| Year |
Citation |
Score |
| 2023 |
Duan Y, Wu W, Cui J, Matsubara JA, Kazlauskas A, Ma G, Li X, Lei H. Ligand-independent activation of platelet-derived growth factor receptor β promotes vitreous-induced contraction of retinal pigment epithelial cells. Bmc Ophthalmology. 23: 344. PMID 37537538 DOI: 10.1186/s12886-023-03089-8 |
0.363 |
|
| 2020 |
Yang Y, Huang X, Ma G, Cui J, Matsubara JA, Kazlauskas A, Zhao J, Wang J, Lei H. PDGFRβ plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes. Experimental Eye Research. 108116. PMID 32561481 DOI: 10.1016/j.exer.2020.108116 |
0.327 |
|
| 2020 |
Wu W, Zhou G, Han H, Huang X, Jiang H, Mukai S, Kazlauskas A, Cui J, Matsubara JA, Vanhaesebroeck B, Xia X, Wang J, Lei H. PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis. Diabetes. PMID 31915155 DOI: 10.2337/db19-0713 |
0.304 |
|
| 2017 |
Gerhardt MJ, Marsh JA, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, DeAngelis MM, Saint-Geniez M, Jacobo SMP. ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. Journal of Molecular Cell Biology. 1-16. PMID 28992183 DOI: 10.1093/Jmcb/Mjx024 |
0.308 |
|
| 2017 |
Kazlauskas A. PDGFs and their receptors. Gene. PMID 28267575 DOI: 10.1016/J.Gene.2017.03.003 |
0.421 |
|
| 2016 |
Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Investigative Ophthalmology & Visual Science. 57: 3935-3943. PMID 27472081 DOI: 10.1167/Iovs.16-19405 |
0.34 |
|
| 2016 |
Pennock S, Kim LA, Kazlauskas A. VEGF-A acts via PDGFRα to promote viability of cells enduring hypoxia. Molecular and Cellular Biology. PMID 27325673 DOI: 10.1128/Mcb.01019-15 |
0.424 |
|
| 2015 |
Moroncini G, Grieco A, Nacci G, Paolini C, Tonnini C, Pozniak KN, Cuccioloni M, Mozzicafreddo M, Svegliati S, Angeletti M, Kazlauskas A, Avvedimento EV, Funaro A, Gabrielli A. Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1891-903. PMID 25808833 DOI: 10.1002/Art.39125 |
0.339 |
|
| 2015 |
Lei H, Qian CX, Lei J, Haddock LJ, Mukai S, Kazlauskas A. RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology. Molecular and Cellular Biology. 35: 1673-85. PMID 25733681 DOI: 10.1128/Mcb.01248-14 |
0.432 |
|
| 2015 |
Jacobo SM, Kazlauskas A. Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels. The Journal of Biological Chemistry. 290: 6349-60. PMID 25564613 DOI: 10.1074/Jbc.M114.634154 |
0.412 |
|
| 2014 |
Pennock S, Haddock LJ, Mukai S, Kazlauskas A. Vascular endothelial growth factor acts primarily via platelet-derived growth factor receptor α to promote proliferative vitreoretinopathy. The American Journal of Pathology. 184: 3052-68. PMID 25261788 DOI: 10.1016/J.Ajpath.2014.07.026 |
0.42 |
|
| 2014 |
Kazlauskas A. Plakophilin-2 promotes activation of epidermal growth factor receptor. Molecular and Cellular Biology. 34: 3778-9. PMID 25113561 DOI: 10.1128/Mcb.00968-14 |
0.433 |
|
| 2014 |
Motiejūnaitė R, Aranda J, Kazlauskas A. Pericytes prevent regression of endothelial cell tubes by accelerating metabolism of lysophosphatidic acid. Microvascular Research. 93: 62-71. PMID 24681425 DOI: 10.1016/J.Mvr.2014.03.003 |
0.33 |
|
| 2014 |
Pennock S, Haddock LJ, Eliott D, Mukai S, Kazlauskas A. Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy? Progress in Retinal and Eye Research. 40: 16-34. PMID 24412519 DOI: 10.1016/J.Preteyeres.2013.12.006 |
0.436 |
|
| 2014 |
Lei H, Kazlauskas A. A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Molecular and Cellular Biology. 34: 110-22. PMID 24190966 DOI: 10.1128/Mcb.00839-13 |
0.479 |
|
| 2013 |
Lei H, Kazlauskas A. Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRα. Methods in Enzymology. 528: 189-94. PMID 23849866 DOI: 10.1016/B978-0-12-405881-1.00011-2 |
0.441 |
|
| 2013 |
Ruan GX, Kazlauskas A. Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis. The Journal of Biological Chemistry. 288: 21161-72. PMID 23754286 DOI: 10.1074/Jbc.M113.474619 |
