Anna M. Diehl - Publications

Affiliations: 
Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Genetics, Molecular Biology, Oncology

409 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Roy S, Saha P, Bose D, Trivedi A, More M, Xiao S, Diehl AM, Chatterjee S. Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit. International Journal of Molecular Sciences. 24. PMID 38003543 DOI: 10.3390/ijms242216354  0.423
2023 Manka P, Coombes JD, Sydor S, Swiderska-Syn MK, Best J, Gauthier K, van Grunsven LA, Oo YH, Wang C, Diehl AM, Hönes GS, Moeller LC, Figge A, Boosman RJ, Faber KN, et al. Thyroid hormone receptor alpha modulates fibrogenesis in hepatic stellate cells. Liver International : Official Journal of the International Association For the Study of the Liver. 44: 125-138. PMID 37872645 DOI: 10.1111/liv.15759  0.348
2023 Dutta RK, Jun J, Du K, Diehl AM. Hedgehog Signaling: Implications in Liver Pathophysiology. Seminars in Liver Disease. 43: 418-428. PMID 37802119 DOI: 10.1055/a-2187-3382  0.373
2023 Du K, Maeso-Díaz R, Oh SH, Wang E, Chen T, Pan C, Xiang K, Dutta RK, Wang XF, Chi JT, Diehl AM. Targeting YAP-mediated hepatic stellate cell death susceptibility and senescence for treatment of liver fibrosis. Hepatology (Baltimore, Md.). PMID 36815382 DOI: 10.1097/HEP.0000000000000326  0.429
2022 Chen T, Dalton G, Oh SH, Maeso-Diaz R, Du K, Meyers RA, Guy C, Abdelmalek MF, Henao R, Guarnieri P, Pullen S, Gregory S, Locker J, Brown JM, Diehl AM. Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease. Cellular and Molecular Gastroenterology and Hepatology. PMID 36535507 DOI: 10.1016/j.jcmgh.2022.12.008  0.329
2022 Sanyal AJ, Williams SA, Lavine JE, Tetri B, Alexander L, Ostroff R, Biegel H, Kowdley K, Chalasani N, Dasarathy S, Diehl AM, Loomba R, Hameed B, Behling C, Kleiner DE, et al. Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in nonalcoholic fatty liver disease. Journal of Hepatology. PMID 36528237 DOI: 10.1016/j.jhep.2022.11.029  0.415
2022 Heinemann F, Gross P, Zeveleva S, Qian HS, Hill J, Höfer A, Jonigk D, Diehl AM, Abdelmalek M, Lenter MC, Pullen SS, Guarnieri P, Stierstorfer B. Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies. Scientific Reports. 12: 19236. PMID 36357500 DOI: 10.1038/s41598-022-23905-3  0.37
2022 Riegl SD, Starnes C, Jima DD, Baptissart M, Diehl AM, Belcher SM, Cowley M. The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced non-alcoholic fatty liver disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 36200916 DOI: 10.1093/toxsci/kfac106  0.321
2022 Sahoo S, Mishra A, Diehl AM, Jolly MK. Dynamics of hepatocyte-cholangiocyte cell-fate decisions during liver development and regeneration. Iscience. 25: 104955. PMID 36060070 DOI: 10.1016/j.isci.2022.104955  0.36
2022 Moylan CA, Mavis AM, Jima D, Maguire R, Bashir M, Hyun J, Cabezas MN, Parish A, Niedzwiecki D, Diehl AM, Murphy SK, Abdelmalek MF, Hoyo C. Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children. Epigenetics. 1-16. PMID 35188871 DOI: 10.1080/15592294.2022.2039850  0.301
2022 Baptissart M, Bradish CM, Jones BS, Walsh E, Tehrani J, Marrero-Colon V, Mehta S, Jima DD, Oh SH, Diehl AM, Fougeray T, Guillou H, Cowley M. Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome. Hepatology (Baltimore, Md.). PMID 35083765 DOI: 10.1002/hep.32363  0.322
2022 Maeso-Díaz R, Dalton GD, Oh S, Du K, Tang L, Chen T, Dutta RK, Hartman JH, Meyer JN, Diehl AM. Aging reduces liver resiliency by dysregulating Hedgehog signaling. Aging Cell. e13530. PMID 34984806 DOI: 10.1111/acel.13530  0.351
2021 Pailhoriès H, Boursier J, Diehl AM. Determinants of the severity of fatty liver diseases: Need all the pieces to solve the puzzle. Hepatology (Baltimore, Md.). PMID 34919744 DOI: 10.1002/hep.32282  0.37
2021 Salah HM, Pandey A, Soloveva A, Abdelmalek MF, Diehl AM, Moylan CA, Wegermann K, Rao VN, Hernandez AF, Tedford RJ, Parikh KS, Mentz RJ, McGarrah RW, Fudim M. Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction. Jacc. Basic to Translational Science. 6: 918-932. PMID 34869957 DOI: 10.1016/j.jacbts.2021.07.010  0.345
2021 Du K, Oh SH, Dutta RK, Sun T, Yang WH, Chi JA, Diehl AM. Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury. Liver International : Official Journal of the International Association For the Study of the Liver. PMID 33991158 DOI: 10.1111/liv.14945  0.417
2021 Hyun J, Al Abo M, Dutta RK, Oh SH, Xiang K, Zhou X, Maeso-Díaz R, Caffrey R, Sanyal AJ, Freedman JA, Patierno SR, Moylan CA, Abdelmalek MF, Diehl AM. Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. Journal of Hepatology. PMID 33964370 DOI: 10.1016/j.jhep.2021.04.033  0.387
2021 Wegermann K, Howe C, Henao R, Wang Y, Guy CD, Abdelmalek MF, Diehl AM, Moylan CA. Serum Bile Acid, Vitamin E, and Serotonin Metabolites Are Associated With Future Liver-Related Events in Nonalcoholic Fatty Liver Disease. Hepatology Communications. 5: 608-617. PMID 33860119 DOI: 10.1002/hep4.1665  0.373
2021 Chen T, Diehl AM. A beautiful day in the neighborhood: Application of single cell transcriptomics to unravel liver cell heterogeneity in diseased human livers. Hepatology (Baltimore, Md.). PMID 33756021 DOI: 10.1002/hep.31827  0.4
2021 Alexopoulos AS, Crowley MJ, Wang Y, Moylan CA, Guy CD, Henao R, Piercy DL, Seymour KA, Sudan R, Portenier DD, Diehl AM, Coviello AD, Abdelmalek MF. Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease. Hepatology (Baltimore, Md.). PMID 33724511 DOI: 10.1002/hep.31806  0.392
2021 Peters AE, Pandey A, Ayers C, Wegermann K, McGarrah RW, Grodin JL, Abdelmalek MF, Bekfani T, Blumer VL, Diehl AM, Moylan CA, Fudim M. Association of liver fibrosis risk scores with clinical outcomes in patients with heart failure with preserved ejection fraction: findings from TOPCAT. Esc Heart Failure. PMID 33586354 DOI: 10.1002/ehf2.13250  0.376
2021 Diehl AM, Farpour-Lambert NJ, Zhao L, Tilg H. Why we need to curb the emerging worldwide epidemic of nonalcoholic fatty liver disease. Nature Metabolism. 1: 1027-1029. PMID 32694863 DOI: 10.1038/s42255-019-0140-x  0.378
2020 Chen T, Oh S, Gregory S, Shen X, Diehl AM. Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration. Jci Insight. 5. PMID 33208554 DOI: 10.1172/jci.insight.141024  0.413
2020 Maung K, Ramalingam S, Chaudhry M, Ren Y, Jung SH, Romero K, Corbet K, Chao NJ, Choi T, Diehl AM, Diehl L, Gasparetto C, Horwitz M, Long GD, Lopez RD, et al. Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality. Plos One. 15: e0238824. PMID 32915853 DOI: 10.1371/Journal.Pone.0238824  0.358
2020 Wegermann K, Suzuki A, Mavis AM, Abdelmalek MF, Diehl AM, Moylan CA. Tackling NAFLD: Three Targeted Populations. Hepatology (Baltimore, Md.). PMID 32865242 DOI: 10.1002/Hep.31533  0.454
2020 Loomba R, Neuschwander-Tetri BA, Sanyal A, Chalasani N, Diehl AM, Terrault N, Kowdley K, Dasarathy S, Kleiner D, Behling C, Lavine J, Van Natta M, Middleton M, Tonascia J, Sirlin C, et al. Multicenter validation of association between decline in MRI-PDFF and histologic response in nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). PMID 31965579 DOI: 10.1002/Hep.31121  0.383
2020 Hyun J, Sun Z, Ahmadi AR, Bangru S, Chembazhi UV, Du K, Chen T, Tsukamoto H, Rusyn I, Kalsotra A, Diehl AM. Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. The Journal of Clinical Investigation. PMID 31945016 DOI: 10.1172/Jci132691  0.5
2020 Liu XJ, Xie L, Du K, Liu C, Zhang NP, Gu CJ, Wang Y, Abdelmalek MF, Dong WY, Liu XP, Niu C, Yang C, Diehl AM, Wu J. Succinate-GPR-91 Receptor Signaling Is Responsible for Nonalcoholic Steatohepatitis-Associated Fibrosis: Effects of DHA Supplementation. Liver International : Official Journal of the International Association For the Study of the Liver. PMID 31903720 DOI: 10.1111/Liv.14370  0.359
2020 Alexopoulos A, Crowley M, Wang Y, Guy CD, Henao R, Seymour KA, Sudan R, Portenier D, Diehl AM, Abdelmalek MF, Coviello AD. 1839-P: Glycemic Control Impacts Severity of Hepatic Fibrosis in NAFLD/NASH Diabetes. 69. DOI: 10.2337/Db20-1839-P  0.439
2020 Machado MV, Diehl AM. Developmental Morphogens and Adult Liver Repair Liver. 539-549. DOI: 10.1002/9781119436812.Ch43  0.425
2019 Du K, Chitneni SK, Suzuki A, Wang Y, Henao R, Hyun J, Premont RT, Naggie S, Moylan CA, Bashir MR, Abdelmalek MF, Diehl AM. Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression. Cellular and Molecular Gastroenterology and Hepatology. PMID 31881361 DOI: 10.1016/J.Jcmgh.2019.12.006  0.465
2019 Kleiner DE, Brunt EM, Wilson LA, Behling C, Guy C, Contos M, Cummings O, Yeh M, Gill R, Chalasani N, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Terrault N, Kowdley K, et al. Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease. Jama Network Open. 2: e1912565. PMID 31584681 DOI: 10.1001/jamanetworkopen.2019.12565  0.374
2019 Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. The Journal of Clinical Investigation. PMID 31487267 DOI: 10.1172/Jci128289  0.417
2019 Al-Badrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti PS, Jule Y, Diehl AM, Chatterjee S. Exogenous PP2A inhibitor exacerbates progression of nonalcoholic fatty liver disease via NOX2 dependent activation of miR21. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31393787 DOI: 10.1152/Ajpgi.00061.2019  0.358
2019 Sanyal AJ, Harrison SA, Ratziu V, Abdelmalek MF, Diehl AM, Caldwell S, Shiffman ML, Schall RA, Jia C, McColgan B, Djedjos CS, McHutchison JG, Subramanian GM, Myers RP, Younossi Z, et al. The Natural History of Advanced Fibrosis due to Nonalcoholic Steatohepatitis: Data from the Simtuzumab Trials. Hepatology (Baltimore, Md.). PMID 30993748 DOI: 10.1002/Hep.30664  0.462
2019 Hyun J, Oh SH, Premont RT, Guy CD, Berg CL, Diehl AM. Dysregulated activation of fetal liver programme in acute liver failure. Gut. PMID 30670575 DOI: 10.1136/Gutjnl-2018-317603  0.487
2019 Maung KKK, Chaudhry M, Ren Y, Jung S, Romero KM, Corbet K, Chao NJ, Choi T, Diehl AM, Diehl LF, Gasparetto C, Horwitz ME, Long GD, Lopez RD, Rizzieri DA, et al. Pre-Transplant Hepatic Steatosis (fatty liver) Predicts Chronic Graft-Vs-Host Disease but Does Not Affect Mortality Blood. 134: 5731-5731. DOI: 10.1182/Blood-2019-121830  0.418
2019 Moylan CA, Grenier C, Hyun J, Du K, Henao R, Abdelmalek MF, Murphy SK, Diehl AM. Tu1566 – Dysregulated Dna Methylation of Fgfr2, Casp1, and Bcat1 Associates with Nonalcoholic Fatty Liver Disease Severity and Can Be Identified in Peripheral Blood Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)40425-3  0.396
2019 Wegermann K, Howe C, Henao R, Wang Y, Diehl AM, Abdelmalek MF, Moylan CA. 964 – Branched Chain Amino Acid and Bile Acid Metabolites Associate with Future Clinical Decompensation in Nonalcoholic Fatty Liver Disease Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)40043-7  0.368
2018 Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB. Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. Science Translational Medicine. 10. PMID 30463916 DOI: 10.1126/Scitranslmed.Aat0344  0.543
2018 Loomba R, Jain A, Diehl AM, Guy CD, Portenier D, Sudan R, Singh S, Faulkner C, Richards L, Hester KD, Okada L, Li XJ, Mimms L, Abdelmalek MF. Validation of Serum Test for Advanced Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. PMID 30448594 DOI: 10.1016/J.Cgh.2018.11.004  0.472
2018 Diehl AM. Developmental Morphogens & Recovery from Alcoholic Liver Disease. Advances in Experimental Medicine and Biology. 1032: 145-151. PMID 30362097 DOI: 10.1007/978-3-319-98788-0_11  0.544
2018 Jayakumar S, Middleton MS, Lawitz EJ, Mantry PS, Caldwell SH, Arnold H, Diehl AM, Ghalib R, Elkhashab M, Abdelmalek MF, Kowdley KV, Djedjos CS, Xu R, Han L, Subramanian GM, et al. Longitudinal Correlations Between MRE, MRI-PDFF, and Liver Histology in Patients with Nonalcoholic Steatohepatitis: Analysis of Data from a Phase 2 Trial of Selonsertib. Journal of Hepatology. PMID 30291868 DOI: 10.1016/J.Jhep.2018.09.024  0.435
2018 Wegermann K, Henao R, Diehl AM, Murphy SK, Abdelmalek MF, Moylan CA. Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study. Plos One. 13: e0204308. PMID 30265706 DOI: 10.1371/Journal.Pone.0204308  0.453
