Toshihiko Yada - Publications

Affiliations: 
Physiology Jichi Medical University, Shimotsuke-shi, Tochigi-ken, Japan 

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yada T. Glucose-dependent insulinotropic polypeptide receptor systems in the hypothalamus and the brainstem regulate feeding and weight through distinct pathways. Journal of Diabetes Investigation. PMID 38140849 DOI: 10.1111/jdi.14130  0.312
2023 Han W, Wang L, Ohbayashi K, Takeuchi M, O'Farrell L, Coskun T, Rakhat Y, Yabe D, Iwasaki Y, Seino Y, Yada T. Glucose-dependent insulinotropic polypeptide counteracts diet-induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin-responsive and proopiomelanocortin neurons in the arcuate nucleus. Diabetes, Obesity & Metabolism. PMID 36852745 DOI: 10.1111/dom.15001  0.304
2022 Rakhat Y, Kaneko K, Wang L, Han W, Seino Y, Yabe D, Yada T. d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice. Nutrients. 14. PMID 35956293 DOI: 10.3390/nu14153117  0.321
2022 Zhang B, Kario K, Yada T, Nakata M. TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus. Nutrients. 14. PMID 35807782 DOI: 10.3390/nu14132600  0.318
2022 Yermek R, Wang L, Kaneko K, Han W, Seino Y, Yabe D, Yada T. D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice. Biochemical and Biophysical Research Communications. 613: 159-165. PMID 35561584 DOI: 10.1016/j.bbrc.2022.04.027  0.313
2021 Nakata M, Kumari P, Kita R, Katsui N, Takeuchi Y, Kawaguchi T, Yamazaki T, Zhang B, Shimba S, Yada T. Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism. Nutrients. 13. PMID 34960038 DOI: 10.3390/nu13124487  0.305
2021 Wang L, Han W, Iwasaki Y, Yermek R, Sharp GWG, Seino Y, Yada T. Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons. Neuropeptides. 89: 102180. PMID 34293597 DOI: 10.1016/j.npep.2021.102180  0.337
2020 Goswami C, Dezaki K, Wang L, Inui A, Seino Y, Yada T. Ninjin'yoeito Targets Distinct Ca Channels to Activate Ghrelin-Responsive vs. Unresponsive NPY Neurons in the Arcuate Nucleus. Frontiers in Nutrition. 7: 104. PMID 32766273 DOI: 10.3389/Fnut.2020.00104  0.458
2019 Suzuki H, Ataka K, Asakawa A, Cheng KC, Ushikai M, Iwai H, Yagi T, Arai T, Yahiro K, Yamamoto K, Yokoyama Y, Kojima M, Yada T, Hirayama T, Nakamura N, et al. Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice. Scientific Reports. 9: 6011. PMID 30979915 DOI: 10.1038/S41598-019-42163-4  0.334
2019 Goswami C, Dezaki K, Wang L, Inui A, Seino Y, Yada T. Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia. Neuropeptides. PMID 30948035 DOI: 10.1016/J.Npep.2019.03.001  0.426
2018 Suyama S, Yada T. New insight into GABAergic neurons in the hypothalamic feeding regulation. The Journal of Physiological Sciences : Jps. PMID 30003408 DOI: 10.1007/S12576-018-0622-8  0.388
2018 Zhang B, Nakata M, Nakae J, Ogawa W, Yada T. Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation. Scientific Reports. 8: 10415. PMID 29991705 DOI: 10.1038/S41598-018-28816-W  0.476
2018 Zhang B, Nakata M, Lu M, Nakae J, Okada T, Ogawa W, Yada T. Protective role of AgRP neuron's PDK1 against salt-induced hypertension. Biochemical and Biophysical Research Communications. PMID 29705701 DOI: 10.1016/J.Bbrc.2018.04.192  0.387
2018 Goswami C, Iwasaki Y, Yada T. Short-chain fatty acids suppress food intake by activating vagal afferent neurons. The Journal of Nutritional Biochemistry. 57: 130-135. PMID 29702431 DOI: 10.1016/J.Jnutbio.2018.03.009  0.38
2018 Kumari P, Nakata M, Zhang BY, Otgon-Uul Z, Yada T. GLP-1 receptor agonist liraglutide exerts central action to induce β-cell proliferation through medulla to vagal pathway in mice. Biochemical and Biophysical Research Communications. PMID 29601817 DOI: 10.1016/J.Bbrc.2018.03.199  0.357
2018 Ando A, Gantulga D, Nakata M, Maekawa F, Dezaki K, Ishibashi S, Yada T. Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats. Neuropeptides. PMID 29525472 DOI: 10.1016/J.Npep.2018.02.001  0.609
2018 Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, ... ... Yada T, et al. Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. Cell Reports. 22: 706-721. PMID 29346768 DOI: 10.1016/J.Celrep.2017.11.102  0.394
2018 Iwasaki Y, Sendo M, Dezaki K, Hira T, Sato T, Nakata M, Goswami C, Aoki R, Arai T, Kumari P, Hayakawa M, Masuda C, Okada T, Hara H, Drucker DJ, ... ... Yada T, et al. GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose. Nature Communications. 9: 113. PMID 29317623 DOI: 10.1038/S41467-017-02488-Y  0.334
2017 Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Communications. 8: 490. PMID 28887564 DOI: 10.1038/S41467-017-00624-2  0.34
2017 Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. Elife. 6. PMID 28762946 DOI: 10.7554/Elife.25755  0.387
2017 Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki Y. Involvement of thermosensitive TRP channels in energy metabolism. The Journal of Physiological Sciences : Jps. PMID 28656459 DOI: 10.1007/S12576-017-0552-X  0.329
2017 Iwasaki Y, Goswami C, Yada T. Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons. Neuropeptides. PMID 28624122 DOI: 10.1016/J.Npep.2017.05.003  0.506
2017 Suyama S, Lei W, Kubota N, Kadowaki T, Yada T. Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus. Neuropeptides. PMID 28606559 DOI: 10.1016/J.Npep.2017.03.003  0.442
2017 Sasanuma H, Nakata M, Parmila K, Nakae J, Yada T. PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis. Molecular Metabolism. 6: 428-439. PMID 28462077 DOI: 10.1016/J.Molmet.2017.02.003  0.385
2017 Santoso P, Nakata M, Shiizaki K, Boyang Z, Parmila K, Otgon-Uul Z, Hashimoto K, Satoh T, Mori M, Kuro-O M, Yada T. Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. Scientific Reports. 7: 45819. PMID 28374855 DOI: 10.1038/Srep45819  0.45
2017 Santoso P, Nakata M, Ueta Y, Yada T. Suprachiasmatic Vasopressin to Paraventricular Oxytocin Neurocircuit in the Hypothalamus Relays Light Reception to Inhibition of Feeding Behavior. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00338.2016. PMID 28174180 DOI: 10.1152/Ajpendo.00338.2016  0.383