0.5 |
|
| 2013 |
Pennock S, Kim D, Mukai S, Kuhnle M, Chun DW, Matsubara J, Cui J, Ma P, Maberley D, Samad A, Van Geest RJ, Oberstein SL, Schlingemann RO, Kazlauskas A. Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. The American Journal of Pathology. 182: 1659-70. PMID 23582767 DOI: 10.1016/J.Ajpath.2013.01.052 |
0.434 |
|
| 2013 |
Aranda J, Motiejunaite R, Silva P, Aiello LP, Kazlauskas A. Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy. Diabetologia. 56: 1444-53. PMID 23508305 DOI: 10.1007/S00125-013-2884-2 |
0.358 |
|
| 2013 |
Velez G, Weingarden AR, Lei H, Kazlauskas A, Gao G. SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Müller cell-induced rabbit models. Investigative Ophthalmology & Visual Science. 54: 1392-7. PMID 23341018 DOI: 10.1167/Iovs.12-10320 |
0.404 |
|
| 2012 |
Vanarsdall AL, Wisner TW, Lei H, Kazlauskas A, Johnson DC. PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. Plos Pathogens. 8: e1002905. PMID 23028311 DOI: 10.1371/Journal.Ppat.1002905 |
0.426 |
|
| 2012 |
Lei H, Rheaume MA, Cui J, Mukai S, Maberley D, Samad A, Matsubara J, Kazlauskas A. A novel function of p53: a gatekeeper of retinal detachment. The American Journal of Pathology. 181: 866-74. PMID 22901751 DOI: 10.1016/J.Ajpath.2012.05.036 |
0.364 |
|
| 2012 |
Staniszewska M, Gu X, Romano C, Kazlauskas A. A phage display-based approach to investigate abnormal neovessels of the retina. Investigative Ophthalmology & Visual Science. 53: 4371-9. PMID 22661481 DOI: 10.1167/Iovs.12-9690 |
0.3 |
|
| 2012 |
Ruan GX, Kazlauskas A. VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt. Cell Cycle (Georgetown, Tex.). 11: 2047-8. PMID 22647379 DOI: 10.4161/Cc.20535 |
0.393 |
|
| 2012 |
Park EY, Kazlauskas A. Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA). Bioscience Reports. 32: 393-400. PMID 22639801 DOI: 10.1042/Bsr20120033 |
0.435 |
|
| 2012 |
Pennock S, Kazlauskas A. Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses. Molecular and Cellular Biology. 32: 1955-66. PMID 22431518 DOI: 10.1128/Mcb.06668-11 |
0.48 |
|
| 2012 |
Aranda J, Motiejunaite R, Im E, Kazlauskas A. Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid. Diabetes. 61: 1225-33. PMID 22415872 DOI: 10.2337/Db11-1189 |
0.401 |
|
| 2012 |
Ruan GX, Kazlauskas A. Axl is essential for VEGF-A-dependent activation of PI3K/Akt. The Embo Journal. 31: 1692-703. PMID 22327215 DOI: 10.1038/Emboj.2012.21 |
0.46 |
|
| 2011 |
Pennock S, Rheaume MA, Mukai S, Kazlauskas A. A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. The American Journal of Pathology. 179: 2931-40. PMID 22035642 DOI: 10.1016/J.Ajpath.2011.08.043 |
0.4 |
|
| 2011 |
Tian Z, Shen J, Wang F, Xiao P, Yang J, Lei H, Kazlauskas A, Kohane IS, Wu E. Cambogin is preferentially cytotoxic to cells expressing PDGFR. Plos One. 6: e21370. PMID 21712951 DOI: 10.1371/Journal.Pone.0021370 |
0.413 |
|
| 2011 |
Lei H, Rhéaume MA, Velez G, Mukai S, Kazlauskas A. Expression of PDGFRα is a determinant of the PVR potential of ARPE19 cells. Investigative Ophthalmology & Visual Science. 52: 5016-21. PMID 21642621 DOI: 10.1167/Iovs.11-7442 |
0.41 |
|
| 2011 |
Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY. SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. The Journal of Clinical Investigation. 121: 905-17. PMID 21393858 DOI: 10.1172/Jci43690 |
0.442 |
|
| 2011 |
Lei H, Velez G, Kazlauskas A. Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Molecular and Cellular Biology. 31: 1788-99. PMID 21357737 DOI: 10.1128/Mcb.01321-10 |
0.455 |
|
| 2011 |
Fuchsluger TA, Jurkunas U, Kazlauskas A, Dana R. Corneal endothelial cells are protected from apoptosis by gene therapy. Human Gene Therapy. 22: 549-58. PMID 21158568 DOI: 10.1089/Hum.2010.079 |