2018 Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V, Hasson FA, Singh UP, Seth RK, Scappinie E, Tucker JC, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, et al. Sparstolonin B (SSnB) attenuates liver fibrosisvia a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. European Journal of Pharmacology. PMID 30194936 DOI: 10.1016/J.Ejphar.2018.08.040  0.455
2018 Younossi Z, Stepanova M, Sanyal AJ, Harrison SA, Ratziu V, Abdelmalek MF, Diehl AM, Caldwell S, Shiffman ML, Schall RA, McColgan B, Mani Subramanian G, Myers RP, Muir A, Afdhal NH, et al. The Conundrum of Cryptogenic Cirrhosis: Adverse Outcomes without Treatment Options. Journal of Hepatology. PMID 30144554 DOI: 10.1016/J.Jhep.2018.08.013  0.518
2018 Wang S, Jung Y, Hyun J, Friedersdorf M, Oh SH, Kim J, Premont RT, Keene JD, Diehl AM. RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 48: 1215-1229. PMID 30045014 DOI: 10.1159/000491987  0.354
2018 Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, Syn WK, Guy CD, Diehl AM. Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infectious Diseases. 5: ofy138. PMID 29992177 DOI: 10.1093/Ofid/Ofy138  0.343
2018 Harrison SA, Abdelmalek MF, Caldwell S, Shiffman ML, Diehl AM, Ghalib R, Lawitz EJ, Rockey DC, Schall RA, Jia C, McColgan BJ, McHutchison JG, Subramanian GM, Myers RP, Younossi Z, et al. Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis. Gastroenterology. PMID 29990488 DOI: 10.1053/J.Gastro.2018.07.006  0.317
2018 Castro RE, Diehl AM. Towards a definite mouse model of NAFLD. Journal of Hepatology. 69: 272-274. PMID 29858042 DOI: 10.1016/J.Jhep.2018.05.002  0.309
2018 Oh SH, Swiderska-Syn M, Jewell ML, Premont RT, Diehl AM. Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. Journal of Hepatology. PMID 29758331 DOI: 10.1016/J.Jhep.2018.05.008  0.425
2018 Chen KY, Shen X, Diehl AM. Prometheus revisited. The Journal of Clinical Investigation. PMID 29708511 DOI: 10.1172/JCI120933  0.409
2018 Alhasson F, Seth RK, Sarkar S, Kimono DA, Albadrani MS, Dattaroy D, Chandrashekaran V, Scott GI, Raychoudhury S, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. Redox Biology. 17: 1-15. PMID 29660503 DOI: 10.1016/J.Redox.2018.04.002  0.382
2018 Machado MV, Diehl AM. The hedgehog pathway in nonalcoholic fatty liver disease Critical Reviews in Biochemistry and Molecular Biology. 53: 264-278. PMID 29557675 DOI: 10.1080/10409238.2018.1448752  0.55
2018 Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, et al. Fructose and Sugar: A Major Mediator of Nonalcoholic Fatty Liver Disease. Journal of Hepatology. PMID 29408694 DOI: 10.1016/J.Jhep.2018.01.019  0.501
2018 Loomba R, Gindin Y, Jiang Z, Lawitz E, Caldwell S, Djedjos CS, Xu R, Chung C, Myers RP, Subramanian GM, Goodman Z, Charlton M, Afdhal NH, Diehl AM. DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis. Jci Insight. 3. PMID 29367468 DOI: 10.1172/Jci.Insight.96685  0.305
2018 Du K, Hyun J, Premont RT, Choi SS, Michelotti GA, Swiderska-Syn M, Dalton GD, Thelen E, Rizi BS, Jung Y, Diehl AM. Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Hepatic Stellate Cell Activation. Gastroenterology. PMID 29305935 DOI: 10.1053/J.Gastro.2017.12.022  0.451
2018 Charlton M, Diehl AM, Sarkar N, Li B, Wang L, Billin A, Djedjos S, Subramanian M, Myers R, Afdhal N, Caldwell S, Goodman Z, Loomba R. The association of circulating microRNAs (miRs) with liver fibrosis stage and the impact of selonsertib treatment in patients with NASH Journal of Hepatology. 68. DOI: 10.1016/S0168-8278(18)31401-6  0.361
2018 Abdelmalek M, Guy C, Diehl AM, Li X, Mimms L, Hester K, Jain A, Loomba R. FIBROSpect® NASH serum test identifies advanced liver fibrosis in patients with nonalcoholic steatohepatitis: Results of a validation study Journal of Hepatology. 68. DOI: 10.1016/S0168-8278(18)31400-4  0.465
2018 Bae A, Henao R, Suzuki A, Moylan CA, Guy CD, Diehl AM, Abdelmalek MF. 358 - Statin Use and Liver Injury in Nonalcoholic Fatty Liver Disease: Results of a Paired Clinical and Gene Expression Profile Analysis Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)33619-9  0.484
2018 Du K, Premont R, Hyun J, Machado MV, Moylan CA, Abdelmalek MF, Guy CD, Diehl AM. Tu1520 - Pathphysiological Role of Glutaminolysis in Human NAFLD Progression Gastroenterology. 154: S-950-S-951. DOI: 10.1016/S0016-5085(18)33205-0  0.327
2018 Dalton G, Oh SH, Premont R, Matz M, Loeffler B, Gebhardt R, Diehl AM. 808 - Hedgehog Signaling Directly Regulates Metabolism and Proliferation in Hepatocytes and is Critical for Normal Liver Regeneration Following Partial Hepatectomy in Mice Gastroenterology. 154: S-166. DOI: 10.1016/S0016-5085(18)30966-1  0.46
2018 Hyun J, Oh SH, Premont R, Berg C, Diehl AM. 21 - YAP1-Dependent Induction of IGF2BP3 Reprograms Hepatocytes into Stem-Like Cells During Liver Regeneration Gastroenterology. 154: S-7. DOI: 10.1016/S0016-5085(18)30510-9  0.442
2017 Diehl AM, Day C. Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis. The New England Journal of Medicine. 377: 2063-2072. PMID 29166236 DOI: 10.1056/Nejmra1503519  0.398
2017 Perito ER, Ajmera V, Bass NM, Rosenthal P, Lavine JE, Schwimmer JB, Yates KP, Diehl AM, Molleston JP, Murray KF, Scheimann A, Gill R, Glidden D, Aouizerat B. Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatology Communications. 1: 609-622. PMID 29130075 DOI: 10.1002/hep4.1068  0.415
2017 Machado MV, Diehl AM. Hedgehog Signaling in Liver Pathophysiology. Journal of Hepatology. PMID 29107151 DOI: 10.1016/J.Jhep.2017.10.017  0.547
2017 Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP, Subramanian GM, McHutchison JG, Goodman ZD, Afdhal NH, Charlton MR, et al. The ASK1 Inhibitor Selonsertib in Patients with Nonalcoholic Steatohepatitis: A Randomized, Phase 2 Trial. Hepatology (Baltimore, Md.). PMID 28892558 DOI: 10.1002/Hep.29514  0.419
2017 Kim J, Hyun J, Wang S, Lee C, Lee JW, Moon EY, Cha H, Diehl AM, Jung Y. Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling. Scientific Reports. 7: 3815. PMID 28630423 DOI: 10.1038/S41598-017-03782-X  0.355
2017 Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S. HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biology. 13: 8-19. PMID 28551086 DOI: 10.1016/J.Redox.2017.05.005  0.418
2017 Diehl AM. Timing Is Everything. Cell Metabolism. 25: 2-4. PMID 28076761 DOI: 10.1016/J.Cmet.2016.12.015  0.346
2017 Middleton MS, Lawitz E, Jayakumar S, Mantry P, Caldwell S, Diehl AM, Peach M, Xu R, Chen G, Djedjos CS, Myers RP, Subramanian GM, Goodman Z, Charlton M, Afdhal NH, et al. Hepatic proton density fat fraction correlates with histologic measures of steatosis and is responsive to change in those measures in a multi-center nonalcoholic steatohepatitis clinical trial Journal of Hepatology. 66. DOI: 10.1016/S0168-8278(17)31805-6  0.323
2017 Bosch J, Harrison S, Ratziu V, Shiffman M, Diehl A, Caldwell S, Rockey D, Ghalib R, Thuluvath P, Abdelmalek M, Aguilar R, Jia C, Mccolgan B, Myers R, Subramanian M, et al. Impact of modest weight reduction on liver histology, portal pressure, and clinical events in patients with compensated cirrhosis due to nonalcoholic steatohepatitis Journal of Hepatology. 66: S159-S160. DOI: 10.1016/S0168-8278(17)30593-7  0.419
2017 Diehl AM, French D, Xu R, Loomba R, Lawitz E, Freilich B, Shiffman ML, Chalasani N, Hameed B, Caldwell S, Rinella M, Peach M, Huntzicker E, Turner S, Sullivan T, et al. Treatment with selonsertib, an inhibitor of apoptosis signal-regulating kinase 1, hepatic phospho-p38 expression and markers of hepatocellular apoptosis and necrosis in patients with nonalcoholic steatohepatitis Journal of Hepatology. 66. DOI: 10.1016/S0168-8278(17)30366-5  0.362
2017 Sanyal A, Harrison S, Ratziu V, Abdelmalek M, Diehl A, Caldwell S, Shiffman M, Aguilar R, Jia C, McColgan B, Myers R, Subramanian M, McHutchison J, Muir A, Afdhal N, et al. Changes in fibrosis, but not the NAFLD Activity Score (NAS), are associated with disease progression in patients with nonalcoholic steatohepatitis (NASH) and advanced fibrosis Journal of Hepatology. 66. DOI: 10.1016/S0168-8278(17)30267-2  0.378
2017 Loomba R, Lawitz E, Jayakumar S, Mantry PS, Caldwell SH, Diehl AM, Peach M, Xu R, Djedjos CS, Natha M, Myers RP, Subramanian M, Goodman Z, Charlton MR, Afdhal NH, et al. Hepatic Proton Density Fat Fraction Correlates with Histologic Measures of Steatosis and is Responsive to Change in those Measures in a Multi-Center Nonalcoholic Steatohepatitis Clinical Trial Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)33625-9  0.323
2017 Moylan CA, Giraldo RH, Murphy SK, Diehl AM, Abdelmalek MF. Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)33611-9  0.399
2017 Sanyal A, Harrison SA, Ratziu V, Abdelmalek MF, Diehl AM, Caldwell SH, Shiffman ML, Aguilar R, Jia C, McColgan BJ, Natha M, Myers RP, Subramanian M, McHutchison J, Muir AJ, et al. Changes in Fibrosis, but not the Nafld Activity Score (NAS), are Associated with Disease Progression in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)33563-1  0.378
2017 Dalton G, Michelotti GA, Chen Y, Xie G, Swiderska-Syn M, Diehl AM. Hedgehog-Dependent yap Signaling Activates Serine Biogenesis and Glutaminolysis to Promote Hepatic Stellate Cell Transdifferentiation Gastroenterology. 152: S559. DOI: 10.1016/S0016-5085(17)32023-1  0.422
2016 Seth RK, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Bell DP, Liedtke W, Chatterjee S. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free Radical Biology & Medicine. PMID 27913210 DOI: 10.1016/J.Freeradbiomed.2016.11.047  0.488
2016 Suzuki A, Diehl AM. Nonalcoholic Steatohepatitis. Annual Review of Medicine. PMID 27732787 DOI: 10.1146/annurev-med-051215-031109  0.371
2016 Pereira TA, Syn WK, Pereira FE, Lambertucci JR, Secor WE, Diehl AM. Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. International Journal For Parasitology. PMID 27729270 DOI: 10.1016/J.Ijpara.2016.08.004  0.317
2016 Patel YA, Henao R, Moylan CA, Guy CD, Piercy DL, Diehl AM, Abdelmalek MF. Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis. The American Journal of Gastroenterology. PMID 27644736 DOI: 10.1038/Ajg.2016.406  0.414
2016 Ajmera V, Perito ER, Bass NM, Terrault NA, Yates KP, Gill R, Loomba R, Diehl AM, Aouizerat B. Novel Plasma Biomarkers Associated with Liver Disease Severity in Adults with Nonalcoholic Fatty Liver Disease. Hepatology (Baltimore, Md.). PMID 27532276 DOI: 10.1002/Hep.28776  0.442
2016 Yang JD, Abdelmalek MF, Guy CD, Gill RM, Lavine JE, Yates K, Klair J, Terrault NA, Clark JM, Unalp-Arida A, Diehl AM, Suzuki A. Patient Sex, Reproductive Status, and Synthetic Hormone use Associate With Histologic Severity of Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. PMID 27523635 DOI: 10.1016/J.Cgh.2016.07.034  0.359
2016 Verdelho Machado M, Diehl AM. Role of Hedgehog Signaling Pathway in NASH. International Journal of Molecular Sciences. 17. PMID 27258259 DOI: 10.3390/ijms17060857  0.401
2016 Swiderska-Syn M, Xie G, Michelotti GA, Jewell ML, Premont RT, Syn WK, Diehl AM. Hedgehog regulates Yes-associated protein 1 in regenerating mouse liver. Hepatology (Baltimore, Md.). PMID 26970079 DOI: 10.1002/Hep.28542  0.54
2016 Machado MV, Diehl AM. Pathogenesis of Nonalcoholic Steatohepatitis. Gastroenterology. PMID 26928243 DOI: 10.1053/J.Gastro.2016.02.066  0.483
2016 Klair JS, Yang JD, Abdelmalek MF, Guy CD, Gill RM, Yates K, Unalp-Adrida A, Lavine J, Clark J, Diehl AM, Suzuki A. A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). PMID 26919573 DOI: 10.1002/Hep.28514  0.363
2016 Markowitz GJ, Yang P, Fu J, Michelotti GA, Chen R, Sui J, Yang B, Qin WH, Zhang Z, Wang FS, Diehl AM, Li QJ, Wang H, Wang XF. Inflammation-dependent IL-18 signaling restricts hepatocellular carcinoma growth by enhancing the accumulation and activity of tumor-infiltrating lymphocytes. Cancer Research. PMID 26893476 DOI: 10.1158/0008-5472.Can-15-1548  0.334
2016 Machado MV, Michelotti GA, Jewell ML, Pereira TA, Xie G, Premont RT, Diehl AM. Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. Cell Death & Disease. 7: e2096. PMID 26890135 DOI: 10.1038/Cddis.2016.19  0.429
