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Matt Trudeau, Ph.D. - Publications

Affiliations: 
Physiology University of Maryland School of Medicine, Baltimore, MD, United States 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Codding SJ, Johnson AA, Trudeau MC. Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains. Channels (Austin, Tex.). 14: 294-309. PMID 32924766 DOI: 10.1080/19336950.2020.1816107  0.549
2018 Codding SJ, Trudeau MC. The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure. The Journal of General Physiology. PMID 30425124 DOI: 10.1085/Jgp.201812129  0.521
2018 Johnson AA, Trudeau MC. Dynamics of the EAG Domain and Cyclic Nucleotide-Binding Homology Domain Interaction Probed with a Fluorescent Noncanonical Amino Acid (L-ANAP) in hERG Potassium Channels Biophysical Journal. 114: 294a. DOI: 10.1016/J.Bpj.2017.11.1679  0.316
2017 McNally BA, Pendon Z, Trudeau MC. hERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channels. The Journal of Biological Chemistry. PMID 29089383 DOI: 10.1074/Jbc.M117.816488  0.509
2016 Johnson AA, Jones D, Roti Roti EC, Robertson G, Trudeau M. The F-Actin Binding Protein TRIOBP-1 Regulates hERG K+ Channels Biophysical Journal. 110: 186a. DOI: 10.1016/J.Bpj.2015.11.1036  0.458
2015 Liu QN, Trudeau MC. Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Plos One. 10: e0123951. PMID 25923442 DOI: 10.1371/Journal.Pone.0123951  0.466
2015 Gallagher CD, Trudeau MC. An Eag Domain Polypeptide Regulates the Deactivation Kinetics of the hERG 1A-3.1 Splice Variant Linked to Schizophrenia Biophysical Journal. 108: 277a. DOI: 10.1016/J.Bpj.2014.11.1516  0.445
2015 McNally BA, Trudeau MC. Direct Preferential Interactions between hERG1a and hERG1b Subunits: Evidence for hERG1a-hERG1b Dimers Biophysical Journal. 108: 276a. DOI: 10.1016/J.Bpj.2014.11.1514  0.434
2014 Jones DK, Liu F, Vaidyanathan R, Eckhardt LL, Trudeau MC, Robertson GA. hERG 1b is critical for human cardiac repolarization. Proceedings of the National Academy of Sciences of the United States of America. 111: 18073-7. PMID 25453103 DOI: 10.1073/Pnas.1414945111  0.313
2013 Gianulis EC, Liu Q, Trudeau MC. Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels. The Journal of General Physiology. 142: 351-66. PMID 24043860 DOI: 10.1085/Jgp.201310995  0.454
2013 Brelidze TI, Gianulis EC, DiMaio F, Trudeau MC, Zagotta WN. Structure of the C-terminal region of an ERG channel and functional implications. Proceedings of the National Academy of Sciences of the United States of America. 110: 11648-53. PMID 23801759 DOI: 10.1073/Pnas.1306887110  0.703
2013 Gustina AS, Trudeau MC. The eag domain regulates hERG channel inactivation gating via a direct interaction. The Journal of General Physiology. 141: 229-41. PMID 23319729 DOI: 10.1085/Jgp.201210870  0.462
2013 Brelidze TI, DiMaio F, Trudeau MC, Zagotta WN. Structure of the C-Terminal Region of an ERG Channel and Functional Implications for Long-QT Syndrome Biophysical Journal. 104: 356a. DOI: 10.1016/J.Bpj.2012.11.1978  0.704
2013 Gianulis EC, Trudeau MC. Determining the role of the S4-S5 Linker in hERG eag Domain Regulation of Channel Gating Biophysical Journal. 104: 264a-265a. DOI: 10.1016/j.bpj.2012.11.1487  0.403
2012 Trudeau MC. Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels. The Journal of General Physiology. 140: 457-61. PMID 23071267 DOI: 10.1085/Jgp.201210898  0.488
2012 Gustina AS, Trudeau MC. HERG potassium channel regulation by the N-terminal eag domain. Cellular Signalling. 24: 1592-8. PMID 22522181 DOI: 10.1016/J.Cellsig.2012.04.004  0.422
2012 Gustina AS, Trudeau MC. N-Terminal Region Regulation of hERG Potassium Channel Gating: Contributions of the Eag/Pas Domain and the Proximal N-Terminus Biophysical Journal. 102: 330a-331a. DOI: 10.1016/J.Bpj.2011.11.1811  0.426
2012 Gianulis EC, Trudeau MC. Determining the Role of the hERG Intracellular Loop Regions in Regulating Channel Gating Biophysical Journal. 102: 329a. DOI: 10.1016/J.Bpj.2011.11.1802  0.469
2012 Trudeau M. Role of the N-Terminal PAS Domain of hERG K Channels in Gating, Disease and Rescue Biophysical Journal. 102: 2-2. DOI: 10.1016/J.Bpj.2011.11.1158  0.537
2011 Trudeau MC, Leung LM, Roti ER, Robertson GA. hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome. The Journal of General Physiology. 138: 581-92. PMID 22124116 DOI: 10.1085/Jgp.201110683  0.534
2011 Gianulis EC, Trudeau MC. Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels. The Journal of Biological Chemistry. 286: 22160-9. PMID 21536673 DOI: 10.1074/Jbc.M110.205948  0.529
