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Cole M. Haynes, Ph.D. - Publications

Affiliations: 
2003 University of Missouri - Kansas City, USA 
Area:
Cell Biology, General Biophysics
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dai CY, Ng CC, Hung GCC, Kirmes I, Hughes LA, Du Y, Brosnan CA, Ahier A, Hahn A, Haynes CM, Rackham O, Filipovska A, Zuryn S. ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription. Nature Cell Biology. PMID 37460695 DOI: 10.1038/s41556-023-01192-y  0.348
2022 Uma Naresh N, Kim S, Shpilka T, Yang Q, Du Y, Haynes CM. Mitochondrial genome recovery by ATFS-1 is essential for development after starvation. Cell Reports. 41: 111875. PMID 36577367 DOI: 10.1016/j.celrep.2022.111875  0.397
2022 Haynes CM, Hekimi S. Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. Genetics. PMID 36342845 DOI: 10.1093/genetics/iyac160  0.41
2022 Statzer C, Meng J, Venz R, Bland M, Robida-Stubbs S, Patel K, Petrovic D, Emsley R, Liu P, Morantte I, Haynes C, Mair WB, Longchamp A, Filipovic MR, Blackwell TK, et al. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Nature Communications. 13: 967. PMID 35181679 DOI: 10.1038/s41467-022-28599-9  0.337
2022 Yang Q, Liu P, Anderson NS, Shpilka T, Du Y, Naresh NU, Li R, Zhu LJ, Luk K, Lavelle J, Zeinert RD, Chien P, Wolfe SA, Haynes CM. LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria. Nature Cell Biology. 24: 181-193. PMID 35165413 DOI: 10.1038/s41556-021-00840-5  0.369
2021 Shpilka T, Du Y, Yang Q, Melber A, Uma Naresh N, Lavelle J, Kim S, Liu P, Weidberg H, Li R, Yu J, Zhu LJ, Strittmatter L, Haynes CM. UPR scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans. Nature Communications. 12: 479. PMID 33473112 DOI: 10.1038/s41467-020-20784-y  0.393
2020 Ali L, Haynes CM. Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan. The Journal of Cell Biology. 219. PMID 32434220 DOI: 10.1083/Jcb.202005084  0.427
2020 Anderson NS, Haynes CM. Folding the Mitochondrial UPR into the Integrated Stress Response. Trends in Cell Biology. 30: 428-439. PMID 32413314 DOI: 10.1016/J.Tcb.2020.03.001  0.517
2020 Milstone ZJ, Saheera S, Bourke LM, Shpilka T, Haynes CM, Trivedi CM. Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis. Science Advances. 6: eaax5150. PMID 32300642 DOI: 10.1126/Sciadv.Aax5150  0.397
2020 Tremblay BP, Haynes CM. Mitochondrial distress call moves to the cytosol to trigger a response to stress. Nature. 579: 348-349. PMID 32173719 DOI: 10.1038/D41586-020-00552-0  0.512
2019 Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP. Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611372 DOI: 10.1073/Pnas.1909666116  0.345
2019 Wang YT, Lim Y, McCall MN, Huang KT, Haynes CM, Nehrke K, Brookes PS. Cardioprotection by the mitochondrial unfolded protein response (UPR) requires ATF5. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31274354 DOI: 10.1152/Ajpheart.00244.2019  0.469
2019 Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM. Mitochondrial UPR repression during infection requires the bZIP protein ZIP-3. Proceedings of the National Academy of Sciences of the United States of America. PMID 30850535 DOI: 10.1073/Pnas.1817259116  0.498
2019 Peterson ND, Cheesman HK, Liu P, Anderson SM, Foster KJ, Chhaya R, Perrat P, Thekkiniath J, Yang Q, Haynes CM, Pukkila-Worley R. The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans. Plos Genetics. 15: e1007935. PMID 30668573 DOI: 10.1371/Journal.Pgen.1007935  0.339
2019 Naresh NU, Haynes CM. Signaling and Regulation of the Mitochondrial Unfolded Protein Response. Cold Spring Harbor Perspectives in Biology. PMID 30617048 DOI: 10.1101/Cshperspect.A033944  0.548
