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Streamson Chua - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Animal Physiology Biology, Neuroscience Biology, Nutrition
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Iqbal NJ, Schwartz GJ, Zhao H, Zhu L, Chua S. Cyclin-dependent kinase 4/6 inhibitors require an arcuate to paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity. American Journal of Physiology. Endocrinology and Metabolism. PMID 33356996 DOI: 10.1152/ajpendo.00386.2020  0.346
2020 Iqbal J, Mascareno E, Chua S, Hussain MM. Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids. The Journal of Biological Chemistry. PMID 32047110 DOI: 10.1074/Jbc.Ra119.011881  0.364
2017 Liu S, Marcelin G, Blouet C, Jeong JH, Jo YH, Schwartz GJ, Chua S. A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Molecular Metabolism. PMID 29290621 DOI: 10.1016/J.Molmet.2017.12.003  0.326
2017 Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife. 6. PMID 28532548 DOI: 10.7554/Elife.22848  0.37
2017 Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu S, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. Author response: mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice Elife. DOI: 10.7554/Elife.22848.016  0.388
2016 Jeong JH, Woo YJ, Chua S, Jo YH. Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus. Plos One. 11: e0162839. PMID 27611685 DOI: 10.1371/Journal.Pone.0162839  0.379
2015 Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW. Leptin potentiates astrogenesis in the developing hypothalamus. Molecular Metabolism. 4: 881-889. PMID 26629411 DOI: 10.1016/J.Molmet.2015.08.005  0.418
2015 Jeong JH, Lee DK, Blouet C, Ruiz HH, Buettner C, Chua S, Schwartz GJ, Jo YH. Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism. Molecular Metabolism. 4: 483-92. PMID 26042202 DOI: 10.1016/J.Molmet.2015.03.006  0.41
2015 Lee DK, Jeong JH, Chun SK, Chua S, Jo YH. Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons. Nature Communications. 6: 6618. PMID 25808323 DOI: 10.1038/Ncomms7618  0.382
2014 Tavernier A, Cavin JB, Le Gall M, Ducroc R, Denis RG, Cluzeaud F, Guilmeau S, Sakar Y, Barbot L, Kapel N, Le Beyec J, Joly F, Chua S, Luquet S, Bado A. Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4100-10. PMID 24928195 DOI: 10.1096/Fj.14-255158  0.411
2014 Marcelin G, Jo YH, Li X, Schwartz GJ, Zhang Y, Dun NJ, Lyu RM, Blouet C, Chang JK, Chua S. Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism. Molecular Metabolism. 3: 19-28. PMID 24567901 DOI: 10.1016/J.Molmet.2013.10.002  0.405
2013 Sheffer-Babila S, Sun Y, Israel DD, Liu SM, Neal-Perry G, Chua SC. Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction. American Journal of Physiology. Endocrinology and Metabolism. 305: E1512-20. PMID 24169048 DOI: 10.1152/ajpendo.00241.2013  0.371
2013 Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW. Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11972-85. PMID 23864684 DOI: 10.1523/Jneurosci.0830-13.2013  0.384
2013 Lu Z, Marcelin G, Bauzon F, Wang H, Fu H, Dun SL, Zhao H, Li X, Jo YH, Wardlaw S, Dun N, Chua S, Zhu L. pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. The Embo Journal. 32: 844-57. PMID 23403926 DOI: 10.1038/Emboj.2013.25  0.439
2012 Marino JS, Iler J, Dowling AR, Chua S, Bruning JC, Coppari R, Hill JW. Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation. Plos One. 7: e48643. PMID 23119079 DOI: 10.1371/Journal.Pone.0048643  0.418
2012 Akhter N, Odle AK, Allensworth-James ML, Haney AC, Syed MM, Cozart MA, Chua S, Kineman R, Childs GV. Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesity. Endocrinology. 153: 4705-15. PMID 22865370 DOI: 10.1210/En.2012-1331  0.302
2012 Blouet C, Liu SM, Jo YH, Chua S, Schwartz GJ. TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9870-7. PMID 22815502 DOI: 10.1523/Jneurosci.0353-12.2012  0.398
