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Year Citation  Score
2015 Preissler S, Chambers JE, Crespillo-Casado A, Avezov E, Miranda E, Perez J, Hendershot LM, Harding HP, Ron D. Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker. Elife. 4. PMID 26473973 DOI: 10.7554/eLife.08961  1
2015 Nobre L, Wise D, Ron D, Volmer R. Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization. Plos One. 10: e0136883. PMID 26317833 DOI: 10.1371/journal.pone.0136883  1
2015 Abdulkarim B, Nicolino M, Igoillo-Esteve M, Daures M, Romero S, Philippi A, Senée V, Lopes M, Cunha DA, Harding HP, Derbois C, Bendelac N, Hattersley AT, Eizirik DL, Ron D, et al. A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Diabetes. 64: 3951-62. PMID 26159176 DOI: 10.2337/db15-0477  1
2015 Sekine Y, Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D. Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science (New York, N.Y.). 348: 1027-30. PMID 25858979 DOI: 10.1126/science.aaa6986  1
2015 Chen R, Rato C, Yan Y, Crespillo-Casado A, Clarke HJ, Harding HP, Marciniak SJ, Read RJ, Ron D. G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. Elife. 4. PMID 25774600 DOI: 10.7554/eLife.04871  1
2015 Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife. 4. PMID 25774599 DOI: 10.7554/eLife.04872  1
2015 Chen W, Avezov E, Schlachter SC, Gielen F, Laine RF, Harding HP, Hollfelder F, Ron D, Kaminski CF. A method to quantify FRET stoichiometry with phasor plot analysis and acceptor lifetime ingrowth. Biophysical Journal. 108: 999-1002. PMID 25762312 DOI: 10.1016/j.bpj.2015.01.012  1
2015 Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci GR. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death & Disease. 6: e1672. PMID 25741597 DOI: 10.1038/cddis.2015.49  1
2015 Avezov E, Konno T, Zyryanova A, Chen W, Laine R, Crespillo-Casado A, Melo EP, Ushioda R, Nagata K, Kaminski CF, Harding HP, Ron D. Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum. Bmc Biology. 13: 2. PMID 25575667 DOI: 10.1186/s12915-014-0112-2  1
2015 Volmer R, Ron D. Lipid-dependent regulation of the unfolded protein response. Current Opinion in Cell Biology. 33: 67-73. PMID 25543896 DOI: 10.1016/j.ceb.2014.12.002  1
2014 Lin Y, Pang X, Huang G, Jamison S, Fang J, Harding HP, Ron D, Lin W. Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12182-91. PMID 25186761 DOI: 10.1523/JNEUROSCI.1373-14.2014  1
2014 Tsunoda S, Avezov E, Zyryanova A, Konno T, Mendes-Silva L, Pinho Melo E, Harding HP, Ron D. Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants. Elife. 3: e03421. PMID 25073928 DOI: 10.7554/eLife.03421.001  1
2014 Le Pape S, Dimitrova E, Hannaert P, Konovalov A, Volmer R, Ron D, Thuillier R, Hauet T. Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury. Febs Letters. 588: 3062-7. PMID 24945730 DOI: 10.1016/j.febslet.2014.05.065  1
2014 Maurin AC, Benani A, Lorsignol A, Brenachot X, Parry L, Carraro V, Guissard C, Averous J, Jousse C, Bruhat A, Chaveroux C, B'chir W, Muranishi Y, Ron D, Pénicaud L, et al. Hypothalamic eIF2α signaling regulates food intake. Cell Reports. 6: 438-44. PMID 24485657 DOI: 10.1016/j.celrep.2014.01.006  1
2014 Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science (New York, N.Y.). 343: 313-7. PMID 24310610 DOI: 10.1126/science.1246829  1
2014 Lin Y, Huang G, Jamison S, Li J, Harding HP, Ron D, Lin W. PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases. The American Journal of Pathology. 184: 507-19. PMID 24269558 DOI: 10.1016/j.ajpath.2013.10.009  1
2014 Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Molecular and Cellular Biology. 34: 428-38. PMID 24248597 DOI: 10.1128/MCB.00946-13  1
2013 Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, ... ... Ron D, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. The New England Journal of Medicine. 369: 2391-405. PMID 24325359 DOI: 10.1056/NEJMoa1312542  1
