Zhiheng Xu - Publications

Affiliations: 
Neurology Columbia University, New York, NY 
 2015- Institute of Genetics and Developmental Biology Chinese Academy of Sciences, Beijing, China 

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhi Y, Zhou X, Yu J, Yuan L, Zhang H, Ng DCH, Xu Z, Xu D. Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases. Frontiers in Cell and Developmental Biology. 9: 640753. PMID 33937237 DOI: 10.3389/fcell.2021.640753  0.341
2019 Shohayeb B, Ho U, Yeap YY, Parton RG, Millard SS, Xu Z, Piper M, Ng DCH. The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics. PMID 31816041 DOI: 10.1093/Hmg/Ddz281  0.329
2019 Zhang M, Fu Z, Li C, Liu A, Peng D, Xue F, He W, Gao S, Xu F, Xu D, Yuan L, Zhang F, Xu Z, Xu T, Xu P. Fast super-resolution imaging technique and immediate early nanostructure capturing by a photo-convertible fluorescent protein. Nano Letters. PMID 31576756 DOI: 10.1021/Acs.Nanolett.9B02855  0.309
2019 Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, ... ... Xu Z, et al. Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. PMID 30713029 DOI: 10.1016/J.Neuron.2019.01.010  0.427
2018 Xu D, Yao M, Wang Y, Yuan L, Hoeck JD, Yu J, Liu L, Yeap YYC, Zhang W, Zhang F, Feng Y, Ma T, Wang Y, Ng DCH, Niu X, ... ... Xu Z, et al. MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. Plos Biology. 16: e2006613. PMID 30566428 DOI: 10.1371/Journal.Pbio.2006613  0.482
2018 Zhang F, Wang Y, Wang T, Yao L, Lam SM, Huang X, Fan J, Wang Q, Liu L, Jiang Y, Zhang H, Shi L, Yu M, Shui G, Wang Y, ... ... Xu Z, et al. cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224460 DOI: 10.1073/Pnas.1804083115  0.376
2018 Zhou Y, Qin Y, Qin Y, Xu B, Guo T, Ke H, Chen M, Zhang L, Han F, Li Y, Chen M, Behrens A, Wang Y, Xu Z, Chen ZJ, et al. Wdr62 is involved in meiotic initiation via activating JNK signaling and associated with POI in humans. Plos Genetics. 14: e1007463. PMID 30102701 DOI: 10.1371/Journal.Pgen.1007463  0.388
2017 Shohayeb B, Lim NR, Ho U, Xu Z, Dottori M, Quinn L, Ng DCH. The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Molecular Neurobiology. PMID 28940170 DOI: 10.1007/S12035-017-0778-X  0.363
2017 Yoon KJ, Song G, Qian X, Pan J, Xu D, Rho HS, Kim NS, Habela C, Zheng L, Jacob F, Zhang F, Lee EM, Huang WK, Ringeling FR, Vissers C, ... ... Xu Z, et al. Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. Cell Stem Cell. PMID 28826723 DOI: 10.1016/J.Stem.2017.07.014  0.375
2017 Oh Y, Zhang F, Wang Y, Lee EM, Choi IY, Lim H, Mirakhori F, Li R, Huang L, Xu T, Wu H, Li C, Qin CF, Wen Z, Wu QF, ... ... Xu Z, et al. Zika virus directly infects peripheral neurons and induces cell death. Nature Neuroscience. PMID 28758997 DOI: 10.1038/Nn.4612  0.367
2017 Fang Y, Xu Z, Shi Y, Pei F, Yang W, Ma N, Kimatu BM, Liu K, Qiu W, Hu Q. Protection mechanism of Se-containing protein hydrolysates from Se-enriched rice on Pb2+-induced apoptosis in PC12 and RAW264.7 cells Food Chemistry. 219: 391-398. DOI: 10.1016/j.foodchem.2016.09.131  0.302
2016 Zhang L, Zhang F, Yang T, Zhu X, Zheng N, Li H, Zhu D, Zhu Y, Xu Z. The B cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration. Journal of Molecular Cell Biology. PMID 27436754 DOI: 10.1093/Jmcb/Mjw034  0.339
2016 Zhang H, Kang E, Wang Y, Yang C, Yu H, Wang Q, Chen Z, Zhang C, Christian KM, Song H, Ming GL, Xu Z. Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nature Communications. 7. PMID 27249678 DOI: 10.1038/Ncomms11773  0.331
2016 Li C, Xu D, Ye Q, Hong S, Jiang Y, Liu X, Zhang N, Shi L, Qin CF, Xu Z. Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell. PMID 27179424 DOI: 10.1016/J.Stem.2016.04.017  0.32