2016 Machado MV, Diehl AM. Role of hedgehog signaling pathway in NASH International Journal of Molecular Sciences. 17. DOI: 10.3390/Ijms17060857  0.498
2016 Moylan CA, Wegermann KJ, Henao RG, Murphy SK, Diehl AM, Abdelmalek MF. BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study: 871 The American Journal of Gastroenterology. 111. DOI: 10.14309/00000434-201610001-00871  0.473
2016 Diehl AM. Hedgehog Signaling In NAFLD The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.103.2  0.475
2016 Manka P, Coombes J, Bechmann L, Swiderska-Syn M, Reid D, Claridge L, Younis R, Mehta K, Briones M, Kitamura N, Mi Z, Kuo P, Williams R, Eksteen B, Diehl A, et al. Thyroid Hormone Receptor (TR): a regulator in Liver Fibrogenesis Zeitschrift Fur Gastroenterologie. 54: 1343-1404. DOI: 10.1055/S-0036-1597375  0.506
2016 Coombes JD, Manka PP, Swiderska-Syn M, Reid D, Riva A, Claridge LC, Dolle L, Younis R, Briones-Orta MA, Kitamura N, Mehta K, Mi Z, Kuo PC, Williams R, Diehl AM, et al. Osteopontin Promotes Cholangiocyte Chemokine Secretion and Macrophage Accumulation in Murine Liver Fibrosis Journal of Hepatology. 64. DOI: 10.1016/S0168-8278(16)00898-9  0.48
2016 Sanyal A, Goodman Z, Harrison S, Rockey D, Diehl A, Caldwell S, Shiffman M, Thuluvath P, Myers R, Mani Subramanian G, McHutchison J, Abdelmalek M, Ratziu V, Afdhal N, Bosch J. Correlation between the Hepatic Venous Pressure Gradient and Alpha-Smooth Muscle Actin (SMA) Expression in Patients with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis Journal of Hepatology. 64: S251. DOI: 10.1016/S0168-8278(16)00267-1  0.326
2016 Boursier J, Diehl AM. Nonalcoholic Fatty Liver Disease and the Gut Microbiome Clinics in Liver Disease. 20: 263-275. DOI: 10.1016/J.Cld.2015.10.012  0.446
2015 Boursier J, Diehl AM. Nonalcoholic Fatty Liver Disease and the Gut Microbiome. Clinics in Liver Disease. 20: 263-75. PMID 27063268 DOI: 10.1016/j.cld.2015.10.012  0.338
2015 Dattaroy D, Seth RK, Das S, Alhasson F, Chandrashekaran V, Michelotti GA, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4-trafficking in lipid rafts via NADPH oxidase activation. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00259.2015. PMID 26718771 DOI: 10.1152/Ajpgi.00259.2015  0.4
2015 Boursier J, Mueller O, Barret M, Machado M, Fizanne L, Araujo-Perez F, Guy CD, Seed PC, Rawls JF, David LA, Hunault G, Oberti F, Calès P, Diehl AM. The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology (Baltimore, Md.). PMID 26600078 DOI: 10.1002/Hep.28356  0.426
2015 Coombes JD, Choi SS, Swiderska-Syn M, Manka PP, Reid D, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, Della Peruta M, Bitencourt S, Dollé L, Oo YH, Mi Z, ... ... Diehl AM, et al. Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. Biochimica Et Biophysica Acta. PMID 26529285 DOI: 10.1016/J.Bbadis.2015.10.028  0.531
2015 Zhou Q, Patel D, Kwa T, Haque A, Matharu Z, Stybayeva G, Gao Y, Diehl AM, Revzin A. Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury. Lab On a Chip. PMID 26480303 DOI: 10.1039/C5Lc00874C  0.41
2015 Chandrashekaran V, Das S, Seth RK, Dattaroy D, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. Biochimica Et Biophysica Acta. 1862: 32-45. PMID 26474534 DOI: 10.1016/J.Bbadis.2015.10.009  0.39
2015 Zhu R, Baker SS, Moylan CA, Abdelmalek MF, Guy CD, Zamboni F, Wu D, Lin W, Liu W, Baker RD, Govindarajan S, Cao Z, Farci P, Diehl AM, Zhu L. Systematic Transcriptome Analysis Reveals Elevated Expression of Alcohol Metabolizing Genes in NAFLD Livers. The Journal of Pathology. PMID 26415102 DOI: 10.1002/Path.4650  0.463
2015 Machado MV, Kruger L, Jewell ML, Michelotti GA, Pereira TA, Xie G, Moylan CA, Diehl AM. Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model. Digestive Diseases and Sciences. PMID 26403427 DOI: 10.1007/S10620-015-3871-X  0.502
2015 Pereira TA, Syn WK, MacHado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, ... ... Diehl AM, et al. Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clinical Science (London, England : 1979). PMID 26201095 DOI: 10.1042/Cs20150117  0.739
2015 Machado MV, Michelotti GA, Pereira TA, Xie G, Premont R, Cortez-Pinto H, Diehl AM. Accumulation of duct cells with activated YAP parallels fibrosis progression in NonAlcoholic Fatty Liver Disease. Journal of Hepatology. PMID 26070409 DOI: 10.1016/J.Jhep.2015.05.031  0.545
2015 Markowitz GJ, Michelotti GA, Diehl AM, Wang XF. Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma. Science Bulletin (Beijing). 60: 762-772. PMID 26029472 DOI: 10.1007/S11434-015-0772-5  0.419
2015 Machado MV, Michelotti GA, Xie G, de Almeida TP, Boursier J, Bohnic B, Guy CD, Diehl AM. Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. Plos One. 10: e0127991. PMID 26017539 DOI: 10.1371/Journal.Pone.0127991  0.435
2015 Das S, Alhasson F, Dattaroy D, Pourhoseini S, Seth RK, Nagarkatti M, Nagarkatti PS, Michelotti GA, Diehl AM, Kalyanaraman B, Chatterjee S. NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. The American Journal of Pathology. 185: 1944-57. PMID 25989356 DOI: 10.1016/J.Ajpath.2015.03.024  0.443
2015 Angulo P, Machado MV, Diehl AM. Fibrosis in nonalcoholic Fatty liver disease: mechanisms and clinical implications. Seminars in Liver Disease. 35: 132-45. PMID 25974899 DOI: 10.1055/S-0035-1550065  0.512
2015 Boursier J, Diehl AM. Implication of gut microbiota in nonalcoholic fatty liver disease. Plos Pathogens. 11: e1004559. PMID 25625278 DOI: 10.1371/journal.ppat.1004559  0.376
2015 Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, ... Diehl AM, et al. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut. PMID 25596181 DOI: 10.1136/Gutjnl-2014-308176  0.379
2015 Karaca G, Xie G, Moylan C, Swiderska-Syn M, Guy CD, Krüger L, Machado MV, Choi SS, Michelotti GA, Burkly LC, Diehl AM. Role of Fn14 in acute alcoholic steatohepatitis in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G325-34. PMID 25524063 DOI: 10.1152/Ajpgi.00429.2013  0.446
2015 Dattaroy D, Pourhoseini S, Das S, Alhasson F, Seth RK, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G298-312. PMID 25501551 DOI: 10.1152/Ajpgi.00346.2014  0.357
2015 Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, Dasarathy S, Diehl AM, Hameed B, Kowdley KV, McCullough A, Terrault N, Clark JM, Tonascia J, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 385: 956-65. PMID 25468160 DOI: 10.1016/S0140-6736(14)61933-4  0.386
2015 Asai A, Malladi S, Misch J, Pan X, Malladi P, Diehl AM, Whitington PF. Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease. Human Pathology. 46: 84-93. PMID 25387814 DOI: 10.1016/J.Humpath.2014.09.010  0.502
2015 Guy C, Suzuki A, Abdelmalek M, Burchette J, Diehl AM. Reply: To PMID 24849310. Hepatology (Baltimore, Md.). 61: 1770-1. PMID 25209009 DOI: 10.1002/Hep.27430  0.497
2015 Machado MV, Michelotti GA, Pereira Tde A, Boursier J, Kruger L, Swiderska-Syn M, Karaca G, Xie G, Guy CD, Bohinc B, Lindblom KR, Johnson E, Kornbluth S, Diehl AM. Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. Gut. 64: 1148-57. PMID 25053716 DOI: 10.1136/Gutjnl-2014-307362  0.435
2015 Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, ... ... Diehl AM, et al. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut. 64: 1120-31. PMID 24902765 DOI: 10.1136/Gutjnl-2013-306484  0.548
2015 Guy CD, Suzuki A, Abdelmalek MF, Burchette JL, Diehl AM. Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity. Hepatology (Baltimore, Md.). 61: 98-107. PMID 24849310 DOI: 10.1002/Hep.27235  0.348
2015 Boursier J, Diehl AM. Implication of Gut Microbiota in Nonalcoholic Fatty Liver Disease Plos Pathogens. 11: 1-6. DOI: 10.1371/Journal.Ppat.1004559  0.537
2015 Swiderska-Syn M, Choi S, Lan A, Ferrari G, Diehl AM, Naggie S. P0469 : Markers of tissue repair and cellular aging are increased in liver tissue of patients with dual chronic HIV/HCV infections Journal of Hepatology. 62. DOI: 10.1016/S0168-8278(15)30677-2  0.338
2015 Suzuki A, Price TM, Nakamura N, Yang X, Chang C, Swiderska-Syn M, Diehl AM, Cullen J. Tu1006 Sex and Female Sex Hormones Significantly Impact Tissue Damage in Acetaminophen-Induced Liver Injury Model Gastroenterology. 148. DOI: 10.1016/S0016-5085(15)33695-7  0.368
2015 Zhu R, Baker SS, Moylan CA, Abdelmalek MF, Guy CD, Zamboni F, Wu D, Lin W, Liu W, Baker RD, Govindarajan S, Cao Z, Farci P, Diehl AM, Zhu L. Su1800 Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers Gastroenterology. 148. DOI: 10.1016/S0016-5085(15)33597-6  0.439
2015 Machado MV, Diehl AM. Hedgehog signaling in the liver Signaling Pathways in Liver Diseases: Third Edition. 262-274. DOI: 10.1016/J.Jhep.2010.10.003  0.524
2014 Kelley CE, Brown AJ, Diehl AM, Setji TL. Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. World Journal of Gastroenterology : Wjg. 20: 14172-84. PMID 25339805 DOI: 10.3748/Wjg.V20.I39.14172  0.453
2014 Bohinc BN, Michelotti G, Xie G, Pang H, Suzuki A, Guy CD, Piercy D, Kruger L, Swiderska-Syn M, Machado M, Pereira T, Zavacki AM, Abdelmalek M, Diehl AM. Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism. Endocrinology. 155: 4591-601. PMID 25121996 DOI: 10.1210/En.2014-1302  0.429
2014 Soeda J, Mouralidarane A, Ray S, Novelli M, Thomas S, Roskams T, Diehl AM, Oben JA. The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. Hepatology (Baltimore, Md.). 60: 1023-34. PMID 24923719 DOI: 10.1002/Hep.27266  0.381
2014 Choi SS, Claridge LC, Jhaveri R, Swiderska-Syn M, Clark P, Suzuki A, Pereira TA, Mi Z, Kuo PC, Guy CD, Pereira FE, Diehl AM, Patel K, Syn WK. Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication. Clinical Science (London, England : 1979). 126: 845-55. PMID 24438228 DOI: 10.1042/Cs20130473  0.376
2014 Karaca G, Swiderska-Syn M, Xie G, Syn WK, Krüger L, Machado MV, Garman K, Choi SS, Michelotti GA, Burkly LC, Ochoa B, Diehl AM. TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. Plos One. 9: e83987. PMID 24416188 DOI: 10.1371/Journal.Pone.0083987  0.466
2014 Machado MV, Diehl AM. Liver renewal: detecting misrepair and optimizing regeneration. Mayo Clinic Proceedings. 89: 120-30. PMID 24388030 DOI: 10.1016/j.mayocp.2013.10.009  0.428
2014 Seth RK, Das S, Kumar A, Chanda A, Kadiiska MB, Michelotti G, Manautou J, Diehl AM, Chatterjee S. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. Toxicology and Applied Pharmacology. 274: 42-54. PMID 24211274 DOI: 10.1016/J.Taap.2013.10.029  0.338
2014 Swiderska-Syn M, Syn WK, Xie G, Krüger L, Machado MV, Karaca G, Michelotti GA, Choi SS, Premont RT, Diehl AM. Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. Gut. 63: 1333-44. PMID 24173292 DOI: 10.1136/Gutjnl-2013-305962  0.491
2014 Chan IS, Guy CD, Machado MV, Wank A, Kadiyala V, Michelotti G, Choi S, Swiderska-Syn M, Karaca G, Pereira TA, Yip-Schneider MT, Max Schmidt C, Diehl AM. Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis. Alcoholism, Clinical and Experimental Research. 38: 787-800. PMID 24164383 DOI: 10.1111/Acer.12279  0.697
2014 Yang JD, Abdelmalek MF, Pang H, Guy CD, Smith AD, Diehl AM, Suzuki A. Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 59: 1406-14. PMID 24123276 DOI: 10.1002/Hep.26761  0.36
2014 Hyun J, Choi SS, Diehl AM, Jung Y. Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse Journal of Molecular Histology. 45: 103-112. PMID 23949847 DOI: 10.1007/S10735-013-9532-5  0.367
2014 Moylan CA, Pang H, Dellinger A, Suzuki A, Garrett ME, Guy CD, Murphy SK, Ashley-Koch AE, Choi SS, Michelotti GA, Hampton DD, Chen Y, Tillmann HL, Hauser MA, Abdelmalek MF, ... Diehl AM, et al. Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 59: 471-82. PMID 23913408 DOI: 10.1002/Hep.26661  0.483
2014 Diehl A. Hedgehog signalling in liver regeneration European Journal of Medical Research. 19: 1-2. DOI: 10.1186/2047-783X-19-S1-S4  0.518
2014 Naqvi IA, White RR, Moylan CA, Diehl AM, Choi SS. Abstract 4117: Utilizing RNA aptamers for biomarker discovery in a novel cell culture system for hepatocellular carcinoma Cancer Research. 74: 4117-4117. DOI: 10.1158/1538-7445.Am2014-4117  0.324