2013 Coelho DS, Cairrão F, Zeng X, Pires E, Coelho AV, Ron D, Ryoo HD, Domingos PM. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Cell Reports. 5: 791-801. PMID 24183663 DOI: 10.1016/j.celrep.2013.09.046  1
2013 Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, Nagata K. Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases. The Journal of Cell Biology. 202: 861-74. PMID 24043701 DOI: 10.1083/jcb.201303027  1
2013 Tomasio SM, Harding HP, Ron D, Cross BC, Bond PJ. Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification. Molecular Biosystems. 9: 2408-16. PMID 23884086 DOI: 10.1039/c3mb70234k  1
2013 Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation. Cell Structure and Function. 38: 183-95. PMID 23812432 DOI: DN/JST.JSTAGE/csf/13012  1
2013 Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host & Microbe. 13: 558-69. PMID 23684307 DOI: 10.1016/j.chom.2013.03.011  1
2013 Avezov E, Cross BC, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, Ron D. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. The Journal of Cell Biology. 201: 337-49. PMID 23589496 DOI: 10.1083/jcb.201211155  1
2013 Lin W, Lin Y, Li J, Fenstermaker AG, Way SW, Clayton B, Jamison S, Harding HP, Ron D, Popko B. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 5980-91. PMID 23554479 DOI: 10.1523/JNEUROSCI.1636-12.2013  1
2013 D'Antonio M, Musner N, Scapin C, Ungaro D, Del Carro U, Ron D, Feltri ML, Wrabetz L. Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. The Journal of Experimental Medicine. 210: 821-38. PMID 23547100 DOI: 10.1084/jem.20122005  1
2013 Volmer R, van der Ploeg K, Ron D. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proceedings of the National Academy of Sciences of the United States of America. 110: 4628-33. PMID 23487760 DOI: 10.1073/pnas.1217611110  1
2013 Tsuru A, Fujimoto N, Takahashi S, Saito M, Nakamura D, Iwano M, Iwawaki T, Kadokura H, Ron D, Kohno K. Negative feedback by IRE1β optimizes mucin production in goblet cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2864-9. PMID 23386727 DOI: 10.1073/pnas.1212484110  1
2013 Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proceedings of the National Academy of Sciences of the United States of America. 110: 2557-62. PMID 23359686 DOI: 10.1073/pnas.1222796110  1
2013 Martino MB, Jones L, Brighton B, Ehre C, Abdulah L, Davis CW, Ron D, O'Neal WK, Ribeiro CM. The ER stress transducer IRE1β is required for airway epithelial mucin production. Mucosal Immunology. 6: 639-54. PMID 23168839 DOI: 10.1038/mi.2012.105  1
2012 Ron D, Harding HP. Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209157 DOI: 10.1101/cshperspect.a013177  1
2012 Harding HP, Zyryanova AF, Ron D. Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK. The Journal of Biological Chemistry. 287: 44338-44. PMID 23148209 DOI: 10.1074/jbc.M112.428987  1
2012 Cross BC, Ron D. New twists in the unfolded protein response. Elife. 1: e00243. PMID 23066509 DOI: 10.7554/eLife.00243  1
2012 Zito E, Hansen HG, Yeo GS, Fujii J, Ron D. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Molecular Cell. 48: 39-51. PMID 22981861 DOI: 10.1016/j.molcel.2012.08.010  1
2012 Landau G, Ran A, Bercovich Z, Feldmesser E, Horn-Saban S, Korkotian E, Jacob-Hirsh J, Rechavi G, Ron D, Kahana C. Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells. The Journal of Biological Chemistry. 287: 35825-37. PMID 22942278 DOI: 10.1074/jbc.M112.381335  1
2012 Chambers JE, Petrova K, Tomba G, Vendruscolo M, Ron D. ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load. The Journal of Cell Biology. 198: 371-85. PMID 22869598 DOI: 10.1083/jcb.201202005  1
2012 Zak J, Ron D, Riva E, Harding HP, Cross BC, Baxendale IR. Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 9901-10. PMID 22782929 DOI: 10.1002/chem.201201039  1
2012 Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, et al. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes. 61: 2763-75. PMID 22773666 DOI: 10.2337/db12-0123  1