2017 Suyama S, Ralevski A, Liu Z, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao X, Diano S, Horvath TL. Author response: Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons Elife. DOI: 10.7554/Elife.25755.014  0.306
2016 Nakata M, Zhang B, Yang Y, Okada T, Shintani N, Hashimoto H, Yada T. High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance. Journal of Diabetes Research. 2016: 9321395. PMID 28044141 DOI: 10.1155/2016/9321395  0.367
2016 Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M. Endogenous α2A-Adrenoceptor-Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling. Diabetes. PMID 28028077 DOI: 10.2337/Db16-1166  0.413
2016 Kohno D, Koike M, Ninomiya Y, Kojima I, Kitamura T, Yada T. Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness. Frontiers in Neuroscience. 10: 502. PMID 27877104 DOI: 10.3389/Fnins.2016.00502  0.486
2016 Otgon-Uul Z, Suyama S, Onodera H, Yada T. Optogenetic activation of leptin- and glucose-regulated GABAergic neurons in dorsomedial hypothalamus promotes food intake via inhibitory synaptic transmission to paraventricular nucleus of hypothalamus. Molecular Metabolism. 5: 709-15. PMID 27656408 DOI: 10.1016/J.Molmet.2016.06.010  0.41
2016 Suyama S, Maekawa F, Maejima Y, Kubota N, Kadowaki T, Yada T. Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding. Scientific Reports. 6: 30796. PMID 27503800 DOI: 10.1038/Srep30796  0.629
2016 Kakei M, Yoshida M, Dezaki K, Ito K, Yamada H, Funazaki S, Kawakami M, Sugawara H, Yada T. Glucose and GTP-binding protein-coupled receptor cooperatively regulate transient receptor potential-channels to stimulate insulin secretion [Review]. Endocrine Journal. PMID 27321586 DOI: 10.1507/Endocrj.Ej16-0262  0.36
2016 Katsurada K, Yada T. Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist. Journal of Diabetes Investigation. 7: 64-9. PMID 27186358 DOI: 10.1111/Jdi.12464  0.37
2016 Yamada H, Yoshida M, Ito K, Dezaki K, Yada T, Ishikawa SE, Kakei M. Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells. Scientific Reports. 6: 25912. PMID 27180622 DOI: 10.1038/Srep25912  0.404
2016 Nakata M, Gantulga D, Santoso P, Zhang B, Masuda C, Mori M, Okada T, Yada T. Paraventricular NUCB2/nesfatin-1 supports oxytocin and vasopressin neurons to control feeding behavior and fluid balance in male mice. Endocrinology. en20152082. PMID 27105386 DOI: 10.1210/En.2015-2082  0.36
2016 Li E, Nakata M, Shinozaki A, Yang Y, Zhang B, Yada T. Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice. Endocrine Journal. PMID 27097546 DOI: 10.1507/Endocrj.Ej16-0164  0.328
2016 Taguchi M, Dezaki K, Koizumi M, Kurashina K, Hosoya Y, Lefor AK, Sata N, Yada T. Total gastrectomy-induced reductions in food intake and weight are counteracted by rikkunshito by attenuating glucagon-like peptide-1 elevation in rats. Surgery. PMID 26775072 DOI: 10.1016/J.Surg.2015.12.003  0.307
2016 Taguchi M, Dezaki K, Koizumi M, Kurashina K, Hosoya Y, Sakuma Y, Horie H, Kitayama J, Foster C, Lefor AK, Sata N, Yada T. 1016 Rikkunshito Counteracts Total Gastrectomy-Induced Reductions in Food Intake and Weight By Attenuating Glucagon-Like Peptide 1 Elevation in Rats Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)34049-5  0.309
2015 Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M. Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders. Scientific Reports. 5: 15883. PMID 26515636 DOI: 10.1038/Srep15883  0.306
2015 Nakata M, Yamamoto S, Okada T, Gantulga D, Okano H, Ozawa K, Yada T. IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin. International Journal of Obesity (2005). PMID 26435324 DOI: 10.1038/Ijo.2015.201  0.333
2015 Kurashina T, Dezaki K, Yoshida M, Sukma Rita R, Ito K, Taguchi M, Miura R, Tominaga M, Ishibashi S, Kakei M, Yada T. The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin. Scientific Reports. 5: 14041. PMID 26370322 DOI: 10.1038/Srep14041  0.381
2015 Suyama S, Kodaira-Hirano M, Otgon-Uul Z, Ueta Y, Nakata M, Yada T. Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus. Neuropeptides. PMID 26344333 DOI: 10.1016/J.Npep.2015.08.008  0.373
2015 Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, et al. A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet. British Journal of Pharmacology. PMID 26140534 DOI: 10.1111/Bph.13236  0.353
2015 Iwasaki Y, Dezaki K, Kumari P, Kakei M, Yada T. Ghrelin counteracts insulin-induced activation of vagal afferent neurons via growth hormone secretagogue receptor. Neuropeptides. 52: 55-60. PMID 26138507 DOI: 10.1016/J.Npep.2015.06.003  0.486
2015 Kurita H, Xu KY, Maejima Y, Nakata M, Dezaki K, Santoso P, Yang Y, Arai T, Gantulga D, Muroya S, Lefor AK, Kakei M, Watanabe E, Yada T. Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons. American Journal of Physiology. Endocrinology and Metabolism. 309: E320-33. PMID 26081283 DOI: 10.1152/Ajpendo.00446.2014  0.465
2015 Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantulga D, Shimomura K, Yada T. Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology. 101: 35-44. PMID 25573626 DOI: 10.1159/000371636  0.429
2015 Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Nakabayashi H, Kakei M, Yada T. Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R360-9. PMID 25540101 DOI: 10.1152/Ajpregu.00344.2014  0.44
2015 Darambazar G, Nakata M, Okada T, Wang L, Li E, Shinozaki A, Motoshima M, Mori M, Yada T. Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect. Biochemical and Biophysical Research Communications. 456: 913-8. PMID 25534851 DOI: 10.1016/J.Bbrc.2014.12.065  0.441
2015 Ayush EA, Iwasaki Y, Iwamoto S, Nakabayashi H, Kakei M, Yada T. Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptors. Biochemical and Biophysical Research Communications. 456: 727-32. PMID 25511693 DOI: 10.1016/J.Bbrc.2014.12.031  0.493
2015 Sukma Rita R, Dezaki K, Kurashina T, Kakei M, Yada T. Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice. Endocrinology. 156: 114-23. PMID 25337656 DOI: 10.1210/En.2014-1728  0.421
