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Jason A. Mears, Ph.D. - Publications

Affiliations: 
1999-2005 Biochemistry and Molecular Genetics University of Alabama, Birmingham, Birmingham, AL, United States 
 2005-2010 Laboratory of Cell & Molecular Biology Natiional Institutes of Health, NIDDK 
 2010- Pharmacology Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Biochemistry, General Biophysics, Structural Biology, Cryo-EM, mitochondrial dynamics
Website:
https://www.mearslab.com/
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Rochon K, Bauer BL, Roethler NA, Buckley Y, Su CC, Huang W, Ramachandran R, Stoll MSK, Yu EW, Taylor DJ, Mears JA. Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1. Nature Communications. 15: 1328. PMID 38351080 DOI: 10.1038/s41467-024-45524-4  0.482
2024 Pérez-Jover I, Rochon K, Hu D, Mahajan M, Madan Mohan P, Santos-Pérez I, Ormaetxea Gisasola J, Martinez Galvez JM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R. Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif. Nature Communications. 15: 52. PMID 38168038 DOI: 10.1038/s41467-023-44413-6  0.376
2023 Pérez-Jover I, Rochon K, Hu D, Mohan PM, Santos-Perez I, Gisasola JO, Galvez JMM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R. Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif. Research Square. PMID 37503116 DOI: 10.21203/rs.3.rs-3161608/v1  0.391
2023 Bauer BL, Rochon K, Liu JC, Ramachandran R, Mears JA. Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery. Human Molecular Genetics. PMID 36795043 DOI: 10.1093/hmg/ddad029  0.327
2023 Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, ... ... Mears JA, et al. DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. Journal of Cell Science. 136. PMID 36763487 DOI: 10.1242/jcs.260370  0.351
2022 Mears JA, Ramachandran R. Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division. Current Opinion in Physiology. 29. PMID 36406887 DOI: 10.1016/j.cophys.2022.100574  0.316
2021 Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA. Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Scientific Reports. 11: 22106. PMID 34764359 DOI: 10.1038/s41598-021-01512-y  0.325
2020 Montecinos-Franjola F, Bauer BL, Mears JA, Ramachandran R. GFP fluorescence tagging alters dynamin-related protein 1 oligomerization dynamics and creates disassembly-refractory puncta to mediate mitochondrial fission. Scientific Reports. 10: 14777. PMID 32901052 DOI: 10.1038/S41598-020-71655-X  0.482
2020 Clinton RW, Bauer BL, Mears JA. Affinity Purification and Functional Characterization of Dynamin-Related Protein 1. Methods in Molecular Biology (Clifton, N.J.). 2159: 41-53. PMID 32529362 DOI: 10.1007/978-1-0716-0676-6_4  0.444
2020 Hoppins S, Lackner LL, Lee JE, Mears JA. In vitro and in vivo assays for mitochondrial fission and fusion. Methods in Cell Biology. 155: 491-518. PMID 32183974 DOI: 10.1016/Bs.Mcb.2019.11.010  0.447
2020 Whiddon K, Clinton R, Mears J. Investigating Interactions in the Drp1-Mff Copolymer That Contributes to Mitochondrial Fission Microscopy and Microanalysis. 1-3. DOI: 10.1017/S1431927620017663  0.43
2020 Rochon K, Blanco AT, Mears J. Conformational Changes in Solution Multimers of Dynamin-related Protein 1 (Drp1) Facilitate Functional Assembly Microscopy and Microanalysis. 1-2. DOI: 10.1017/S1431927620015895  0.376
2019 Tiosano D, Mears JA, Buchner DA. Mitochondrial Dysfunction in Primary Ovarian Insufficiency. Endocrinology. PMID 31393557 DOI: 10.1210/En.2019-00441  0.391
2019 Rochon K, Mears JA. Determining the Solution Structure of the Drp1 and its Role in the Assembly of the Mitochondrial Fission Machinery Microscopy and Microanalysis. 25: 1322-1323. DOI: 10.1017/S1431927619007347  0.462
2019 Whiddon KT, Clinton RW, Mears JA. Elucidating Molecular Mechanisms of Mitochondrial Fission Machinery via Helical Studies of Drp1 and its Partner Proteins Microscopy and Microanalysis. 25: 1320-1321. DOI: 10.1017/S1431927619007335  0.469
