Zhenyu Yue - Publications

Neurosciences Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Neuroscience Biology

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kearney P, Zhang Y, Tan Y, Kahuno E, Conklin T, Fagan R, Pavchinskiy R, Shaffer S, Yue Z, Melikian H. Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype. Research Square. PMID 37293098 DOI: 10.21203/rs.3.rs-2944614/v1  0.311
2023 Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE. Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype. Biorxiv : the Preprint Server For Biology. PMID 37162843 DOI: 10.1101/2023.04.26.538430  0.311
2022 Choi I, Heaton GR, Lee YK, Yue Z. Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy. Science Advances. 8: eabn1298. PMID 36288297 DOI: 10.1126/sciadv.abn1298  0.392
2021 Deng Z, Zhou X, Lu JH, Yue Z. Autophagy deficiency in neurodevelopmental disorders. Cell & Bioscience. 11: 214. PMID 34920755 DOI: 10.1186/s13578-021-00726-x  0.373
2020 Seegobin SP, Heaton GR, Liang D, Choi I, Blanca Ramirez M, Tang B, Yue Z. Progress in -Associated Parkinson's Disease Animal Models. Frontiers in Neuroscience. 14: 674. PMID 32765209 DOI: 10.3389/Fnins.2020.00674  0.402
2020 Lu J, Wu M, Yue Z. Autophagy and Parkinson's Disease. Advances in Experimental Medicine and Biology. 1207: 21-51. PMID 32671737 DOI: 10.1007/978-981-15-4272-5_2  0.452
2020 Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M, et al. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 1-19. PMID 32543313 DOI: 10.1080/15548627.2020.1760623  0.359
2020 Choi I, Seegobin SP, Liang D, Yue Z. Synucleinphagy: a microglial "community cleanup program" for neuroprotection. Autophagy. PMID 32453651 DOI: 10.1080/15548627.2020.1774149  0.419
2020 Pan PY, Sheehan P, Wang Q, Zhu X, Zhang Y, Choi I, Li X, Saenz J, Zhu J, Wang J, El Gaamouch F, Zhu L, Cai D, Yue Z. Synj1 Haploinsufficiency Causes Dopamine Neuron Vulnerability and alpha-synuclein Accumulation in Mice. Human Molecular Genetics. PMID 32356558 DOI: 10.1093/Hmg/Ddaa080  0.685
2020 Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nature Communications. 11: 1386. PMID 32170061 DOI: 10.1038/S41467-020-15119-W  0.373
2020 Wu MY, Liu L, Wang EJ, Xiao HT, Cai CZ, Wang J, Su H, Wang Y, Tan J, Zhang Z, Wang J, Yao M, Ouyang DF, Yue Z, Li M, et al. PI3KC3 subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation. Autophagy. PMID 32160108 DOI: 10.1080/15548627.2020.1741332  0.318
2020 Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, Li Y, Zhou L, He H, Yu C, Liu J, Dang Y, Xia Y, He Q, Jin H, ... ... Yue Z, et al. The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis. Autophagy. PMID 32160082 DOI: 10.1080/15548627.2020.1741202  0.311
2019 Dong Y, Hu Y, Sarkar S, Zong WX, Li M, Feng D, Song JX, Li M, Medina DL, Tan J, Zhang Z, Yue Z, Lu JH. Autophagy Modulator Scoring System: a User-friendly Tool for Quantitative Analysis of Methodological Integrity of Chemical Autophagy Modulator Studies. Autophagy. PMID 31841063 DOI: 10.1080/15548627.2019.1704119  0.324
2019 Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z. Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice. Molecular Neurodegeneration. 14: 43. PMID 31775806 DOI: 10.1186/S13024-019-0342-4  0.307
2019 Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z, Zhang B. The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease. Nature Communications. 10: 5234. PMID 31748532 DOI: 10.1038/S41467-019-13144-Y  0.672
2019 Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31483900 DOI: 10.1002/Mds.27823  0.432