0.33 |
|
| 2010 |
Caglayan E, Romeo GR, Kappert K, Odenthal M, Südkamp M, Body SC, Shernan SK, Hackbusch D, Vantler M, Kazlauskas A, Rosenkranz S. Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. Plos One. 5: e13608. PMID 21049052 DOI: 10.1371/Journal.Pone.0013608 |
0.382 |
|
| 2010 |
Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J, Kazlauskas A. N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. The American Journal of Pathology. 177: 132-40. PMID 20489144 DOI: 10.2353/Ajpath.2010.090604 |
0.324 |
|
| 2010 |
Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A. The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Cancer Research. 70: 4195-203. PMID 20442296 DOI: 10.1158/0008-5472.Can-09-4712 |
0.369 |
|
| 2010 |
Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A. Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Molecular and Cellular Biology. 30: 2401-10. PMID 20231358 DOI: 10.1128/Mcb.01275-09 |
0.436 |
|
| 2010 |
Lei H, Rheaume MA, Kazlauskas A. Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Experimental Eye Research. 90: 376-81. PMID 19931527 DOI: 10.1016/J.Exer.2009.11.003 |
0.46 |
|
| 2010 |
Feng H, Cheng S, Hu B, Liu K, Yiin J, Kazlauskas A, Ravichandran KS, Vuori K, Nishikawa R, Nagane M. Abstract 5208: PDGFRα stimulates glioma cell invasion through tyrosine phosphorylation of Dock180 at Y1811 and activation of the Dock180-CrkII-p130cas-Rac1 pathway Cancer Research. 70: 5208-5208. DOI: 10.1158/1538-7445.Am10-5208 |
0.393 |
|
| 2010 |
Liu K, Hu B, Feng H, Kazlauskas A, Smith E, Symed K, Bachoo R, Cheng S. Abstract 3124: Platelet-derived growth factor receptor α cooperates with loss of p16/INK4a and p19/ARF to enhance tumorigenesis through the PI3K- and SHP-2-mediated signaling in the brain Cancer Research. 70: 3124-3124. DOI: 10.1158/1538-7445.Am10-3124 |
0.412 |
|
| 2010 |
Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A. Abstract 1468: Antagonism of platelet-derived growth factor receptor-α as a potential therapeutic for prostate cancer bone metastases Cancer Research. 70: 1468-1468. DOI: 10.1158/1538-7445.Am10-1468 |
0.34 |
|
| 2010 |
Fuchsluger T, Jurkunas U, Kazlauskas A, Dana R. Modulation of apoptotic signaling pathways to promote survival of endothelial cells by gene therapy Acta Ophthalmologica. 88: 0-0. DOI: 10.1111/J.1755-3768.2010.3135.X |
0.333 |
|
| 2009 |
Lei H, Velez G, Hovland P, Hirose T, Gilbertson D, Kazlauskas A. Growth factors outside the PDGF family drive experimental PVR. Investigative Ophthalmology & Visual Science. 50: 3394-403. PMID 19324843 DOI: 10.1167/Iovs.08-3042 |
0.45 |
|
| 2009 |
Lei H, Kazlauskas A. Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. The Journal of Biological Chemistry. 284: 6329-36. PMID 19126548 DOI: 10.1074/Jbc.M808426200 |
0.478 |
|
| 2009 |
Cui J, Lei H, Samad A, Basavanthappa S, Maberley D, Matsubara J, Kazlauskas A. PDGF receptors are activated in human epiretinal membranes. Experimental Eye Research. 88: 438-44. PMID 19032953 DOI: 10.1016/J.Exer.2008.10.020 |
0.406 |
|
| 2009 |
Ricono JM, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury GG, Abboud HE. PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. American Journal of Physiology. Renal Physiology. 296: F406-17. PMID 19019919 DOI: 10.1152/Ajprenal.90368.2008 |
0.359 |
|
| 2008 |
Romeo GR, Kazlauskas A. Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. The Journal of Biological Chemistry. 283: 9595-605. PMID 18230613 DOI: 10.1074/Jbc.M710092200 |
0.37 |
|
| 2008 |
Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A. Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Investigative Ophthalmology & Visual Science. 49: 42-8. PMID 18172073 DOI: 10.1167/Iovs.07-0776 |
0.361 |
|
| 2008 |