2014 Maejima Y, Sakuma K, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T. Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. Febs Letters. 588: 4404-12. PMID 25448678 DOI: 10.1016/J.Febslet.2014.10.010  0.424
2014 Sedbazar U, Ayush EA, Maejima Y, Yada T. Neuropeptide Y and α-melanocyte-stimulating hormone reciprocally regulate nesfatin-1 neurons in the paraventricular nucleus of the hypothalamus. Neuroreport. 25: 1453-8. PMID 25383463 DOI: 10.1097/Wnr.0000000000000293  0.42
2014 Yada T, Damdindorj B, Rita RS, Kurashina T, Ando A, Taguchi M, Koizumi M, Sone H, Nakata M, Kakei M, Dezaki K. Ghrelin signalling in β-cells regulates insulin secretion and blood glucose. Diabetes, Obesity & Metabolism. 16: 111-7. PMID 25200304 DOI: 10.1111/Dom.12344  0.42
2014 Katsurada K, Maejima Y, Nakata M, Kodaira M, Suyama S, Iwasaki Y, Kario K, Yada T. Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons. Biochemical and Biophysical Research Communications. 451: 276-81. PMID 25089000 DOI: 10.1016/J.Bbrc.2014.07.116  0.44
2014 Yosida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M. Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion. Diabetes. 63: 3394-403. PMID 24824430 DOI: 10.2337/Db13-1868  0.391
2014 Yanagida K, Maejima Y, Santoso P, Otgon-Uul Z, Yang Y, Sakuma K, Shimomura K, Yada T. Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose. Aging. 6: 207-14. PMID 24704640  0.306
2014 Uramura K, Maejima Y, Shimomura K, Santoso P, Katsuda S, Kobayashi D, Jodo E, Kodaira M, Otgon-Uul Z, Yang Y, Sakuma K, Takigawa M, Hazama A, Yada T. Chronic phencyclidine treatment induces long-lasting glutamatergic activation of VTA dopamine neurons. Neuroscience Letters. 564: 72-7. PMID 24525246 DOI: 10.1016/J.Neulet.2014.01.032  0.4
2014 Manaka K, Nakata M, Shimomura K, Rita RS, Maejima Y, Yoshida M, Dezaki K, Kakei M, Yada T. Chronic exposure to valproic acid promotes insulin release, reduces KATP channel current and does not affect Ca (2+) signaling in mouse islets. The Journal of Physiological Sciences : Jps. 64: 77-83. PMID 24105600 DOI: 10.1007/S12576-013-0294-3  0.42
2013 Maekawa F, Fujiwara K, Toriya M, Maejima Y, Nishio T, Toyoda Y, Nohara K, Yashiro T, Yada T. Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats. Frontiers in Synaptic Neuroscience. 5: 7. PMID 24106476 DOI: 10.3389/Fnsyn.2013.00007  0.595
2013 Maejima Y, Shimomura K, Sakuma K, Yang Y, Arai T, Mori M, Yada T. Paraventricular nucleus nesfatin-1 neurons are regulated by pituitary adenylate cyclase-activating polypeptide (PACAP). Neuroscience Letters. 551: 39-42. PMID 23872089 DOI: 10.1016/J.Neulet.2013.07.006  0.427
2013 Iwasaki Y, Shimomura K, Kohno D, Dezaki K, Ayush EA, Nakabayashi H, Kubota N, Kadowaki T, Kakei M, Nakata M, Yada T. Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca(2+) Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity. Plos One. 8: e67198. PMID 23840624 DOI: 10.1371/Journal.Pone.0067198  0.453
2013 Arai T, Maejima Y, Muroya S, Yada T. Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. Neuropeptides. 47: 225-30. PMID 23756052 DOI: 10.1016/J.Npep.2013.05.004  0.378
2013 Iwata T, Nakada T, Toyoda F, Yada T, Shioda S, Kikuyama S. Responsiveness of vomeronasal cells to a newt peptide pheromone, sodefrin as monitored by changes of intracellular calcium concentrations. Peptides. 45: 15-21. PMID 23619348 DOI: 10.1016/J.Peptides.2013.04.006  0.373
2013 Sedbazar U, Maejima Y, Nakata M, Mori M, Yada T. Paraventricular NUCB2/nesfatin-1 rises in synchrony with feeding suppression during early light phase in rats. Biochemical and Biophysical Research Communications. 434: 434-8. PMID 23583201 DOI: 10.1016/J.Bbrc.2013.03.090  0.307
2013 Nakata M, Yada T. Role of NUCB2/nesfatin-1 in glucose control: diverse functions in islets, adipocytes and brain. Current Pharmaceutical Design. 19: 6960-5. PMID 23537085 DOI: 10.2174/138161281939131127130112  0.378
2013 Mori M, Yamada M, Okada S, Hashimoto K, Satoh T, Shimizu H, Yada T. Discovery of nesfatin-1 and overview of biological actions and new developments. Current Pharmaceutical Design. 19: 6921-8. PMID 23537081 DOI: 10.2174/138161281939131127123527  0.333
2013 Yang Y, Shimomura K, Sakuma K, Maejima Y, Iwasaki Y, Galvanovskis J, Dezaki K, Nakata M, Yada T. Bupropion can close KATP channel and induce insulin secretion. Journal of Pediatric Endocrinology & Metabolism : Jpem. 26: 343-6. PMID 23348218 DOI: 10.1515/Jpem-2012-0295  0.328
2013 Aoki H, Nakata M, Dezaki K, Lu M, Gantulga D, Yamamoto K, Shimada K, Kario K, Yada T. Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats. Endocrine Journal. 60: 571-81. PMID 23328675 DOI: 10.1507/Endocrj.Ej12-0371  0.306
2013 Takei M, Dezaki K, Ishii H, Nishio S, Sato Y, Suzuki S, Yada T, Komatsu M. A new experimental model of ATP-sensitive K⁺ channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells. Endocrine Journal. 60: 599-607. PMID 23327802 DOI: 10.1507/Endocrj.Ej12-0388  0.441
2013 Kodera SY, Yoshida M, Dezaki K, Yada T, Murayama T, Kawakami M, Kakei M. Inhibition of insulin secretion from rat pancreatic islets by dexmedetomidine and medetomidine, two sedatives frequently used in clinical settings. Endocrine Journal. 60: 337-46. PMID 23171706 DOI: 10.1507/Endocrj.Ej12-0308  0.38
2013 Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T. Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons. Neuropeptides. 47: 19-23. PMID 22944736 DOI: 10.1016/J.Npep.2012.07.006  0.457
2012 Kohno D, Yada T. Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding. Neuropeptides. 46: 315-9. PMID 23107365 DOI: 10.1016/J.Npep.2012.09.004  0.426
2012 Iwasaki Y, Yada T. Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role. Neuropeptides. 46: 291-7. PMID 23020951 DOI: 10.1016/J.Npep.2012.08.009  0.38
2012 Dezaki K, Yada T. Islet β-cell ghrelin signaling for inhibition of insulin secretion. Methods in Enzymology. 514: 317-31. PMID 22975062 DOI: 10.1016/B978-0-12-381272-8.00020-9  0.442