2018 Pires J, Haynes CM. Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria. Current Biology : Cb. 28: R669-R671. PMID 29870708 DOI: 10.1016/J.Cub.2018.04.094  0.462
2018 Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Garcia-Ocaña A, Herman MA, Haynes CM, Chipuk JE, Scott DK. Activation of Nrf2 is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. Diabetes. PMID 29764859 DOI: 10.2337/Db17-0943  0.334
2018 Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M. Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. Cell Reports. 22: 3115-3125. PMID 29562168 DOI: 10.1016/J.Celrep.2018.02.099  0.444
2018 Melber A, Haynes CM. UPRregulation and output: a stress response mediated by mitochondrial-nuclear communication. Cell Research. PMID 29424373 DOI: 10.1038/Cr.2018.16  0.519
2017 Shpilka T, Haynes CM. The mitochondrial UPR: mechanisms, physiological functions and implications in ageing. Nature Reviews. Molecular Cell Biology. PMID 29165426 DOI: 10.1038/Nrm.2017.110  0.498
2017 Lamech L, Haynes CM. Mitochondrial Sterol Oxidation Marks the Spot. Molecular Cell. 68: 641-642. PMID 29149591 DOI: 10.1016/J.Molcel.2017.11.003  0.469
2017 Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Reports. 21: 1481-1494. PMID 29117555 DOI: 10.1016/J.Celrep.2017.10.038  0.46
2017 Lamech L, Haynes CM. Vms1 Relieves a Mitochondrial Import Chokehold. Developmental Cell. 43: 259-260. PMID 29112848 DOI: 10.1016/J.Devcel.2017.10.022  0.483
2017 Qureshi MAMH, Haynes CM, Pellegrino MW. The mitochondrial unfolded protein response: signaling from the powerhouse. The Journal of Biological Chemistry. PMID 28687630 DOI: 10.1074/Jbc.R117.791061  0.572
2017 Deng P, Haynes CM. Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR. Seminars in Cancer Biology. PMID 28499833 DOI: 10.1016/J.Semcancer.2017.05.002  0.484
2017 Fiorese CJ, Haynes CM. Integrating the UPR(mt) into the mitochondrial maintenance network. Critical Reviews in Biochemistry and Molecular Biology. 1-10. PMID 28276702 DOI: 10.1080/10409238.2017.1291577  0.501
2016 Deng P, Haynes CM. The mitokine quest(ion). Cell Research. PMID 27886169 DOI: 10.1038/Cr.2016.138  0.495
2016 Fiorese CJ, Schulz AM, Lin YF, Rosin N, Pellegrino MW, Haynes CM. The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR. Current Biology : Cb. PMID 27426517 DOI: 10.1016/J.Cub.2016.06.002  0.538
2016 Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM. Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature. PMID 27135930 DOI: 10.1038/Nature17989  0.492
2016 Lin YF, Haynes CM. Metabolism and the UPR(mt). Molecular Cell. 61: 677-682. PMID 26942672 DOI: 10.1016/J.Molcel.2016.02.004  0.554
2016 Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel ER. The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity. Cell Reports. 14: 1581-9. PMID 26876169 DOI: 10.1016/J.Celrep.2016.01.055  0.353
2015 Haynes CM. Cell biology: Surviving import failure. Nature. 524: 419-20. PMID 26245372 DOI: 10.1038/Nature14644  0.55
2015 Lamech LT, Haynes CM. The unpredictability of prolonged activation of stress response pathways. The Journal of Cell Biology. 209: 781-7. PMID 26101215 DOI: 10.1083/Jcb.201503107  0.421
2015 Schulz AM, Haynes CM. UPR(mt)-mediated cytoprotection and organismal aging. Biochimica Et Biophysica Acta. 1847: 1448-56. PMID 25857997 DOI: 10.1016/J.Bbabio.2015.03.008  0.48
2015 Pellegrino MW, Haynes CM. Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection. Bmc Biology. 13: 22. PMID 25857750 DOI: 10.1186/S12915-015-0129-1  0.504
2015 Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D. Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science (New York, N.Y.). 347: 1374-7. PMID 25792330 DOI: 10.1126/Science.Aaa2361  0.419