Motiejūnaite R, Kazlauskas A. Pericytes and ocular diseases. Experimental Eye Research. 86: 171-7. PMID 18078933 DOI: 10.1016/J.Exer.2007.10.013 |
0.308 |
|
| 2008 |
Lei H, Kazlauskas A. Focus on molecules: platelet-derived growth factor C, PDGF-C. Experimental Eye Research. 86: 711-2. PMID 17904120 DOI: 10.1016/J.Exer.2007.08.007 |
0.311 |
|
| 2007 |
Im E, Kazlauskas A. Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. The Journal of Biological Chemistry. 282: 29122-9. PMID 17684019 DOI: 10.1074/Jbc.M702637200 |
0.371 |
|
| 2007 |
Romeo GR, Moulton KS, Kazlauskas A. Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circulation Research. 101: 357-67. PMID 17615372 DOI: 10.1161/Circresaha.107.151399 |
0.334 |
|
| 2007 |
Singh PK, Wen Y, Swanson BJ, Shanmugam K, Kazlauskas A, Cerny RL, Gendler SJ, Hollingsworth MA. Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Research. 67: 5201-10. PMID 17545600 DOI: 10.1158/0008-5472.Can-06-4647 |
0.44 |
|
| 2007 |
Lei H, Hovland P, Velez G, Haran A, Gilbertson D, Hirose T, Kazlauskas A. A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Investigative Ophthalmology & Visual Science. 48: 2335-42. PMID 17460299 DOI: 10.1167/Iovs.06-0965 |
0.373 |
|
| 2007 |
Im E, Kazlauskas A. PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis. Expert Opinion On Therapeutic Targets. 11: 443-51. PMID 17373875 DOI: 10.1517/14728222.11.4.443 |
0.33 |
|
| 2007 |
Lei H, Venkatakrishnan A, Yu S, Kazlauskas A. Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. The Journal of Biological Chemistry. 282: 9364-71. PMID 17202141 DOI: 10.1074/Jbc.M608985200 |
0.372 |
|
| 2006 |
Im E, Kazlauskas A. Regulating angiogenesis at the level of PtdIns-4,5-P2. The Embo Journal. 25: 2075-82. PMID 16628216 DOI: 10.1038/Sj.Emboj.7601100 |
0.372 |
|
| 2005 |
Kazlauskas A. The priming/completion paradigm to explain growth factor-dependent cell cycle progression. Growth Factors (Chur, Switzerland). 23: 203-10. PMID 16243712 DOI: 10.1080/08977190500096020 |
0.364 |
|
| 2005 |
Lee JS, Kim JH, Jang IH, Kim HS, Han JM, Kazlauskas A, Yagisawa H, Suh PG, Ryu SH. Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity. Journal of Cell Science. 118: 4405-13. PMID 16179605 DOI: 10.1242/Jcs.02564 |
0.415 |
|
| 2005 |
Van Stry M, Kazlauskas A, Schreiber SL, Symes K. Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 8233-8. PMID 15919820 DOI: 10.1073/Pnas.0502885102 |
0.437 |
|
| 2005 |
Im E, Venkatakrishnan A, Kazlauskas A. Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Molecular Biology of the Cell. 16: 3488-500. PMID 15901832 DOI: 10.1091/Mbc.E04-11-1029 |
0.382 |
|
| 2004 |
Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA. Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Investigative Ophthalmology & Visual Science. 45: 3974-81. PMID 15505044 DOI: 10.1167/Iovs.04-0508 |
0.336 |
|
| 2004 |
Calera MR, Venkatakrishnan A, Kazlauskas A. VE-cadherin increases the half-life of VEGF receptor 2. Experimental Cell Research. 300: 248-56. PMID 15383331 DOI: 10.1016/J.Yexcr.2004.07.007 |
0.447 |
|
| 2004 |
James MF, Beauchamp RL, Manchanda N, Kazlauskas A, Ramesh V. A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration. Journal of Cell Science. 117: 2951-61. PMID 15161943 DOI: 10.1242/Jcs.01156 |
0.407 |
|
| 2004 |
Plattner R, Koleske AJ, Kazlauskas A, Pendergast AM. Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Molecular and Cellular Biology. 24: 2573-83. PMID 14993293 DOI: 10.1128/Mcb.24.6.2573-2583.2004 |
0.457 |
|
| 2004 |
Romeo G, Frangioni JV, Kazlauskas A. Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 725-7. PMID 14977885 DOI: 10.1096/Fj.03-0841Fje |
0.347 |
|
| 2004 |
Wang Y, Pennock SD, Chen X, Kazlauskas A, Wang Z. Platelet-derived growth factor receptor-mediated signal transduction from endosomes. The Journal of Biological Chemistry. 279: 8038-46. PMID 14660565 DOI: 10.1074/jbc.M311494200 |