2016 Zhang F, Yu J, Yang T, Xu D, Chi Z, Xia Y, Xu Z. A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. The Journal of Biological Chemistry. PMID 27026702 DOI: 10.1074/Jbc.M116.716811  0.493
2016 Shao X, Liu Y, Yu Q, Ding Z, Qian W, Zhang L, Zhang J, Jiang N, Gui L, Xu Z, Hong Y, Ma Y, Wei Y, Liu X, Jiang C, et al. Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Research. PMID 26987402 DOI: 10.1038/Cr.2016.34  0.34
2016 Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Scientific Reports. 6: 21534. PMID 26867947 DOI: 10.1038/Srep21534  0.379
2016 Peng C, Li Z, Niu Z, Niu W, Xu Z, Gao H, Niu W, Wang J, He Z, Gao C, Lin P, Agrez M, Zhang Z, Niu J. Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the αvβ6-ERK-Ets1 Signaling Pathway. Scientific Reports. 6: 20500. PMID 26846153 DOI: 10.1038/srep20500  0.487
2015 Wang Z, Xu Z, Niu Z, Liang B, Niu J. Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells. Cell Biochemistry and Biophysics. 73: 559-564. PMID 27352353 DOI: 10.1007/s12013-015-0687-4  0.481
2015 Niu J, Li Y, Shang E, Xu Z, Liu J. Electrochemical oxidation of perfluorinated compounds in water. Chemosphere. 146: 526-538. PMID 26745381 DOI: 10.1016/j.chemosphere.2015.11.115  0.38
2015 Maharana D, Niu J, Gao D, Xu Z, Shi J. Electrochemical Degradation of Rhodamine B over Ti/SnO2-Sb Electrode. Water Environment Research : a Research Publication of the Water Environment Federation. 87: 304-11. PMID 26462074 DOI: 10.2175/106143015X14212658613514  0.363
2015 Liu E, Qadir Khan A, Niu J, Xu Z, Peng C. Natural Orifice Total Transtracheal Endoscopic Thyroidectomy Surgery: First Reported Experiment. Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. 25: 586-91. PMID 26075801 DOI: 10.1089/lap.2014.0452  0.348
2015 Maharana D, Xu Z, Niu J, Rao NN. Electrochemical oxidation of 2,4,5-trichlorophenoxyacetic acid by metal-oxide-coated Ti electrodes. Chemosphere. 136: 145-52. PMID 25981800 DOI: 10.1016/j.chemosphere.2015.04.100  0.36
2015 Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Williamson NA, Xu Z, Bogoyevitch MA, Ng DC. Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules. Journal of Cell Science. 128: 527-40. PMID 25501809 DOI: 10.1242/Jcs.157537  0.423
2015 Xu Z, Chen Y, Xu G, Peng C, Liu E, Li Y, Niu J, Li C. Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level. Oncology Reports. 33: 905-12. PMID 25484138 DOI: 10.3892/or.2014.3656  0.496
2014 Zhang F, Xu D, Yuan L, Sun Y, Xu Z. Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance. Nature Communications. 5: 5815. PMID 25519973 DOI: 10.1038/Ncomms6815  0.348
2014 Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z. BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12039-48. PMID 25186749 DOI: 10.1523/Jneurosci.0486-14.2014  0.41
2014 Bao Y, Niu J, Xu Z, Gao D, Shi J, Sun X, Huang Q. Removal of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) from water by coagulation: mechanisms and influencing factors. Journal of Colloid and Interface Science. 434: 59-64. PMID 25168583 DOI: 10.1016/J.Jcis.2014.07.041  0.37
2014 Xu D, Zhang F, Wang Y, Sun Y, Xu Z. Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Reports. 6: 104-16. PMID 24388750 DOI: 10.1016/J.Celrep.2013.12.016  0.365
2013 Zhu Y, Wang C, Yu M, Cui J, Liu L, Xu Z. ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression. Protein & Cell. 4: 711-21. PMID 27023913 DOI: 10.1007/S13238-013-3910-3  0.383
2013 Shi W, Chen Y, Gan G, Wang D, Ren J, Wang Q, Xu Z, Xie W, Zhang YQ. Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12352-63. PMID 23884941 DOI: 10.1523/Jneurosci.0386-13.2013  0.32
2013 Xu Z, Chen X, Peng C, Liu E, Li Y, Li C, Niu J. The expression and clinical significance of Omi/Htra2 in hepatocellular carcinoma. Hepato-Gastroenterology. 60: 6-13. PMID 23682386  0.364
