Year |
Citation |
Score |
2022 |
Bhatt DP, Mills CA, Anderson KA, Henriques BJ, Lucas TG, Francisco S, Liu J, Ilkayeva OR, Adams AE, Kulkarni SR, Backos DS, Major MB, Grimsrud PA, Gomes CM, Hirschey MD. Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice. The Journal of Biological Chemistry. 101723. PMID 35157847 DOI: 10.1016/j.jbc.2022.101723 |
0.336 |
|
2020 |
Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, Hirschey MD, Meyer JN. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology. 152630. PMID 33188857 DOI: 10.1016/j.tox.2020.152630 |
0.312 |
|
2019 |
Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva OR, Abramovich I, Yaron O, ... ... Hirschey MD, et al. SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports. 29: 4127-4143.e8. PMID 31851938 DOI: 10.1016/J.Celrep.2019.11.067 |
0.41 |
|
2019 |
Assiri MA, Ali HR, Marentette JO, Yun Y, Liu J, Hirschey MD, Saba LM, Harris PS, Fritz KS. Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. Human Genomics. 13: 65. PMID 31823815 DOI: 10.1186/S40246-019-0251-1 |
0.316 |
|
2019 |
Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS. Quantifying competition among mitochondrial protein acylation events induced by ethanol metabolism. Journal of Proteome Research. PMID 30644754 DOI: 10.1021/Acs.Jproteome.8B00800 |
0.44 |
|
2018 |
Mills CA, Trub AG, Hirschey MD. Sensing Mitochondrial Acetyl-CoA to Tune Respiration. Trends in Endocrinology and Metabolism: Tem. PMID 30442533 DOI: 10.1016/J.Tem.2018.10.003 |
0.403 |
|
2018 |
Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB. Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. Cell Reports. 24: 209-223.e6. PMID 29972782 DOI: 10.1016/J.Celrep.2018.05.088 |
0.447 |
|
2018 |
Hershberger KA, Abraham DM, Liu J, Locasale JW, Grimsrud PA, Hirschey MD. Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. The Journal of Biological Chemistry. PMID 29769314 DOI: 10.1074/Jbc.Ra118.002187 |
0.381 |
|
2018 |
Trub AG, Hirschey MD. Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress. Trends in Biochemical Sciences. PMID 29478872 DOI: 10.1016/J.Tibs.2018.02.002 |
0.435 |
|
2017 |
Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB. Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways. The Journal of Biological Chemistry. PMID 29222328 DOI: 10.1074/Jbc.M117.782557 |
0.305 |
|
2017 |
Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB. Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell Metabolism. PMID 29107506 DOI: 10.1016/J.Cmet.2017.09.024 |
0.398 |
|
2017 |
Hibshman JD, Doan AE, Moore BT, Kaplan RE, Hung A, Webster AK, Bhatt DP, Chitrakar R, Hirschey MD, Baugh LR. daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival. Elife. 6. PMID 29063832 DOI: 10.7554/Elife.30057 |
0.373 |
|
2017 |
Hershberger KA, Abraham DM, Martin AS, Mao L, Liu J, Gu H, Locasale JW, Hirschey MD. Sirtuin 5 is required for mouse survival in response to cardiac pressure overload. The Journal of Biological Chemistry. PMID 28972174 DOI: 10.1074/Jbc.M117.809897 |
0.436 |
|
2017 |
Anderson KA, Madsen AS, Olsen CA, Hirschey MD. Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio. Biochimica Et Biophysica Acta. PMID 28947253 DOI: 10.1016/J.Bbabio.2017.09.005 |
0.347 |
|
2017 |
Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcoholism, Clinical and Experimental Research. PMID 28804911 DOI: 10.1111/Acer.13473 |
0.383 |
|
2017 |
Huynh FK, Hu X, Lin Z, Johnson JD, Hirschey MD. Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. Journal of Inherited Metabolic Disease. PMID 28726069 DOI: 10.1007/S10545-017-0069-8 |
0.403 |
|
2017 |
Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. Jci Insight. 2. PMID 28724806 DOI: 10.1172/Jci.Insight.93885 |
0.4 |
|
2017 |
Stram AR, Wagner GR, Fogler BD, Pride PM, Hirschey MD, Payne RM. Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy. Plos One. 12: e0178354. PMID 28542596 DOI: 10.1371/Journal.Pone.0178354 |
0.359 |
|
2017 |
Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, ... ... Hirschey MD, et al. SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metabolism. 25: 838-855.e15. PMID 28380376 DOI: 10.1016/J.Cmet.2017.03.003 |