2012 Damdindorj B, Dezaki K, Kurashina T, Sone H, Rita R, Kakei M, Yada T. Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells. Febs Letters. 586: 2555-62. PMID 22750144 DOI: 10.1016/J.Febslet.2012.06.034  0.456
2012 Yada T, Kohno D, Maejima Y, Sedbazar U, Arai T, Toriya M, Maekawa F, Kurita H, Niijima A, Yakabi K. Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia. Current Pharmaceutical Design. 18: 4854-64. PMID 22632865 DOI: 10.2174/138161212803216898  0.607
2012 Gantulga D, Maejima Y, Nakata M, Yada T. Glucose and insulin induce Ca2+ signaling in nesfatin-1 neurons in the hypothalamic paraventricular nucleus. Biochemical and Biophysical Research Communications. 420: 811-5. PMID 22465118 DOI: 10.1016/J.Bbrc.2012.03.079  0.482
2011 Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A. Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival. Translational Psychiatry. 1: e23. PMID 22832525 DOI: 10.1038/Tp.2011.25  0.323
2011 Maejima Y, Kohno D, Iwasaki Y, Yada T. Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Aging. 3: 1092-7. PMID 22081645  0.377
2011 Dezaki K, Damdindorj B, Sone H, Dyachok O, Tengholm A, Gylfe E, Kurashina T, Yoshida M, Kakei M, Yada T. Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. Diabetes. 60: 2315-24. PMID 21788571 DOI: 10.2337/Db11-0368  0.469
2011 Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, et al. PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. Plos One. 6: e18324. PMID 21694754 DOI: 10.1371/Journal.Pone.0018324  0.424
2011 Eiki J, Yada T. Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia. Endocrine Journal. 58: 691-8. PMID 21673460 DOI: 10.1507/Endocrj.K11E-096  0.395
2011 Kohno D, Sone H, Tanaka S, Kurita H, Gantulga D, Yada T. AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. Neuroscience Letters. 499: 194-8. PMID 21658429 DOI: 10.1016/J.Neulet.2011.05.060  0.452
2011 Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M. Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behavioural Brain Research. 221: 172-81. PMID 21377499 DOI: 10.1016/J.Bbr.2011.02.037  0.495
2011 Nakata M, Manaka K, Yamamoto S, Mori M, Yada T. Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet β-cells. Endocrine Journal. 58: 305-13. PMID 21325742 DOI: 10.1507/Endocrj.K11E-056  0.444
2011 Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes. 60: 119-26. PMID 20921208 DOI: 10.2337/Db10-0276  0.428
2010 Koizumi M, Dezaki K, Hosoda H, Damdindorj B, Sone H, Ming L, Hosoya Y, Sata N, Kobayashi E, Kangawa K, Nagai H, Yasuda Y, Yada T. Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats. International Journal of Peptides. 2010. PMID 20721337 DOI: 10.1155/2010/365416  0.312
2010 Toriya M, Maekawa F, Maejima Y, Onaka T, Fujiwara K, Nakagawa T, Nakata M, Yada T. Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology. 22: 987-95. PMID 20561155 DOI: 10.1111/J.1365-2826.2010.02039.X  0.582
2010 Nakata M, Shintani N, Hashimoto H, Baba A, Yada T. Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity. Journal of Molecular Neuroscience : Mn. 42: 404-10. PMID 20461496 DOI: 10.1007/S12031-010-9383-4  0.413
2010 Yoshida M, Nakata M, Yamato S, Dezaki K, Sugawara H, Ishikawa SE, Kawakami M, Yada T, Kakei M. Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells. Biochemical and Biophysical Research Communications. 396: 304-9. PMID 20403337 DOI: 10.1016/J.Bbrc.2010.04.088  0.323
2010 Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S, Itoh H, Noda T, Kasuga M, Nakae J. PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. American Journal of Physiology. Endocrinology and Metabolism. 298: E787-98. PMID 20103739 DOI: 10.1152/Ajpendo.00512.2009  0.396
2009 Mori S, Takizawa M, Satou M, Sakasai M, Kusuoku H, Nojiri H, Yoshizuka N, Hotta M, Kitahara T, Hase T, Takema Y, Saito M, Yada T. Enhancement of lipolytic responsiveness of adipocytes by novel plant extract in rat. Experimental Biology and Medicine (Maywood, N.J.). 234: 1445-9. PMID 19934365 DOI: 10.3181/0904-Rm-123  0.328
2009 Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, ... ... Yada T, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metabolism. 10: 355-65. PMID 19883614 DOI: 10.1016/J.Cmet.2009.09.002  0.437
2009 Iwasaki Y, Nakabayashi H, Kakei M, Shimizu H, Mori M, Yada T. Nesfatin-1 evokes Ca2+ signaling in isolated vagal afferent neurons via Ca2+ influx through N-type channels. Biochemical and Biophysical Research Communications. 390: 958-62. PMID 19852938 DOI: 10.1016/J.Bbrc.2009.10.085  0.433
2009 Yoshida M, Dezaki K, Yamato S, Aoki A, Sugawara H, Toyoshima H, Ishikawa SE, Kawakami M, Nakata M, Yada T, Kakei M. Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells. Febs Letters. 583: 2225-30. PMID 19500583 DOI: 10.1016/J.Febslet.2009.05.050  0.357
2009 Mori S, Satou M, Kanazawa S, Yoshizuka N, Hase T, Tokimitsu I, Takema Y, Nishizawa Y, Yada T. Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract. International Journal of Biological Sciences. 5: 311-8. PMID 19421341 DOI: 10.7150/Ijbs.5.311  0.307
2009 Eiki J, Saeki K, Nagano N, Iino T, Yonemoto M, Takayenoki-Iino Y, Ito S, Nishimura T, Sato Y, Bamba M, Watanabe H, Sasaki K, Ohyama S, Kanatani A, Nagase T, ... Yada T, et al. A selective small molecule glucagon-like peptide-1 secretagogue acting via depolarization-coupled Ca(2+) influx. The Journal of Endocrinology. 201: 361-7. PMID 19332449 DOI: 10.1677/Joe-08-0528  0.416
2009 Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology. 150: 662-71. PMID 19176321 DOI: 10.1210/En.2008-0598  0.355
2009 Maekawa F, Yada T, Ando A, Kurita H. Metabolic factor-coupled signal transduction regulates hypothalamic NPY neurons and feeding Neuroscience Research. 65: S11. DOI: 10.1016/J.Neures.2009.09.1532  0.578
2008 Takayanagi Y, Matsumoto H, Nakata M, Mera T, Fukusumi S, Hinuma S, Ueta Y, Yada T, Leng G, Onaka T. Endogenous prolactin-releasing peptide regulates food intake in rodents. The Journal of Clinical Investigation. 118: 4014-24. PMID 19033670 DOI: 10.1172/Jci34682  0.371
