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Gareth R. John, D.V.M.-Ph.D. - Publications

Affiliations: 
Neurology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
MS, Glia
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, ... ... John GR, et al. Correction: Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination (doi:10.1242/dev.106492). Development (Cambridge, England). 145. PMID 30006479 DOI: 10.1242/Dev.168708  0.757
2017 Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. The Journal of Clinical Investigation. PMID 28737509 DOI: 10.1172/Jci91301  0.771
2017 Laitman BM, Mariani JN, Zhang C, Sawai S, John GR. Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation. Plos One. 12: e0170477. PMID 28107514 DOI: 10.1371/Journal.Pone.0170477  0.78
2016 Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, ... ... John GR, et al. The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. Plos Biology. 14: e1002467. PMID 27213272 DOI: 10.1371/Journal.Pbio.1002467  0.783
2016 Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJ, Fan G, Zhu J, Dupree JL, et al. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Reports. PMID 27149841 DOI: 10.1016/J.Celrep.2016.03.060  0.381
2015 Mealy MA, Shin K, John G, Levy M. Bevacizumab is safe in acute relapses of neuromyelitis optica. Clinical & Experimental Neuroimmunology. 6: 413-418. PMID 26834844 DOI: 10.1111/Cen3.12239  0.304
2015 Laitman BM, John GR. Understanding How Exercise Promotes Cognitive Integrity in the Aging Brain. Plos Biology. 13: e1002300. PMID 26558429 DOI: 10.1371/Journal.Pbio.1002300  0.641
2015 Chapouly C, Tadesse Argaw A, Horng S, Castro K, Zhang J, Asp L, Loo H, Laitman BM, Mariani JN, Straus Farber R, Zaslavsky E, Nudelman G, Raine CS, John GR. Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions. Brain : a Journal of Neurology. 138: 1548-67. PMID 25805644 DOI: 10.1093/Brain/Awv077  0.787
2014 Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, ... ... John G, et al. SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease. Neurobiology of Disease. 73: 254-268. PMID 25461192 DOI: 10.1016/J.Nbd.2014.10.008  0.492
2014 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, ... ... John GR, et al. Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination. Development (Cambridge, England). 141: 2414-28. PMID 24917498 DOI: 10.1242/Jcs.157677  0.785
2014 Rusielewicz T, Nam J, Damanakis E, John GR, Raine CS, Melendez-Vasquez CV. Accelerated repair of demyelinated CNS lesions in the absence of non-muscle myosin IIB. Glia. 62: 580-91. PMID 24470341 DOI: 10.1002/Glia.22627  0.489
2012 Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, et al. Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathologica. 124: 411-24. PMID 22766690 DOI: 10.1007/S00401-012-1009-1  0.47
2012 Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. The Journal of Clinical Investigation. 122: 2454-68. PMID 22653056 DOI: 10.1172/Jci60842  0.773
2012 John GR. Investigation of astrocyte - oligodendrocyte interactions in human cultures. Methods in Molecular Biology (Clifton, N.J.). 814: 401-14. PMID 22144322 DOI: 10.1007/978-1-61779-452-0_27  0.477
2012 Bruck W, John G, Pfortner R, Hayardeny Nisimov L, Piryatinsky V, Wegner C. Laquinimod Protects from Cuprizone-Induced Demyelination through Modulation of Astrocyte Activation Via Interfering with the NF -B Pathway (S31.002) Neurology. 78: S31.002-S31.002. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S31.002  0.361
2012 Pham T, Zhang J, Hayardeny Nisimov L, John G. Laquinimod Restricts Inflammatory Gene Expression in a Human Model of Reactive Astrogliosis (P02.111) Neurology. 78: P02.111-P02.111. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P02.111  0.525
2012 Argaw A, Asp L, Zhang J, Pham T, Mariani J, Dutta D, Kramer E, John G. Astrocyte-Derived VEGF-A Drives Blood-Brain Barrier Disruption, Lymphocyte Infiltration and Neuropathology in Inflammatory and Demyelinating CNS Disease (P02.084) Neurology. 78: P02.084-P02.084. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P02.084  0.754
2011 Gaupp S, Arezzo J, Dutta DJ, John GR, Raine CS. On the occurrence of hypomyelination in a transgenic mouse model: a consequence of the myelin basic protein promoter? Journal of Neuropathology and Experimental Neurology. 70: 1138-50. PMID 22082665 DOI: 10.1097/Nen.0B013E31823B188B  0.45
2011 Zhang J, Kramer EG, Asp L, Dutta DJ, Navrazhina K, Pham T, Mariani JN, Argaw AT, Melendez-Vasquez CV, John GR. Promoting myelin repair and return of function in multiple sclerosis. Febs Letters. 585: 3813-20. PMID 21864535 DOI: 10.1016/J.Febslet.2011.08.017  0.756
2011 Zhang J, Zhang Y, Dutta DJ, Argaw AT, Bonnamain V, Seto J, Braun DA, Zameer A, Hayot F, Lòpez CB, Raine CS, John GR. Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Journal of Immunology (Baltimore, Md. : 1950). 187: 1129-41. PMID 21709156 DOI: 10.4049/Jimmunol.1004066  0.478
2011 Zhang J, Kramer EG, Mahase S, Dutta DJ, Bonnamain V, Argaw AT, John GR. Targeting oligodendrocyte protection and remyelination in multiple sclerosis. The Mount Sinai Journal of Medicine, New York. 78: 244-57. PMID 21425268 DOI: 10.1002/Msj.20244  0.447