0.435 |
|
2017 |
Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, Hirschey MD. A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. Cell Metabolism. 25: 823-837.e8. PMID 28380375 DOI: 10.1016/J.Cmet.2017.03.006 |
0.42 |
|
2017 |
Wagner GR, Hirschey MD. A Prob(e)able Route to Lysine Acylation. Cell Chemical Biology. 24: 126-128. PMID 28212757 DOI: 10.1016/J.Chembiol.2017.01.011 |
0.374 |
|
2017 |
Hershberger KA, Martin AS, Hirschey MD. Role of NAD(+) and mitochondrial sirtuins in cardiac and renal diseases. Nature Reviews. Nephrology. PMID 28163307 DOI: 10.1038/Nrneph.2017.5 |
0.396 |
|
2016 |
McDonnell E, Crown SB, Fox DB, Kitir B, Ilkayeva OR, Olsen CA, Grimsrud PA, Hirschey MD. Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. Cell Reports. 17: 1463-1472. PMID 27806287 DOI: 10.1016/J.Celrep.2016.10.012 |
0.389 |
|
2016 |
Luz AT, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans. Toxicological Sciences : An Official Journal of the Society of Toxicology. 154: 195. PMID 27794142 DOI: 10.1093/Toxsci/Kfw185 |
0.37 |
|
2016 |
Luz AL, Lagido C, Hirschey MD, Meyer JN. In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. 69: 25.8.1-25.8.22. PMID 27479364 DOI: 10.1002/Cptx.10 |
0.417 |
|
2016 |
Luz AL, Godebo T, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. Arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27208080 DOI: 10.1093/Toxsci/Kfw093 |
0.431 |
|
2016 |
Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, Hirschey MD, Olsen CA. Investigating the Sensitivity of NAD+-Dependent Sirtuin Deacylation Activities to NADH. The Journal of Biological Chemistry. PMID 26861872 DOI: 10.1074/Jbc.M115.668699 |
0.32 |
|
2015 |
Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002 |
0.303 |
|
2015 |
Huynh FK, Muoio DM, Hirschey MD. SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. Diabetes. 64: 3058-60. PMID 26294425 DOI: 10.2337/Db15-0709 |
0.457 |
|
2015 |
Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES. Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. The Journal of Biological Chemistry. PMID 26240137 DOI: 10.1074/Jbc.M115.655837 |
0.32 |
|
2015 |
McDonnell E, Peterson BS, Bomze HM, Hirschey MD. SIRT3 regulates progression and development of diseases of aging. Trends in Endocrinology and Metabolism: Tem. PMID 26138757 DOI: 10.1016/J.Tem.2015.06.001 |
0.413 |
|
2015 |
Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW. High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. Molecular & Cellular Proteomics : McP. 14: 1489-500. PMID 25795660 DOI: 10.1074/Mcp.M114.044859 |
0.415 |
|
2015 |
Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell. 160: 842-55. PMID 25723162 DOI: 10.1016/J.Cell.2015.02.004 |
0.447 |
|
2015 |
Hirschey MD, Zhao Y. Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. Molecular & Cellular Proteomics : McP. 14: 2308-15. PMID 25717114 DOI: 10.1074/Mcp.R114.046664 |
0.429 |
|
2014 |
Anderson KA, Green MF, Huynh FK, Wagner GR, Hirschey MD. SnapShot: Mammalian Sirtuins. Cell. 159: 956-956.e1. PMID 25417168 DOI: 10.1016/J.Cell.2014.10.045 |
0.358 |
|
2014 |
Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, et al. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environmental Health Perspectives. 122: 1271-8. PMID 25127496 DOI: 10.1289/Ehp.1408418 |
0.4 |
|
2014 |
Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. Journal of Lipid Research. 55: 2458-70. PMID 25114170 DOI: 10.1194/Jlr.M046961 |
0.399 |
|
2014 |
Huynh FK, Green MF, Koves TR, Hirschey MD. Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods in Enzymology. 542: 391-405. PMID 24862277 DOI: 10.1016/B978-0-12-416618-9.00020-0 |
0.339 |
|
2014 |
Wagner GR, Hirschey MD. Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. Molecular Cell. 54: 5-16. PMID 24725594 DOI: 10.1016/J.Molcel.2014.03.027 |
0.377 |
|
2014 |
Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, ... ... Hirschey MD, et al. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metabolism. 19: 605-17. PMID 24703693 DOI: 10.1016/J.Cmet.2014.03.014 |
0.43 |
|
2014 |