2008 Kohno D, Suyama S, Yada T. Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2+ signaling in neuropeptide Y neurons of the arcuate nucleus. World Journal of Gastroenterology : Wjg. 14: 6347-54. PMID 19009650 DOI: 10.3748/Wjg.14.6347  0.487
2008 Tomimoto S, Ojika T, Shintani N, Hashimoto H, Hamagami K, Ikeda K, Nakata M, Yada T, Sakurai Y, Shimada T, Morita Y, Ishida C, Baba A. Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice. Journal of Pharmacological Sciences. 107: 41-8. PMID 18446003 DOI: 10.1254/Jphs.Fp0072173  0.386
2008 Koizumi M, Yada T. Sub-chronic stimulation of glucocorticoid receptor impairs and mineralocorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic beta-cells. The Journal of Endocrinology. 197: 221-9. PMID 18434352 DOI: 10.1677/Joe-07-0462  0.417
2008 Dezaki K, Sone H, Yada T. Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacology & Therapeutics. 118: 239-49. PMID 18433874 DOI: 10.1016/J.Pharmthera.2008.02.008  0.421
2008 Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M. Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential. Current Diabetes Reviews. 4: 18-23. PMID 18220691 DOI: 10.2174/157339908783502352  0.419
2008 Kohno D, Sone H, Minokoshi Y, Yada T. Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons. Biochemical and Biophysical Research Communications. 366: 388-92. PMID 18068666 DOI: 10.1016/J.Bbrc.2007.11.166  0.462
2008 Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Yoshida N, Dezaki K, Onaka T, Mori M, Yada T. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology. 149: 1295-301. PMID 18048495 DOI: 10.1210/En.2007-1276  0.397
2008 Hori Y, Kageyama H, Guan JL, Kohno D, Yada T, Takenoya F, Nonaka N, Kangawa K, Shioda S, Yoshida T. Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus. Regulatory Peptides. 145: 122-7. PMID 17931715 DOI: 10.1016/J.Regpep.2007.09.027  0.408
2008 Nakata M, Yada T. Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors. Regulatory Peptides. 145: 49-53. PMID 17884194 DOI: 10.1016/J.Regpep.2007.08.009  0.418
2008 Dezaki K, Kageyama H, Seki M, Shioda S, Yada T. Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca2+ influx through L-type Ca2+ channels in beta-cells and localization in islets. Regulatory Peptides. 145: 153-8. PMID 17868932 DOI: 10.1016/J.Regpep.2007.08.008  0.475
2007 Iwasaki H, Yada T. Protein arginine methylation regulates insulin signaling in L6 skeletal muscle cells. Biochemical and Biophysical Research Communications. 364: 1015-21. PMID 17971302 DOI: 10.1016/J.Bbrc.2007.10.113  0.359
2007 Maekawa F, Nakamori T, Uchimura M, Fujiwara K, Yada T, Tsukahara S, Kanamatsu T, Tanaka K, Ohki-Hamazaki H. Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior. Journal of Neurochemistry. 102: 1645-57. PMID 17697050 DOI: 10.1111/J.1471-4159.2007.04733.X  0.543
2007 Dezaki K, Kakei M, Yada T. Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin. Diabetes. 56: 2319-27. PMID 17575083 DOI: 10.2337/Db07-0345  0.459
2007 Nakata M, Yada T. PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential. Current Pharmaceutical Design. 13: 1105-12. PMID 17430174 DOI: 10.2174/138161207780618948  0.432
2007 Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T. Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway. Endocrinology. 148: 2251-63. PMID 17303662 DOI: 10.1210/En.2006-1240  0.657
2007 Fujiwara K, Maekawa F, Dezaki K, Nakata M, Yashiro T, Yada T. Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via endoplasmic reticulum Ca2+ release and Ca2+ influx in the rat islet alpha-cells. Endocrinology. 148: 2496-504. PMID 17289853 DOI: 10.1210/En.2006-1156  0.619
2007 Nakata M, Okada T, Ozawa K, Yada T. Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochemical and Biophysical Research Communications. 353: 1046-51. PMID 17207771 DOI: 10.1016/J.Bbrc.2006.12.134  0.379
2007 Fujiwara K, Maekawa F, Kikuchi M, Takigami S, Yada T, Yashiro T. Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats. Cell and Tissue Research. 328: 129-35. PMID 17180597 DOI: 10.1007/S00441-006-0345-7  0.537
2006 Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes. 55: 3486-93. PMID 17130496 DOI: 10.2337/Db06-0878  0.411
2006 Momose K, Nunomiya S, Nakata M, Yada T, Kikuchi M, Yashiro T. Immunohistochemical and electron-microscopic observation of beta-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. Medical Molecular Morphology. 39: 146-53. PMID 16998625 DOI: 10.1007/S00795-006-0324-9  0.332
2006 Maekawa F, Fujiwara K, Kohno D, Kuramochi M, Kurita H, Yada T. Young adult-specific hyperphagia in diabetic Goto-kakizaki rats is associated with leptin resistance and elevation of neuropeptide Y mRNA in the arcuate nucleus. Journal of Neuroendocrinology. 18: 748-56. PMID 16965293 DOI: 10.1111/J.1365-2826.2006.01470.X  0.575
2006 Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL, Kohno D, Uramura K, Sougawa H, Yada T, Wayner MJ, et al. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides. 27: 2738-49. PMID 16914228 DOI: 10.1016/J.Peptides.2006.07.001  0.381
2006 Nakata M, Nagasaka S, Kusaka I, Matsuoka H, Ishibashi S, Yada T. Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control. Diabetologia. 49: 1881-92. PMID 16685502 DOI: 10.1007/S00125-006-0269-5  0.368
2006 Kuramochi M, Onaka T, Kohno D, Kato S, Yada T. Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat. Endocrinology. 147: 1744-52. PMID 16410310 DOI: 10.1210/En.2005-0907  0.4
2006 Maekawa F, Fujiwara K, Tsukahara S, Yada T. Pituitary adenylate cyclase-activating polypeptide neurons of the ventromedial hypothalamus project to the midbrain central gray. Neuroreport. 17: 221-4. PMID 16407775 DOI: 10.1097/01.Wnr.0000198945.62326.Ba  0.59
2005 Ikeda Y, Iguchi H, Nakata M, Ioka RX, Tanaka T, Iwasaki S, Magoori K, Takayasu S, Yamamoto TT, Kodama T, Yada T, Sakurai T, Yanagisawa M, Sakai J. Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. Biochemical and Biophysical Research Communications. 333: 778-86. PMID 15967412 DOI: 10.1016/J.Bbrc.2005.06.005  0.423