2012 Iqbal J, Queiroz J, Li Y, Jiang XC, Ron D, Hussain MM. Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice. Circulation Research. 110: 1575-84. PMID 22556338 DOI: 10.1161/CIRCRESAHA.112.264283  1
2012 Pavitt GD, Ron D. New insights into translational regulation in the endoplasmic reticulum unfolded protein response. Cold Spring Harbor Perspectives in Biology. 4. PMID 22535228 DOI: 10.1101/cshperspect.a012278  1
2012 Ma M, Harding HP, O'Rahilly S, Ron D, Yeo GS. Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. The Biochemical Journal. 444: 183-7. PMID 22435707 DOI: 10.1042/BJ20120065  1
2012 Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proceedings of the National Academy of Sciences of the United States of America. 109: E869-78. PMID 22315414 DOI: 10.1073/pnas.1115623109  1
2012 Maurin AC, Chaveroux C, Lambert-Langlais S, Carraro V, Jousse C, Bruhat A, Averous J, Parry L, Ron D, Alliot J, Fafournoux P. The amino acid sensor GCN2 biases macronutrient selection during aging. European Journal of Nutrition. 51: 119-26. PMID 21614613 DOI: 10.1007/s00394-011-0205-4  1
2011 Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science (New York, N.Y.). 334: 1081-6. PMID 22116877 DOI: 10.1126/science.1209038  1
2011 Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, ... Ron D, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893  1
2011 Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, ... Ron D, et al. Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. The Journal of Biological Chemistry. 286: 36163-70. PMID 21832042 DOI: 10.1074/jbc.M111.228817  1
2011 Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Molecular Biology of the Cell. 22: 2994-3009. PMID 21737679 DOI: 10.1091/mbc.E11-04-0286  1
2011 Wang D, Zavadil J, Martin L, Parisi F, Friedman E, Levy D, Harding H, Ron D, Gardner LB. Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Molecular and Cellular Biology. 31: 3670-80. PMID 21730287 DOI: 10.1128/MCB.05704-11  1
2011 Lin W, Lin Y, Li J, Harding HP, Ron D, Jamison S. A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma. Journal of Neuroscience Research. 89: 1586-95. PMID 21688289 DOI: 10.1002/jnr.22693  1
2011 Cui W, Li J, Ron D, Sha B. The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallographica. Section D, Biological Crystallography. 67: 423-8. PMID 21543844 DOI: 10.1107/S0907444911006445  1
2011 Chin KT, Kang G, Qu J, Gardner LB, Coetzee WA, Zito E, Fishman GI, Ron D. The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2583-91. PMID 21507899 DOI: 10.1096/fj.11-184622  1
2011 Tsaytler P, Harding HP, Ron D, Bertolotti A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science (New York, N.Y.). 332: 91-4. PMID 21385720 DOI: 10.1126/science.1201396  1
2011 Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature Cell Biology. 13: 184-90. PMID 21364565 DOI: 10.1038/ncb0311-184  1
2011 Ron D, Ito K. Cell biology. A translational pause to localize. Science (New York, N.Y.). 331: 543-4. PMID 21292960 DOI: 10.1126/science.1202075  1
2011 Marion V, Sankaranarayanan S, de Theije C, van Dijk P, Lindsey P, Lamers MC, Harding HP, Ron D, Lamers WH, Köhler SE. Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2. The Journal of Biological Chemistry. 286: 8866-74. PMID 21239484 DOI: 10.1074/jbc.M110.216119  1
2010 Zito E, Melo EP, Yang Y, Wahlander Ã…, Neubert TA, Ron D. Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Molecular Cell. 40: 787-97. PMID 21145486 DOI: 10.1016/j.molcel.2010.11.010  1
2010 Wang H, Blais J, Ron D, Cardozo T. Structural determinants of PERK inhibitor potency and selectivity. Chemical Biology & Drug Design. 76: 480-95. PMID 21070610 DOI: 10.1111/j.1747-0285.2010.01048.x  1
2010 Haynes CM, Ron D. The mitochondrial UPR - protecting organelle protein homeostasis. Journal of Cell Science. 123: 3849-55. PMID 21048161 DOI: 10.1242/jcs.075119  1
2010 Marcinak SJ, Ron D. The unfolded protein response in lung disease. Proceedings of the American Thoracic Society. 7: 356-62. PMID 21030513 DOI: 10.1513/pats.201001-015AW  1