2018 Lu B, Kennedy B, Clinton RW, Wang EJ, McHugh D, Stepanyants N, Macdonald PJ, Mears JA, Qi X, Ramachandran R. Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission. Scientific Reports. 8: 10879. PMID 30022112 DOI: 10.1038/S41598-018-29001-9  0.547
2018 Tandler B, Hoppel CL, Mears JA. Morphological Pathways of Mitochondrial Division. Antioxidants (Basel, Switzerland). 7. PMID 29462856 DOI: 10.3390/Antiox7020030  0.511
2018 Mears JA, Francy CA, Clinton RW, Lee S. Structural Studies that Define Regulatory Interactions Within the Mitochondrial Fission Machinery Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2066  0.477
2017 Francy CA, Clinton RW, Fröhlich C, Murphy C, Mears JA. Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer. Scientific Reports. 7: 10744. PMID 28878368 DOI: 10.1038/S41598-017-11008-3  0.542
2017 Clinton RW, Mears JA. Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro. Journal of Visualized Experiments : Jove. PMID 28117823 DOI: 10.3791/54971  0.474
2017 Clinton RW, Francy CA, Mears JA. Structural Studies that Define Regulatory Interactions within the Mitochondrial Fission Machinery Microscopy and Microanalysis. 23: 1244-1245. DOI: 10.1017/S1431927617006882  0.477
2016 Francy CA, Frohlich C, Daumke O, Mears JA. Defining Membrane Interactions that Drive Dynamin Related Protein 1 (Drp1) Oligomerization using cryo-EM Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.882  0.567
2016 Clinton RW, Ramachandran R, Mears JA. Mitochondrial Recruitment of Drp1 by Mff is Opposed by the Variable Domain Biophysical Journal. 110: 216. DOI: 10.1016/J.Bpj.2015.11.1201  0.558
2015 Clinton RW, Francy CA, Ramachandran R, Qi X, Mears JA. Dynamin-Related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-Anchored Mitochondrial Fission Factor. The Journal of Biological Chemistry. PMID 26578514 DOI: 10.1074/Jbc.M115.680025  0.562
2015 Macdonald PJ, Francy CA, Stepanyants N, Lehman L, Baglio A, Mears JA, Qi X, Ramachandran R. Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity. The Journal of Biological Chemistry. PMID 26578513 DOI: 10.1074/Jbc.M115.680181  0.51
2015 Stepanyants N, Macdonald PJ, Francy CA, Mears JA, Qi X, Ramachandran R. Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission. Molecular Biology of the Cell. PMID 26157169 DOI: 10.1091/Mbc.E15-06-0330  0.514
2015 Francy CA, Alvarez FJ, Zhou L, Ramachandran R, Mears JA. The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction. The Journal of Biological Chemistry. 290: 11692-703. PMID 25770210 DOI: 10.1074/Jbc.M114.610881  0.53
2015 Francy CA, Alvarez FJD, Zhou L, Mears JA. The Mechanoenzymatic Properties of Drp1 in Nucleotide Induced Constriction of Lipid Bilayers Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2039  0.545
2014 Macdonald PJ, Stepanyants N, Mehrotra N, Mears JA, Qi X, Sesaki H, Ramachandran R. A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Molecular Biology of the Cell. 25: 1905-15. PMID 24790094 DOI: 10.1091/Mbc.E14-02-0728  0.514
2014 Francy CA, Frölich C, Daumke O, Mears JA. Examining Drp1 Conformational Changes and Domain Interactions in the Mitochondrial Fission Complex using Cryo-Em Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3328  0.537
2014 Alvarez FJD, Francy CA, Mears JA. Cryo-Em Studies of DRP1 Self-Assembly Provide Insights into the Mechanism of Mitochondrial Fission Biophysical Journal. 106: 5-8. DOI: 10.1016/J.Bpj.2013.11.3312  0.551
2013 Fröhlich C, Grabiger S, Schwefel D, Faelber K, Rosenbaum E, Mears J, Rocks O, Daumke O. Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. The Embo Journal. 32: 1280-92. PMID 23584531 DOI: 10.1038/Emboj.2013.74  0.548
2013 Alvarez F, Zhou L, Mears JA. Structural Studies of Dynamin-Related Protein 1 (DRP1) Provide Mechanistic Insight into Mitochondrial Fission. Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.1948  0.586
2012 Mears JA, Alvarez F, Zhou L, Fang S, Hinshaw J. Cryo-EM studies of dynamin-related proteins that regulate mitochondrial fission Microscopy and Microanalysis. 18: 60-61. DOI: 10.1017/S1431927612002152  0.472