2014 Coombes JD, Swiderska-Syn M, Dollé L, Reid DT, Eksteen B, Claridge LC, Briones-Orta MA, Shishir S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, ... ... Diehl AM, et al. P612 Osteopontin Neutralization Abrogates The Liver Progenitor Cell Response And Fibrogenic Outcomes In Mice Journal of Hepatology. 60. DOI: 10.1016/S0168-8278(14)60774-1  0.415
2014 Moylan CA, Owzar K, Muir AJ, Cauchy F, Belghiti J, Diehl AM, Paradis V. Mo1638 Gene Expression and Pathway Analyses Reveal Distinctions Between Hepatocellular Carcinoma Arising in Fibrotic and Non-Fibrotic Nonalcoholic Fatty Liver Disease Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)63630-1  0.457
2014 Yang JD, Abdelmalek MF, Guy CD, Gill RM, Yates KP, Unalp A, Lavine JE, Diehl AM, Suzuki A. Sa1043 Associations of Sex and Menopause With Histologic Severity of Necroinflammation and Portal Inflammation Among Patients With Nonalcoholic Fatty Liver Disease (NAFLD) Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)63434-X  0.489
2013 Xie G, Diehl AM. Evidence for and against epithelial-to-mesenchymal transition in the liver. American Journal of Physiology. Gastrointestinal and Liver Physiology. 305: G881-90. PMID 24157970 DOI: 10.1152/Ajpgi.00289.2013  0.524
2013 Das S, Seth RK, Kumar A, Kadiiska MB, Michelotti G, Diehl AM, Chatterjee S. Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 305: G950-63. PMID 24157968 DOI: 10.1152/Ajpgi.00235.2013  0.303
2013 Michelotti GA, Machado MV, Diehl AM. NAFLD, NASH and liver cancer. Nature Reviews. Gastroenterology & Hepatology. 10: 656-65. PMID 24080776 DOI: 10.1038/Nrgastro.2013.183  0.468
2013 Deng YR, Ma HD, Tsuneyama K, Yang W, Wang YH, Lu FT, Liu CH, Liu P, He XS, Diehl AM, Gershwin ME, Lian ZX. STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. Journal of Autoimmunity. 46: 25-34. PMID 23948302 DOI: 10.1016/J.Jaut.2013.07.008  0.517
2013 Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, Abdelmalek MF, Garrett ME, Ashley-Koch A, Suzuki A, Tillmann HL, Hauser MA, Diehl AM. Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology. 145: 1076-87. PMID 23916847 DOI: 10.1053/J.Gastro.2013.07.047  0.435
2013 Xie G, Karaca G, Swiderska-Syn M, Michelotti GA, Krüger L, Chen Y, Premont RT, Choi SS, Diehl AM. Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. Hepatology (Baltimore, Md.). 58: 1801-13. PMID 23703657 DOI: 10.1002/Hep.26511  0.422
2013 Seth RK, Kumar A, Das S, Kadiiska MB, Michelotti G, Diehl AM, Chatterjee S. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice Toxicological Sciences. 134: 291-303. PMID 23640861 DOI: 10.1093/Toxsci/Kft104  0.401
2013 Diehl AM, Chute J. Underlying potential: Cellular and molecular determinants of adult liver repair Journal of Clinical Investigation. 123: 1858-1860. PMID 23635782 DOI: 10.1172/Jci69966  0.538
2013 Boursier J, Rawls JF, Diehl AM. Obese humans with nonalcoholic fatty liver disease display alterations in fecal microbiota and volatile organic compounds. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 11: 876-8. PMID 23628504 DOI: 10.1016/J.Cgh.2013.04.016  0.394
2013 Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Krüger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM. Smoothened is a master regulator of adult liver repair. The Journal of Clinical Investigation. 123: 2380-94. PMID 23563311 DOI: 10.1172/Jci66904  0.513
2013 Swiderska-Syn M, Suzuki A, Guy CD, Schwimmer JB, Abdelmalek MF, Lavine JE, Diehl AM. Hedgehog pathway and pediatric nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 57: 1814-25. PMID 23300059 DOI: 10.1002/Hep.26230  0.518
2013 Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1674-89. PMID 23292069 DOI: 10.1096/Fj.12-219097  0.334
2013 Machado MV, Yang Y, Diehl AM. The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis. The Journal of Clinical Investigation. 123: 115-7. PMID 23257364 DOI: 10.1172/Jci67238  0.304
2013 Pereira TA, Xie G, Choi SS, Syn WK, Voieta I, Lu J, Chan IS, Swiderska M, Amaral KB, Antunes CM, Secor WE, Witek RP, Lambertucci JR, Pereira FL, Diehl AM. Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. Liver International : Official Journal of the International Association For the Study of the Liver. 33: 149-61. PMID 23121638 DOI: 10.1111/Liv.12016  0.727
2013 Xie G, Choi SS, Syn WK, Michelotti GA, Swiderska M, Karaca G, Chan IS, Chen Y, Diehl AM. Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. Gut. 62: 299-309. PMID 22362915 DOI: 10.1136/Gutjnl-2011-301494  0.749
2013 Bohinc B, Michelotti G, Diehl AM. Hedgehog signaling in human medullary thyroid carcinoma: A novel signaling pathway Thyroid. 23: 1119-1126. DOI: 10.1089/Thy.2012.0474  0.312
2013 Soeda J, Mouralidarane A, Ray S, Diehl AM, Oben JA. 312 Prazosin An Alpha1 Adrenoceptor Antagonist Protects Liver From Acetaminophen Induced Acute Liver Injury And Expands The Progenitor Cell Population Journal of Hepatology. 58. DOI: 10.1016/S0168-8278(13)60314-1  0.367
2013 Xie G, Karaca G, Swiderska M, Michelotti GA, Krüger L, Choi SS, Diehl AM. Su1676 Notch Signaling Regulates Hepatic Stellate Cell Fate by Cross-Talking With Hedgehog Signaling Gastroenterology. 144: S-995. DOI: 10.1016/S0016-5085(13)63693-8  0.406
2012 Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, Karaca G, Xie G, Krüger L, Syn WK, Anderson BR, Pereira TA, Choi SS, Baldwin AS, Diehl AM. Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer Research. 72: 6344-50. PMID 23066040 DOI: 10.1158/0008-5472.Can-12-1068  0.684
2012 Arzumanyan A, Sambandam V, Clayton MM, Choi SS, Xie G, Diehl AM, Yu DY, Feitelson MA. Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein. Cancer Research. 72: 5912-20. PMID 22986746 DOI: 10.1158/0008-5472.Can-12-2329  0.415
2012 Rangwala F, Williams KP, Smith GR, Thomas Z, Allensworth JL, Lyerly HK, Diehl AM, Morse MA, Devi GR. Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. Bmc Cancer. 12: 402. PMID 22963400 DOI: 10.1186/1471-2407-12-402  0.37
2012 Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM. Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology. 143: 1319-29.e1-11. PMID 22885334 DOI: 10.1053/J.Gastro.2012.07.115  0.736
2012 Bohinc BN, Diehl AM. Mechanisms of Disease Progression in NASH: New Paradigms Clinics in Liver Disease. 16: 549-565. PMID 22824480 DOI: 10.1016/J.Cld.2012.05.002  0.521
2012 Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 142: 1592-609. PMID 22656328 DOI: 10.1053/J.Gastro.2012.04.001  0.431
2012 Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. The American Journal of Gastroenterology. 107: 811-26. PMID 22641309 DOI: 10.1038/Ajg.2012.128  0.431
2012 Bell LN, Wang J, Muralidharan S, Chalasani S, Fullenkamp AM, Wilson LA, Sanyal AJ, Kowdley KV, Neuschwander-Tetri BA, Brunt EM, McCullough AJ, Bass NM, Diehl AM, Unalp-Arida A, Chalasani N, et al. Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: a pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study. Hepatology (Baltimore, Md.). 56: 1311-8. PMID 22532269 DOI: 10.1002/Hep.25805  0.331
2012 Diehl AM. Neighborhood watch orchestrates liver regeneration Nature Medicine. 18: 497-499. PMID 22481408 DOI: 10.1038/Nm.2719  0.496
2012 Abdelmalek MF, Lazo M, Horska A, Bonekamp S, Lipkin EW, Balasubramanyam A, Bantle JP, Johnson RJ, Diehl AM, Clark JM. Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes Hepatology. 56: 952-960. PMID 22467259 DOI: 10.1002/Hep.25741  0.421
2012 Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, Xie G, Philips G, Chan IS, Karaca GF, Pereira Tde A, Chen Y, Mi Z, Kuo PC, Choi SS, ... ... Diehl AM, et al. NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. Gut. 61: 1323-9. PMID 22427237 DOI: 10.1136/Gutjnl-2011-301857  0.752
2012 Suzuki A, Abdelmalek MF, Schwimmer JB, Lavine JE, Scheimann AO, Unalp-Arida A, Yates KP, Sanyal AJ, Guy CD, Diehl AM. Association between puberty and features of nonalcoholic fatty liver disease. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 10: 786-94. PMID 22343513 DOI: 10.1016/J.Cgh.2012.01.020  0.415
2012 Guerrerio AL, Colvin RM, Schwartz AK, Molleston JP, Murray KF, Diehl A, Mohan P, Schwimmer JB, Lavine JE, Torbenson MS, Scheimann AO. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. The American Journal of Clinical Nutrition. 95: 892-900. PMID 22338037 DOI: 10.3945/Ajcn.111.020156  0.411
2012 Guy CD, Suzuki A, Zdanowicz M, Abdelmalek MF, Burchette J, Unalp A, Diehl AM. Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 55: 1711-21. PMID 22213086 DOI: 10.1002/Hep.25559  0.527
2012 Guy CD, Suzuki A, Burchette JL, Brunt EM, Abdelmalek MF, Cardona D, McCall SJ, Ünalp A, Belt P, Ferrell LD, Diehl AM. Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease. Human Pathology. 43: 790-800. PMID 22036053 DOI: 10.1016/J.Humpath.2011.07.007  0.516
2012 Bohinc B, Suzuki A, Guy C, Pang H, Piercy D, Feinglos M, Yen P, Diehl AM, Abdelmalek M. The Association of Serum Thyroid Hormone Levels and Hepatic Gene Expression of Potential Regulators of Intracellular Thyroid Hormone Concentration with Severity of Nonalcoholic Fatty Liver Disease: 464 The American Journal of Gastroenterology. 107. DOI: 10.14309/00000434-201210001-00464  0.397
2012 Liaskou E, Claridge LC, Younis R, Shah H, Shaw J, Oo YH, Mi Z, Kuo PC, Canbay A, Adams DH, Diehl AM, Syn WK. PMO-121 Osteopontin promotes natural killer T (NKT) cell accumulation in nonalcoholic steatohepatitis (NASH) Gut. 61. DOI: 10.1136/Gutjnl-2012-302514B.121  0.528
2012 Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. Erratum: The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the american association for the study of liver diseases, American College of Gastroenterology, and the American Gastroenterological Association (American Journal of Gastroenterology (2012) 107 (811-826) DOI: 10.1038/ajg.2012.128) The American Journal of Gastroenterology. 107. DOI: 10.1038/Ajg.2012.217  0.413
2012 Chan IS, Swiderska M, Guy CD, Chen Y, Karaca G, Xie G, Choi SS, Michelotti GA, Diehl AM. Su1587 Hedgehog Inhibition Regulates the Stromal Microenvironment in Hepatocellular Carcinoma via Suppression of the Warburg Effect Gastroenterology. 142: S-972. DOI: 10.1016/S0016-5085(12)63767-6  0.65
2012 Choi SS, Syn W, Swiderska M, Smith MP, Diehl AM, Michelotti GA. 294 Nr4a1 Nuclear Orphan Receptor is a Novel Regulator of Hepatic Fibrosis Gastroenterology. 142: S-910. DOI: 10.1016/S0016-5085(12)63534-3  0.381
2012 Jones L, Diehl AM. Diabetes and the Liver Diabetes: Chronic Complications: Third Edition. 67-82. DOI: 10.1002/9781118405550.ch3  0.432
2011 Philips GM, Chan IS, Swiderska M, Schroder VT, Guy C, Karaca GF, Moylan C, Venkatraman T, Feuerlein S, Syn WK, Jung Y, Witek RP, Choi S, Michelotti GA, Rangwala F, ... ... Diehl AM, et al. Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. Plos One. 6: e23943. PMID 21912653 DOI: 10.1371/Journal.Pone.0023943  0.751
2011 Rangwala F, Guy CD, Lu J, Suzuki A, Burchette JL, Abdelmalek MF, Chen W, Diehl AM. Increased production of sonic hedgehog by ballooned hepatocytes. The Journal of Pathology. 224: 401-10. PMID 21547909 DOI: 10.1002/Path.2888  0.451
2011 Seth D, Haber PS, Syn W, Diehl AM, Day CP. Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances Journal of Gastroenterology and Hepatology. 26: 1089-1105. PMID 21545524 DOI: 10.1111/J.1440-1746.2011.06756.X  0.492
2011 Omenetti A, Bass LM, Anders RA, Clemente MG, Francis H, Guy CD, McCall S, Choi SS, Alpini G, Schwarz KB, Diehl AM, Whitington PF. Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. Hepatology (Baltimore, Md.). 53: 1246-58. PMID 21480329 DOI: 10.1002/Hep.24156  0.4
2011 Tilg H, Diehl AM. NAFLD and extrahepatic cancers: Have a look at the colon Gut. 60: 745-746. PMID 21454382 DOI: 10.1136/Gut.2011.239392  0.322
2011 Omenetti A, Diehl AM. Hedgehog signaling in cholangiocytes Current Opinion in Gastroenterology. 27: 268-275. PMID 21423008 DOI: 10.1097/Mog.0B013E32834550B4  0.441
