| Year |
Citation |
Score |
| 2024 |
Keeney MT, Rocha EM, Hoffman EK, Farmer K, Di Maio R, Weir J, Wagner WG, Hu X, Clark CL, Castro SL, Scheirer A, Fazzari M, De Miranda BR, Pintchovski SA, Shrader WD, et al. LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease. Science Translational Medicine. 16: eadl3438. PMID 39356746 DOI: 10.1126/scitranslmed.adl3438 |
0.643 |
|
| 2024 |
Keeney MT, Hoffman EK, Weir J, Wagner WG, Rocha EM, Castro S, Farmer K, Fazzari M, Di Maio R, Konradi A, Hastings TG, Pintchovski SA, Shrader WD, Greenamyre JT. 15-Lipoxygenase-Mediated Lipid Peroxidation Regulates LRRK2 Kinase Activity. Biorxiv : the Preprint Server For Biology. PMID 38915558 DOI: 10.1101/2024.06.12.598654 |
0.635 |
|
| 2024 |
Sturchio A, Rocha EM, Kauffman MA, Marsili L, Mahajan A, Saraf AA, Vizcarra JA, Guo Z, Espay AJ. Recalibrating the Why and Whom of Animal Models in Parkinson Disease: A Clinician's Perspective. Brain Sciences. 14. PMID 38391726 DOI: 10.3390/brainsci14020151 |
0.347 |
|
| 2023 |
Rocha E, Chamoli M, Chinta SJ, Andersen JK, Wallis R, Bezard E, Goldberg M, Greenamyre T, Hirst W, Kuan WL, Kirik D, Niedernhofer L, Rappley I, Padmanabhan S, Trudeau LE, et al. Aging, Parkinson's Disease, and Models: What Are the Challenges? Aging Biology. 1. PMID 38978807 DOI: 10.59368/agingbio.20230010 |
0.401 |
|
| 2023 |
Van Laar AD, Webb KR, Keeney MT, Van Laar VS, Zharikov A, Burton EA, Hastings TG, Glajch KE, Hirst WD, Greenamyre JT, Rocha EM. Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy. Npj Parkinson's Disease. 9: 121. PMID 37567894 DOI: 10.1038/s41531-023-00561-6 |
0.562 |
|
| 2023 |
Mamais A, Wallings R, Rocha EM. Disease mechanisms as subtypes: Lysosomal dysfunction in the endolysosomal Parkinson's disease subtype. Handbook of Clinical Neurology. 193: 33-51. PMID 36803821 DOI: 10.1016/B978-0-323-85555-6.00009-6 |
0.449 |
|
| 2022 |
Rocha EM, Keeney MT, Di Maio R, De Miranda BR, Greenamyre JT. LRRK2 and idiopathic Parkinson's disease. Trends in Neurosciences. PMID 34991886 DOI: 10.1016/j.tins.2021.12.002 |
0.638 |
|
| 2021 |
De Miranda BR, Castro SL, Rocha EM, Bodle CR, Johnson KE, Greenamyre JT. The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease. Neurobiology of Disease. 105312. PMID 33636387 DOI: 10.1016/j.nbd.2021.105312 |
0.672 |
|
| 2020 |
De Miranda BR, Rocha EM, Castro SL, Greenamyre JT. Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20. Npj Parkinson's Disease. 6: 38. PMID 33293540 DOI: 10.1038/s41531-020-00139-6 |
0.603 |
|
| 2019 |
Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT. LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626. PMID 31618685 DOI: 10.1016/J.Nbd.2019.104626 |
0.692 |
|
| 2019 |
De Miranda BR, Fazzari M, Rocha EM, Castro S, Greenamyre JT. Sex differences in rotenone sensitivity reflect the male-to-female ratio in human Parkinson's disease incidence. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30907971 DOI: 10.1093/Toxsci/Kfz082 |
0.561 |
|
| 2018 |
Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT. LRRK2 activation in idiopathic Parkinson's disease. Science Translational Medicine. 10. PMID 30045977 DOI: 10.1126/Scitranslmed.Aar5429 |
0.692 |
|
| 2018 |
Hallett PJ, Huebecker M, Brekk OR, Moloney EB, Rocha EM, Priestman DA, Platt FM, Isacson O. Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. Neurobiology of Aging. 67: 189-200. PMID 29735433 DOI: 10.1016/j.neurobiolaging.2018.02.028 |
0.363 |
|
| 2018 |
De Miranda BR, Rocha EM, Bai Q, El Ayadi A, Hinkle D, Burton EA, Timothy Greenamyre J. Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease. Neurobiology of Disease. 115: 101-114. PMID 29649621 DOI: 10.1016/J.Nbd.2018.04.008 |
0.5 |
|
| 2017 |
Rocha EM, De Miranda B, Sanders LH. Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Neurobiology of Disease. PMID 28400134 DOI: 10.1016/J.Nbd.2017.04.004 |
0.676 |
|
| 2015 |
Smith GA, Jansson J, Rocha EM, Osborn T, Hallett PJ, Isacson O. Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Molecular Neurobiology. PMID 26399642 DOI: 10.1007/S12035-015-9435-4 |
0.468 |
|
| 2015 |
Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease. PMID 26392287 DOI: 10.1016/J.Nbd.2015.09.009 |
0.45 |
|
| 2015 |
Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Chronic pharmacological glucocerebrosidase inhibition induces α-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice. Antioxidants & Redox Signaling. PMID 26094487 DOI: 10.1089/Ars.2015.6307 |
0.455 |
|
| 2015 |
Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson O. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology. 2: 433-8. PMID 25909088 DOI: 10.1002/Acn3.177 |
0.439 |
|
| 2015 |
Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O. A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). Plos One. 10: e0121072. PMID 25815475 DOI: 10.1371/Journal.Pone.0121072 |
0.371 |
|
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