2012 Alvarez FJD, Zhou L, Mears JA. Structural studies of Dnm1/Drp1 provide mechanistic insight into mitochondrial fission Mitochondrion. 12: 573-574. DOI: 10.1016/J.Mito.2012.07.060  0.474
2012 Hinshaw JE, Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Dyda F. Structural Analysis of Dynamin Reveals Power Stroke Biophysical Journal. 102: 321a. DOI: 10.1016/J.Bpj.2011.11.1764  0.469
2011 Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 147: 209-22. PMID 21962517 DOI: 10.1016/J.Cell.2011.09.003  0.708
2011 Jomaa A, Stewart G, Mears JA, Kireeva I, Brown ED, Ortega J. Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor. Rna (New York, N.Y.). 17: 2026-38. PMID 21960487 DOI: 10.1261/rna.2922311  0.374
2011 Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nature Structural & Molecular Biology. 18: 20-6. PMID 21170049 DOI: 10.1038/Nsmb.1949  0.74
2011 Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. An Improved Model for Dynamin Assembly Revealed by Cryo-EM Biophysical Journal. 100: 324a. DOI: 10.1016/J.Bpj.2010.12.1969  0.498
2010 Mears J, Ray P, Fang S, Heymann J, Hinshaw J. Dynamin Family Members and Their Role in Membrane Remodeling Microscopy and Microanalysis. 16: 1072-1073. DOI: 10.1017/S1431927610055480  0.305
2009 Schulz TA, Choi MG, Raychaudhuri S, Mears JA, Ghirlando R, Hinshaw JE, Prinz WA. Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. The Journal of Cell Biology. 187: 889-903. PMID 20008566 DOI: 10.1083/Jcb.200905007  0.685
2009 Ray P, Fang S, Mears JA, Hinshaw JE. The Role of the Proline Rich Domain in the Structural Organization of Dynamin Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.295  0.44
2009 Mears JA, Lackner LL, Fang S, Nunnari JM, Hinshaw JE. Mitochondrial Fission is Mediated by Conformational Changes in the Dynamin-related Protein, Dnm1 Biophysical Journal. 96: 413a. DOI: 10.1016/J.Bpj.2008.12.2105  0.531
2008 Mears JA, Hinshaw JE. Visualization of dynamins. Methods in Cell Biology. 88: 237-56. PMID 18617037 DOI: 10.1016/S0091-679X(08)00413-5  0.737
2008 Hinshaw JE, Mears JA, Ray P, Fang S. Structural analysis of dynamin family members provide insight into membrane fission Microscopy and Microanalysis. 14: 1566-1567. DOI: 10.1017/S1431927608082846  0.368
2008 Ray P, Fang S, Mears JA, Hinshaw JE. The role of dynamin domains in membrane constriction Microscopy and Microanalysis. 14: 1318-1319. DOI: 10.1017/S1431927608081993  0.396
2008 Mears JA, Stagg SM, Harvey SC. Modeling Large RNA Assemblies using a Reduced Representation Handbook of Rna Biochemistry. 546-559. DOI: 10.1002/9783527619504.ch33  0.63
2007 Mears JA, Ray P, Hinshaw JE. A corkscrew model for dynamin constriction. Structure (London, England : 1993). 15: 1190-202. PMID 17937909 DOI: 10.1016/J.Str.2007.08.012  0.699
2006 Mears JA, Sharma MR, Gutell RR, McCook AS, Richardson PE, Caulfield TR, Agrawal RK, Harvey SC. A structural model for the large subunit of the mammalian mitochondrial ribosome. Journal of Molecular Biology. 358: 193-212. PMID 16510155 DOI: 10.1016/J.Jmb.2006.01.094  0.756
2005 Ingerman E, Perkins EM, Marino M, Mears JA, McCaffery JM, Hinshaw JE, Nunnari J. Dnm1 forms spirals that are structurally tailored to fit mitochondria. The Journal of Cell Biology. 170: 1021-7. PMID 16186251 DOI: 10.1083/Jcb.200506078  0.727
2004 Ivanov VI, Mears JA. Using Cross-links to Study Ribosomal Dynamics. Journal of Biomolecular Structure & Dynamics. 21: 691-698. PMID 22650307 DOI: 10.1080/07391102.2004.10506962  0.32
2003 Stagg SM, Mears JA, Harvey SC. A structural model for the assembly of the 30S subunit of the ribosome. Journal of Molecular Biology. 328: 49-61. PMID 12683996 DOI: 10.1016/S0022-2836(03)00174-8  0.697
2002 Mears JA, Cannone JJ, Stagg SM, Gutell RR, Agrawal RK, Harvey SC. Modeling a minimal ribosome based on comparative sequence analysis. Journal of Molecular Biology. 321: 215-34. PMID 12144780 DOI: 10.1016/S0022-2836(02)00568-5  0.732
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