Lachlan Thompson - Publications

Affiliations: 
Lund University, Lund, Skåne län, Sweden 

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hunt CPJ, Moriarty N, van Deursen CBJ, Gantner CW, Thompson LH, Parish CL. Understanding and modeling regional specification of the human ganglionic eminence. Stem Cell Reports. PMID 36801004 DOI: 10.1016/j.stemcr.2023.01.010  0.341
2022 Moriarty N, Kauhausen JA, Pavan C, Hunt CP, de Luzy IR, Penna V, Ermine CM, Thompson LH, Parish CL. Understanding the influence of target acquisition on survival, integration and phenotypic maturation of dopamine neurons within stem cell-derived neural grafts in a Parkinson's disease model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35610045 DOI: 10.1523/JNEUROSCI.2431-21.2022  0.586
2022 Moriarty N, Gantner CW, Hunt CPJ, Ermine CM, Frausin S, Viventi S, Ovchinnikov DA, Kirik D, Parish CL, Thompson LH. A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells. Cell Stem Cell. PMID 35180398 DOI: 10.1016/j.stem.2022.01.013  0.692
2021 de Luzy IR, Law KCL, Moriarty N, Hunt CPJ, Durnall JC, Thompson LH, Nagy A, Parish CL. Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats. Nature Communications. 12: 3275. PMID 34045451 DOI: 10.1038/s41467-021-23125-9  0.502
2021 Parish CL, Thompson LH. Embryonic stem cells go from bench to bedside for Parkinson's disease. Cell Reports. Medicine. 2: 100251. PMID 33948581 DOI: 10.1016/j.xcrm.2021.100251  0.333
2021 Gantner CW, Hunt CPJ, Niclis JC, Penna V, McDougall SJ, Thompson LH, Parish CL. FGF-MAPK signaling regulates human deep-layer corticogenesis. Stem Cell Reports. PMID 33836146 DOI: 10.1016/j.stemcr.2021.03.014  0.346
2021 Viventi S, Frausin S, Howden SE, Lim SY, Finol-Urdaneta RK, McArthur JR, Abu-Bonsrah KD, Ng W, Ivanusic J, Thompson L, Dottori M. In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia. Stem Cells Translational Medicine. PMID 33734599 DOI: 10.1002/sctm.20-0334  0.501
2020 Gantner CW, Cota-Coronado A, Thompson LH, Parish CL. An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions. Star Protocols. 1: 100065. PMID 33111103 DOI: 10.1016/j.xpro.2020.100065  0.467
2020 Ermine CM, Wright JL, Stanic D, Parish CL, Thompson LH. Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis. Iscience. 23: 101175. PMID 32480130 DOI: 10.1016/j.isci.2020.101175  0.353
2020 Gantner CW, de Luzy IR, Kauhausen JA, Moriarty N, Niclis JC, Bye CR, Penna V, Hunt CPJ, Ermine CM, Pouton CW, Kirik D, Thompson LH, Parish CL. Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease. Cell Stem Cell. PMID 32059808 DOI: 10.1016/J.Stem.2020.01.010  0.647
2020 Cota-Coronado A, Thompson LH, Diaz-Martinez NE. Novel pluripotent stem cell lines for enriched grafting in Parkinson's disease. Neural Regeneration Research. 15: 255-256. PMID 31552892 DOI: 10.4103/1673-5374.265548  0.358
2019 Bye CR, Penna V, de Luzy IR, Gantner CW, Hunt CPJ, Thompson LH, Parish CL. Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain. Stem Cell Reports. PMID 31680060 DOI: 10.1016/j.stemcr.2019.10.001  0.312
2019 de Luzy IR, Niclis JC, Gantner CW, Kauhausen JA, Hunt CPJ, Ermine C, Pouton CW, Thompson LH, Parish CL. Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31641054 DOI: 10.1523/JNEUROSCI.1160-19.2019  0.581
2019 Bye CR, Rytova V, Alsanie WF, Parish CL, Thompson LH. Axonal growth of midbrain dopamine neurons is modulated by the cell adhesion molecule ALCAM through -heterophilic interaction with L1Cam, ChL1 and Semaphorin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31300520 DOI: 10.1523/JNEUROSCI.0278-19.2019  0.319