2019 Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S, Yue Z. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 1-15. PMID 31362587 DOI: 10.1080/15548627.2019.1644076  0.405
2019 Schaffner A, Li X, Gomez-Llorente Y, Leandrou E, Memou A, Clemente N, Yao C, Afsari F, Zhi L, Pan N, Morohashi K, Hua X, Zhou MM, Wang C, Zhang H, ... ... Yue Z, et al. Vitamin B modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection. Cell Research. PMID 30858560 DOI: 10.1038/S41422-019-0153-8  0.401
2019 Sheehan P, Yue Z. Deregulation of autophagy and vesicle trafficking in Parkinson's disease. Neuroscience Letters. 697: 59-65. PMID 29627340 DOI: 10.1016/J.Neulet.2018.04.013  0.457
2018 Lee YA, Noon LA, Akat KM, Ybanez MD, Lee TF, Berres ML, Fujiwara N, Goossens N, Chou HI, Parvin-Nejad FP, Khambu B, Kramer EGM, Gordon R, Pfleger C, Germain D, ... ... Yue Z, et al. Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap. Nature Communications. 9: 4962. PMID 30470740 DOI: 10.1038/S41467-018-07338-Z  0.328
2018 Guo JF, Zhang L, Li K, Mei JP, Xue J, Chen J, Tang X, Shen L, Jiang H, Chen C, Guo H, Wu XL, Sun SL, Xu Q, Sun QY, ... ... Yue ZY, et al. Coding mutations in contribute to Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348779 DOI: 10.1073/Pnas.1809969115  0.41
2018 Pan PY, Zhu Y, Shen Y, Yue Z. Crosstalk between presynaptic trafficking and autophagy in Parkinson's disease. Neurobiology of Disease. PMID 29723605 DOI: 10.1016/J.Nbd.2018.04.020  0.679
2018 Wang P, Shao BZ, Deng Z, Chen S, Yue Z, Miao CY. Autophagy in ischemic stroke. Progress in Neurobiology. PMID 29331396 DOI: 10.1016/J.Pneurobio.2018.01.001  0.344
2018 Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, ... ... Yue Z, et al. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Science Translational Medicine. 10. PMID 29321258 DOI: 10.1126/Scitranslmed.Aai7795  0.338
2018 Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, Yue Z, et al. Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology. Nature Communications. 9: 81. PMID 29311685 DOI: 10.1038/S41467-017-02593-Y  0.46
2017 Deng Z, Sheehan P, Chen S, Yue Z. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease? Molecular Neurodegeneration. 12: 90. PMID 29282133 DOI: 10.1186/S13024-017-0232-6  0.369
2017 Yang N, Yue Z. A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish. Trends in Neurosciences. PMID 29248177 DOI: 10.1016/J.Tins.2017.12.001  0.4
2017 Pan PY, Li X, Wang J, Powell J, Wang Q, Zhang Y, Chen Z, Wicinski B, Hof P, Ryan TA, Yue Z. Parkinson's disease associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29054882 DOI: 10.1523/Jneurosci.0964-17.2017  0.687
2017 Yang C, Cai CZ, Song JX, Tan JQ, Durairajan SSK, Iyaswamy A, Wu MY, Chen LL, Yue Z, Li M, Lu JH. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 0. PMID 28980867 DOI: 10.1080/15548627.2017.1379633  0.337
2017 Fribourg M, Ni J, Papavasiliou FN, Yue Z, Heeger PS, Leventhal JS. Allospecific Memory B Cell Responses are Dependent on Autophagy. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28621910 DOI: 10.1111/Ajt.14394  0.33
2017 Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, ... ... Yue Z, et al. Molecular definitions of autophagy and related processes. The Embo Journal. PMID 28596378 DOI: 10.15252/Embj.201796697  0.318
2017 Deng Z, Purtell K, Lachance V, Wold MS, Chen S, Yue Z. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology. PMID 28169082 DOI: 10.1016/J.Tcb.2017.01.001  0.392
2017 Ma X, Zhang S, He L, Rong Y, Wilz Brier L, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 0. PMID 28059666 DOI: 10.1080/15548627.2016.1269988  0.334