2013 Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 110: 4604-9. PMID 23487739 DOI: 10.1073/Pnas.1207586110  0.331
2012 Xu Z, Chen X, Peng C, Liu E, Li Y, Li C, Niu J. Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion. Oncology Research. 20: 213-20. PMID 23581228 DOI: 10.3727/096504013X13589503482815  0.479
2012 Yang T, Sun Y, Zhang F, Zhu Y, Shi L, Li H, Xu Z. POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Reports. 2: 640-51. PMID 22959435 DOI: 10.1016/J.Celrep.2012.08.007  0.364
2012 Niu J, Yu M, Wang C, Xu Z. Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein. Journal of Neurochemistry. 122: 650-8. PMID 22639965 DOI: 10.1111/J.1471-4159.2012.07809.X  0.564
2012 Xu ZQ, Chen XP, Niu J, Liu EY, Li CH, Peng C. [The prognostic significance of Omi/HtrA2 expression, and correlation between Omi/HtrA2 and hypoxia-inducible factor-1α in primary hepatocellular carcinoma cells]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]. 50: 49-52. PMID 22490291  0.415
2012 Wilhelm M, Kukekov NV, Schmit TL, Biagas KV, Sproul AA, Gire S, Maes ME, Xu Z, Greene LA. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. The Journal of Biological Chemistry. 287: 2247-56. PMID 22128169 DOI: 10.1074/Jbc.M111.269431  0.808
2012 Xu Z, Liu E, Peng C, Li Y, He Z, Zhao C, Niu J. Role of hypoxia-inducible-1α in hepatocellular carcinoma cells using a Tet-on inducible system to regulate its expression in vitro. Oncology Reports. 27: 573-8. PMID 22075557 DOI: 10.3892/or.2011.1533  0.498
2011 Cui J, Yu M, Niu J, Yue Z, Xu Z. Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. Bioscience Reports. 31: 429-37. PMID 21370995 DOI: 10.1042/Bsr20100127  0.577
2010 Wang C, Tao Y, Wang Y, Xu Z. Regulation of the protein stability of POSH and MLK family. Protein & Cell. 1: 871-8. PMID 21203929 DOI: 10.1007/S13238-010-0111-1  0.51
2010 Zhang M, Zhang Y, Xu Z. POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila Journal of Genetics and Genomics. 37: 605-619. PMID 20933214 DOI: 10.1016/S1673-8527(09)60080-1  0.435
2010 Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z. The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development. The Journal of Biological Chemistry. 285: 39039-50. PMID 20926379 DOI: 10.1074/Jbc.M110.168351  0.428
2010 Ren J, Wang Y, Liang Y, Zhang Y, Bao S, Xu Z. Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. The Journal of Biological Chemistry. 285: 12695-705. PMID 20159986 DOI: 10.1074/Jbc.M110.103911  0.356
2009 Niu J, Zhao J, Xu Z, Qian J. A two-time scale decentralized model predictive controller based on input and output model. Journal of Automated Methods & Management in Chemistry. 2009: 164568. PMID 19834542 DOI: 10.1155/2009/164568  0.364
2009 Sproul AA, Xu Z, Wilhelm M, Gire S, Greene LA. Cbl negatively regulates JNK activation and cell death. Cell Research. 19: 950-61. PMID 19546888 DOI: 10.1038/Cr.2009.74  0.805
2009 Shen Q, Qin F, Gao Z, Cui J, Xiao H, Xu Z, Yang C. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Molecular and Cellular Biology. 29: 3881-93. PMID 19414600 DOI: 10.1128/Mcb.01509-08  0.47
2009 Cui J, Zhang M, Zhang YQ, Xu ZH. JNK pathway: diseases and therapeutic potential. Acta Pharmacologica Sinica. 28: 601-8. PMID 17439715 DOI: 10.1111/J.1745-7254.2007.00579.X  0.508
2008 Liu S, Yu M, He Y, Xiao L, Wang F, Song C, Sun S, Ling C, Xu Z. Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology (Baltimore, Md.). 47: 1964-73. PMID 18506888 DOI: 10.1002/Hep.22240  0.315
2008 Qiao HX, Hao CJ, Li Y, He X, Chen RS, Cui J, Xu ZH, Li W. JNK activation mediates the apoptosis of xCT-deficient cells. Biochemical and Biophysical Research Communications. 370: 584-8. PMID 18395005 DOI: 10.1016/J.Bbrc.2008.03.134  0.508