2011 Palmeri ML, Wang MH, Rouze NC, Abdelmalek MF, Guy CD, Moser B, Diehl AM, Nightingale KR. Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease. Journal of Hepatology. 55: 666-72. PMID 21256907 DOI: 10.1016/J.Jhep.2010.12.019  0.463
2011 Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. The American Journal of Gastroenterology. 106: 460-8; quiz 469. PMID 21206486 DOI: 10.1038/Ajg.2010.488  0.406
2011 Rangwala F, Omenetti A, Diehl AM. Cancer stem cells: repair gone awry? Journal of Oncology. 2011: 465343. PMID 21188169 DOI: 10.1155/2011/465343  0.304
2011 Omenetti A, Yang L, Gainetdinov RR, Guy CD, Choi SS, Chen W, Caron MG, Diehl AM. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G303-15. PMID 21071507 DOI: 10.1152/Ajpgi.00368.2010  0.432
2011 Choi SS, Omenetti A, Syn WK, Diehl AM. The role of Hedgehog signaling in fibrogenic liver repair International Journal of Biochemistry and Cell Biology. 43: 238-244. PMID 21056686 DOI: 10.1016/J.Biocel.2010.10.015  0.507
2011 Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, Mi Z, Pereira TA, Zdanowicz M, Malladi P, Chen Y, Moylan C, Jung Y, Bhattacharya SD, Teaberry V, ... ... Diehl AM, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 53: 106-15. PMID 20967826 DOI: 10.1002/Hep.23998  0.508
2011 Tillmann HL, Pang H, Dellinger A, Suzuki A, Guy CD, Moylan CA, Piercy D, Smith M, Hauser MA, Diehl AM, Abdelmalek MF. Coffee's beneficial effect on liver disease confirmed in NASH cohort, but only partially confirmation of in vitro pre-described differentially expressed genes in this patient cohort Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)64090-0  0.347
2011 Zdanowicz M, Suzuki A, Guy CD, Schwimmer J, Abdelmalek MF, Lavine JE, Diehl AM. Hedgehog Pathway Activation is Associated With Advanced Fibrosis in Pediatric NAFLD Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)64089-4  0.335
2011 Moylan CA, Dellinger A, Pang H, Suzuki A, Tillmann HL, Hampton D, Chen Y, Choi SS, Hauser MA, Abdelmalek MF, Diehl AM. Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD) Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)63793-1  0.418
2011 Omenetti A, Bass LM, Guy CD, Whitington PF, Diehl AM. Hedgehog Signaling is Innately Active During Infancy and Causes Ductular Dysmorphogenesis by Priming Ductular Cells to Arrest Epithelial Differentiation in Response to Different Types of Biliary Injury Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)63708-6  0.312
2011 Rojkind M, Philips G, Diehl AM. Microarchitecture of the liver: A Jigsaw puzzle Journal of Hepatology. 54: 187-188. DOI: 10.1016/J.Jhep.2010.09.004  0.45
2010 Omenetti A, Choi S, Michelotti G, Diehl AM. Hedgehog signaling in the liver. Journal of Hepatology. 54: 366-73. PMID 21093090 DOI: 10.1016/j.jhep.2010.10.003  0.453
2010 Rojkind M, Philips G, Diehl AM. Microarchitecture of the liver: a jigsaw puzzle. Journal of Hepatology. 54: 187-8. PMID 20951459 DOI: 10.1016/j.jhep.2010.09.004  0.422
2010 Choi SS, Syn WK, Karaca GF, Omenetti A, Moylan CA, Witek RP, Agboola KM, Jung Y, Michelotti GA, Diehl AM. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. The Journal of Biological Chemistry. 285: 36551-60. PMID 20843817 DOI: 10.1074/Jbc.M110.168542  0.453
2010 Suzuki A, Abdelmalek MF, Unalp-Arida A, Yates K, Sanyal A, Guy C, Diehl AM. Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 8: 1062-9. PMID 20728571 DOI: 10.1016/J.Cgh.2010.08.005  0.389
2010 Pereira Tde A, Witek RP, Syn WK, Choi SS, Bradrick S, Karaca GF, Agboola KM, Jung Y, Omenetti A, Moylan CA, Yang L, Fernandez-Zapico ME, Jhaveri R, Shah VH, Pereira FE, ... Diehl AM, et al. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Laboratory Investigation; a Journal of Technical Methods and Pathology. 90: 1690-703. PMID 20697376 DOI: 10.1038/Labinvest.2010.147  0.491
2010 Lazo M, Solga SF, Horska A, Bonekamp S, Diehl AM, Brancati FL, Wagenknecht LE, Pi-Sunyer FX, Kahn SE, Clark JM. Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care. 33: 2156-63. PMID 20664019 DOI: 10.2337/Dc10-0856  0.372
2010 Neuschwander-Tetri BA, Clark JM, Bass NM, Van Natta ML, Unalp-Arida A, Tonascia J, Zein CO, Brunt EM, Kleiner DE, McCullough AJ, Sanyal AJ, Diehl AM, Lavine JE, Chalasani N, Kowdley KV, et al. Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 52: 913-24. PMID 20648476 DOI: 10.1002/Hep.23784  0.474
2010 Choi SS, Witek RP, Yang L, Omenetti A, Syn WK, Moylan CA, Jung Y, Karaca GF, Teaberry VS, Pereira TA, Wang J, Ren XR, Diehl AM. Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. Hepatology (Baltimore, Md.). 52: 278-90. PMID 20578145 DOI: 10.1002/Hep.23649  0.443
2010 Syn WK, Oo YH, Pereira TA, Karaca GF, Jung Y, Omenetti A, Witek RP, Choi SS, Guy CD, Fearing CM, Teaberry V, Pereira FE, Adams DH, Diehl AM. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 51: 1998-2007. PMID 20512988 DOI: 10.1002/Hep.23599  0.52
2010 Jung Y, Diehl AM. Non-alcoholic steatohepatitis pathogenesis: Role of repair in regulating the disease progression Digestive Diseases. 28: 225-228. PMID 20460916 DOI: 10.1159/000282092  0.524
2010 Ochoa B, Syn WK, Delgado I, Karaca GF, Jung Y, Wang J, Zubiaga AM, Fresnedo O, Omenetti A, Zdanowicz M, Choi SS, Diehl AM. Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. Hepatology (Baltimore, Md.). 51: 1712-23. PMID 20432255 DOI: 10.1002/Hep.23525  0.542
2010 Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, Guy CD, Diehl AM. Signals from dying hepatocytes trigger growth of liver progenitors Gut. 59: 655-665. PMID 20427400 DOI: 10.1136/Gut.2009.204354  0.494
2010 Diehl AM. Genetic susceptibility to hepatic steatosis New England Journal of Medicine. 362: 1142-1143. PMID 20335592 DOI: 10.1056/Nejme1000206  0.387
2010 Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, Diehl AM. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 51: 1961-71. PMID 20301112 DOI: 10.1002/Hep.23535  0.429
2010 Diehl AM. Hepatic Complications of Obesity Gastroenterology Clinics of North America. 39: 57-68. PMID 20202579 DOI: 10.1016/J.Gtc.2004.12.012  0.432
2010 Abdelmalek M, Suzuki A, Guy C, Smith A, Adeyefa B, Pan Y, Smith M, Diehl AM. Statin Therapy Decreases Risk of Hepatic Steatosis and Lobular Inflammation in Patients with Nonalcoholic Fatty Liver Disease: 313 The American Journal of Gastroenterology. 105. DOI: 10.14309/00000434-201010001-00313  0.476
2010 Moylan CA, Choi SS, Acharya CR, Syn W, Omenetti A, Jung Y, Sudan DL, Muir AJ, Potti A, Diehl AM. T1964 Gene Expression Profiles During Activation of Human Hepatic Stellate Cells Suggest an Epithelial-to-Mesenchymal Transition-Like Process Gastroenterology. 138. DOI: 10.1016/S0016-5085(10)63860-7  0.35
2010 Choi SS, Syn W, Karaca GF, Omenetti A, Wang X, Jung Y, Teaberry VS, Moylan CA, Diehl AM. T1960 Leptin Activates Hedgehog Pathway Signaling and Promotes Myofibroblastic Transition and Accumulation in Rat Hepatic Stellate Cells Gastroenterology. 138. DOI: 10.1016/S0016-5085(10)63856-5  0.372
2009 Jhaveri R, Qiang G, Diehl AM. Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation Journal of Infectious Diseases. 200: 1781-1788. PMID 19852667 DOI: 10.1086/648094  0.312
2009 Choi SS, Diehl AM. Epithelial-to-mesenchymal transitions in the liver Hepatology. 50: 2007-2013. PMID 19824076 DOI: 10.1002/Hep.23196  0.531
2009 Syn WK, Choi SS, Diehl AM. Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis Clinics in Liver Disease. 13: 565-580. PMID 19818305 DOI: 10.1016/J.Cld.2009.07.003  0.519
2009 Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA, Rojkind M, Diehl AM. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G1093-106. PMID 19815628 DOI: 10.1152/Ajpgi.00292.2009  0.371
2009 Wang MH, Palmeri ML, Guy CD, Yang L, Hedlund LW, Diehl AM, Nightingale KR. In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force. Ultrasound in Medicine & Biology. 35: 1709-21. PMID 19683381 DOI: 10.1016/J.Ultrasmedbio.2009.04.019  0.483
2009 Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, Omenetti A, Jung Y, Teaberry V, Choi SS, Guy CD, Pollard J, Charlton P, Diehl AM. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 50: 1421-30. PMID 19676126 DOI: 10.1002/Hep.23167  0.501
2009 Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, Yang L, Wang J, Witek RP, Fearing CM, Pereira TA, Teaberry V, Choi SS, Conde-Vancells J, Karaca GF, Diehl AM. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology. 137: 1478-1488.e8. PMID 19577569 DOI: 10.1053/J.Gastro.2009.06.051  0.489
2009 Omenetti A, Syn WK, Jung Y, Francis H, Porrello A, Witek RP, Choi SS, Yang L, Mayo MJ, Gershwin ME, Alpini G, Diehl AM. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology (Baltimore, Md.). 50: 518-27. PMID 19575365 DOI: 10.1002/Hep.23019  0.519
2009 Syn WK, Witek RP, Curbishley SM, Jung Y, Choi SS, Enrich B, Omenetti A, Agboola KM, Fearing CM, Tilg H, Adams DH, Diehl AM. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. European Journal of Immunology. 39: 1879-92. PMID 19544307 DOI: 10.1002/Eji.200838890  0.513
2009 Syn WK, Yang L, Chiang DJ, Qian Y, Jung Y, Karaca G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver International : Official Journal of the International Association For the Study of the Liver. 29: 1262-72. PMID 19490416 DOI: 10.1111/J.1478-3231.2009.02036.X  0.458
2009 David K, Kowdley KV, Unalp A, Kanwal F, Brunt EM, Schwimmer JB, Abrams S, Arceo D, Espinosa D, Fairly L, McCullough A, Bringman D, Dasarathy S, Hawkins C, Liu YC, ... ... Diehl AM, et al. Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network Hepatology. 49: 1904-1912. PMID 19434741 DOI: 10.1002/Hep.22868  0.374
2009 Sun B, Li S, Yang L, Damodaran T, Desai D, Diehl AM, Alzate O, Koeberl DD. Activation of glycolysis and apoptosis in glycogen storage disease type Ia. Molecular Genetics and Metabolism. 97: 267-71. PMID 19419892 DOI: 10.1016/J.Ymgme.2009.04.003  0.448
2009 Syn WK, Teaberry V, Choi SS, Diehl AM. Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis Seminars in Liver Disease. 29: 200-210. PMID 19387919 DOI: 10.1055/S-0029-1214375  0.519
2009 Suzuki A, Yuen N, Walsh J, Papay J, Hunt CM, Diehl AM. Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 7: 882-8. PMID 19362607 DOI: 10.1016/J.Cgh.2009.03.034  0.444
2009 Brunt EM, Kleiner DE, Wilson LA, Unalp A, Behling CE, Lavine JE, Neuschwander-Tetri BA, Abrams S, Arceo D, Espinosa D, Fairly L, Bringman D, Hawkins C, Liu YC, Rogers N, ... ... Diehl AM, et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD - Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network Hepatology. 49: 809-820. PMID 19142989 DOI: 10.1002/Hep.22724  0.342
2009 Mao H, Diehl AM, Li YX. Sonic hedgehog ligand partners with caveolin-1 for intracellular transport Laboratory Investigation. 89: 290-300. PMID 19139721 DOI: 10.1038/Labinvest.2008.163  0.302
2009 Witek RP, Yang L, Liu R, Jung Y, Omenetti A, Syn WK, Choi SS, Cheong Y, Fearing CM, Agboola KM, Chen W, Diehl AM. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 136: 320-330.e2. PMID 19013163 DOI: 10.1053/J.Gastro.2008.09.066  0.461
2009 Sun Z, Zhang X, Locke JE, Zheng Q, Tachibana S, Diehl AM, Williams GM. Recruitment of host progenitor cells in rat liver transplants. Hepatology (Baltimore, Md.). 49: 587-97. PMID 18972402 DOI: 10.1002/Hep.22653  0.368
2009 Omenetti A, Syn W, Jung Y, Witek R, Choi S, Diehl A. 75 MYOFIBROBLASTS PROVIDE HEDGEHOG PARACRINE SIGNALS THAT DRIVE CHOLANGIOCYTES TO RECRUIT NKT CELLS TO PORTAL TRACTS Journal of Hepatology. 50: S31-S32. DOI: 10.1016/S0168-8278(09)60077-5  0.313
2009 Suzuki A, Watkins PB, Kaplowitz N, Hunt CM, Sanders CM, Diehl AM, Lee WM. S1002 Co-Medication with Adrenoreceptor Antagonists Is Associated with Lower MELD Scores At Admission in Patients with Acetaminophen-Induced Acute Liver Failure Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)63737-9  0.374
2009 Omenetti A, Yang L, Gainetdinov RR, Choi SS, Witek RP, Jung Y, Syn W, Chen W, Caron MG, Diehl AM. 343 Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytes Gastroenterology. 136: A-800. DOI: 10.1016/S0016-5085(09)63689-1  0.415