2016 Wold MS, Lim J, Lachance V, Deng Z, Yue Z. ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models. Molecular Neurodegeneration. 11: 76. PMID 27938392 DOI: 10.1186/S13024-016-0141-0  0.427
2016 Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB. G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7415-27. PMID 27413152 DOI: 10.1523/Jneurosci.3642-15.2016  0.359
2016 Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, et al. Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proceedings of the National Academy of Sciences of the United States of America. PMID 27357661 DOI: 10.1073/Pnas.1523708113  0.377
2016 Zhang J, Lachance V, Schaffner A, Li X, Fedick A, Kaye LE, Liao J, Rosenfeld J, Yachelevich N, Chu ML, Mitchell WG, Boles RG, Moran E, Tokita M, Gorman E, ... ... Yue Z, et al. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. Plos Genetics. 12: e1005848. PMID 27120463 DOI: 10.1371/Journal.Pgen.1005848  0.353
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Yue Z, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.352
2015 Sweet ES, Saunier-Rebori B, Yue Z, Blitzer RD. The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11190-5. PMID 26269629 DOI: 10.1523/Jneurosci.0040-15.2015  0.444
2015 Chikina MD, Gerald CP, Li X, Ge Y, Pincas H, Nair VD, Wong AK, Krishnan A, Troyanskaya OG, Raymond D, Saunders-Pullman R, Bressman SB, Yue Z, Sealfon SC. Low-variance RNAs identify Parkinson's disease molecular signature in blood. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 813-21. PMID 25786808 DOI: 10.1002/Mds.26205  0.4
2015 Lim J, Lachenmayer ML, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, Yue Z. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. Plos Genetics. 11: e1004987. PMID 25723488 DOI: 10.1371/Journal.Pgen.1004987  0.405
2015 Lim J, Yue Z. Neuronal aggregates: formation, clearance, and spreading. Developmental Cell. 32: 491-501. PMID 25710535 DOI: 10.1016/J.Devcel.2015.02.002  0.379
2015 Yu C, Gorantla SP, Mueller T, Lippert L, Yue Z, Zeiser R, Huber T, Duyster J, Illert AL. Beclin-1 Phosphorylation By BCR-ABL Is Crucial for CML Leukemogenesis By Suppression of Autophagy Blood. 126: 16-16. DOI: 10.1182/Blood.V126.23.16.16  0.408
2014 McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong WX, Yue Z. Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. Plos Genetics. 10: e1004626. PMID 25275521 DOI: 10.1371/Journal.Pgen.1004626  0.459
2014 Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 83: 1131-43. PMID 25155956 DOI: 10.1016/J.Neuron.2014.07.040  0.348
2014 Vodicka P, Lim J, Williams DT, Kegel KB, Chase K, Park H, Marchionini D, Wilkinson S, Mead T, Birch H, Yates D, Lyons K, Dominguez C, Beconi M, Yue Z, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. Journal of Huntington's Disease. 3: 159-74. PMID 25062859 DOI: 10.3233/Jhd-130081  0.316
2014 Lu J, He L, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature Communications. 5: 3920. PMID 24849286 DOI: 10.1038/Ncomms4920  0.354
2014 Yamamoto A, Yue Z. Autophagy and its normal and pathogenic states in the brain. Annual Review of Neuroscience. 37: 55-78. PMID 24821313 DOI: 10.1146/Annurev-Neuro-071013-014149  0.398
2014 Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, ... Yue Z, et al. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Human Molecular Genetics. 23: 4887-905. PMID 24794857 DOI: 10.1093/Hmg/Ddu202  0.461