2019 Tian P, Abberton K, Elefanty A, Stanley E, Hollands J, Thompson L, Elwood N. Production of iPSCs from a small volume of cryopreserved human umbilical cord blood buffy coat under “gmp-compliant” conditions Cytotherapy. 21. DOI: 10.1016/J.Jcyt.2019.03.576  0.41
2018 Ermine CM, Wright JL, Frausin S, Kauhausen JA, Parish CL, Stanic D, Thompson LH. Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis. Hippocampus. PMID 29431270 DOI: 10.1002/hipo.22835  0.422
2017 Alsanie WF, Niclis JC, Hunt CP, De Luzy IR, Penna V, Bye CR, Pouton CW, Haynes J, Firas J, Thompson LH, Parish CL. Specification of murine ground state pluripotent stem cells to regional neuronal populations. Scientific Reports. 7: 16001. PMID 29167563 DOI: 10.1038/s41598-017-16248-x  0.434
2017 Niclis JC, Gantner CW, Hunt CPJ, Kauhausen JA, Durnall JC, Haynes JM, Pouton CW, Parish CL, Thompson LH. A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells. Stem Cell Reports. PMID 28867345 DOI: 10.1016/j.stemcr.2017.08.002  0.589
2017 Alsanie WF, Penna V, Schachner M, Thompson LH, Parish CL. Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways. Scientific Reports. 7: 9368. PMID 28839197 DOI: 10.1038/s41598-017-09599-y  0.371
2017 Somaa FA, Wang TY, Niclis JC, Bruggeman KF, Kauhausen JA, Guo H, McDougall S, Williams RJ, Nisbet DR, Thompson LH, Parish CL. Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke. Cell Reports. 20: 1964-1977. PMID 28834757 DOI: 10.1016/J.Celrep.2017.07.069  0.457
2017 Niclis JC, Gantner CW, Alsanie WF, McDougall SJ, Bye CR, Elefanty AG, Stanley EG, Haynes JM, Pouton CW, Thompson LH, Parish CL. Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents. Stem Cells Translational Medicine. 6: 937-948. PMID 28297587 DOI: 10.5966/Sctm.2016-0073  0.575
2017 Niclis JC, Turner C, Durnall J, McDougal S, Kauhausen JA, Leaw B, Dottori M, Parish CL, Thompson LH. Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived From Human Induced Pluripotent Stem Cells After Intracerebral Transplantation. Stem Cells Translational Medicine. PMID 28198124 DOI: 10.1002/Sctm.16-0198  0.446
2016 Niclis JC, Gantner CW, Alsanie WF, McDougall SJ, Bye CR, Elefanty AG, Stanley EG, Haynes JM, Pouton CW, Thompson LH, Parish CL. Efficiently Specified Ventral Midbrain Dopamine Neurons From Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents. Stem Cells Translational Medicine. PMID 27742845 DOI: 10.5966/sctm.2016-0073  0.482
2016 Barker RA, Parmar M, Kirkeby A, Björklund A, Thompson L, Brundin P. Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? Journal of Parkinson's Disease. PMID 27003785 DOI: 10.3233/Jpd-160798  0.697
2015 Kauhausen JA, Thompson LH, Parish CL. Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice. Molecular and Cellular Neurosciences. 69: 22-29. PMID 26463051 DOI: 10.1016/j.mcn.2015.10.002  0.37
2015 Thompson LH, Björklund A. Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells. Neurobiology of Disease. 79: 28-40. PMID 25913029 DOI: 10.1016/j.nbd.2015.04.003  0.5
2015 Bye CR, Jönsson ME, Björklund A, Parish CL, Thompson LH. Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proceedings of the National Academy of Sciences of the United States of America. 112: E1946-55. PMID 25775569 DOI: 10.1073/pnas.1501989112  0.767
2015 Somaa FA, Bye CR, Thompson LH, Parish CL. Meningeal cells influence midbrain development and the engraftment of dopamine progenitors in Parkinsonian mice. Experimental Neurology. 267: 30-41. PMID 25708989 DOI: 10.1016/j.expneurol.2015.02.017  0.411
2014 Hall H, Reyes S, Landeck N, Bye C, Leanza G, Double K, Thompson L, Halliday G, Kirik D. Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease. Brain : a Journal of Neurology. 137: 2493-508. PMID 25062696 DOI: 10.1093/Brain/Awu193  0.759