2009 Choi SS, Witek RP, Omenetti A, Yang L, Syn W, Jung Y, Sicklick JK, Diehl AM. 89 Sustained Activation of RAC1 Enhances Hedgehog-Mediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury Gastroenterology. 136: A-792. DOI: 10.1016/S0016-5085(09)63655-6  0.429
2009 Jung Y, Witek RP, Syn W, Choi SS, Omenetti A, Diehl AM. 1 Specific Inhibition of Ikkβ in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers Gastroenterology. 136: A-789. DOI: 10.1016/S0016-5085(09)63639-8  0.402
2008 Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease Seminars in Liver Disease. 28: 370-379. PMID 18956293 DOI: 10.1055/S-0028-1091981  0.554
2008 Solga SF, Buckley G, Clark JM, Horska A, Diehl AM. The effect of a probiotic on hepatic steatosis Journal of Clinical Gastroenterology. 42: 1117-1119. PMID 18936646 DOI: 10.1097/Mcg.0B013E31816D920C  0.445
2008 Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. The Journal of Clinical Investigation. 118: 3331-42. PMID 18802480 DOI: 10.1172/Jci35875  0.429
2008 Yang L, Jung Y, Omenetti A, Witek RP, Choi S, Vandongen HM, Huang J, Alpini GD, Diehl AM. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells (Dayton, Ohio). 26: 2104-13. PMID 18511600 DOI: 10.1634/Stemcells.2008-0115  0.396
2008 Jung Y, Brown KD, Witek RP, Omenetti A, Yang L, Vandongen M, Milton RJ, Hines IN, Rippe RA, Spahr L, Rubbia-Brandt L, Diehl AM. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology. 134: 1532-43. PMID 18471524 DOI: 10.1053/J.Gastro.2008.02.022  0.508
2008 Choi SS, Diehl AM. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease Current Opinion in Lipidology. 19: 295-300. PMID 18460922 DOI: 10.1097/Mol.0B013E3282Ff5E55  0.511
2008 Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalek MF. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. Journal of Hepatology. 48: 993-9. PMID 18395287 DOI: 10.1016/J.Jhep.2008.02.011  0.446
2008 Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut. 57: 1275-82. PMID 18375471 DOI: 10.1136/Gut.2008.148619  0.47
2008 Omenetti A, Diehl AM. The Adventures of Sonic Hedgehog in Development and Repair. II. Sonic hedgehog and liver development, inflammation, and cancer American Journal of Physiology - Gastrointestinal and Liver Physiology. 294. PMID 18218671 DOI: 10.1152/ajpgi.00543.2007  0.39
2008 Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. Journal of Hepatology. 48: 98-106. PMID 18022723 DOI: 10.1016/J.Jhep.2007.07.032  0.448
2008 Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 47: 625-35. PMID 18000880 DOI: 10.1002/Hep.21988  0.514
2008 Morgan M, Sigala B, Selden C, Diehl AM, Oben JA. 482 Acetylcholine Induces Fibrogenic Effects In Human Primary Hepatic Stellate Cells Journal of Hepatology. 48. DOI: 10.1016/S0168-8278(08)60484-5  0.41
2008 Maelle M, Sigala B, Selden C, Diehl AM, Oben JA. M1584 The Autonomic Neurotransmitter Acetylcholine Induces Fibrogenic Responses in Human Primary Hepatic Stellate Cells Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)63731-2  0.365
2008 Brown KD, Oben JA, Sigala B, Yang L, Omenetti A, Sicklick JK, Vandongen H, Diehl AM. M1582 Hedgehog Signaling Pathway in Primary Human Hepatic Stellate Cells Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)63729-4  0.37
2008 Choi SS, Omenetti A, Yang L, Witek RP, Brown KD, Vazquez-Chantada M, Huang J, Jung Y, Syn W, Sicklick JK, Diehl AM. M1577 Culture Activation of Murine Hepatic Stellate Cells Involves Hedgehog Pathway Activation and Epithelial-to-Mesenchymal Transitions Gastroenterology. 134: A-797. DOI: 10.1016/S0016-5085(08)63724-5  0.354
2008 Jung Y, Brown KD, Witek RP, Omenetti A, Yang L, Vandongen H, Milton RJ, Hines I, Rippe RA, Spahr L, Rubbia-Brandt L, Diehl AM. S1926 Increased Short-Term Risk for Liver-Related Mortality Parallels Accumulation of Hedgehog-Responsive Progenitors in Patients with Alcoholic Steatohepatitis Gastroenterology. 134: A-785. DOI: 10.1016/S0016-5085(08)63668-9  0.389
2008 Yang L, Jung Y, Huang J, Omenetti A, Witek RP, Choi SS, Alpini G, Diehl AM. 685 Glial Fibrillary Acidic Protein(+) Progenitors Regenerate Adult Livers Gastroenterology. 134: A-768-A-769. DOI: 10.1016/S0016-5085(08)63589-1  0.395
2008 Suzuki A, Yuen NA, Papay JI, Walsh JS, Hunt CM, Diehl AM. 225 An Aers Database Evaluation of the Influence of Co-Medications On Acetaminophen-Associated Liver Injury Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)63543-X  0.384
2008 Witek RP, Liu R, Yang L, Jung Y, Brown K, Omenetti A, Vazquez-Chantada M, Syn W, Choi SS, Huang J, Chen W, Diehl AM. T1821 Liver-Derived Microparticles Carry Biologically-Active Hedgehog Morphogens in Blood and Bile Gastroenterology. 134: A-570. DOI: 10.1016/S0016-5085(08)62662-1  0.407
2008 Malek NP, Rudolph KL, Diehl AM. Regulation of the Liver Cell Mass Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition. 274-289. DOI: 10.1002/9780470691861.ch2e  0.359
2007 Abdelmalek MF, Diehl AM. Nonalcoholic Fatty Liver Disease as a Complication of Insulin Resistance Medical Clinics of North America. 91: 1125-1149. PMID 17964913 DOI: 10.1016/J.Mcna.2007.06.001  0.445
2007 Fleig SV, Choi SS, Yang L, Jung Y, Omenetti A, VanDongen HM, Huang J, Sicklick JK, Diehl AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 1227-39. PMID 17952094 DOI: 10.1038/Labinvest.3700689  0.54
2007 Yang L, Jhaveri R, Huang J, Qi Y, Diehl AM. Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 927-37. PMID 17607300 DOI: 10.1038/Labinvest.3700603  0.477
2007 Abdelmalek MF, Diehl AM. De Novo nonalcoholic fatty liver disease after liver transplantation Liver Transplantation. 13: 788-790. PMID 17538998 DOI: 10.1002/Lt.21103  0.488
2007 Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 45: 1366-74. PMID 17476695 DOI: 10.1002/Hep.21655  0.492
2007 Jung Y, McCall SJ, Li YX, Diehl AM. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis Hepatology. 45: 1091-1096. PMID 17464985 DOI: 10.1002/Hep.21660  0.536
2007 Omenetti A, Yang L, Li YX, McCall SJ, Jung Y, Sicklick JK, Huang J, Choi S, Suzuki A, Diehl AM. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 499-514. PMID 17334411 DOI: 10.1038/Labinvest.3700537  0.494
2007 Yang L, Diehl AM. Role of immune response in nonalcoholic fatty liver disease: Evidence in human and animal studies Liver Immunology: Principles and Practice. 337-345. DOI: 10.1007/978-1-59745-518-3_27  0.451
2006 Choi SS, Sicklick JK, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology (Baltimore, Md.). 44: 1267-77. PMID 17058265 DOI: 10.1002/Hep.21375  0.492
2006 Zhao C, Chen W, Yang L, Chen L, Stimpson SA, Diehl AM. PPARγ Agonists Prevent TGFβ1/Smad3-Signaling in Human Hepatic Stellate Cells Biochemical and Biophysical Research Communications. 350: 385-391. PMID 17010940 DOI: 10.1016/J.Bbrc.2006.09.069  0.378
2006 Suzuki A, McCall S, Choi SS, Sicklick JK, Huang J, Qi Y, Zdanowicz M, Camp T, Li YX, Diehl AM. Interleukin-15 increases hepatic regenerative activity. Journal of Hepatology. 45: 410-8. PMID 16781000 DOI: 10.1016/J.Jhep.2006.04.008  0.446
2006 Solga SF, Alkhuraishe A, Cope K, Tabesh A, Clark JM, Torbenson M, Schwartz P, Magnuson T, Diehl AM, Risby TH. Breath biomarkers and non-alcoholic fatty liver disease: Preliminary observations Biomarkers. 11: 174-183. PMID 16766393 DOI: 10.1080/13547500500421070  0.455
2006 Sicklick JK, Choi SS, Bustamante M, McCall SJ, Pérez EH, Huang J, Li YX, Rojkind M, Diehl AM. Evidence for epithelial-mesenchymal transitions in adult liver cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 291: G575-83. PMID 16710052 DOI: 10.1152/ajpgi.00102.2006  0.361
2006 Setji TL, Holland ND, Sanders LL, Pereira KC, Diehl AM, Brown AJ. Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism. 91: 1741-1747. PMID 16492691 DOI: 10.1210/Jc.2005-2774  0.355
2006 Sicklick JK, Li YX, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, Ludlow JW, Owzar K, Chen W, Torbenson MS, Diehl AM. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis. 27: 748-57. PMID 16339184 DOI: 10.1093/Carcin/Bgi292  0.358
2006 Sicklick JK, Li YX, Melhem A, Schmelzer E, Zdanowicz M, Huang J, Caballero M, Fair JH, Ludlow JW, McClelland RE, Reid LM, Diehl AM. Hedgehog signaling maintains resident hepatic progenitors throughout life. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G859-70. PMID 16322088 DOI: 10.1152/Ajpgi.00456.2005  0.488
2006 Abdelmalek MF, Diehl AM. Mechanisms underlying nonalcoholic steatohepatitis Drug Discovery Today: Disease Mechanisms. 3: 479-488. DOI: 10.1016/J.Ddmec.2006.11.001  0.49
2005 Solga SF, Clark JM, Alkhuraishi AR, Torbenson M, Tabesh A, Schweitzer M, Diehl AM, Magnuson TH. Race and comorbid factors predict nonalcoholic fatty liver disease histopathology in severely obese patients. Surgery For Obesity and Related Diseases : Official Journal of the American Society For Bariatric Surgery. 1: 6-11. PMID 16925194 DOI: 10.1016/J.Soard.2004.12.006  0.458
2005 Suzuki A, Diehl AM. Should nonalcoholic fatty liver disease be treated differently in elderly patients? Nature Clinical Practice Gastroenterology and Hepatology. 2: 208-209. PMID 16265200 DOI: 10.1038/Ncpgasthep0172  0.472
2005 Choi S, Diehl AM. Role of inflammation in nonalcoholic steatohepatitis Current Opinion in Gastroenterology. 21: 702-707. PMID 16220049 DOI: 10.1097/01.Mog.0000182863.96421.47  0.522
2005 Diehl AM. Lessons from animal models of NASH. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 33: 138-44. PMID 16198624 DOI: 10.1016/j.hepres.2005.09.022  0.382
2005 Li Z, Soloski MJ, Diehl AM. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease Hepatology. 42: 880-885. PMID 16175608 DOI: 10.1002/Hep.20826  0.515
2005 Sicklick JK, Li YX, Choi SS, Qi Y, Chen W, Bustamante M, Huang J, Zdanowicz M, Camp T, Torbenson MS, Rojkind M, Diehl AM. Role for hedgehog signaling in hepatic stellate cell activation and viability. Laboratory Investigation; a Journal of Technical Methods and Pathology. 85: 1368-80. PMID 16170335 DOI: 10.1038/Labinvest.3700349  0.406
2005 Clark JM, Alkhuraishi AR, Solga SF, Alli P, Diehl AM, Magnuson TH. Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease. Obesity Research. 13: 1180-6. PMID 16076987 DOI: 10.1038/Oby.2005.140  0.427
2005 Zekry A, McHutchison JG, Diehl AM. Insulin resistance and steatosis in hepatitis C virus infection Gut. 54: 903-906. PMID 15951532 DOI: 10.1136/Gut.2004.059873  0.362
2005 Solga SF, Horska A, Clark JM, Diehl AM. Hepatic 31P magnetic resonance spectroscopy: A hepatologist's user guide Liver International. 25: 490-500. PMID 15910484 DOI: 10.1111/J.1478-3231.2005.01131.X  0.339
2005 Kannangai R, Diehl AM, Sicklick J, Rojkind M, Thomas D, Torbenson M. Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile Human Pathology. 36: 341-347. PMID 15891994 DOI: 10.1016/J.Humpath.2005.01.002  0.461
2005 Diehl AM, Li ZP, Lin HZ, Yang SQ. Cytokines and the pathogenesis of non-alcoholic steatohepatitis Gut. 54: 303-306. PMID 15647199 DOI: 10.1136/Gut.2003.024935  0.446
2005 Diehl AM. Recent events in alcoholic liver disease: V. Effects of ethanol on liver regeneration American Journal of Physiology - Gastrointestinal and Liver Physiology. 288. PMID 15591584 DOI: 10.1152/Ajpgi.00376.2004  0.514
2005 Diehl AM. Lessons from animal models of NASH Hepatology Research. 33: 138-144. DOI: 10.1016/J.Hepres.2005.09.022  0.482
2004 Diehl AM. Obesity and alcoholic liver disease Alcohol. 34: 81-87. PMID 15670669 DOI: 10.1016/J.Alcohol.2004.07.010  0.447
2004 Solga S, Alkhuraishe AR, Clark JM, Torbenson M, Greenwald A, Diehl AM, Magnuson T. Dietary composition and nonalcoholic fatty liver disease. Digestive Diseases and Sciences. 49: 1578-83. PMID 15573908 DOI: 10.1023/B:Ddas.0000043367.69470.B7  0.43
2004 Oben JA, Diehl AM. Sympathetic nervous system regulation of liver repair. The Anatomical Record. Part a, Discoveries in Molecular, Cellular, and Evolutionary Biology. 280: 874-83. PMID 15382023 DOI: 10.1002/Ar.A.20081  0.522
2004 Li Z, Oben JA, Yang S, Lin H, Stafford EA, Soloski MJ, Thomas SA, Diehl AM. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). 40: 434-41. PMID 15368448 DOI: 10.1002/Hep.20320  0.481