2014 Pan PY, Yue Z. Genetic causes of Parkinson's disease and their links to autophagy regulation Parkinsonism and Related Disorders. 20. PMID 24262170 DOI: 10.1016/S1353-8020(13)70037-3  0.698
2014 Song JX, Lu JH, Liu LF, Chen LL, Durairajan SS, Yue Z, Zhang HQ, Li M. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 10: 144-54. PMID 24178442 DOI: 10.4161/Auto.26751  0.445
2013 Krebs CE, Karkheiran S, Powell JC, Cao M, Makarov V, Darvish H, Di Paolo G, Walker RH, Shahidi GA, Buxbaum JD, De Camilli P, Yue Z, Paisán-Ruiz C. The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures. Human Mutation. 34: 1200-7. PMID 23804563 DOI: 10.1002/Humu.22372  0.36
2013 Sepulveda B, Mesias R, Li X, Yue Z, Benson DL. Short- and long-term effects of LRRK2 on axon and dendrite growth. Plos One. 8: e61986. PMID 23646112 DOI: 10.1371/Journal.Pone.0061986  0.371
2013 Yang Y, Coleman M, Zhang L, Zheng X, Yue Z. Autophagy in axonal and dendritic degeneration. Trends in Neurosciences. 36: 418-28. PMID 23639383 DOI: 10.1016/J.Tins.2013.04.001  0.356
2013 Yue Z, Yang XW. Dangerous duet: LRRK2 and α-synuclein jam at CMA. Nature Neuroscience. 16: 375-7. PMID 23528933 DOI: 10.1038/Nn.3361  0.402
2013 He L, Lu J, Yue Z. Autophagy in ageing and ageing-associated diseases. Acta Pharmacologica Sinica. 34: 605-611. PMID 23416930 DOI: 10.1038/Aps.2012.188  0.374
2013 Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Yue Z, et al. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry. 18: 882-8. PMID 22869031 DOI: 10.1038/Mp.2012.115  0.404
2013 Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Yue Z, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry. 18: 889-97. PMID 22850627 DOI: 10.1038/Mp.2012.106  0.356
2013 Bezard E, Yue Z, Kirik D, Spillantini MG. Animal models of Parkinson's disease: limits and relevance to neuroprotection studies. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 61-70. PMID 22753348 DOI: 10.1002/Mds.25108  0.39
2013 Gómez Llorente Y, Renzi F, Li X, Rice WJ, Chavez J, Pan N, Powell J, Yue Z, Ubarretxena-Belandia I. Electron Microscopy Structure of Dimeric LRRK2 Reveals a Structural and Regulatory Role of the COR Domain Biophysical Journal. 104: 351a. DOI: 10.1016/J.Bpj.2012.11.1949  0.361
2012 Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, et al. Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations. Science Translational Medicine. 4: 164ra161. PMID 23241745 DOI: 10.1126/Scitranslmed.3004485  0.405
2012 McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y. Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15704-14. PMID 23136410 DOI: 10.1523/Jneurosci.2392-12.2012  0.356
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Yue Z, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.316
2012 Lachenmayer ML, Yue Z. Genetic animal models for evaluating the role of autophagy in etiopathogenesis of Parkinson disease Autophagy. 8: 1837-1838. PMID 22931754 DOI: 10.4161/Auto.21859  0.457
2012 Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, et al. Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's Disease : Jad. 32: 949-67. PMID 22903131 DOI: 10.3233/Jad-2012-120178  0.373
2012 Lan D, Liu F, Zhao J, Chen Y, Wu J, Ding Z, Yue Z, Ren H, Jiang Y, Wang J. Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein Neurochemical Research. 37: 2025-2032. PMID 22707286 DOI: 10.1007/S11064-012-0823-0  0.363
2012 Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M, Holstein GR, Yue Z. Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7585-93. PMID 22649237 DOI: 10.1523/Jneurosci.5809-11.2012  0.48