2010 Volchuk A, Ron D. The endoplasmic reticulum stress response in the pancreatic β-cell. Diabetes, Obesity & Metabolism. 12: 48-57. PMID 21029300 DOI: 10.1111/j.1463-1326.2010.01271.x  1
2010 Appenzeller-Herzog C, Riemer J, Zito E, Chin KT, Ron D, Spiess M, Ellgaard L. Disulphide production by Ero1α-PDI relay is rapid and effectively regulated. The Embo Journal. 29: 3318-29. PMID 20802462 DOI: 10.1038/emboj.2010.203  1
2010 Onn A, Ron D. Modeling the endoplasmic reticulum unfolded protein response. Nature Structural & Molecular Biology. 17: 924-5. PMID 20683476 DOI: 10.1038/nsmb0810-924  1
2010 Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. The Embo Journal. 29: 2082-96. PMID 20473272 DOI: 10.1038/emboj.2010.81  1
2010 Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. The Journal of Biological Chemistry. 285: 20993-1003. PMID 20442408 DOI: 10.1074/jbc.M110.126599  1
2010 Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/j.molcel.2010.04.001  1
2010 Zito E, Chin KT, Blais J, Harding HP, Ron D. ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. The Journal of Cell Biology. 188: 821-32. PMID 20308425 DOI: 10.1083/jcb.200911086  1
2010 Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, Ron D, Urano F. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. Plos One. 5: e9575. PMID 20221394 DOI: 10.1371/journal.pone.0009575  1
2010 Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Molecular Cell. 37: 529-40. PMID 20188671 DOI: 10.1016/j.molcel.2010.01.015  1
2010 Tao J, Petrova K, Ron D, Sha B. Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR. Journal of Molecular Biology. 397: 1307-15. PMID 20184891 DOI: 10.1016/j.jmb.2010.02.028  1
2010 Wiseman RL, Haynes CM, Ron D. SnapShot: The unfolded protein response. Cell. 140: 590-590.e2. PMID 20178750 DOI: 10.1016/j.cell.2010.02.006  1
2010 Masciarelli S, Fra AM, Pengo N, Bertolotti M, Cenci S, Fagioli C, Ron D, Hendershot LM, Sitia R. CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. Molecular Immunology. 47: 1356-65. PMID 20044139 DOI: 10.1016/j.molimm.2009.12.003  1
2010 Zhao L, Rosales C, Seburn K, Ron D, Ackerman SL. Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome. Human Molecular Genetics. 19: 25-35. PMID 19801575 DOI: 10.1093/hmg/ddp464  1
2010 Zito E, Chin KT, Blais J, Harding HP, Ron D. ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis (The Journal of Cell Biology (2010) 188, 6 (821-832)) Journal of Cell Biology. 189: 769. DOI: 10.1083/jcb.20091108620100423c  1
2009 Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, Tabas I. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nature Cell Biology. 11: 1473-80. PMID 19855386 DOI: 10.1038/ncb1996  1
2009 Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I. Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. The Journal of Cell Biology. 186: 783-92. PMID 19752026 DOI: 10.1083/jcb.200904060  1
2009 Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D, Waldmann H. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 12055-60. PMID 19567830 DOI: 10.1073/pnas.0903919106  1
2009 Thorp E, Li G, Seimon TA, Kuriakose G, Ron D, Tabas I. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metabolism. 9: 474-81. PMID 19416717 DOI: 10.1016/j.cmet.2009.03.003  1
2009 Ron D. Targeting of mRNAs to their sites of unconventional splicing in the unfolded protein response. Molecular Cell. 34: 133-4. PMID 19394288 DOI: 10.1016/j.molcel.2009.04.003  1
2009 Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D. Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. The Journal of Biological Chemistry. 284: 15233-45. PMID 19349280 DOI: 10.1074/jbc.M109.002121  1
2009 Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proceedings of the National Academy of Sciences of the United States of America. 106: 1832-7. PMID 19181853 DOI: 10.1073/pnas.0809632106  1
2009 Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2200-5. PMID 19164757 DOI: 10.1073/pnas.0807611106  1