2015 Nargund AM, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). Molecular Cell. 58: 123-33. PMID 25773600 DOI: 10.1016/J.Molcel.2015.02.008  0.493
2015 Haynes C, Powell K. Cole Haynes: on the trail of mitochondrial dysfunction. The Journal of Cell Biology. 208: 140-1. PMID 25601399 DOI: 10.1083/jcb.2082pi  0.31
2014 Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 516: 414-7. PMID 25274306 DOI: 10.1038/Nature13818  0.495
2013 Haynes CM, Fiorese CJ, Lin YF. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends in Cell Biology. 23: 311-8. PMID 23489877 DOI: 10.1016/J.Tcb.2013.02.002  0.539
2013 Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS. Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel. Biochimica Et Biophysica Acta. 1827: 598-611. PMID 23291191 DOI: 10.1016/J.Bbabio.2012.12.007  0.306
2013 Pellegrino MW, Nargund AM, Haynes CM. Signaling the mitochondrial unfolded protein response. Biochimica Et Biophysica Acta. 1833: 410-6. PMID 22445420 DOI: 10.1016/J.Bbamcr.2012.02.019  0.552
2012 Baker BM, Nargund AM, Sun T, Haynes CM. Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. Plos Genetics. 8: e1002760. PMID 22719267 DOI: 10.1371/Journal.Pgen.1002760  0.534
2012 Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science (New York, N.Y.). 337: 587-90. PMID 22700657 DOI: 10.1126/Science.1223560  0.508
2011 Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nature Cell Biology. 13: 1335-43. PMID 22002674 DOI: 10.1038/Ncb2363  0.384
2011 Baker BM, Haynes CM. Mitochondrial protein quality control during biogenesis and aging. Trends in Biochemical Sciences. 36: 254-61. PMID 21353780 DOI: 10.1016/J.Tibs.2011.01.004  0.514
2010 Haynes CM, Ron D. The mitochondrial UPR - protecting organelle protein homeostasis. Journal of Cell Science. 123: 3849-55. PMID 21048161 DOI: 10.1242/Jcs.075119  0.536
2010 Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/J.Molcel.2010.04.001  0.353
2010 Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Molecular Cell. 37: 529-40. PMID 20188671 DOI: 10.1016/J.Molcel.2010.01.015  0.506
2010 Wiseman RL, Haynes CM, Ron D. SnapShot: The unfolded protein response. Cell. 140: 590-590.e2. PMID 20178750 DOI: 10.1016/J.Cell.2010.02.006  0.368
2009 Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. The Journal of Biological Chemistry. 284: 15233-45. PMID 19349280 DOI: 10.1074/Jbc.M109.002121  0.375
2008 Yun C, Stanhill A, Yang Y, Zhang Y, Haynes CM, Xu CF, Neubert TA, Mor A, Philips MR, Ron D. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 105: 7094-9. PMID 18467495 DOI: 10.1073/Pnas.0707025105  0.42
2007 Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Developmental Cell. 13: 467-80. PMID 17925224 DOI: 10.1016/J.Devcel.2007.07.016  0.53
2006 Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Molecular Cell. 23: 875-85. PMID 16973439 DOI: 10.1016/J.Molcel.2006.07.023  0.45
2006 Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics. 174: 229-39. PMID 16816413 DOI: 10.1534/Genetics.106.061580  0.539
2006 Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.). 313: 324-8. PMID 16794039 DOI: 10.1126/Science.1129462  0.633
2004 Haynes CM, Titus EA, Cooper AA. Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Molecular Cell. 15: 767-76. PMID 15350220 DOI: 10.1016/J.Molcel.2004.08.025  0.68
2002 Haynes CM, Caldwell S, Cooper AA. An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. The Journal of Cell Biology. 158: 91-101. PMID 12105183 DOI: 10.1083/Jcb.200201053  0.609
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