0.34 |
|
| 2003 |
Avrov K, Kazlauskas A. The role of c-Src in platelet-derived growth factor alpha receptor internalization. Experimental Cell Research. 291: 426-34. PMID 14644164 DOI: 10.1016/J.Yexcr.2003.08.001 |
0.45 |
|
| 2003 |
Wang L, Cummings R, Zhao Y, Kazlauskas A, Sham JK, Morris A, Georas S, Brindley DN, Natarajan V. Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. The Journal of Biological Chemistry. 278: 39931-40. PMID 12890682 DOI: 10.1074/Jbc.M302896200 |
0.382 |
|
| 2003 |
Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM. A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nature Cell Biology. 5: 309-19. PMID 12652307 DOI: 10.1038/Ncb949 |
0.419 |
|
| 2002 |
Balciunaite E, Kazlauskas A. The timing and extent of activation of diacylglycerol-responsive protein kinase-cs determines their ability to inhibit or promote platelet-derived growth factor-dependent DNA synthesis. Experimental Cell Research. 281: 167-74. PMID 12460646 DOI: 10.1006/Excr.2002.5659 |
0.432 |
|
| 2002 |
Arbiser JL, Govindarajan B, Bai X, Onda H, Kazlauskas A, Lim SD, Amin MB, Claesson-Welsh L. Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis. The American Journal of Pathology. 161: 781-6. PMID 12213705 DOI: 10.1016/S0002-9440(10)64237-X |
0.455 |
|
| 2002 |
Ikuno Y, Leong FL, Kazlauskas A. PI3K and PLCgamma play a central role in experimental PVR. Investigative Ophthalmology & Visual Science. 43: 483-9. PMID 11818394 |
0.323 |
|
| 2002 |
Stacey D, Kazlauskas A. Regulation of Ras signaling by the cell cycle. Current Opinion in Genetics & Development. 12: 44-6. PMID 11790553 DOI: 10.1016/S0959-437X(01)00262-3 |
0.321 |
|
| 2002 |
Ikuno Y, Kazlauskas A. TGFbeta1-dependent contraction of fibroblasts is mediated by the PDGFalpha receptor. Investigative Ophthalmology & Visual Science. 43: 41-6. PMID 11773010 |
0.353 |
|
| 2001 |
Sternberg DW, Tomasson MH, Carroll M, Curley DP, Barker G, Caprio M, Wilbanks A, Kazlauskas A, Gilliland DG. The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways. Blood. 98: 3390-7. PMID 11719379 DOI: 10.1182/Blood.V98.12.3390 |
0.438 |
|
| 2001 |
Balciunaite E, Kazlauskas A. Early phosphoinositide 3-kinase activity is required for late activation of protein kinase Cepsilon in platelet-derived-growth-factor-stimulated cells: evidence for signalling across a large temporal gap. The Biochemical Journal. 358: 281-5. PMID 11513725 DOI: 10.1042/0264-6021:3580281 |
0.414 |
|
| 2001 |
Nickas ME, Bernard A, Kazlauskas A. The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. Experimental Cell Research. 265: 80-9. PMID 11281646 DOI: 10.1006/Excr.2001.5169 |
0.549 |
|
| 2000 |
Jones SM, Kazlauskas A. Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene. 19: 5558-67. PMID 11114735 DOI: 10.1038/Sj.Onc.1203858 |
0.416 |
|
| 2000 |
Ikuno Y, Leong FL, Kazlauskas A. Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Investigative Ophthalmology & Visual Science. 41: 3107-16. PMID 10967071 |
0.324 |
|
| 2000 |
Kazlauskas A. A new member of an old family. Nature Cell Biology. 2: E78-9. PMID 10806490 DOI: 10.1038/35010508 |
0.369 |
|
| 2000 |
Lashkari K, Hirose T, Yazdany J, McMeel JW, Kazlauskas A, Rahimi N. Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. The American Journal of Pathology. 156: 1337-44. PMID 10751359 DOI: 10.1016/S0002-9440(10)65004-3 |
0.403 |
|
| 2000 |
Bae YS, Sung JY, Kim OS, Kim YJ, Hur KC, Kazlauskas A, Rhee SG. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 275: 10527-31. PMID 10744745 DOI: 10.1074/jbc.275.14.10527 |
0.311 |
|
| 2000 |