McDonnell E, Ilkayeva OR, Stevens RD, Muehlbauer MJ, Bain JR, Becker TC, Hirschey MD. Loss of SIRT3 leads to a compensatory shift in cellular metabolism promoting cancer cell growth Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-O18 |
0.493 |
|
2014 |
Hirschey M. Protein Acylation Regulates Metabolism Biophysical Journal. 106: 4a. DOI: 10.1016/J.Bpj.2013.11.053 |
0.461 |
|
2013 |
Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. The Journal of Biological Chemistry. 288: 33837-47. PMID 24121500 DOI: 10.1074/Jbc.M113.510354 |
0.384 |
|
2013 |
Fritz KS, Green MF, Petersen DR, Hirschey MD. Ethanol metabolism modifies hepatic protein acylation in mice. Plos One. 8: e75868. PMID 24073283 DOI: 10.1371/Journal.Pone.0075868 |
0.48 |
|
2013 |
Wang D, Green MF, McDonnell E, Hirschey MD. Oxygen flux analysis to understand the biological function of sirtuins. Methods in Molecular Biology (Clifton, N.J.). 1077: 241-58. PMID 24014411 DOI: 10.1007/978-1-62703-637-5_16 |
0.454 |
|
2013 |
Hershberger KA, Motley J, Hirschey MD, Anderson KA. Generating mammalian sirtuin tools for protein-interaction analysis. Methods in Molecular Biology (Clifton, N.J.). 1077: 69-78. PMID 24014400 DOI: 10.1007/978-1-62703-637-5_5 |
0.346 |
|
2013 |
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.). 339: 211-4. PMID 23223453 DOI: 10.1126/Science.1227166 |
0.334 |
|
2013 |
Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chemical Biology. 9: 97-104. PMID 23201900 DOI: 10.1038/Nchembio.1136 |
0.385 |
|
2013 |
Anderson KA, Wang D, Hirschey MD. HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint? Hepatology (Baltimore, Md.). 57: 1681-3. PMID 22991239 DOI: 10.1002/Hep.26085 |
0.495 |
|
2013 |
Green MF, Hirschey MD. SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 105-7. PMID 22562958 DOI: 10.1093/Gerona/Gls132 |
0.46 |
|
2012 |
Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays in Biochemistry. 52: 23-35. PMID 22708561 DOI: 10.1042/Bse0520023 |
0.469 |
|
2012 |
Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. Journal of Proteome Research. 11: 1633-43. PMID 22309199 DOI: 10.1016/J.Freeradbiomed.2011.10.044 |
0.468 |
|
2011 |
Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 76: 267-77. PMID 22114326 DOI: 10.1101/Sqb.2011.76.010850 |
0.49 |
|
2011 |
Hirschey MD. Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases. Cell Metabolism. 14: 718-9. PMID 22100408 DOI: 10.1016/J.Cmet.2011.10.006 |
0.318 |
|
2011 |
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proceedings of the National Academy of Sciences of the United States of America. 108: 14608-13. PMID 21873205 DOI: 10.1073/Pnas.1111308108 |
0.39 |
|
2011 |
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, StanÄáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/J.Molcel.2011.07.019 |
0.473 |
|
2010 |
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metabolism. 12: 662-7. PMID 21109198 DOI: 10.1016/J.Cmet.2010.11.015 |
0.348 |
|
2010 |
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/J.Cmet.2010.11.003 |
0.461 |
|
2010 |
Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends in Biochemical Sciences. 35: 669-75. PMID 20863707 DOI: 10.1016/J.Tibs.2010.07.003 |
0.459 |
|
2010 |
Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E. Acetate metabolism and aging: An emerging connection. Mechanisms of Ageing and Development. 131: 511-6. PMID 20478325 DOI: 10.1016/J.Mad.2010.05.001 |
0.461 |
|
2010 |
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778 |
0.479 |
|
2010 |
Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochimica Et Biophysica Acta. 1804: 1645-51. PMID 20060508 DOI: 10.1016/j.bbapap.2009.12.021 |
0.393 |
|
2009 |
Hirschey MD, Shimazu T, Huang JY, Verdin E. Acetylation of mitochondrial proteins. Methods in Enzymology. 457: 137-47. PMID 19426866 DOI: 10.1016/S0076-6879(09)05008-3 |
0.487 |
|
2007 |
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07 |
0.482 |
|
2006 |
Hirschey MD, Han YJ, Stucky GD, Butler A. Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 663-9. PMID 16724226 DOI: 10.1007/S00775-006-0116-7 |
0.55 |
|
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