2014 Bird MJ, Needham K, Frazier AE, van Rooijen J, Leung J, Hough S, Denham M, Thornton ME, Parish CL, Nayagam BA, Pera M, Thorburn DR, Thompson LH, Dottori M. Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain. Plos One. 9: e101718. PMID 25000412 DOI: 10.1371/Journal.Pone.0101718  0.706
2014 Sahin G, Thompson LH, Lavisse S, Ozgur M, Rbah-Vidal L, Dollé F, Hantraye P, Kirik D. Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease. Plos One. 9: e90759. PMID 24614598 DOI: 10.1371/Journal.Pone.0090759  0.599
2014 Parish CL, Thompson LH. Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease. Journal of Molecular Cell Biology. 6: 54-63. PMID 24334258 DOI: 10.1093/jmcb/mjt045  0.457
2014 Turner C, Cretney E, Turner B, Niclis J, Parish C, Thompson L. Stem cell survival in the SOD1 rat model of ALS F1000research. 5. DOI: 10.7490/F1000Research.1097298.1  0.336
2013 Thompson LH, Parish CL. Transplantation of fetal midbrain dopamine progenitors into a rodent model of Parkinson's disease. Methods in Molecular Biology (Clifton, N.J.). 1059: 169-80. PMID 23934843 DOI: 10.1007/978-1-62703-574-3_15  0.493
2013 Wright J, Stanic D, Thompson LH. Generation of striatal projection neurons extends into the neonatal period in the rat brain. The Journal of Physiology. 591: 67-76. PMID 23129797 DOI: 10.1113/jphysiol.2012.246397  0.36
2013 Kauhausen J, Thompson LH, Parish CL. Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice. The Journal of Physiology. 591: 77-91. PMID 23045338 DOI: 10.1113/jphysiol.2012.243063  0.494
2013 Reyes S, Fu Y, Double KL, Cottam V, Thompson LH, Kirik D, Paxinos G, Watson C, Cooper HM, Halliday GM. Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiology of Aging. 34: 873-86. PMID 22926168 DOI: 10.1016/J.Neurobiolaging.2012.07.019  0.699
2012 Thompson L, Björklund A. Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation. Progress in Brain Research. 200: 61-95. PMID 23195415 DOI: 10.1016/B978-0-444-59575-1.00004-1  0.622
2012 Denham M, Bye C, Leung J, Conley BJ, Thompson LH, Dottori M. Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells (Dayton, Ohio). 30: 2400-11. PMID 22911885 DOI: 10.1002/Stem.1204  0.615
2012 Bye CR, Thompson LH, Parish CL. Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into parkinsonian mice. Experimental Neurology. 236: 58-68. PMID 22524988 DOI: 10.1016/j.expneurol.2012.04.002  0.428
2012 Denham M, Parish CL, Leaw B, Wright J, Reid CA, Petrou S, Dottori M, Thompson LH. Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation. Frontiers in Cellular Neuroscience. 6: 11. PMID 22470319 DOI: 10.3389/Fncel.2012.00011  0.728
2012 Reyes S, Fu Y, Double K, Thompson L, Kirik D, Paxinos G, Halliday GM. GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. The Journal of Comparative Neurology. 520: 2591-607. PMID 22252428 DOI: 10.1002/Cne.23051  0.716
2012 Jørgensen JR, Fransson A, Fjord-Larsen L, Thompson LH, Houchins JP, Andrade N, Torp M, Kalkkinen N, Andersson E, Lindvall O, Ulfendahl M, Brunak S, Johansen TE, Wahlberg LU. Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. Experimental Neurology. 233: 172-81. PMID 21985865 DOI: 10.1016/J.Expneurol.2011.09.027  0.612
2011 Jørgensen JR, Emerich DF, Thanos C, Thompson LH, Torp M, Bintz B, Fjord-Larsen L, Johansen TE, Wahlberg LU. Lentiviral delivery of meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model. Neurobiology of Disease. 41: 160-8. PMID 20840868 DOI: 10.1016/j.nbd.2010.09.003  0.473
