, Auernigg-Haselmaier S, Longo V, Pignitter M, Duszka K. Restrictive diets have a beneficial impact on DSS-induced colitis in male mice. The Journal of Nutrition. PMID 37952777 DOI: 10.1016/j.tjnut.2023.11.005  0.109
2024 Koppold DA, Breinlinger C, Hanslian E, Kessler C, Cramer H, Khokhar AR, Peterson CM, Tinsley G, Vernieri C, Bloomer RJ, Boschmann M, Bragazzi NL, Brandhorst S, Gabel K, Goldhamer AC, ... ... Longo V, et al. International consensus on fasting terminology. Cell Metabolism. PMID 39059384 DOI: 10.1016/j.cmet.2024.06.013  0.1
2015 Shim HS, Longo VD. A protein restriction-dependent sulfur code for longevity. Cell. 160: 15-7. PMID 25594171 DOI: 10.1016/j.cell.2014.12.027  0.1
2016 Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. Jama Internal Medicine. PMID 27479196 DOI: 10.1001/Jamainternmed.2016.4182  0.099
2020 Longo VD, Cortellino S. Fasting, dietary restriction, and immunosenescence. The Journal of Allergy and Clinical Immunology. PMID 32853639 DOI: 10.1016/j.jaci.2020.07.035  0.097
2022 Sulaj A, Kopf S, von Rauchhaupt E, Kliemank E, Brune M, Kender Z, Bartl H, Cortizo FG, Klepac K, Han Z, Kumar V, Longo V, Teleman A, Okun JG, Morgenstern J, et al. Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study. The Journal of Clinical Endocrinology and Metabolism. PMID 35661214 DOI: 10.1210/clinem/dgac197  0.095
2014 Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. Medical research: treat ageing. Nature. 511: 405-7. PMID 25056047 DOI: 10.1038/511405A  0.095
2011 Longo VD, Fontana L. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging. 3: 1039-40. PMID 22147496  0.094
2002 Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3484-92. PMID 11978825  0.094
2021 Salvadori G, Longo VD. Diet comparison suggests a lipid imbalance can slow tumour growth. Nature. 599: 206-207. PMID 34671149 DOI: 10.1038/d41586-021-02775-1  0.094
2015 Caffa I, Longo VD, Nencioni A. Fasting plus tyrosine kinase inhibitors in cancer. Aging. 7: 1026-7. PMID 26645151  0.091
2016 Longo VD, Cortellino S. Enhancing Stem Cell Transplantation with "Nutri-technology". Cell Stem Cell. 19: 681-682. PMID 27912088 DOI: 10.1016/j.stem.2016.11.015  0.087
2023 Mainas G, Santamaria P, Ide M, Longo V, Vinciguerra M, Nart J, Nibali L. Could dietary restrictions affect periodontal disease? A systematic review. Clinical Oral Investigations. PMID 37199773 DOI: 10.1007/s00784-023-05052-9  0.087
2020 van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle ME, van Dijk KW, Longo VD, Lamb HJ, Numans ME, Pijl H. Correction to: Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. Bmc Endocrine Disorders. 20: 164. PMID 33143722 DOI: 10.1186/s12902-020-00635-z  0.086
2022 Nardon M, Venturelli M, Ruzzante F, Longo VD, Bertucco M. Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial. European Journal of Applied Physiology. 122: 651-661. PMID 35034194 DOI: 10.1007/s00421-021-04867-2  0.085
2021 Fanti M, Mishra A, Longo VD, Brandhorst S. Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss. Current Obesity Reports. PMID 33512641 DOI: 10.1007/s13679-021-00424-2  0.084
2022 Rahmani J, Montesanto A, Giovannucci E, Zand H, Barati M, Kopchick JJ, Mirisola MG, Lagani V, Bawadi H, Vardavas R, Laviano A, Christensen K, Passarino G, Longo VD. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Aging Cell. 21: e13540. PMID 35048526 DOI: 10.1111/acel.13540  0.084
2024 van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle EM, Lamb HJ, Longo VD, Numans ME, Pijl H. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. PMID 38546821 DOI: 10.1007/s00125-024-06137-0  0.08
2010 Longo VD. Dietary Restriction: Standing Up for Sirtuins--Response Science. 329: 1013-1014. DOI: 10.1126/science.329.5995.1013-b  0.075
2000 Longo VD, Viola KL, Klein WL, Finch CE. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. Journal of Neurochemistry. 75: 1977-85. PMID 11032887 DOI: 10.1046/j.1471-4159.2000.0751977.x  0.072
2023 Kender Z, von Rauchhaupt E, Schwarz D, Tsilingiris D, Schimpfle L, Bartl H, Longo VD, Bendszus M, Kopf S, Herzig S, Heiland S, Szendroedi J, Sulaj A. Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients. Frontiers in Endocrinology. 14: 1143799. PMID 37251671 DOI: 10.3389/fendo.2023.1143799  0.067
2011 Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD, Arvat E. L’iposomatismo congenito dovuto a deficit del recettore per il GH è associato nell’uomo a una drastica riduzione dell’incidenza di tumori, diabete mellito e invecchiamento cellulare L'Endocrinologo. 12: 150-150. DOI: 10.1007/BF03344812  0.059
2014 Bai B, Joshi A, Brandhorst S, Longo VD, Conti PS, Leahy RM. A registration-based segmentation method with application to adiposity analysis of mice microCT images Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9038. DOI: 10.1117/12.2043744  0.052
2022 Brandhorst S, Longo VD. Breakfast keeps hunger in check. Cell Metabolism. 34: 1420-1421. PMID 36198286 DOI: 10.1016/j.cmet.2022.09.015  0.051
2010 Fontana L, Partridge L, Longo VD. Dietary restriction: Theory fails to satiate - Response Science. 329: 1015. DOI: 10.1126/science.329.5995.1015  0.05
2020 Dong TS, Mayer EA, Osadchiy V, Chang C, Katzka W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Longo VD, Gupta A. A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction. Obesity (Silver Spring, Md.). 28: 1477-1486. PMID 32935533 DOI: 10.1002/oby.22870  0.048
2025 Longo VD. Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus. Nature Reviews. Endocrinology. 21: 73-74. PMID 39672887 DOI: 10.1038/s41574-024-01078-5  0.043
2022 Nardon M, Venturelli M, Ruzzante F, Longo V, Bertucco M. Response to: Dealing with menstrual cycle in sport: stop finding excuses to exclude women from research. European Journal of Applied Physiology. PMID 35918557 DOI: 10.1007/s00421-022-05015-0  0.041
2019 Longo V, Brum T, Dal Ponte A, Vitiello R, Dal Ponte M, Brambilla E. Transplante de microbiota intestinal na infecção por clostridium difficile Journal of Coloproctology. 39: 31. DOI: 10.1016/j.jcol.2019.11.057  0.024
2019 Nencioni A, Caffa I, Cortellino S, Longo VD. Reply to 'Fasting in oncology: a word of caution'. Nature Reviews. Cancer. PMID 30651605 DOI: 10.1038/s41568-018-0100-x  0.017
2017 Longo V. Interview with Professor Valter Longo. Fems Yeast Research. PMID 29186374 DOI: 10.1093/femsyr/fox052  0.014
2019 Longo VD. Programmed longevity, youthspan, and juventology. Aging Cell. 18: e12843. PMID 30334314 DOI: 10.1111/acel.12843  0.012
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