Rosenkranz S, Ikuno Y, Leong FL, Klinghoffer RA, Miyake S, Band H, Kazlauskas A. Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. The Journal of Biological Chemistry. 275: 9620-7. PMID 10734113 DOI: 10.1074/jbc.275.13.9620 |
0.35 |
|
| 2000 |
Balciunaite E, Jones S, Toker A, Kazlauskas A. PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Current Biology : Cb. 10: 261-7. PMID 10712903 DOI: 10.1016/S0960-9822(00)00358-4 |
0.416 |
|
| 1999 |
Bernard A, Kazlauskas A. Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. Experimental Cell Research. 253: 704-12. PMID 10585294 DOI: 10.1006/Excr.1999.4715 |
0.591 |
|
| 1999 |
DeMali KA, Godwin SL, Soltoff SP, Kazlauskas A. Multiple roles for Src in a PDGF-stimulated cell. Experimental Cell Research. 253: 271-9. PMID 10579928 DOI: 10.1006/Excr.1999.4669 |
0.475 |
|
| 1999 |
Schlesinger TK, Demali KA, Johnson GL, Kazlauskas A. Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. The Biochemical Journal. 344: 519-26. PMID 10567236 DOI: 10.1042/Bj3440519 |
0.446 |
|
| 1999 |
Rosenkranz S, Böhm M, Kazlauskas A. [Pathophysiologic significance of growth factors and new therapeutic concepts in cardiovascular disease]. Medizinische Klinik (Munich, Germany : 1983). 94: 496-504. PMID 10544612 DOI: 10.1007/Bf03044941 |
0.367 |
|
| 1999 |
Rahimi N, Kazlauskas A. A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells. Molecular Biology of the Cell. 10: 3401-7. PMID 10512875 DOI: 10.1091/Mbc.10.10.3401 |
0.468 |
|
| 1999 |
Andrews A, Balciunaite E, Leong FL, Tallquist M, Soriano P, Refojo M, Kazlauskas A. Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Investigative Ophthalmology & Visual Science. 40: 2683-9. PMID 10509666 |
0.335 |
|
| 1999 |
Plattner R, Kadlec L, DeMali KA, Kazlauskas A, Pendergast AM. c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes & Development. 13: 2400-11. PMID 10500097 DOI: 10.1101/Gad.13.18.2400 |
0.328 |
|
| 1999 |
Rosenkranz S, DeMali KA, Gelderloos JA, Bazenet C, Kazlauskas A. Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. The Journal of Biological Chemistry. 274: 28335-43. PMID 10497192 DOI: 10.1074/Jbc.274.40.28335 |
0.44 |
|
| 1999 |
Olivera A, Edsall L, Poulton S, Kazlauskas A, Spiegel S. Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1593-600. PMID 10463951 DOI: 10.1096/Fasebj.13.12.1593 |
0.474 |
|
| 1999 |
Rice PL, Porter SE, Koski KM, Ramakrishna G, Chen A, Schrump D, Kazlauskas A, Malkinson AM. Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Molecular Carcinogenesis. 25: 285-94. PMID 10449035 DOI: 10.1002/(Sici)1098-2744(199908)25:4<285::Aid-Mc7>3.0.Co;2-F |
0.407 |
|
| 1999 |
DeMali KA, Balciunaite E, Kazlauskas A. Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. The Journal of Biological Chemistry. 274: 19551-8. PMID 10391888 DOI: 10.1074/Jbc.274.28.19551 |
0.338 |
|
| 1999 |
Fambrough D, McClure K, Kazlauskas A, Lander ES. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell. 97: 727-41. PMID 10380925 DOI: 10.1016/S0092-8674(00)80785-0 |
0.352 |
|
| 1999 |
Rosenkranz S, Kazlauskas A. Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors (Chur, Switzerland). 16: 201-16. PMID 10372961 DOI: 10.3109/08977199909002130 |
0.437 |
|
| 1999 |
Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Current Biology : Cb. 9: 512-21. PMID 10339426 DOI: 10.1016/S0960-9822(99)80235-8 |
0.39 |
|
| 1999 |
Wang D, Huang HJ, Kazlauskas A, Cavenee WK. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Research. 59: 1464-72. PMID 10197615 |
0.361 |
|
| 1999 |
Hossain MZ, Jagdale AB, Ao P, Kazlauskas A, Boynton AL. Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways. The Journal of Biological Chemistry. 274: 10489-96. PMID 10187840 DOI: 10.1074/Jbc.274.15.10489 |
0.471 |
|
| 1998 |
Roche S, Alonso G, Kazlauskas A, Dixit VM, Courtneidge SA, Pandey A. Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Current Biology : Cb. 8: 975-8. PMID 9742401 DOI: 10.1016/S0960-9822(98)70400-2 |