2012 Yu W, Jiang T, Lan D, Lu J, Yue Z, Wang J, Zhou P. Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils. Archives of Biochemistry and Biophysics. 523: 144-150. PMID 22575388 DOI: 10.1016/J.Abb.2012.04.021  0.36
2012 Lim J, Lee Y, Kim HW, Rhyu IJ, Oh MS, Youdim MB, Yue Z, Oh YJ. Nigericin-induced impairment of autophagic flux in neuronal cells is inhibited by overexpression of Bak. The Journal of Biological Chemistry. 287: 23271-82. PMID 22493436 DOI: 10.1074/Jbc.M112.364281  0.374
2012 Grundmann K, Glöckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, et al. Generation of a novel rodent model for DYT1 dystonia. Neurobiology of Disease. 47: 61-74. PMID 22472189 DOI: 10.1016/J.Nbd.2012.03.024  0.304
2012 Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host & Microbe. 11: 264-76. PMID 22423966 DOI: 10.1016/J.Chom.2012.01.018  0.309
2012 Konishi A, Arakawa S, Yue Z, Shimizu S. Involvement of Beclin 1 in engulfment of apoptotic cells. The Journal of Biological Chemistry. 287: 13919-29. PMID 22393062 DOI: 10.1074/Jbc.M112.348375  0.304
2012 Yue Z. Genetic mouse models for understanding LRRK2 biology, pathology and pre-clinical application Parkinsonism and Related Disorders. 18. PMID 22166428 DOI: 10.1016/S1353-8020(11)70056-6  0.428
2012 Yue Z, Chu CT. Autophagy of the nervous system: Cellular self-digestion in neurons and neurological diseases Autophagy of the Nervous System: Cellular Self-Digestion in Neurons and Neurological Diseases. 1-426. DOI: 10.1142/9789814350457  0.309
2011 Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. Plos Genetics. 7: e1002321. PMID 22022281 DOI: 10.1371/Journal.Pgen.1002321  0.341
2011 Yue Z, Lachenmayer ML. Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications Movement Disorders. 26: 1386-1397. PMID 21538530 DOI: 10.1002/Mds.23737  0.366
2011 Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z. Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. Plos One. 6: e17153. PMID 21390248 DOI: 10.1371/Journal.Pone.0017153  0.412
2011 Cui J, Yu M, Niu J, Yue Z, Xu Z. Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. Bioscience Reports. 31: 429-37. PMID 21370995 DOI: 10.1042/Bsr20100127  0.328
2011 Ishii Y, Papa L, Bahadur U, Yue Z, Aguirre-Ghiso J, Shioda T, Waxman S, Germain D. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2292-300. PMID 21292820 DOI: 10.1158/1078-0432.Ccr-10-1745  0.301
2011 Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, MacNeil M, Papavasiliou FN, Yue Z, Ortiz BD. A role for autophagic protein beclin 1 early in lymphocyte development. Journal of Immunology (Baltimore, Md. : 1950). 186: 2201-9. PMID 21239722 DOI: 10.4049/Jimmunol.1002223  0.315
2010 Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, Zong WX. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. The Journal of Cell Biology. 191: 827-43. PMID 21059846 DOI: 10.1083/Jcb.201006056  0.336
2010 Yue Z, Zhong Y. From a global view to focused examination: Understanding cellular function of lipid kinase VPS34-Beclin 1 complex in autophagy Journal of Molecular Cell Biology. 2: 305-307. PMID 20846953 DOI: 10.1093/Jmcb/Mjq028  0.361
2010 Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors. Analytical Biochemistry. 404: 186-92. PMID 20566370 DOI: 10.1016/J.Ab.2010.05.033  0.32
2010 Yue Z. Autophagy in lurcher mice: Indicted but yet to be acquitted for the death of Purkinje cells Autophagy. 6: 571-572. PMID 20404573 DOI: 10.4161/Auto.6.4.11957  0.366
2010 Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends in Cell Biology. 20: 355-62. PMID 20356743 DOI: 10.1016/J.Tcb.2010.03.002  0.387