2010 Zhang Y, Jalili F, Ouamara N, Zameer A, Cosentino G, Mayne M, Hayardeny L, Antel JP, Bar-Or A, John GR. Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2. Journal of Neuroimmunology. 227: 71-9. PMID 20637510 DOI: 10.1016/J.Jneuroim.2010.06.014  0.334
2010 Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation. Glia. 58: 964-74. PMID 20169621 DOI: 10.1002/Glia.20978  0.803
2009 Zhang Y, Argaw AT, Gurfein BT, Zameer A, Snyder BJ, Ge C, Lu QR, Rowitch DH, Raine CS, Brosnan CF, John GR. Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proceedings of the National Academy of Sciences of the United States of America. 106: 19162-7. PMID 19855010 DOI: 10.1073/Pnas.0902834106  0.797
2009 Gurfein BT, Zhang Y, López CB, Argaw AT, Zameer A, Moran TM, John GR. IL-11 regulates autoimmune demyelination. Journal of Immunology (Baltimore, Md. : 1950). 183: 4229-40. PMID 19734214 DOI: 10.4049/Jimmunol.0900622  0.795
2009 Argaw AT, Gurfein BT, Zhang Y, Zameer A, John GR. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proceedings of the National Academy of Sciences of the United States of America. 106: 1977-82. PMID 19174516 DOI: 10.1073/Pnas.0808698106  0.773
2009 Brosnan CF, John GR. Revisiting Notch in remyelination of multiple sclerosis lesions. The Journal of Clinical Investigation. 119: 10-3. PMID 19104146 DOI: 10.1172/Jci37786  0.618
2006 Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR. Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12174-85. PMID 17122042 DOI: 10.1523/Jneurosci.2289-06.2006  0.668
2006 Argaw AT, Zhang Y, Snyder BJ, Zhao ML, Kopp N, Lee SC, Raine CS, Brosnan CF, John GR. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. Journal of Immunology (Baltimore, Md. : 1950). 177: 5574-84. PMID 17015745 DOI: 10.4049/Jimmunol.177.8.5574  0.656
2006 Omari KM, John G, Lango R, Raine CS. Role for CXCR2 and CXCL1 on glia in multiple sclerosis. Glia. 53: 24-31. PMID 16086366 DOI: 10.1002/Glia.20246  0.523
2005 Omari KM, John GR, Sealfon SC, Raine CS. CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain : a Journal of Neurology. 128: 1003-15. PMID 15774504 DOI: 10.1093/Brain/Awh479  0.525
2005 Rivieccio MA, John GR, Song X, Suh HS, Zhao Y, Lee SC, Brosnan CF. The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture. Journal of Immunology (Baltimore, Md. : 1950). 174: 3719-26. PMID 15749911 DOI: 10.4049/Jimmunol.174.6.3719  0.775
2005 John GR, Lee SC, Song X, Rivieccio M, Brosnan CF. IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia. 49: 161-76. PMID 15472994 DOI: 10.1002/Glia.20109  0.788
2004 John GR, Chen L, Rivieccio MA, Melendez-Vasquez CV, Hartley A, Brosnan CF. Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2837-45. PMID 15028778 DOI: 10.1523/Jneurosci.4789-03.2004  0.769
2003 John GR, Lee SC, Brosnan CF. Cytokines: powerful regulators of glial cell activation. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 9: 10-22. PMID 12580336 DOI: 10.1177/1073858402239587  0.623
2002 John GR, Shankar SL, Shafit-Zagardo B, Massimi A, Lee SC, Raine CS, Brosnan CF. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nature Medicine. 8: 1115-21. PMID 12357247 DOI: 10.1038/Nm781  0.656
2001 John GR, Simpson JE, Woodroofe MN, Lee SC, Brosnan CF. Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4134-42. PMID 11404398  0.572
2001 John GR, Simpson JE, Woodroofe MN, Lee SC, Brosnan CF. Extracellular Nucleotides Differentially Regulate Interleukin-1β Signaling in Primary Human Astrocytes: Implications for Inflammatory Gene Expression The Journal of Neuroscience. 21: 4134-4142. DOI: 10.1523/Jneurosci.21-12-04134.2001  0.414
2000 Duffy HS, John GR, Lee SC, Brosnan CF, Spray DC. Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: RC114. PMID 11090614 DOI: 10.1523/Jneurosci.20-23-J0004.2000  0.623
2000 Liu JS, John GR, Sikora A, Lee SC, Brosnan CF. Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5292-9. PMID 10884313  0.667
2000 Smith KJ, Felts PA, John GR. Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension. Brain : a Journal of Neurology. 123: 171-84. PMID 10611131 DOI: 10.1093/Brain/123.1.171  0.342
2000 Liu JSH, John GR, Sikora A, Lee SC, Brosnan CF. Modulation of Interleukin-1β and Tumor Necrosis Factor α Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes The Journal of Neuroscience. 20: 5292-5299. DOI: 10.1523/Jneurosci.20-14-05292.2000  0.597
1999 Ashton AW, Yokota R, John G, Zhao S, Suadicani SO, Spray DC, Ware JA. Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). The Journal of Biological Chemistry. 274: 35562-70. PMID 10585431 DOI: 10.1074/Jbc.274.50.35562  0.343
1999 John GR, Scemes E, Suadicani SO, Liu JS, Charles PC, Lee SC, Spray DC, Brosnan CF. IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proceedings of the National Academy of Sciences of the United States of America. 96: 11613-8. PMID 10500225 DOI: 10.1073/Pnas.96.20.11613  0.673
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