2009 Lin JH, Li H, Zhang Y, Ron D, Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. Plos One. 4: e4170. PMID 19137072 DOI: 10.1371/journal.pone.0004170  1
2008 Petrova K, Oyadomari S, Hendershot LM, Ron D. Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. The Embo Journal. 27: 2862-72. PMID 18923430 DOI: 10.1038/emboj.2008.199  1
2008 Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B. Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. The American Journal of Pathology. 173: 1508-17. PMID 18818381 DOI: 10.2353/ajpath.2008.080449  1
2008 Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. The Journal of Clinical Investigation. 118: 3378-89. PMID 18776938 DOI: 10.1172/JCI34587  1
2008 Lackey JG, Ron D, Damha MJ, Harding HP. Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p. Nucleic Acids Symposium Series (2004). 475-6. PMID 18776460 DOI: 10.1093/nass/nrn241  1
2008 Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA. Novel function of PERK as a mediator of force-induced apoptosis. The Journal of Biological Chemistry. 283: 23462-72. PMID 18550523 DOI: 10.1074/jbc.M803194200  1
2008 Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metabolism. 7: 520-32. PMID 18522833 DOI: 10.1016/j.cmet.2008.04.011  1
2008 Yun C, Stanhill A, Yang Y, Zhang Y, Haynes CM, Xu CF, Neubert TA, Mor A, Philips MR, Ron D. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 105: 7094-9. PMID 18467495 DOI: 10.1073/pnas.0707025105  1
2008 Iqbal J, Dai K, Seimon T, Jungreis R, Oyadomari M, Kuriakose G, Ron D, Tabas I, Hussain MM. IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metabolism. 7: 445-55. PMID 18460335 DOI: 10.1016/j.cmet.2008.03.005  1
2008 Tao J, Wu Y, Ron D, Sha B. Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 108-10. PMID 18259061 DOI: 10.1107/S1744309108000833  1
2008 Pennuto M, Tinelli E, Malaguti M, Del Carro U, D'Antonio M, Ron D, Quattrini A, Feltri ML, Wrabetz L. Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron. 57: 393-405. PMID 18255032 DOI: 10.1016/j.neuron.2007.12.021  1
2008 Ron D, Hubbard SR. How IRE1 reacts to ER stress. Cell. 132: 24-6. PMID 18191217 DOI: 10.1016/j.cell.2007.12.017  1
2008 Harding HP, Lackey JG, Hsu HC, Zhang Y, Deng J, Xu RM, Damha MJ, Ron D. An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. Rna (New York, N.Y.). 14: 225-32. PMID 18094117 DOI: 10.1261/rna.859908  1
2008 Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE. Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation. The Journal of Biological Chemistry. 283: 469-75. PMID 17998206 DOI: 10.1074/jbc.M704612200  1
2007 Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Developmental Cell. 13: 467-80. PMID 17925224 DOI: 10.1016/j.devcel.2007.07.016  1
2007 Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, Yin XM. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. The American Journal of Pathology. 171: 513-24. PMID 17620365 DOI: 10.2353/ajpath.2007.070188  1
2007 Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews. Molecular Cell Biology. 8: 519-29. PMID 17565364 DOI: 10.1038/nrm2199  1
2007 Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA. Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. The Journal of Cell Biology. 176: 605-16. PMID 17325203 DOI: 10.1083/jcb.200607007  1
2007 Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. The Journal of Clinical Investigation. 117: 448-56. PMID 17273557 DOI: 10.1172/JCI29571  1
2006 Ron D, Hinnebusch AG. Targeting translation in hypoxic tumors. Acs Chemical Biology. 1: 145-8. PMID 17163661 DOI: 10.1021/cb600125y  1
2006 Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metabolism. 4: 441-51. PMID 17141628 DOI: 10.1016/j.cmet.2006.10.010  1
2006 Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Molecular Cell. 23: 875-85. PMID 16973439 DOI: 10.1016/j.molcel.2006.07.023  1
2006 Clase AC, Dimcheff DE, Favara C, Dorward D, McAtee FJ, Parrie LE, Ron D, Portis JL. Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses. The American Journal of Pathology. 169: 1026-38. PMID 16936275 DOI: 10.2353/ajpath.2006.051357  1