2004 Diehl AM. Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease Clinics in Liver Disease. 8: 619-638. PMID 15331067 DOI: 10.1016/J.Cld.2004.04.012  0.462
2004 Gao D, Wei C, Chen L, Huang J, Yang S, Diehl AM. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. American Journal of Physiology-Gastrointestinal and Liver Physiology. 287. PMID 15231485 DOI: 10.1152/Ajpgi.00228.2004  0.413
2004 Nair S, Diehl AM, Wiseman M, Farr GH, Perrillo RP. Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial. Alimentary Pharmacology & Therapeutics. 20: 23-8. PMID 15225167 DOI: 10.1111/J.1365-2036.2004.02025.X  0.364
2004 Diehl AM. Fatty liver, hypertension, and the metabolic syndrome Gut. 53: 923-924. PMID 15194635 DOI: 10.1136/Gut.2003.037309  0.548
2004 Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ. Hematopoietic stem cells convert into liver cells within days without fusion Nature Cell Biology. 6: 532-539. PMID 15133469 DOI: 10.1038/Ncb1132  0.487
2004 Solga SF, Diehl AM. Gut Flora-Based Therapy in Liver Disease? The Liver Cares about the Gut Hepatology. 39: 1197-1200. PMID 15122746 DOI: 10.1002/hep.20220  0.355
2004 Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, Thomas SA, Diehl AM. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut. 53: 438-45. PMID 14960531 DOI: 10.1136/Gut.2003.026658  0.452
2004 Yang S, Koteish A, Lin H, Huang J, Roskams T, Dawson V, Diehl AM. Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology (Baltimore, Md.). 39: 403-11. PMID 14767993 DOI: 10.1002/Hep.20082  0.516
2003 Li Z, Diehl AM. Innate immunity in the liver Current Opinion in Gastroenterology. 19: 565-571. PMID 15703606 DOI: 10.1097/00001574-200311000-00009  0.483
2003 Diehl AM, Clarke J, Brancati F. Insulin resistance syndrome and nonalcoholic fatty liver disease. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 9: 93-6. PMID 14698985 DOI: 10.4158/Ep.9.S2.93  0.396
2003 Roskams T, Yang SQ, Koteish A, Durnez A, DeVos R, Huang X, Achten R, Verslype C, Diehl AM. Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. American Journal of Pathology. 163: 1301-1311. PMID 14507639 DOI: 10.1016/S0002-9440(10)63489-X  0.541
2003 Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Li Z, Torbenson M, Huang J, Guarino P, Kafrouni M, Diehl AM. Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. Hepatology (Baltimore, Md.). 38: 664-73. PMID 12939593 DOI: 10.1053/Jhep.2003.50371  0.446
2003 Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Li Z, Torbenson M, Thomas SA, Diehl AM. Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. Biochemical and Biophysical Research Communications. 308: 284-92. PMID 12901866 DOI: 10.1016/S0006-291X(03)01360-3  0.434
2003 Sun Z, Klein AS, Radaeva S, Hong F, El-Assal O, Pan HN, Jaruga B, Batkai S, Hoshino S, Tian Z, Kunos G, Diehl AM, Gao B. In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology. 125: 202-15. PMID 12851884 DOI: 10.1016/S0016-5085(03)00696-6  0.473
2003 Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States American Journal of Gastroenterology. 98: 960-967. PMID 12809815 DOI: 10.1111/J.1572-0241.2003.07486.X  0.422
2003 Clark JM, Diehl AM. Nonalcoholic Fatty Liver Disease: An Underrecognized Cause of Cryptogenic Cirrhosis Journal of the American Medical Association. 289: 3000-3004. PMID 12799409 DOI: 10.1001/Jama.289.22.3000  0.487
2003 Hughes DE, Stolz DB, Yu S, Tan Y, Reddy JK, Watkins SC, Diehl AM, Costa RH. Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. Hepatology (Baltimore, Md.). 37: 1414-24. PMID 12774021 DOI: 10.1053/Jhep.2003.50253  0.435
2003 Sun Z, Wada T, Maemura K, Uchikura K, Hoshino S, Diehl AM, Klein AS. Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. 9: 489-97. PMID 12740792 DOI: 10.1053/Jlts.2003.50091  0.433
2003 Solga SF, Diehl AM. Non-alcoholic fatty liver disease: Lumen-liver interactions and possible role for probiotics Journal of Hepatology. 38: 681-687. PMID 12713883 DOI: 10.1016/S0168-8278(03)00097-7  0.473
2003 Oben JA, Yang S, Lin H, Ono M, Diehl AM. Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells. Biochemical and Biophysical Research Communications. 302: 685-90. PMID 12646223 DOI: 10.1016/S0006-291X(03)00232-8  0.509
2003 Nair S, Chacko VP, Arnold C, Diehl AM. Hepatic ATP reserve and efficiency of replenishing: Comparison between obese and nonobese normal individuals American Journal of Gastroenterology. 98: 466-470. PMID 12591070 DOI: 10.1016/S0002-9270(02)05889-6  0.372
2003 Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, DeSimone C, Song XY, Diehl AM. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology. 37: 343-350. PMID 12540784 DOI: 10.1053/Jhep.2003.50048  0.414
2003 Clark JM, Diehl AM. Defining nonalcoholic fatty liver disease: Implications for epidemiologic studies Gastroenterology. 124: 248-250. PMID 12512048 DOI: 10.1053/Gast.2003.50032  0.492
2003 Oben JA, Yang S, Lin H, Ono M, Diehl AM. Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. Biochemical and Biophysical Research Communications. 300: 172-7. PMID 12480538 DOI: 10.1016/S0006-291X(02)02773-0  0.518
2003 Al-Khuraishi ARA, Solga SF, Clark JM, Torbenson M, Cohen A, Diehl AM, Magnuson TH. 734 Dietary composition and fatty liver disease Hepatology. 38: 513-513. DOI: 10.1016/S0270-9139(03)80776-0  0.452
2003 Oben JA, Roskams T, Yang S, Sinelli N, Torbenson M, Li Z, Smedh U, Moran TH, Thomas SA, Diehl AM. 349 Hepatic fibrogenesis requires sympathetic neurotransmitters Hepatology. 38: 328-328. DOI: 10.1016/S0270-9139(03)80392-0  0.417
2003 Oben JA, Roskams T, Sinelli N, Torbenson M, Yang S, Lin H, Diehl AM. 348 Norepinephrine induces hepatic fibrogenesis in leptin deficient OB/OB mice Hepatology. 38: 328-328. DOI: 10.1016/S0270-9139(03)80391-9  0.372
2003 Li Z, Oben JA, Yang S, Lin H, Diehl AM. 77 Norepinephrine mediates effects of leptin deficiency on hepatic innate immune system in a mouse model of nonalcoholic steatohepatitis Hepatology. 38: 192-193. DOI: 10.1016/S0270-9139(03)80120-9  0.36
2003 Clark JM, Solga SS, Horska A, Kafrouni M, Brancati FL, Diggs CE, Shields T, Diehl AM. Prevalence of fatty liver in overweight adults with type 2 diabetes Gastroenterology. 124: A702. DOI: 10.1016/S0016-5085(03)83549-7  0.381
2003 Koteish A, Roskams T, Yang S, Huang J, Anne D, Devos R, Verslype C, Diehl AM. Oxidative stress and oval cell accumulation in mice and humans with fatty liver disease Gastroenterology. 124. DOI: 10.1016/S0016-5085(03)83485-6  0.423
2003 Oben JA, Yang S, Lin H, Ono M, Diehl AM. Autonomic neurotransmitters promote proliferation and collagen gene expression of myofibroblastic hepatic stellate cells Gastroenterology. 124. DOI: 10.1016/S0016-5085(03)83386-3  0.386
2003 Clark JM, Diehl AM. Diagnosis of Nonalcoholic Fatty Liver Disease—Reply Jama. 290: 1577-1577. DOI: 10.1001/Jama.290.12.1577-A  0.485
2002 Clark JM, Diehl AM. Hepatic steatosis and type 2 diabetes mellitus Curr Diab Rep. 2: 210-215. PMID 12643175 DOI: 10.1007/S11892-002-0085-3  0.483
2002 Li Z, Clark J, Diehl AM. The liver in obesity and type 2 diabetes mellitus Clinics in Liver Disease. 6: 867-877. PMID 12516196 DOI: 10.1016/S1089-3261(02)00060-0  0.359
2002 Koteish A, Yang S, Lin H, Huang J, Diehl AM. Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy Alcoholism: Clinical and Experimental Research. 26: 1710-1718. PMID 12436061 DOI: 10.1111/J.1530-0277.2002.Tb02475.X  0.389
2002 Koteish A, Diehl AM. Animal models of steatohepatitis Bailliere's Best Practice and Research in Clinical Gastroenterology. 16: 679-690. PMID 12406439 DOI: 10.1053/Bega.2002.0332  0.502
2002 Li Z, Lin H, Yang S, Diehl AM. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system Gastroenterology. 123: 1304-1310. PMID 12360490 DOI: 10.1053/Gast.2002.35997  0.391
2002 Torbenson M, Yang SQ, Liu HZ, Huang J, Gage W, Diehl AM. STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. American Journal of Pathology. 161: 155-161. PMID 12107100 DOI: 10.1016/S0002-9440(10)64167-3  0.516
2002 Diehl AM. Liver regeneration Frontiers in Bioscience : a Journal and Virtual Library. 7. PMID 12086922  0.458
2002 Diehl AM. Liver disease in alcohol abusers: Clinical perspective Alcohol. 27: 7-11. PMID 12062630 DOI: 10.1016/S0741-8329(02)00204-5  0.481
2002 Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology. 122: 1649-57. PMID 12016429 DOI: 10.1053/Gast.2002.33573  0.525
2002 Harrison SA, Diehl AM. Fat and the liver - A molecular overview Seminars in Gastrointestinal Disease. 13: 3-16. PMID 11944631  0.425
2002 Younossi ZM, Diehl AM, Ong JP. Nonalcoholic fatty liver disease: An agenda for clinical research Hepatology. 35: 746-752. PMID 11915019 DOI: 10.1053/Jhep.2002.32483  0.443
2002 Koteish A, Yang S, Lin H, Huang X, Diehl AM. Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation Journal of Biological Chemistry. 277: 13037-13044. PMID 11812769 DOI: 10.1074/Jbc.M101632200  0.381
2002 Diehl AM. IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines American Journal of Physiology-Gastrointestinal and Liver Physiology. 282. PMID 11751151 DOI: 10.1152/Ajpgi.00384.2001  0.513
2002 Molina PE, McClain C, Valla D, Guidot D, Diehl AM, Lang CH, Neuman M. Molecular pathology and clinical aspects of alcohol-induced tissue injury. Alcoholism: Clinical and Experimental Research. 26: 120-128. DOI: 10.1111/J.1530-0277.2002.Tb02440.X  0.366
2001 Yang SQ, Mandal AK, Huang J, Diehl AM. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology Hepatology. 34: 694-706. PMID 11584365 DOI: 10.1053/Jhep.2001.28054  0.485
2001 Yang S, Lin H, Diehl AM. Fatty liver vulnerability to endotoxin-induced damage despite NF-κB induction and inhibited caspase 3 activation American Journal of Physiology - Gastrointestinal and Liver Physiology. 281. PMID 11447019 DOI: 10.1152/Ajpgi.2001.281.2.G382  0.452
2001 Diehl AM. Nonalcoholic fatty liver disease: Implications for alcoholic liver disease pathogenesis Alcoholism: Clinical and Experimental Research. 25. PMID 11391044 DOI: 10.1111/J.1530-0277.2001.Tb02368.X  0.494
2001 Nair S, Cope K, Terence RH, Diehl AM. Obesity and female gender increase breath ethanol concentration: Potential implications for the pathogenesis of nonalcoholic steatohepatitis American Journal of Gastroenterology. 96: 1200-1204. PMID 11316170 DOI: 10.1016/S0002-9270(01)02265-1  0.334
2001 Koteish A, Diehl AM. Animal models of steatosis Seminars in Liver Disease. 21: 89-104. PMID 11296700 DOI: 10.1055/S-2001-12932  0.414
2001 Diehl AM. Reply to 'TNF-α is not the cause of fatty liver disease in obese diabetic mice' Nature Medicine. 7: 2-3. DOI: 10.1038/83319  0.384
2001 Yang S, Lin H, Diehl AM. Hepatocyte hyperplasia in obesity-related fatty livers Gastroenterology. 120. DOI: 10.1016/S0016-5085(08)80527-6  0.433
2001 Yang S, Lin H, Schwenk R, Krytch U, Diehl AM. Leptin and hepatic innate immunity Gastroenterology. 120. DOI: 10.1016/S0016-5085(08)80128-X  0.338
2001 Koteish A, Diehl AM. Obesity and liver disease Current Treatment Options in Gastroenterology. 4: 101-105. DOI: 10.1007/S11938-001-0020-8  0.488
2000 Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis New England Journal of Medicine. 343: 1467-1467. PMID 11078773 DOI: 10.1056/Nejm200011163432007  0.386
2000 Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice Nature Medicine. 6: 998-1003. PMID 10973319 DOI: 10.1038/79697  0.459
2000 Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, Diehl AM. Mitochondrial adaptations to obesity-related oxidant stress. Archives of Biochemistry and Biophysics. 378: 259-68. PMID 10860543 DOI: 10.1006/Abbi.2000.1829  0.354
2000 Diehl AM. Cytokine regulation of liver injury and repair Immunological Reviews. 174: 160-171. PMID 10807515 DOI: 10.1034/J.1600-0528.2002.017411.X  0.461
2000 Meijer C, Wiezer MJ, Diehl AM, Yang S, Schouten HJ, Meijer S, Rooijen NV, Lambalgen AAV, Dijkstra CD, Leeuwen PAMV. Kupffer cell depletion by CI2MDP‐liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy Liver. 20: 66-77. PMID 10726963 DOI: 10.1034/J.1600-0676.2000.020001066.X  0.451