2005 Muroya S, Funahashi H, Uramura K, Shioda S, Yada T. Gamma aminobutyric acid regulates glucosensitive neuropeptide Y neurons in arcuate nucleus via A/B receptors. Neuroreport. 16: 897-901. PMID 15931058 DOI: 10.1097/00001756-200506210-00005  0.312
2005 Nakata M, Maruyama I, Yada T. Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line. Diabetes Research and Clinical Practice. 70: 209-16. PMID 15927298 DOI: 10.1016/J.Diabres.2005.03.036  0.384
2005 Fujiwara K, Maekawa F, Yada T. Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release. American Journal of Physiology. Endocrinology and Metabolism. 289: E670-7. PMID 15914509 DOI: 10.1152/Ajpendo.00035.2005  0.643
2005 Onaka T, Kuramochi M, Saito J, Ueta Y, Yada T. Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats. Neuroreport. 16: 243-7. PMID 15706228 DOI: 10.1097/00001756-200502280-00008  0.338
2005 Fujiwara K, Matsumoto H, Yada T, Inoue K. Identification of the prolactin-releasing peptide-producing cell in the rat adrenal gland. Regulatory Peptides. 126: 97-102. PMID 15620421 DOI: 10.1016/J.Regpep.2004.08.039  0.319
2005 Kuramochi M, Kohno D, Onaka T, Kato S, Yada T. Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus. Regulatory Peptides. 126: 85-9. PMID 15620419 DOI: 10.1016/J.Regpep.2004.08.017  0.454
2004 Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes. 53: 3142-51. PMID 15561944 DOI: 10.2337/Diabetes.53.12.3142  0.457
2004 Yamada H, Watanabe M, Yada T. Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic beta-cells are mediated by VPAC2 and PAC1 receptors. Regulatory Peptides. 123: 147-53. PMID 15518905 DOI: 10.1016/J.Regpep.2004.03.020  0.37
2004 Kakei M, Dezaki K, Yada T. [Methods for preparation and functional analysis of islet beta-cells]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 124: 345-52. PMID 15502400 DOI: 10.1254/Fpj.124.345  0.361
2004 Nakata M, Kohno D, Shintani N, Nemoto Y, Hashimoto H, Baba A, Yada T. PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus. Neuroscience Letters. 370: 252-6. PMID 15488333 DOI: 10.1016/J.Neulet.2004.08.034  0.508
2004 Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T. Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. The European Journal of Neuroscience. 19: 1524-34. PMID 15066149 DOI: 10.1111/J.1460-9568.2004.03255.X  0.492
2004 Nakata M, Yada T. [Physiological and therapeutic roles of PACAP in glucose metabolism and diabetes]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 123: 267-73. PMID 15056942 DOI: 10.1254/Fpj.123.267  0.44
2003 Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S. Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors. Neuroreport. 14: 1997-2000. PMID 14561937 DOI: 10.1097/00001756-200310270-00024  0.337
2003 Funahashi H, Takenoya F, Guan JL, Kageyama H, Yada T, Shioda S. Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding. Anatomical Science International. 78: 123-38. PMID 14527127 DOI: 10.1046/J.0022-7722.2003.00055.X  0.414
2003 Nakata M, Yada T. Endocrinology: nitric oxide-mediated insulin secretion in response to citrulline in islet beta-cells. Pancreas. 27: 209-13. PMID 14508123 DOI: 10.1097/00006676-200310000-00001  0.429
2003 Sasa M, Nishi A, Kobayashi K, Sano H, Momiyama T, Uramura K, Yada T, Mori N, Suzuki K, Minabe Y. [Regulation of psychomotor functions by dopamine: integration of various approaches]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 122: 215-25. PMID 12939539 DOI: 10.1254/Fpj.122.215  0.38
2003 Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Journal of Pharmacological Sciences. 92: 259-66. PMID 12890892 DOI: 10.1254/Jphs.92.259  0.384
2003 Funahashi H, Yada T, Suzuki R, Shioda S. Distribution, function, and properties of leptin receptors in the brain. International Review of Cytology. 224: 1-27. PMID 12722947 DOI: 10.1016/S0074-7696(05)24001-9  0.373
2003 Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes. 52: 948-56. PMID 12663466 DOI: 10.2337/Diabetes.52.4.948  0.493
2002 Kakei M, Yada T, Nakagawa A, Nakabayashi H. Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons. Autonomic Neuroscience : Basic & Clinical. 102: 39-44. PMID 12492134 DOI: 10.1016/S1566-0702(02)00182-0  0.43
2002 Zhou CJ, Shioda S, Yada T, Inagaki N, Pleasure SJ, Kikuyama S. PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Current Protein & Peptide Science. 3: 423-39. PMID 12370005 DOI: 10.2174/1389203023380576  0.318
2002 Zhu L, Onaka T, Sakurai T, Yada T. Activation of orexin neurones after noxious but not conditioned fear stimuli in rats. Neuroreport. 13: 1351-3. PMID 12151801 DOI: 10.1097/00001756-200207190-00027  0.372
2002 Nakazaki M, Kakei M, Ishihara H, Koriyama N, Hashiguchi H, Aso K, Fukudome M, Oka Y, Yada T, Tei C. Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. The Journal of Physiology. 540: 781-9. PMID 11986368 DOI: 10.1113/Jphysiol.2001.013048  0.414
2002 Yamada S, Komatsu M, Aizawa T, Sato Y, Yajima H, Yada T, Hashiguchi S, Yamauchi K, Hashizume K. Time-dependent potentiation of the beta-cell is a Ca2+-independent phenomenon. The Journal of Endocrinology. 172: 345-54. PMID 11834452 DOI: 10.1677/Joe.0.1720345  0.415
2002 Yanagida K, Yaekura K, Arima T, Yada T. Glucose-insensitivity induced by Ca(2+) toxicity in islet beta-cells and its prevention by PACAP. Peptides. 23: 135-42. PMID 11814628 DOI: 10.1016/S0196-9781(01)00589-7  0.406
2002 Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes. 51: 124-9. PMID 11756331 DOI: 10.2337/Diabetes.51.1.124  0.412
2001 Aizawa T, Kaneko T, Yamauchi K, Yajima H, Nishizawa T, Yada T, Matsukawa H, Nagai M, Yamada S, Sato Y, Komatsu M, Itoh N, Hidaka H, Kajimoto Y, Hashizume K. Size-related and size-unrelated functional heterogeneity among pancreatic islets. Life Sciences. 69: 2627-39. PMID 11712666 DOI: 10.1016/S0024-3205(01)01332-7  0.379
2001 Koriyama N, Kakei M, Nakazaki M, Yaekura K, Hashiguchi H, Aso K, Fukudome M, Yada T, Ito S, Tei C. Free radical-mediated tolbutamide desensitization of K+ATP channels in rat pancreatic beta-cells. Endocrine Journal. 48: 337-44. PMID 11523905 DOI: 10.1507/Endocrj.48.337  0.343