2010 Denham M, Thompson LH, Leung J, Pébay A, Björklund A, Dottori M. Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells. Stem Cells (Dayton, Ohio). 28: 1805-15. PMID 20799336 DOI: 10.1002/Stem.510  0.701
2010 Grealish S, Jönsson ME, Li M, Kirik D, Björklund A, Thompson LH. The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease. Brain : a Journal of Neurology. 133: 482-95. PMID 20123725 DOI: 10.1093/Brain/Awp328  0.786
2009 Thompson LH, Grealish S, Kirik D, Björklund A. Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain. The European Journal of Neuroscience. 30: 625-38. PMID 19674082 DOI: 10.1111/J.1460-9568.2009.06878.X  0.809
2009 Thompson LH, Björklund A. Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts. Progress in Brain Research. 175: 53-79. PMID 19660649 DOI: 10.1016/S0079-6123(09)17505-2  0.524
2009 Jönsson ME, Ono Y, Björklund A, Thompson LH. Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis. Experimental Neurology. 219: 341-54. PMID 19555687 DOI: 10.1016/j.expneurol.2009.06.006  0.791
2009 Friling S, Andersson E, Thompson LH, Jönsson ME, Hebsgaard JB, Nanou E, Alekseenko Z, Marklund U, Kjellander S, Volakakis N, Hovatta O, El Manira A, Björklund A, Perlmann T, Ericson J. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 7613-8. PMID 19383789 DOI: 10.1073/pnas.0902396106  0.771
2009 Jørgensen JR, Thompson L, Fjord-Larsen L, Krabbe C, Torp M, Kalkkinen N, Hansen C, Wahlberg L. Characterization of Meteorin--an evolutionary conserved neurotrophic factor. Journal of Molecular Neuroscience : Mn. 39: 104-16. PMID 19259827 DOI: 10.1007/S12031-009-9189-4  0.397
2008 Thompson LH, Kirik D, Björklund A. Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain. Experimental Neurology. 213: 220-8. PMID 18602916 DOI: 10.1016/J.Expneurol.2008.06.005  0.673
2008 Irvin DK, Kirik D, Björklund A, Thompson LH. In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway. Neurobiology of Disease. 30: 343-52. PMID 18417351 DOI: 10.1016/J.Nbd.2008.02.006  0.801
2008 Jönsson M, Parmar M, Thompson L, Björklund A. [P2.62]: Embryonic dopaminergic precursors can be isolated at different states of differentiation and function upon grafting into an animal model of Parkinson's disease International Journal of Developmental Neuroscience. 26: 887-888. DOI: 10.1016/J.Ijdevneu.2008.09.187  0.728
2006 Thompson LH, Andersson E, Jensen JB, Barraud P, Guillemot F, Parmar M, Björklund A. Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon. Experimental Neurology. 198: 183-98. PMID 16438966 DOI: 10.1016/J.Expneurol.2005.11.025  0.8
2005 Barraud P, Thompson L, Kirik D, Björklund A, Parmar M. Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse. The European Journal of Neuroscience. 22: 1555-69. PMID 16197496 DOI: 10.1111/J.1460-9568.2005.04352.X  0.742
2005 Thompson L, Barraud P, Andersson E, Kirik D, Björklund A. Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6467-77. PMID 16000637 DOI: 10.1523/Jneurosci.1676-05.2005  0.793
2005 Sørensen AT, Thompson L, Kirik D, Björklund A, Lindvall O, Kokaia M. Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts. The European Journal of Neuroscience. 21: 2793-9. PMID 15926926 DOI: 10.1111/J.1460-9568.2005.04116.X  0.794
2005 Navarro-Galve B, Villa A, Bueno C, Thompson L, Johansen J, Martínez-Serrano A. Gene marking of human neural stem/precursor cells using green fluorescent proteins. The Journal of Gene Medicine. 7: 18-29. PMID 15508144 DOI: 10.1002/Jgm.639  0.417
2004 Jakobsson J, Rosenqvist N, Thompson L, Barraud P, Lundberg C. Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator. Experimental Cell Research. 298: 611-23. PMID 15265707 DOI: 10.1016/J.Yexcr.2004.04.037  0.72
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