2000 Chuckaree C, Yang SQ, Lin H, Diehl AM. Metformin improves nonalcoholic fatty liver disease in obese mice Gastroenterology. 118: A919. DOI: 10.1016/S0016-5085(00)85812-6  0.425
2000 Mandal AK, Chuckaree C, Diehl AM. Delayed liver regeneration, increased injury and mortality in heterozyogous or homozygous obmutant mice Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)85794-7  0.476
2000 Sun Z, Yang S, Wada T, Uchikura K, Diehl AM, Klein A. Transplantation of fatty livers from genetically obese rats: A new small animal model for primary graft non-function Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)82044-2  0.352
1999 Diehl AM. Effect of ethanol on tumor necrosis factor signaling during liver regeneration Clinical Biochemistry. 32: 571-578. PMID 10614720 DOI: 10.1016/S0009-9120(99)00057-0  0.473
1999 Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM. Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis: A Pilot Study Jama. 282: 1659-1664. PMID 10553793 DOI: 10.1001/Jama.282.17.1659  0.477
1999 Diehl AM. Cytokines and the molecular mechanisms of alcoholic liver disease Alcoholism: Clinical and Experimental Research. 23: 1419-1424. PMID 10512305 DOI: 10.1111/J.1530-0277.1999.Tb04662.X  0.43
1999 Diehl AM. Nonalcoholic steatohepatitis Seminars in Liver Disease. 19: 221-230. PMID 10422202  0.401
1999 Cortez–Pinto H, Lin HZ, Yang SQ, Costa SOd, Diehl AM. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. Gastroenterology. 116: 1184-1193. PMID 10220511 DOI: 10.1016/S0016-5085(99)70022-3  0.393
1999 Rashid A, Wu TC, Huang CC, Chen CH, Lin HZ, Yang SQ, Lee FYJ, Diehl AM. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver Hepatology. 29: 1131-1138. PMID 10094957 DOI: 10.1002/Hep.510290428  0.505
1999 Chavin KD, Yang S, Lin HZ, Chatham J, Chacko VP, Hoek JB, Walajtys-Rode E, Rashid A, Chen CH, Huang CC, Wu TC, Lane MD, Diehl AM. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. The Journal of Biological Chemistry. 274: 5692-700. PMID 10026188 DOI: 10.1074/Jbc.274.9.5692  0.421
1998 Diehl AM. Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth Journal of Biological Chemistry. 273: 30843-30846. PMID 9812973 DOI: 10.1074/Jbc.273.47.30843  0.443
1998 Rai RM, Lee FYJ, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, Zaragoza C, Lowenstein C, Diehl AM. Impaired liver regeneration in inducible nitric oxide synthasedeficient mice Proceedings of the National Academy of Sciences of the United States of America. 95: 13829-13834. PMID 9811886 DOI: 10.1073/Pnas.95.23.13829  0.451
1998 Cortez-Pinto H, Yang SQ, Lin HZ, Costa S, Hwang CS, Lane MD, Bagby G, Diehl AM. Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. Biochemical and Biophysical Research Communications. 251: 313-9. PMID 9790953 DOI: 10.1006/Bbrc.1998.9473  0.39
1998 Yang SQ, Lin HZ, Yin M, Albrecht JH, Diehl AM. Effects of chronic ethanol consumption on cytokine regulation of liver regeneration American Journal of Physiology - Gastrointestinal and Liver Physiology. 275. PMID 9756499 DOI: 10.1111/J.1530-0277.1998.Tb04338.X  0.386
1998 Lin HZ, Yang SQ, Zeldin G, Diehl AM. Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. Alcoholism: Clinical and Experimental Research. 22. DOI: 10.1111/J.1530-0277.1998.Tb04008.X  0.414
1998 Diehl AM. Alcohol And Liver Regeneration Clinics in Liver Disease. 2: 723-738. DOI: 10.1016/S1089-3261(05)70038-6  0.476
1998 Rai R, Lee F, Rosen A, Yang S, Lin H, Lowenstein C, Diehl A. Impaired liver regeneration in inducible nitric oxide synthase (iNOS) deficient mice Gastroenterology. 114: A1326. DOI: 10.1016/S0016-5085(98)85380-8  0.386
1998 Chavin K, Chatham J, Chako V, Yang S, Lin H, Diehl A. Impaired ATP synthesis may explain fatty liver susceptibility to primary nonfunction (PNF) Gastroenterology. 114: A1224. DOI: 10.1016/S0016-5085(98)84965-2  0.449
1997 Diehl AM. Alcoholic liver disease: Natural history Liver Transplantation and Surgery. 3: 206-211. PMID 9346741 DOI: 10.1002/Lt.500030303  0.411
1997 Loffreda S, Rai R, Yang SQ, Lin HZ, Diehl AM. Bile ducts and portal and central veins are major producers of tumor necrosis factor alpha in regenerating rat liver Gastroenterology. 112: 2089-2098. PMID 9178702 DOI: 10.1053/Gast.1997.V112.Pm9178702  0.375
1997 Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America. 94: 2557-62. PMID 9122234 DOI: 10.1073/Pnas.94.6.2557  0.41
1997 Diehl AM. The role of cytokines in hepatic regeneration Current Opinion in Gastroenterology. 13: 525-533. DOI: 10.1097/00001574-199711000-00014  0.467
1996 Zeldin G, Yang SQ, Yin M, Lin HZ, Rai R, Diehl AM. Alcohol and Cytokine-inducible Transcription Factors Alcoholism: Clinical and Experimental Research. 20: 1639-1645. PMID 8986216 DOI: 10.1111/J.1530-0277.1996.Tb01710.X  0.353
1996 Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA, Brenner DA, Diehl AM. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo American Journal of Physiology-Gastrointestinal and Liver Physiology. 271. PMID 8944691 DOI: 10.1152/Ajpgi.1996.271.5.G780  0.324
1996 Rai RM, Zhang JX, Clemens MG, Diehl AM. Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and antiinflammatory cytokines Shock. 6: 243-247. PMID 8902939 DOI: 10.1097/00024382-199610000-00003  0.433
1996 Rai RM, Yang SQ, McClain C, Karp CL, Klein AS, Diehl AM. Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats. The American Journal of Physiology. 270: G909-18. PMID 8764196 DOI: 10.1152/Ajpgi.1996.270.6.G909  0.447
1996 Diehl AM, Rai RM. Regulation of signal transduction during liver regeneration Faseb Journal. 10: 215-227. PMID 8641555 DOI: 10.1096/Fasebj.10.2.8641555  0.519
1996 Diehl AM, Rai R. REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines Journal of Gastroenterology and Hepatology (Australia). 11: 466-470. DOI: 10.1111/J.1440-1746.1996.Tb00292.X  0.509
1995 Liu S, Esposti SD, Yao T, Diehl AM, Zern MA. Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding Hepatology. 22: 1474-1481. DOI: 10.1002/Hep.1840220522  0.393
1995 Diehl AM, Yang SQ, Yin M, Lin HZ, Nelson S, Bagby G. Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins-DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration☆ Hepatology. 22: 252-261. DOI: 10.1002/Hep.1840220136  0.331
1994 Silverman AL, Smith MR, Sasaki D, Mutchnick MG, Diehl AM. Altered levels of prothymosin immunoreactive peptide, a growth-related gene product, during liver regeneration after chronic ethanol feeding Alcoholism: Clinical and Experimental Research. 18: 616-619. PMID 7943664 DOI: 10.1111/J.1530-0277.1994.Tb00919.X  0.362
1994 Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ, Brenner DA, Westwick J, Bagby G, Nelson S. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury American Journal of Physiology-Gastrointestinal and Liver Physiology. 267. PMID 7943321 DOI: 10.1152/Ajpgi.1994.267.4.G552  0.429
1994 Diehl AM, Michaelson P, Yang SQ. Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development Gastroenterology. 106: 1625-1637. PMID 7910803 DOI: 10.1016/0016-5085(94)90420-0  0.363
1993 McClain C, Hill D, Schmidt J, Diehl AM. Cytokines and alcoholic liver disease Seminars in Liver Disease. 13: 170-182. PMID 8337603 DOI: 10.1055/S-2007-1007347  0.459
1992 Diehl AM, Yang SQ, Brown N, Smith J, Raiford D, Gordon R, Casero R. Ethanol-associated alterations in the kinetics of putrescine uptake and metabolism by the regenerating liver. Alcoholism, Clinical and Experimental Research. 16: 5-10. PMID 1558302 DOI: 10.1111/J.1530-0277.1992.Tb00626.X  0.377
1992 Akerman P, Cote P, Yang SQ, Mcclain C, Nelson S, Bagby GJ, Diehl AM. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. American Journal of Physiology-Gastrointestinal and Liver Physiology. 263. PMID 1415718 DOI: 10.1152/Ajpgi.1992.263.4.G579  0.451
1992 Diehl AM, Yang SQ, Cote P, Wand GS. Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver Hepatology. 16: 1212-1219. PMID 1330868 DOI: 10.1002/Hep.1840160518  0.367
1992 Diehl AM, Yang SQ, Wolfgang D, Wand G. Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver Journal of Clinical Investigation. 89: 1706-1712. PMID 1318322 DOI: 10.1172/Jci115771  0.352
1991 Diehl AM. Nutrition, hormones, metabolism, and liver regeneration Seminars in Liver Disease. 11: 315-320. PMID 1763337 DOI: 10.1055/S-2008-1040449  0.437
1991 Mendenhall CL, Seeff L, Diehl AM, Ghosn SJ, French SW, Gartside PS, Rouster SD, Buskell-Bales Z, Grossman CJ, Roselle GA, Weesner RE, Garcia-Pont P, Goldberg SJ, Kiernan TW, Tamburro CH, et al. Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevance Hepatology. 14: 581-589. DOI: 10.1002/Hep.1840140402  0.425
1990 Diehl AM, Thorgeirsson SS, Steer CJ. Ethanol inhibits liver regeneration in rats without reducing transcripts of key protooncogenes Gastroenterology. 99: 1105-1112. PMID 2394331 DOI: 10.1016/0016-5085(90)90631-A  0.427
1990 Diehl AM, Wells M, Brown ND, Thorgeirsson SS, Steer CJ. Effect of ethanol on polyamine synthesis during liver regeneration in rats. The Journal of Clinical Investigation. 85: 385-90. PMID 2298913 DOI: 10.1172/Jci114450  0.41
1990 Van Ness MM, Diehl AM. Liver enzymes and liver biopsy (I: Reply) Annals of Internal Medicine. 112: 311.  0.387
1989 Van Ness MM, Diehl AM. Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes? Annals of Internal Medicine. 111: 473-478. PMID 2774372 DOI: 10.7326/0003-4819-111-6-473  0.492
1989 Diehl AM. Alcoholic liver disease Medical Clinics of North America. 73: 815-830. PMID 2657264 DOI: 10.1016/B978-0-443-06633-7.50011-9  0.364
1989 Carithers RL, Herlong HF, Diehl AM, Shaw EW, Combes B, Fallon HJ, Maddrey WC. Methylprednisolone Therapy in Patients with Severe Alcoholic Hepatitis: A Randomized Multicenter Trial Annals of Internal Medicine. 110: 685-690. PMID 2648927 DOI: 10.7326/0003-4819-110-9-685  0.345
1988 Diehl AM, Goodman Z, Ishak KG. Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury Gastroenterology. 95: 1056-1062. PMID 3410220 DOI: 10.1016/0016-5085(88)90183-7  0.444
1988 Mezey E, Kolman CJ, Diehl AM, Mitchell MC, Herlong HF. Alcohol and dietary intake in the development of chronic pancreatitis and liver disease in alcoholism American Journal of Clinical Nutrition. 48: 148-151. PMID 3389321 DOI: 10.1093/Ajcn/48.1.148  0.361
1988 Diehl AM, Goodman Z, Ishak KG. Alcohollike liver disease in nonalcoholics Gastroenterology. 95: 1056-1062. DOI: 10.5555/Uri:Pii:0016508588901837  0.444
1987 Diehl AM, Chacon MA, Potter JJ, Rolfes D, Cruess DF, Mezey E. Pyridoxine deficiency and ethanol-induced liver injury. Alcoholism, Clinical and Experimental Research. 11: 385-91. PMID 3307510 DOI: 10.1111/J.1530-0277.1987.Tb01329.X  0.416
1987 Johnson DA, Diehl AM, Sjogren MH, Lazar J, Cattau EL, Smallridge RC. Serum angiotensin converting enzyme activity in evaluation of patients with liver disease The American Journal of Medicine. 83: 256-260. PMID 3039843 DOI: 10.1016/0002-9343(87)90694-2  0.369
1986 Mezey E, Potter JJ, Diehl AM. Depression of alcohol dehydrogenase activity in rat hepatocyte culture by dihydrotestosterone Biochemical Pharmacology. 35: 335-339. PMID 2935156 DOI: 10.1016/0006-2952(86)90535-6  0.301
1985 Diehl AM, Boitnott JK, Herlong HF, Potter JJ, Duyn MAV, Chandler E, Mezey E. Effect of parenteral amino acid supplementation in alcoholic hepatitis Hepatology. 5: 57-63. PMID 3917968 DOI: 10.1002/Hep.1840050114  0.399
1984 Diehl AM, Latham P, Boitnott JK, Mann J, Maddrey WC. Cholestatic hepatitis from erythromycin ethylsuccinate. Report of two cases. The American Journal of Medicine. 76: 931-4. PMID 6609640 DOI: 10.1016/0002-9343(84)91013-1  0.348
1984 Diehl AM, Latham P, Boitnott JK, Mann J, Maddrey WC. Cholestatic Hepatitis From Erythromycin Ethylsuccinate. Report of Two Cases The Journal of Urology. 132: 843-843. DOI: 10.1016/S0022-5347(17)49891-0  0.353
1984 Diehl AM, Potter J, Boitnott J, Duyn MAV, Herlong HF, Mezey E. Relationship between pyridoxal 5'-phosphate deficiency and aminotransferase levels in alcoholic hepatitis. Gastroenterology. 86: 632-636. DOI: 10.1016/S0016-5085(84)80110-9  0.473
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