2010 Liu M, Dobson B, Glicksman MA, Yue Z, Stein RL. Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities. Biochemistry. 49: 2008-17. PMID 20146535 DOI: 10.1021/Bi901851Y  0.356
2010 Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z. Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1788-97. PMID 20130188 DOI: 10.1523/Jneurosci.5604-09.2010  0.417
2010 Funderburk SF, Marcellino BK, Yue Z. Cell "self-eating" (autophagy) mechanism in Alzheimer's disease. The Mount Sinai Journal of Medicine, New York. 77: 59-68. PMID 20101724 DOI: 10.1002/Msj.20161  0.433
2009 Yue Z. LRRK2 in Parkinson's disease: In vivo models and approaches for understanding pathogenic roles Febs Journal. 276: 6445-6454. PMID 19804414 DOI: 10.1111/J.1742-4658.2009.07343.X  0.434
2009 Zhong Y, Wang QJ, Yue Z. Atg14L and Rubicon: yin and yang of Beclin 1-mediated autophagy control. Autophagy. 5: 890-1. PMID 19556860 DOI: 10.4161/Auto.9162  0.385
2009 Yue Z, Friedman L, Komatsu M, Tanaka K. The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochimica Et Biophysica Acta. 1793: 1496-507. PMID 19339210 DOI: 10.1016/J.Bbamcr.2009.01.016  0.41
2009 Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nature Cell Biology. 11: 468-76. PMID 19270693 DOI: 10.1038/Ncb1854  0.384
2009 Yue Z, Holstein GR, Chait BT, Wang QJ. Using genetic mouse models to study the biology and pathology of autophagy in the central nervous system. Methods in Enzymology. 453: 159-80. PMID 19216906 DOI: 10.1016/S0076-6879(08)04008-1  0.41
2009 Liu X, Yue Z. Recent patents and patent applications relating to mTOR pathway. Recent Patents On Dna & Gene Sequences. 3: 44-52. PMID 19149738 DOI: 10.2174/187221509787236192  0.31
2008 Tang G, Yue Z, Tallóczy Z, Goldman JE. Adaptive autophagy in Alexander disease-affected astrocytes. Autophagy. 4: 701-703. PMID 28186854 DOI: 10.4161/Auto.6028  0.42
2008 Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, Sealfon SC, Yue Z. BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death and Differentiation. 15: 1385-95. PMID 18451870 DOI: 10.1038/Cdd.2008.59  0.342
2008 Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Human Molecular Genetics. 17: 1540-55. PMID 18276609 DOI: 10.1093/Hmg/Ddn042  0.39
2008 Yue Z, Wang QJ, Komatsu M. Neuronal autophagy: going the distance to the axon. Autophagy. 4: 94-6. PMID 18000396 DOI: 10.4161/Auto.5202  0.397
2007 Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, ... ... Yue Z, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 131: 1149-63. PMID 18083104 DOI: 10.1016/J.Cell.2007.10.035  0.393
2007 Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. Journal of Neurochemistry. 103: 238-47. PMID 17623048 DOI: 10.1111/J.1471-4159.2007.04743.X  0.407
2007 Yue Z. Regulation of neuronal autophagy in axon: Implication of autophagy in axonal function and dysfunction/degeneration Autophagy. 3: 139-141. PMID 17204855 DOI: 10.4161/Auto.3602  0.333
2006 Wang QJ, Ding Y, Kohtz DS, Kohtz S, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z. Induction of autophagy in axonal dystrophy and degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8057-68. PMID 16885219 DOI: 10.1523/Jneurosci.2261-06.2006  0.351
2003 Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 100: 15077-82. PMID 14657337 DOI: 10.1073/Pnas.2436255100  0.328
2002 Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N. A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron. 35: 921-33. PMID 12372286 DOI: 10.1016/S0896-6273(02)00861-9  0.377
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