0.481 |
|
| 1998 |
Baxter RM, Secrist JP, Vaillancourt RR, Kazlauskas A. Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. The Journal of Biological Chemistry. 273: 17050-5. PMID 9642269 DOI: 10.1074/Jbc.273.27.17050 |
0.447 |
|
| 1998 |
DeMali KA, Kazlauskas A. Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Molecular and Cellular Biology. 18: 2014-22. PMID 9528773 DOI: 10.1128/Mcb.18.4.2014 |
0.454 |
|
| 1998 |
Gelderloos JA, Rosenkranz S, Bazenet C, Kazlauskas A. A role for Src in signal relay by the platelet-derived growth factor alpha receptor. The Journal of Biological Chemistry. 273: 5908-15. PMID 9488729 DOI: 10.1074/Jbc.273.10.5908 |
0.492 |
|
| 1997 |
Montmayeur JP, Valius M, Vandenheede J, Kazlauskas A. The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs. The Journal of Biological Chemistry. 272: 32670-8. PMID 9405485 DOI: 10.1074/jbc.272.51.32670 |
0.344 |
|
| 1997 |
Lopez-Ilasaca M, Li W, Uren A, Yu JC, Kazlauskas A, Gutkind JS, Heidaran MA. Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Biochemical and Biophysical Research Communications. 232: 273-7. PMID 9125162 DOI: 10.1006/Bbrc.1997.6289 |
0.456 |
|
| 1997 |
DeMali KA, Whiteford CC, Ulug ET, Kazlauskas A. Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase. The Journal of Biological Chemistry. 272: 9011-8. PMID 9083025 DOI: 10.1074/Jbc.272.14.9011 |
0.477 |
|
| 1996 |
Holm C, Gineitis D, McConville G, Kazlauskas A. Expression of PDGF, VEGF and their receptors in non-small cell lung tumor cell lines. International Journal of Oncology. 9: 1077-86. PMID 21541615 |
0.326 |
|
| 1996 |
Bazenet CE, Gelderloos JA, Kazlauskas A. Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Molecular and Cellular Biology. 16: 6926-36. PMID 8943348 |
0.359 |
|
| 1996 |
Whiteford CC, Best C, Kazlauskas A, Ulug ET. D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor. The Biochemical Journal. 319: 851-60. PMID 8920990 DOI: 10.1042/Bj3190851 |
0.416 |
|
| 1996 |
Quon MJ, Chen H, Lin CH, Zhou L, Ing BL, Zarnowski MJ, Klinghoffer R, Kazlauskas A, Cushman SW, Taylor SI. Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochemical and Biophysical Research Communications. 226: 587-94. PMID 8831662 DOI: 10.1006/Bbrc.1996.1400 |
0.335 |
|
| 1996 |
Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Molecular and Cellular Biology. 16: 5905-14. PMID 8816504 DOI: 10.1128/Mcb.16.10.5905 |
0.33 |
|
| 1996 |
Vaillancourt RR, Gardner AM, Kazlauskas A, Johnson GL. The kinase-inactive PDGF beta-receptor mediates activation of the MAP kinase cascade via the endogenous PDGF alpha-receptor in HepG2 cells. Oncogene. 13: 151-9. PMID 8700541 |
0.336 |
|
| 1996 |
Valenzuela CF, Xiong Z, MacDonald JF, Weiner JL, Frazier CJ, Dunwiddie TV, Kazlauskas A, Whiting PJ, Harris RA. Platelet-derived growth factor induces a long-term inhibition of N-methyl-D-aspartate receptor function. The Journal of Biological Chemistry. 271: 16151-9. PMID 8663218 DOI: 10.1074/Jbc.271.27.16151 |
0.339 |
|
| 1996 |
Akimoto K, Takahashi R, Moriya S, Nishioka N, Takayanagi J, Kimura K, Fukui Y, Osada Si, Mizuno K, Hirai Si, Kazlauskas A, Ohno S. EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. The Embo Journal. 15: 788-98. PMID 8631300 |
0.4 |
|
| 1996 |
Moriya S, Kazlauskas A, Akimoto K, Hirai S, Mizuno K, Takenawa T, Fukui Y, Watanabe Y, Ozaki S, Ohno S. Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 93: 151-5. PMID 8552594 DOI: 10.1073/pnas.93.1.151 |
0.358 |
|
| 1995 |
Joly M, Kazlauskas A, Corvera S. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. The Journal of Biological Chemistry. 270: 13225-30. PMID 7768921 DOI: 10.1074/Jbc.270.22.13225 |
0.323 |
|
| 1995 |