2011 Gustina AS, Trudeau MC. hERG potassium channel gating is mediated by N- and C-terminal region interactions. The Journal of General Physiology. 137: 315-25. PMID 21357734 DOI: 10.1085/Jgp.201010582  0.499
2010 Gianulis EC, Trudeau MC. Rescue of Gating in hERG1 Potassium Channels Containing LQT2 Mutations in the N-Terminal PAS Domain Biophysical Journal. 98: 120a. DOI: 10.1016/J.Bpj.2009.12.654  0.417
2010 Gustina AS, Trudeau MC. The Eag Domain Regulates Outward Current Density and Recovery from Inactivation of the hERG K+ Channel Through a Non-Covalent Interaction Biophysical Journal. 98: 119a-120a. DOI: 10.1016/J.Bpj.2009.12.652  0.443
2010 Trudeau M, Roti ER, Robertson G. A New Mechanism for Long QT Syndrome: Polypeptides Encoded by hERG1a Non-Sense Mutations Regulate hERG1a/1b Channels Biophysical Journal. 98: 119. DOI: 10.1016/J.Bpj.2009.12.651  0.473
2009 Gustina AS, Trudeau MC. A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 106: 13082-7. PMID 19651618 DOI: 10.1073/Pnas.0900180106  0.492
2009 Gustina AS, Gianulis EC, Trudeau MC. Restoration of Deactivation in N-truncated and LQTS HERG K+ Channel Mutants by a Recombinant N-terminal Region Fragment Biophysical Journal. 96: 191a. DOI: 10.1016/J.Bpj.2008.12.895  0.461
2008 Shepard PD, Trudeau MC. Emerging roles for ether-á-go-go-related gene potassium channels in the brain. The Journal of Physiology. 586: 4785-6. PMID 18854431 DOI: 10.1113/Jphysiol.2008.162669  0.451
2006 Trudeau MM, Dalton JC, Day JW, Ranum LP, Meisler MH. Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation. Journal of Medical Genetics. 43: 527-30. PMID 16236810 DOI: 10.1136/Jmg.2005.035667  0.366
2004 Trudeau MC, Zagotta WN. Dynamics of Ca2+-calmodulin-dependent inhibition of rod cyclic nucleotide-gated channels measured by patch-clamp fluorometry. The Journal of General Physiology. 124: 211-23. PMID 15314069 DOI: 10.1085/Jgp.200409101  0.673
2003 Buchner DA, Trudeau M, Meisler MH. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science (New York, N.Y.). 301: 967-9. PMID 12920299 DOI: 10.1126/Science.1086187  0.301
2003 Trudeau MC, Zagotta WN. Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. The Journal of Biological Chemistry. 278: 18705-8. PMID 12626507 DOI: 10.1074/Jbc.R300001200  0.683
2003 Weiss LA, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH. Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Molecular Psychiatry. 8: 186-94. PMID 12610651 DOI: 10.1038/Sj.Mp.4001241  0.347
2002 Zheng J, Trudeau MC, Zagotta WN. Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit. Neuron. 36: 891-6. PMID 12467592 DOI: 10.1016/S0896-6273(02)01099-1  0.689
2002 Trudeau MC, Zagotta WN. Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels. Proceedings of the National Academy of Sciences of the United States of America. 99: 8424-9. PMID 12048242 DOI: 10.1073/Pnas.122015999  0.663
2002 Trudeau MC, Zagotta WN. An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindness. Neuron. 34: 197-207. PMID 11970862 DOI: 10.1016/S0896-6273(02)00647-5  0.671
1999 Ganetzky B, Robertson GA, Wilson GF, Trudeau MC, Titus SA. The eag family of K+ channels in Drosophila and mammals. Annals of the New York Academy of Sciences. 868: 356-69. PMID 10414305 DOI: 10.1111/J.1749-6632.1999.Tb11297.X  0.526
1999 Furutani M, Trudeau MC, Hagiwara N, Seki A, Gong Q, Zhou Z, Imamura S, Nagashima H, Kasanuki H, Takao A, Momma K, January CT, Robertson GA, Matsuoka R. Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel. Circulation. 99: 2290-4. PMID 10226095 DOI: 10.1161/01.Cir.99.17.2290  0.414
1999 Trudeau MC, Titus SA, Branchaw JL, Ganetzky B, Robertson GA. Functional analysis of a mouse brain Elk-type K+ channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2906-18. PMID 10191308 DOI: 10.1523/Jneurosci.19-08-02906.1999  0.488
1998 Wang J, Trudeau MC, Zappia AM, Robertson GA. Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels. The Journal of General Physiology. 112: 637-47. PMID 9806971 DOI: 10.1085/Jgp.112.5.637  0.459
1998 Herzberg IM, Trudeau MC, Robertson GA. Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. The Journal of Physiology. 511: 3-14. PMID 9679158 DOI: 10.1111/J.1469-7793.1998.003Bi.X  0.414
1997 London B, Trudeau MC, Newton KP, Beyer AK, Copeland NG, Gilbert DJ, Jenkins NA, Satler CA, Robertson GA. Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current. Circulation Research. 81: 870-8. PMID 9351462 DOI: 10.1161/01.Res.81.5.870  0.311
1995 Trudeau MC, Warmke JW, Ganetzky B, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science (New York, N.Y.). 269: 92-5. PMID 7604285 DOI: 10.1126/Science.7604285  0.517
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