2006 Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 126: 727-39. PMID 16923392 DOI: 10.1016/j.cell.2006.06.051  1
2006 Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B. Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain : a Journal of Neurology. 129: 1306-18. PMID 16504972 DOI: 10.1093/brain/awl044  1
2006 Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D. Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. The Journal of Cell Biology. 172: 201-9. PMID 16418533 DOI: 10.1083/jcb.200508099  1
2006 Huang G, Yao J, Zeng W, Mizuno Y, Kamm KE, Stull JT, Harding HP, Ron D, Muallem S. ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. Journal of Cell Science. 119: 153-61. PMID 16352659 DOI: 10.1242/jcs.02731  1
2006 Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding H, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload (DOI:10.1016/j.cell.2006.06.051) Cell. 127: 1284. DOI: 10.1016/j.cell.2006.11.027  1
2005 Harding HP, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman RJ, Javitt N, Chang YT, Ron D. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metabolism. 2: 361-71. PMID 16330322 DOI: 10.1016/j.cmet.2005.11.005  1
2005 Skalet AH, Isler JA, King LB, Harding HP, Ron D, Monroe JG. Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. The Journal of Biological Chemistry. 280: 39762-71. PMID 16188879 DOI: 10.1074/jbc.M502640200  1
2005 Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. The Embo Journal. 24: 3470-81. PMID 16148948 DOI: 10.1038/sj.emboj.7600777  1
2005 Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, Kholodilov N, Greene LA, Burke RE. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Journal of Neurochemistry. 95: 974-86. PMID 16135078 DOI: 10.1111/j.1471-4159.2005.03428.x  1
2005 Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, ... Ron D, et al. Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature. 436: 1166-73. PMID 16121183 DOI: 10.1038/nature03897  1
2005 Federovitch CM, Ron D, Hampton RY. The dynamic ER: experimental approaches and current questions. Current Opinion in Cell Biology. 17: 409-14. PMID 15975777 DOI: 10.1016/j.ceb.2005.06.010  1
2005 Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/science.1101902  1
2004 Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology. 24: 10161-8. PMID 15542827 DOI: 10.1128/MCB.24.23.10161-10168.2004  1
2004 Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. The Journal of Cell Biology. 167: 23-5. PMID 15479733 DOI: 10.1083/jcb.200408117  1
2004 Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 429: 841-7. PMID 15215856 DOI: 10.1038/nature02656  1
2004 Hartman MG, Lu D, Kim ML, Kociba GJ, Shukri T, Buteau J, Wang X, Frankel WL, Guttridge D, Prentki M, Grey ST, Ron D, Hai T. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Molecular and Cellular Biology. 24: 5721-32. PMID 15199129 DOI: 10.1128/MCB.24.13.5721-5732.2004  1
2004 Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Molecular and Cellular Biology. 24: 1365-77. PMID 14729979 DOI: 10.1128/MCB.24.3.1365-1377.2004  1
2004 Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. The Embo Journal. 23: 169-79. PMID 14713949 DOI: 10.1038/sj.emboj.7600030  1
2003 Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell. 11: 619-33. PMID 12667446 DOI: 10.1016/S1097-2765(03)00105-9  1
2002 Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10690-8. PMID 12486162  1
2002 Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D, Katze MG. Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proceedings of the National Academy of Sciences of the United States of America. 99: 15920-5. PMID 12446838 DOI: 10.1073/pnas.252341799  1
2002 Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. Activation of GCN2 in UV-irradiated cells inhibits translation. Current Biology : Cb. 12: 1279-86. PMID 12176355 DOI: 10.1016/S0960-9822(02)01037-0  1