2012 Israel DD, Sheffer-Babila S, de Luca C, Jo YH, Liu SM, Xia Q, Spergel DJ, Dun SL, Dun NJ, Chua SC. Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction. Endocrinology. 153: 2408-19. PMID 22408174 DOI: 10.1210/En.2011-1822  0.592
2012 Marcelin G, Liu SM, Li X, Schwartz GJ, Chua S. Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice. Journal of Lipid Research. 53: 964-72. PMID 22383686 DOI: 10.1194/Jlr.M022467  0.414
2012 Pan W, Hsuchou H, Cornelissen-Guillaume GG, Jayaram B, Wang Y, Tu H, Halberg F, Wu X, Chua SC, Kastin AJ. Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity. Journal of Applied Physiology (Bethesda, Md. : 1985). 112: 1410-8. PMID 22323652 DOI: 10.1152/japplphysiol.00590.2011  0.365
2011 Caviglia JM, Betters JL, Dapito DH, Lord CC, Sullivan S, Chua S, Yin T, Sekowski A, Mu H, Shapiro L, Brown JM, Brasaemle DL. Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity. Journal of Lipid Research. 52: 2032-42. PMID 21885429 DOI: 10.1194/Jlr.M019117  0.424
2011 Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 71: 142-54. PMID 21745644 DOI: 10.1016/J.Neuron.2011.05.028  0.414
2011 Luo N, Marcelin G, Liu SM, Schwartz G, Chua S. Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency. Endocrinology. 152: 883-9. PMID 21285324 DOI: 10.1210/En.2010-1135  0.437
2011 Donato J, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S, Coppari R, Zigman JM, et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. The Journal of Clinical Investigation. 121: 355-68. PMID 21183787 DOI: 10.1172/Jci45106  0.39
2011 Childs GV, Akhter N, Haney A, Syed M, Odle A, Cozart M, Brodrick Z, Gaddy D, Suva LJ, Akel N, Crane C, Benes H, Charlesworth A, Luque R, Chua S, et al. The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity. Endocrinology. 152: 69-81. PMID 21084451 DOI: 10.1210/En.2010-0498  0.406
2010 Chua S, Li Y, Liu SM, Liu R, Chan KT, Martino J, Zheng Z, Susztak K, D'Agati VD, Gharavi AG. A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8. Kidney International. 78: 453-62. PMID 20520596 DOI: 10.1038/Ki.2010.160  0.36
2010 Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, ... Chua S, et al. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metabolism. 11: 286-97. PMID 20374961 DOI: 10.1016/J.Cmet.2010.03.002  0.333
2010 Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S, Itoh H, Noda T, Kasuga M, Nakae J. PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. American Journal of Physiology. Endocrinology and Metabolism. 298: E787-98. PMID 20103739 DOI: 10.1152/Ajpendo.00512.2009  0.487
2010 Israel D, Chua S. Leptin receptor modulation of adiposity and fertility. Trends in Endocrinology and Metabolism: Tem. 21: 10-6. PMID 19854659 DOI: 10.1016/J.Tem.2009.07.004  0.395
2009 Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S, Diano S, Horvath TL, et al. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metabolism. 10: 89-98. PMID 19656487 DOI: 10.1016/J.Cmet.2009.06.011  0.409
2009 Nagajyothi F, Desruisseaux MS, Jelicks LA, Machado FS, Chua S, Scherer PE, Tanowitz HB. Perspectives on adipose tissue, chagas disease and implications for the metabolic syndrome. Interdisciplinary Perspectives On Infectious Diseases. 2009: 824324. PMID 19644556 DOI: 10.1155/2009/824324  0.301
2009 Jo YH, Chua S. Transcription factors in the development of medial hypothalamic structures. American Journal of Physiology. Endocrinology and Metabolism. 297: E563-7. PMID 19383874 DOI: 10.1152/Ajpendo.00064.2009  0.368
2009 Chua S. Signal transduction pathways for leptin: an embarrassment of riches. Diabetes. 58: 513-4. PMID 19246598 DOI: 10.2337/Db08-1646  0.428
2008 Kim KW, Jo YH, Zhao L, Stallings NR, Chua SC, Parker KL. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Molecular Endocrinology (Baltimore, Md.). 22: 1950-61. PMID 18511494 DOI: 10.1210/me.2008-0127  0.301