Drummond-Barbosa DA, Vaillancourt RR, Kazlauskas A, DiMaio D. Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Molecular and Cellular Biology. 15: 2570-81. PMID 7739538 DOI: 10.1128/Mcb.15.5.2570 |
0.341 |
|
| 1995 |
Vaillancourt RR, Heasley LE, Zamarripa J, Storey B, Valius M, Kazlauskas A, Johnson GL. Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Molecular and Cellular Biology. 15: 3644-53. PMID 7540718 DOI: 10.1128/Mcb.15.7.3644 |
0.361 |
|
| 1994 |
Joly M, Kazlauskas A, Fay FS, Corvera S. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science (New York, N.Y.). 263: 684-7. PMID 8303278 DOI: 10.1126/Science.8303278 |
0.311 |
|
| 1994 |
Kazlauskas A. Receptor tyrosine kinases and their targets. Current Opinion in Genetics & Development. 4: 5-14. PMID 8193540 DOI: 10.1016/0959-437X(94)90085-X |
0.429 |
|
| 1994 |
Feng GS, Shen R, Heng HH, Tsui LC, Kazlauskas A, Pawson T. Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene. 9: 1545-50. PMID 8183548 |
0.304 |
|
| 1994 |
Kundra V, Escobedo JA, Kazlauskas A, Kim HK, Rhee SG, Williams LT, Zetter BR. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature. 367: 474-6. PMID 8107807 DOI: 10.1038/367474A0 |
0.315 |
|
| 1994 |
Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature. 370: 71-5. PMID 8015612 DOI: 10.1038/370071A0 |
0.326 |
|
| 1994 |
Yeo EJ, Kazlauskas A, Exton JH. Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor. The Journal of Biological Chemistry. 269: 27823-6. PMID 7961710 |
0.392 |
|
| 1993 |
Kazlauskas A, Feng GS, Pawson T, Valius M. The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proceedings of the National Academy of Sciences of the United States of America. 90: 6939-43. PMID 7688466 DOI: 10.1073/Pnas.90.15.6939 |
0.318 |
|
| 1993 |
Valius M, Bazenet C, Kazlauskas A. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Molecular and Cellular Biology. 13: 133-43. PMID 7678051 |
0.301 |
|
| 1992 |
McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu G, Reith AD, Panayotou G, End P, Bernstein A, Kazlauskas A. SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Molecular and Cellular Biology. 12: 991-7. PMID 1372092 |
0.331 |
|
| 1992 |
Kashishian A, Kazlauskas A, Cooper JA. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. The Embo Journal. 11: 1373-82. PMID 1314164 |
0.311 |
|
| 1991 |
Courtneidge SA, Kypta RM, Cooper JA, Kazlauskas A. Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 2: 483-6. PMID 1661130 |
0.351 |
|
| 1991 |
Kazlauskas A, Durden DL, Cooper JA. Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit. Cell Regulation. 2: 413-25. PMID 1653029 |
0.346 |
|
| 1990 |
Kazlauskas A, Cooper JA. Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase. The Embo Journal. 9: 3279-86. PMID 2170111 |
0.327 |
|
| 1990 |
Kazlauskas A, Ellis C, Pawson T, Cooper JA. Binding of GAP to activated PDGF receptors. Science (New York, N.Y.). 247: 1578-81. PMID 2157284 |
0.325 |
|
| 1989 |
Kazlauskas A, Cooper JA. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell. 58: 1121-33. PMID 2550144 |
0.316 |
|
| 1988 |
Kazlauskas A, Bowen-Pope D, Seifert R, Hart CE, Cooper JA. Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts. The Embo Journal. 7: 3727-35. PMID 2463166 |
0.322 |
|
| 1986 |
Kazlauskas A, DiCorleto PE. A comparison of the platelet-derived growth factor-dependent tyrosine kinase activity in sparse and confluent fibroblasts. Journal of Cellular Physiology. 126: 225-36. PMID 3003124 DOI: 10.1002/jcp.1041260211 |
0.388 |
|
| 1985 |
Kazlauskas A, DiCorleto PE. Cultured endothelial cells do not respond to a platelet-derived growth-factor-like protein in an autocrine manner. Biochimica Et Biophysica Acta. 846: 405-12. PMID 2994752 DOI: 10.1016/0167-4889(85)90013-8 |
0.344 |
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