2001 Muroya S, Uramura K, Sakurai T, Takigawa M, Yada T. Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus. Neuroscience Letters. 309: 165-8. PMID 11514067 DOI: 10.1016/S0304-3940(01)02053-5  0.485
2001 Zhou CJ, Yada T, Kohno D, Kikuyama S, Suzuki R, Mizushima H, Shioda S. PACAP activates PKA, PKC and Ca(2+) signaling cascades in rat neuroepithelial cells. Peptides. 22: 1111-7. PMID 11445242 DOI: 10.1016/S0196-9781(01)00437-5  0.381
2001 Uramura K, Funahashi H, Muroya S, Shioda S, Takigawa M, Yada T. Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area. Neuroreport. 12: 1885-9. PMID 11435917 DOI: 10.1097/00001756-200107030-00024  0.405
2001 Hashiguchi S, Yada T, Arima T. A new hypoglycemic agent, JTT-608, evokes protein kinase A-mediated Ca(2+) signaling in rat islet beta-cells: strict regulation by glucose, link to insulin release, and cooperation with glucagon-like peptide-1(7-36)amide and pituitary adenylate cyclase-activating polypeptide. The Journal of Pharmacology and Experimental Therapeutics. 296: 22-30. PMID 11123358  0.353
2000 Yada T, Nakata M, Shioda S. Insulinotropin PACAP potentiates insulin action. Stimulation of glucose uptake in 3T3-LI adipocytes. Annals of the New York Academy of Sciences. 921: 473-7. PMID 11193879 DOI: 10.1111/J.1749-6632.2000.Tb07018.X  0.384
2000 Shioda S, Yada T, Muroya S, Uramura S, Nakajo S, Ohtaki H, Hori T, Shimoda Y, Funahashi H. Functional significance of colocalization of PACAP and catecholamine in nerve terminals. Annals of the New York Academy of Sciences. 921: 211-7. PMID 11193825 DOI: 10.1111/J.1749-6632.2000.Tb06968.X  0.438
2000 Uramura K, Yada T, Muroya S, Takigawa M. Ca2+ oscillations in response to methamphetamine in dopamine neurons of the ventral tegmental area in rats subchronically treated with this drug. Annals of the New York Academy of Sciences. 914: 316-22. PMID 11085332 DOI: 10.1111/J.1749-6632.2000.Tb05207.X  0.403
2000 Koriyama N, Kakei M, Nakazaki M, Yaekura K, Ichinari K, Gong Q, Morimitsu S, Yada T, Tei C. PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells. Diabetes. 49: 1830-9. PMID 11078449 DOI: 10.2337/Diabetes.49.11.1830  0.343
2000 Nakazaki M, Kakei M, Yaekura K, Koriyama N, Morimitsu S, Ichinari K, Yada T, Tei C. Diverse effects of hydrogen peroxide on cytosolic Ca2+ homeostasis in rat pancreatic beta-cells. Cell Structure and Function. 25: 187-93. PMID 10984102 DOI: 10.1247/Csf.25.187  0.372
2000 Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Research. 873: 181-7. PMID 10915829 DOI: 10.1016/S0006-8993(00)02555-5  0.351
2000 Uramura K, Yada T, Muroya S, Shioda S, Shiratani T, Takigawa M. Methamphetamine induces cytosolic Ca2+ oscillations in the VTA dopamine neurons. Neuroreport. 11: 1057-61. PMID 10790882 DOI: 10.1097/00001756-200004070-00031  0.41
1999 Nakata M, Uto N, Maruyama I, Yada T. Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6. Cell Structure and Function. 24: 451-5. PMID 10698259 DOI: 10.1247/Csf.24.451  0.365
1999 Nakata M, Shioda S, Oka Y, Maruyama I, Yada T. Insulinotropin PACAP potentiates insulin-stimulated glucose uptake in 3T3 L1 cells. Peptides. 20: 943-8. PMID 10503772 DOI: 10.1016/S0196-9781(99)00085-6  0.389
1999 Funahashi H, Yada T, Muroya S, Takigawa M, Ryushi T, Horie S, Nakai Y, Shioda S. The effect of leptin on feeding-regulating neurons in the rat hypothalamus. Neuroscience Letters. 264: 117-20. PMID 10320028 DOI: 10.1016/S0304-3940(99)00186-X  0.491
1999 Muroya S, Yada T, Shioda S, Takigawa M. Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y. Neuroscience Letters. 264: 113-6. PMID 10320027 DOI: 10.1016/S0304-3940(99)00185-8  0.48
1999 Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. British Journal of Pharmacology. 126: 1205-13. PMID 10205010 DOI: 10.1038/Sj.Bjp.0702397  0.435
1998 Yaekura K, Yada T. [Ca]-reducing action of cAMP in rat pancreatic β-cells: involvement of thapsigargin-sensitive stores. American Journal of Physiology. Cell Physiology. 274: C513-C521. PMID 29590922 DOI: 10.1152/ajpcell.1998.274.2.C513  0.311
1998 Yada T, Sakurada M, Nakata M, Shioda S, Yaekura K, Kikuchi M. Autocrine action of PACAP in islets augments glucose-induced insulin secretion. Annals of the New York Academy of Sciences. 865: 451-7. PMID 9928048 DOI: 10.1111/J.1749-6632.1998.Tb11214.X  0.374
1998 Yaekura K, Yanagida K, Yada T. PACAP and GLP-1 protect islet beta-cells against Ca2+ toxicity induced by high K+. Annals of the New York Academy of Sciences. 865: 445-50. PMID 9928047 DOI: 10.1111/J.1749-6632.1998.Tb11213.X  0.334
1998 Shioda S, Yada T, Nakajo S, Nakai Y, Arimura A. PACAP increases cytosolic calcium in vasopressin neurons: synergism with noradrenaline. Annals of the New York Academy of Sciences. 865: 427-30. PMID 9928043 DOI: 10.1111/J.1749-6632.1998.Tb11209.X  0.331
1998 Nakazaki M, Ishihara H, Kakei M, Inukai K, Asano T, Miyazaki JI, Tanaka H, Kikuchi M, Yada T, Oka Y. Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6. Diabetologia. 41: 279-86. PMID 9541167 DOI: 10.1007/S001250050904  0.368
1998 Shioda S, Funahashi H, Nakajo S, Yada T, Maruta O, Nakai Y. Immunohistochemical localization of leptin receptor in the rat brain. Neuroscience Letters. 243: 41-4. PMID 9535108 DOI: 10.1016/S0304-3940(98)00082-2  0.302
1998 Yaekura K, Yada T. [Ca2+]i-reducing action of cAMP in rat pancreatic beta-cells: involvement of thapsigargin-sensitive stores. The American Journal of Physiology. 274: C513-21. PMID 9486142 DOI: 10.1152/Ajpcell.1998.274.2.C513  0.385
1997 Yaekura K, Nakata M, Tanaka H, Yada T. Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells. Advances in Experimental Medicine and Biology. 426: 211-6. PMID 9544276 DOI: 10.1007/978-1-4899-1819-2_28  0.446
1997 Yada T, Sakurada M, Nakata M, Yaekura K, Kikuchi M. PACAP as low as 10(-13) M raises cytosolic Ca2+ activity in pancreatic B-cells by augmenting Ca2+ influx through L-type Ca2+ channels to trigger insulin release. Advances in Experimental Medicine and Biology. 426: 165-71. PMID 9544270 DOI: 10.1007/978-1-4899-1819-2_22  0.405
