| Year |
Citation |
Score |
| 2016 |
Joshi AA, Vaidya SS, St-Pierre MV, Mikheev AM, Desino KE, Nyandege AN, Audus KL, Unadkat JD, Gerk PM. Placental ABC Transporters: Biological Impact and Pharmaceutical Significance. Pharmaceutical Research. PMID 27644937 DOI: 10.1007/S11095-016-2028-8 |
0.501 |
|
| 2009 |
Desino KE, Ansar S, Georg GI, Himes RH, Michaelis ML, Powell DR, Reiff EA, Telikepalli H, Audus KL. (3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent. Journal of Medicinal Chemistry. 52: 7537-43. PMID 19728715 DOI: 10.1021/Jm900254K |
0.544 |
|
| 2009 |
Desino KE, Pignatello R, Guccione S, Basile L, Ansar S, Michaelis ML, Ramsay RR, Audus KL. TCP-FA4: a derivative of tranylcypromine showing improved blood-brain permeability. Biochemical Pharmacology. 78: 1412-7. PMID 19679106 DOI: 10.1016/J.Bcp.2009.07.027 |
0.562 |
|
| 2008 |
Turunen BJ, Ge H, Oyetunji J, Desino KE, Vasandani V, Güthe S, Himes RH, Audus KL, Seelig A, Georg GI. Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability. Bioorganic & Medicinal Chemistry Letters. 18: 5971-4. PMID 18926701 DOI: 10.1016/J.Bmcl.2008.09.103 |
0.596 |
|
| 2007 |
Ansar S, Burlison JA, Hadden MK, Yu XM, Desino KE, Bean J, Neckers L, Audus KL, Michaelis ML, Blagg BS. A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity. Bioorganic & Medicinal Chemistry Letters. 17: 1984-90. PMID 17276679 DOI: 10.1016/J.Bmcl.2007.01.017 |
0.528 |
|
| 2006 |
Spletstoser JT, Turunen BJ, Desino K, Rice A, Datta A, Dutta D, Huff JK, Himes RH, Audus KL, Seelig A, Georg GI. Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorganic & Medicinal Chemistry Letters. 16: 495-8. PMID 16289636 DOI: 10.1016/J.Bmcl.2005.10.063 |
0.536 |
|
| 2006 |
Chappa AK, Desino KE, Lunte SM, Audus KL. Functional Aspects Of Vasoactive Peptides At The Blood-Brain Barrier Handbook of Biologically Active Peptides. 1461-1468. DOI: 10.1016/B978-012369442-3/50207-5 |
0.487 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2011 |
Mudra DR, Desino KE, Desai PV. In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp. Current Drug Metabolism. 12: 750-73. PMID 21568936 |
0.225 |
|
| 2008 |
Khojasteh SC, Leipold DD, Lai F, La H, Baumgardner MJ, Desino KE, Gudmundsson OS, Bloedow DC, Bodary SC, Reynolds ME, Gadek TR, Kenkare-Mitra S. Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug Xenobiotica. 38: 340-352. PMID 18274961 DOI: 10.1080/00498250701813248 |
0.117 |
|
| 2017 |
Wang X, Liu B, Searle X, Yeung C, Bogdan AR, Greszler SN, Singh A, Fan Y, Swensen AM, Vortherms T, Balut C, Jia Y, Desino KE, Gao W, Yong H, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. Journal of Medicinal Chemistry. PMID 29251932 DOI: 10.1021/Acs.Jmedchem.7B01339 |
0.111 |
|
| 2016 |
Dinges J, Harris CM, Wallace GA, Argiriadi MA, Queeney KL, Perron DC, Dominguez E, Kebede T, Desino KE, Patel H, Vasudevan A. Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27020302 DOI: 10.1016/j.bmcl.2016.03.043 |
0.101 |
|
| 2019 |
Gauld S, Jacquet S, Gauvin D, Wallace C, Wang Y, McCarthy R, Goess C, Leys L, Huang S, Su Z, Edelmayer R, Wetter J, Salte K, McGaraughty S, Argiriadi M, ... ... Desino K, et al. Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt. The Journal of Pharmacology and Experimental Therapeutics. PMID 31375639 DOI: 10.1124/Jpet.119.258046 |
0.09 |
|
| 2023 |
Zhang X, Jenkins GJ, Desino KE, Liu J, Larsen M, Stresser DM. A Simplified Method for Determining Blood-to-Plasma Ratios in vitro and ex vivo by Matrix Matching with Blank Blood or Plasma. Drug Metabolism and Bioanalysis Letters. PMID 37592774 DOI: 10.2174/2949681016666230817150551 |
0.088 |
|
| 2023 |
Wang YT, Maes EM, Heinle L, Ruterbories K, Doktor S, Larsen M, Olson A, Lee A, Handel CV, Ji QC, Desino K, Jenkins GJ. Integrity and efficiency: AbbVie's journey of building an integrated nonregulated bioanalytical laboratory. Bioanalysis. PMID 36961367 DOI: 10.4155/bio-2023-0012 |
0.065 |
|
| 2017 |
Lombardo F, Desai PV, Arimoto R, Desino KE, Fischer H, Keefer CE, Petersson C, Winiwarter S, Broccatelli F. In silico absorption, distribution, metabolism, excretion and pharmacokinetics (ADME-PK): utility and best practices - An industry perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development. Journal of Medicinal Chemistry. PMID 28609624 DOI: 10.1021/acs.jmedchem.7b00487 |
0.055 |
|
| 2019 |
Stresser D, Lesniak P, Desino K, Sun J. Revisiting evaluation of CYP2C9 and CYP2C19 Induction in vitro: potential for robust induction responses with ≥ 4-Day hepatocyte exposure times Drug Metabolism and Pharmacokinetics. 34: S43-S44. DOI: 10.1016/j.dmpk.2018.09.158 |
0.041 |
|
| 2021 |
Price E, Kalvass JC, DeGoey D, Hosmane B, Doktor S, Desino K. Global Analysis of Models for Predicting Human Absorption: QSAR, , and Preclinical Models. Journal of Medicinal Chemistry. PMID 34152772 DOI: 10.1021/acs.jmedchem.1c00669 |
0.028 |
|
| Hide low-probability matches. |