2001 Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Molecular Cell. 7: 1153-63. PMID 11430819 DOI: 10.1016/S1097-2765(01)00264-7  1
2001 Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, DeGracia DJ. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. Journal of Neurochemistry. 77: 1418-21. PMID 11389192 DOI: 10.1046/j.1471-4159.2001.00387.x  1
2000 Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nature Cell Biology. 2: 863-70. PMID 11146649 DOI: 10.1038/35046500  1
2000 Kopito RR, Ron D. Conformational disease. Nature Cell Biology. 2: E207-9. PMID 11056553 DOI: 10.1038/35041139  1
1999 Maytin EV, Lin JC, Krishnamurthy R, Batchvarova N, Ron D, Mitchell PJ, Habener JF. Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Developmental Biology. 216: 164-81. PMID 10588870 DOI: 10.1006/dbio.1999.9460  1
1999 Kuroda M, Wang X, Sok J, Yin Y, Chung P, Giannotti JW, Jacobs KA, Fitz LJ, Murtha-Riel P, Turner KJ, Ron D. Induction of a secreted protein by the myxoid liposarcoma oncogene. Proceedings of the National Academy of Sciences of the United States of America. 96: 5025-30. PMID 10220412 DOI: 10.1073/pnas.96.9.5025  1
1998 Wang XZ, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P, Zinszner H, Ron D. Identification of novel stress-induced genes downstream of chop. The Embo Journal. 17: 3619-30. PMID 9649432 DOI: 10.1093/emboj/17.13.3619  0.72
1997 Zinszner H, Sok J, Immanuel D, Yin Y, Ron D. TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling. Journal of Cell Science. 110: 1741-50. PMID 9264461  0.72
1996 Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Molecular and Cellular Biology. 16: 1479-89. PMID 8657121  1
1994 Zinszner H, Albalat R, Ron D. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP. Genes & Development. 8: 2513-26. PMID 7958914  1
1993 Vallejo M, Ron D, Miller CP, Habener JF. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proceedings of the National Academy of Sciences of the United States of America. 90: 4679-83. PMID 8506317  1
1993 McGehee RE, Ron D, Brasier AR, Habener JF. Differentiation-specific element: a cis-acting developmental switch required for the sustained transcriptional expression of the angiotensinogen gene during hormonal-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Molecular Endocrinology (Baltimore, Md.). 7: 551-60. PMID 7684818 DOI: 10.1210/mend.7.4.7684818  1
1992 Ron D, Brasier AR, McGehee RE, Habener JF. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). The Journal of Clinical Investigation. 89: 223-33. PMID 1729273 DOI: 10.1172/JCI115566  1
1992 Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes & Development. 6: 439-53. PMID 1547942  1
1991 Ron D, Brasier AR, Habener JF. Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Molecular and Cellular Biology. 11: 2887-95. PMID 2017183  1
1990 Ron D, Brasier AR, Wright KA, Habener JF. The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Molecular and Cellular Biology. 10: 4389-95. PMID 2370871  1
1990 Brasier AR, Ron D, Tate JE, Habener JF. A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. The Embo Journal. 9: 3933-44. PMID 2174352  1
1990 Ron D, Brasier AR, Habener JF. Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response. Molecular and Cellular Endocrinology. 74: C97-104. PMID 2128877 DOI: 10.1016/0303-7207(90)90221-S  1
1990 Ron D, Brasier AR, Wright KA, Tate JE, Habener JF. An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Molecular and Cellular Biology. 10: 1023-32. PMID 2106065  1
1990 Brasier AR, Ron D, Tate JE, Habener JF. Synergistic enhansons located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription. Molecular Endocrinology (Baltimore, Md.). 4: 1921-33. PMID 1707127 DOI: 10.1210/mend-4-12-1921  1
1989 Brasier AR, Tate JE, Ron D, Habener JF. Multiple cis-acting DNA regulatory elements mediate hepatic angiotensinogen gene expression. Molecular Endocrinology (Baltimore, Md.). 3: 1022-34. PMID 2544800 DOI: 10.1210/mend-3-6-1022  1
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