1997 Yada T. Extracellular messages for pancreatic B-cells. Advances in Experimental Medicine and Biology. 426: 103-12. PMID 9544262 DOI: 10.1007/978-1-4899-1819-2_14  0.349
1997 Shioda S, Yada T, Muroya S, Takigawa M, Nakai Y. Nicotine increases cytosolic Ca2+ in vasopressin neurons. Neuroscience Research. 29: 311-8. PMID 9527622 DOI: 10.1016/S0168-0102(97)00103-X  0.411
1997 Yada T, Sakurada M, Ishihara H, Nakata M, Shioda S, Yaekura K, Hamakawa N, Yanagida K, Kikuchi M, Oka Y. Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats. The Journal of Physiology. 505: 319-28. PMID 9423175 DOI: 10.1111/J.1469-7793.1997.319Bb.X  0.458
1997 Tanizawa Y, Okuya S, Ishihara H, Asano T, Yada T, Oka Y. Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells. Endocrinology. 138: 4513-6. PMID 9322975 DOI: 10.1210/Endo.138.10.5576  0.414
1997 Shioda S, Yada T, Nakajo S, Nakaya K, Nakai Y, Arimura A. Pituitary adenylate cyclase-activating polypeptide (PACAP): a novel regulator of vasopressin-containing neurons. Brain Research. 765: 81-90. PMID 9310397 DOI: 10.1016/S0006-8993(97)00512-X  0.454
1997 Nakata M, Yada T, Nakagawa S, Kobayashi K, Maruyama I. Citrulline-argininosuccinate-arginine cycle coupled to Ca2+-signaling in rat pancreatic beta-cells. Biochemical and Biophysical Research Communications. 235: 619-24. PMID 9207208 DOI: 10.1006/Bbrc.1997.6854  0.358
1997 Shioda S, Yada T, Muroya S, Takigawa M, Nakai Y. Noradrenaline activates vasopressin neurons via alpha1-receptor-mediated Ca2+ signaling pathway. Neuroscience Letters. 226: 210-2. PMID 9175604 DOI: 10.1016/S0304-3940(97)00275-9  0.416
1997 Fujitani S, Okazaki K, Yada T. The ability of a new hypoglycaemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition. British Journal of Pharmacology. 120: 1191-8. PMID 9105692 DOI: 10.1038/Sj.Bjp.0701017  0.412
1996 Yada T, Sakurada M, Nakata M, Ihida K, Yaekura K, Shioda S, Kikuchi M. Current status of PACAP as a regulator of insulin secretion in pancreatic islets. Annals of the New York Academy of Sciences. 805: 329-40; discussion 3. PMID 8993414 DOI: 10.1111/J.1749-6632.1996.Tb17494.X  0.466
1996 Fujitani S, Ikenoue T, Akiyoshi M, Maki T, Yada T. Somatostatin and insulin secretion due to common mechanisms by a new hypoglycemic agent, A-4166, in perfused rat pancreas. Metabolism: Clinical and Experimental. 45: 184-9. PMID 8596487 DOI: 10.1016/S0026-0495(96)90051-7  0.448
1996 Yaekura K, Kakei M, Yada T. cAMP-signaling pathway acts in selective synergism with glucose or tolbutamide to increase cytosolic Ca2+ in rat pancreatic beta-cells. Diabetes. 45: 295-301. PMID 8593933 DOI: 10.2337/Diab.45.3.295  0.432
1996 Yada T, Hamakawa N, Yaekura K. Two distinct modes of Ca2+ signalling by ACh in rat pancreatic beta-cells: concentration, glucose dependence and Ca2+ origin. The Journal of Physiology. 13-24. PMID 8568649 DOI: 10.1113/Jphysiol.1995.Sp020942  0.409
1995 Aizawa T, Yada T, Asanuma N, Sato Y, Ishihara F, Hamakawa N, Yaekura K, Hashizume K. Effects of thapsigargin, an intracellular CA2+ pump inhibitor, on insulin release by rat pancreatic B-cell. Life Sciences. 57: 1375-81. PMID 7564885 DOI: 10.1016/0024-3205(95)02095-Z  0.441
1995 Hamakawa N, Yada T. Interplay of glucose-stimulated Ca2+ sequestration and acetylcholine-induced Ca2+ release at the endoplasmic reticulum in rat pancreatic beta-cells. Cell Calcium. 17: 21-31. PMID 7553778 DOI: 10.1016/0143-4160(95)90099-3  0.305
1994 Fujitani S, Yada T. A novel D-phenylalanine-derivative hypoglycemic agent A-4166 increases cytosolic free Ca2+ in rat pancreatic beta-cells by stimulating Ca2+ influx. Endocrinology. 134: 1395-400. PMID 8119179 DOI: 10.1210/Endo.134.3.8119179  0.442
1994 Nakahara K, Yada T, Kuriyama M, Osame M. Cytosolic Ca2+ increase and cell damage in L6 rat myoblasts by HMG-CoA reductase inhibitors. Biochemical and Biophysical Research Communications. 202: 1579-85. PMID 8060342 DOI: 10.1006/Bbrc.1994.2112  0.369
1993 Yada T, Vigh S, Arimura A. Pituitary adenylate cyclase activating polypeptide (PACAP) increases cytosolic-free calcium concentration in folliculo-stellate cells and somatotropes of rat pituitary. Peptides. 14: 235-9. PMID 8483802 DOI: 10.1016/0196-9781(93)90035-F  0.363
1993 Yada T, Itoh K, Nakata M. Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity. Endocrinology. 133: 1685-92. PMID 8404610 DOI: 10.1210/Endo.133.4.8404610  0.425
1992 Yada T, Kakei M, Tanaka H. Single pancreatic beta-cells from normal rats exhibit an initial decrease and subsequent increase in cytosolic free Ca2+ in response to glucose. Cell Calcium. 13: 69-76. PMID 1540989 DOI: 10.1016/0143-4160(92)90031-M  0.316
1992 Tatsuno I, Yada T, Vigh S, Hidaka H, Arimura A. Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide increase cytosolic free calcium concentration in cultured rat hippocampal neurons. Endocrinology. 131: 73-81. PMID 1319331 DOI: 10.1210/ENDO.131.1.1319331  0.331
1991 Nakamura H, Yada T, Saheki T, Noda T, Nakagawa S. L-argininosuccinate modulates L-glutamate response in acutely isolated cerebellar neurons of immature rat. Brain Research. 539: 312-5. PMID 1675909 DOI: 10.1016/0006-8993(91)91635-E  0.311
1990 Sorimachi M, Yamagami K, Yada T, Nishimura S. Spontaneous and secretagogue-induced changes in cytosolic free Ca concentration measured by microfluorimetry with fura-2 on single bovine adrenal chromaffin cells. The Japanese Journal of Physiology. 39: 687-701. PMID 2482378 DOI: 10.2170/Jjphysiol.39.687  0.361
1988 Pian-Smith MC, Yada T, Yaney GC, Abdel el Motal SM, Wiedenkeller DE, Sharp GW. Mobilization of Ca2+ from intracellular stores of pancreatic beta-cells by the calcium store blocker TMB-8. Endocrinology. 123: 1984-91. PMID 3046929 DOI: 10.1210/ENDO-123-4-1984  0.317
1988 Sorimachi M, Nishimura S, Yamagami K, Yada T. Fluoroaluminates stimulate histamine secretion in the digitonin-permeabilized rat mast cells. The Japanese Journal of Physiology. 38: 227-32. PMID 2459433 DOI: 10.2170/Jjphysiol.38.227  0.34
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