2008 van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, ... ... Chua SC, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 149: 1773-85. PMID 18162515 DOI: 10.1210/En.2007-1132  0.62
2007 Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L, Loh D, Li C, Chua S, Zhang Y. Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology. 148: 3987-97. PMID 17495001 DOI: 10.1210/En.2007-0261  0.446
2007 Dapito D, Caviglia JM, Chua S, Sekowski A, Yin T, Mu H, Shapiro L, Brasaemle DL. Adipose‐Selective Overexpression of CGI‐58 Does Not Alter Lipolysis or Protect Against Diet‐Induced Obesity The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A704-C  0.308
2006 Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metabolism. 4: 291-302. PMID 17011502 DOI: 10.1016/J.Cmet.2006.09.005  0.316
2006 Luo N, Liu SM, Liu H, Li Q, Xu Q, Sun X, Davis B, Li J, Chua S. Allelic variation on chromosome 5 controls beta-cell mass expansion during hyperglycemia in leptin receptor-deficient diabetes mice. Endocrinology. 147: 2287-95. PMID 16484328 DOI: 10.1210/En.2005-0853  0.401
2006 Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Elmquist JK, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 49: 191-203. PMID 16423694 DOI: 10.1016/J.Neuron.2005.12.021  0.472
2005 Jo YH, Chen YJ, Chua SC, Talmage DA, Role LW. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron. 48: 1055-66. PMID 16364907 DOI: 10.1016/J.Neuron.2005.10.021  0.324
2005 de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. The Journal of Clinical Investigation. 115: 3484-93. PMID 16284652 DOI: 10.1172/Jci24059  0.578
2005 Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC, Lowell BB, Elmquist JK. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metabolism. 1: 63-72. PMID 16054045 DOI: 10.1016/J.Cmet.2004.12.004  0.343
2005 Wang Z, Jiang T, Li J, Proctor G, McManaman JL, Lucia S, Chua S, Levi M. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes. 54: 2328-35. PMID 16046298 DOI: 10.2337/Diabetes.54.8.2328  0.34
2004 McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC. An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 677-85. PMID 15389315 DOI: 10.1007/S00335-004-2340-1  0.329
2004 Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC, Elmquist JK, Lowell BB. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 42: 983-91. PMID 15207242 DOI: 10.1016/j.neuron.2004.06.004  0.393
2004 Savontaus E, Breen TL, Kim A, Yang LM, Chua SC, Wardlaw SL. Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology. 145: 3881-91. PMID 15117873 DOI: 10.1210/En.2004-0263  0.328
2004 Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology. 145: 3258-64. PMID 15059949 DOI: 10.1210/En.2004-0219  0.398
2004 Tortoriello DV, McMinn J, Chua SC. Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology. 145: 1238-47. PMID 14670988 DOI: 10.1210/en.2003-1406  0.313
2004 Chua SC, Liu SM, Li Q, Sun A, DeNino WF, Heymsfield SB, Guo XE. Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. American Journal of Physiology. Endocrinology and Metabolism. 286: E384-92. PMID 14600075 DOI: 10.1152/Ajpendo.00349.2003  0.36
2002 Chua S, Liu SM, Li Q, Yang L, Thassanapaff VT, Fisher P. Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia. 45: 976-90. PMID 12136396 DOI: 10.1007/S00125-002-0880-Z  0.344
2001 Kowalski TJ, Liu SM, Leibel RL, Chua SC. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes. 50: 425-35. PMID 11272157 DOI: 10.2337/DIABETES.50.2.425  0.438
1998 Schreyer SA, Chua SC, Leboeuf RC. Obesity and diabetes in TNF-α receptor-deficient mice Journal of Clinical Investigation. 102: 402-411. PMID 9664082 DOI: 10.1172/Jci2849  0.305
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