2008 Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA. β-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation: JNK activation and Aβ-induced death Journal of Neurochemistry. 77: 157-164. DOI: 10.1046/J.1471-4159.2001.00218.X  0.501
2007 Sun Y, Yang T, Xu Z. The JNK pathway and neuronal migration. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 34: 957-65. PMID 18037132 DOI: 10.1016/S1673-8527(07)60108-8  0.488
2007 Wilhelm M, Kukekov NV, Xu Z, Greene LA. Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH. Developmental Neuroscience. 29: 355-62. PMID 17762203 DOI: 10.1159/000105476  0.823
2007 Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells. Cancer Research. 67: 4700-8. PMID 17510397 DOI: 10.1158/0008-5472.Can-06-4645  0.471
2007 Niu J, Xu Z, Li XN, Han Z. siRNA-mediated type 1 insulin-like growth factor receptor silencing induces chemosensitization of a human liver cancer cell line with mutant P53. Cell Biology International. 31: 156-64. PMID 17097318 DOI: 10.1016/j.cellbi.2006.09.021  0.465
2007 Wilhelm M, Xu Z, Kukekov NV, Gire S, Greene LA. Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. The Journal of Biological Chemistry. 282: 1288-95. PMID 17095503 DOI: 10.1074/Jbc.M607038200  0.819
2006 Tang G, Xu Z, Goldman JE. Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. The Journal of Biological Chemistry. 281: 38634-43. PMID 17038307 DOI: 10.1074/Jbc.M604942200  0.455
2006 Kukekov NV, Xu Z, Greene LA. Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. The Journal of Biological Chemistry. 281: 15517-24. PMID 16571722 DOI: 10.1074/Jbc.M601056200  0.801
2006 Xu Z, Greene LA. Activation of the apoptotic JNK pathway through the Rac1-binding scaffold protein POSH. Methods in Enzymology. 406: 479-89. PMID 16472680 DOI: 10.1016/S0076-6879(06)06036-8  0.637
2006 Xu Z, Sproul A, Wang W, Kukekov N, Greene LA. Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis. The Journal of Biological Chemistry. 281: 303-12. PMID 16230351 DOI: 10.1074/Jbc.M509060200  0.784
2005 Xu Z, Kukekov NV, Greene LA. Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop. Molecular and Cellular Biology. 25: 9949-59. PMID 16260609 DOI: 10.1128/Mcb.25.22.9949-9959.2005  0.813
2005 Zeng S, Xu Z, Lipkowitz S, Longley JB. Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood. 105: 226-32. PMID 15315962 DOI: 10.1182/Blood-2004-05-1768  0.481
2005 Wilhelm M, Gire S, Xu Z, Kukekov NV, Greene LA. POSH REGULATES JNK ACTIVATION BY THE BH3-ONLY PROTEIN NIX. Critical Care Medicine. 33: A16. DOI: 10.1097/00003246-200512002-00064  0.778
2004 Hanlon SE, Xu Z, Norris DN, Vershon AK. Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae. Yeast (Chichester, England). 21: 1241-52. PMID 15543521 DOI: 10.1002/Yea.1174  0.337
2004 Wilhelm M, Vannucci SJ, Kukekov NV, Xu Z, Greene LA. A NOVEL POSH HOMOLOGUE AND ITS ROLE IN NEURONAL APOPTOSIS Critical Care Medicine. 32: A98. DOI: 10.1097/00003246-200412001-00354  0.775
2003 Xu Z, Kukekov NV, Greene LA. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. The Embo Journal. 22: 252-61. PMID 12514131 DOI: 10.1093/Emboj/Cdg021  0.816
2001 Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Molecular and Cellular Biology. 21: 4713-24. PMID 11416147 DOI: 10.1128/Mcb.21.14.4713-4724.2001  0.819
2001 Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL. Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. The Journal of Biological Chemistry. 276: 25302-8. PMID 11325962 DOI: 10.1074/Jbc.M011601200  0.637
2001 Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA. beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. Journal of Neurochemistry. 77: 157-64. PMID 11279271 DOI: 10.1046/J.1471-4159.2001.T01-1-00218.X  0.569
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