| Year |
Citation |
Score |
| 2024 |
Aguilar K, Canal C, Comes G, Díaz-Clavero S, Llanos MA, Quintana A, Sanz E, Hidalgo J. Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome. Journal of Inflammation (London, England). 21: 1. PMID 38212783 DOI: 10.1186/s12950-023-00369-4 |
0.466 |
|
| 2023 |
Naón D, Hernández-Alvarez MI, Shinjo S, Wieczor M, Ivanova S, Martins de Brito O, Quintana A, Hidalgo J, Palacín M, Aparicio P, Castellanos J, Lores L, Sebastián D, Fernández-Veledo S, Vendrell J, et al. Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria. Science (New York, N.Y.). 380: eadh9351. PMID 37347868 DOI: 10.1126/science.adh9351 |
0.47 |
|
| 2022 |
Aguilar K, Comes G, Canal C, Quintana A, Sanz E, Hidalgo J. Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome. Glia. PMID 35770802 DOI: 10.1002/glia.24234 |
0.588 |
|
| 2021 |
Ait Ahmed Y, Fu Y, Rodrigues RM, He Y, Guan Y, Guillot A, Ren R, Feng D, Hidalgo J, Ju C, Lafdil F, Gao B. Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners. Cellular & Molecular Immunology. PMID 34282300 DOI: 10.1038/s41423-021-00731-7 |
0.344 |
|
| 2020 |
Sanchis P, Fernández-Gayol O, Comes G, Aguilar K, Escrig A, Giralt M, Palmiter RD, Hidalgo J. A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 17: 304. PMID 33059703 DOI: 10.1186/s12974-020-01969-0 |
0.528 |
|
| 2020 |
Laitano O, Robinson GP, Garcia CK, Mattingly AJ, Sheikh LH, Murray KO, Iwaniec JD, Alzahrani J, Morse D, Hidalgo J, Clanton TL. Skeletal Muscle INTERLEUKIN-6 Contributes to the Innate Immune Response in Septic MICE. Shock (Augusta, Ga.). PMID 32826815 DOI: 10.1097/Shk.0000000000001641 |
0.427 |
|
| 2020 |
Escrig A, Molinero A, Méndez B, Giralt M, Comes G, Sanchis P, Fernández-Gayol O, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J. IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease. Cells. 9. PMID 32630818 DOI: 10.3390/Cells9071605 |
0.413 |
|
| 2020 |
Chowdhury S, Schulz LC, Palmisano B, Singh P, Berger JM, Yadav VK, Mera P, Ellingsgaard H, Hidalgo J, Brüning JC, Karsenty G. Muscle derived interleukin-6 increases exercise capacity by signaling in osteoblasts. The Journal of Clinical Investigation. PMID 32078586 DOI: 10.1172/Jci133572 |
0.353 |
|
| 2020 |
Sanchis P, Fernández-Gayol O, Comes G, Escrig A, Giralt M, Palmiter RD, Hidalgo J. Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner. Cells. 9. PMID 32023844 DOI: 10.3390/Cells9020330 |
0.574 |
|
| 2020 |
Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proceedings of the National Academy of Sciences of the United States of America. PMID 31980524 DOI: 10.1073/Pnas.1920004117 |
0.414 |
|
| 2020 |
Sanchis P, Fernández-Gayol O, Vizueta J, Comes G, Canal C, Escrig A, Molinero A, Giralt M, Hidalgo J. Microglial cell-derived interleukin-6 influences behavior and inflammatory response in the brain following traumatic brain injury. Glia. 68: 999-1016. PMID 31799746 DOI: 10.1002/Glia.23758 |
0.476 |
|
| 2019 |
Wilkinson AN, Chang K, Kuns RD, Henden AS, Minnie SA, Ensbey KS, Clouston AD, Zhang P, Koyama M, Hidalgo J, Rose-John S, Varelias A, Vuckovic S, Gartlan KH, Hill GR. IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling. Blood. PMID 31578204 DOI: 10.1182/Blood.2019000396 |
0.375 |
|
| 2019 |
Escrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, Molinero A, Giralt M, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J. IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease. Brain, Behavior, and Immunity. 82: 145-159. PMID 31401302 DOI: 10.1016/J.Bbi.2019.08.005 |
0.421 |
|
| 2019 |
Whitham M, Pal M, Petzold T, Hjorth M, Egan CL, Brunner JS, Estevez E, Iliades P, Zivanovic B, Reibe S, Hughes WE, Findeisen M, Hidalgo J, Febbraio MA. Adipocyte specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 31386565 DOI: 10.1152/Ajpendo.00206.2019 |
0.385 |
|
| 2019 |
Fernández-Gayol O, Sanchis P, Aguilar K, Navarro A, Comes G, Molinero A, Giralt M, Hidalgo J. Different responses to a high-fat diet in IL-6 conditional knock-out mice driven by constitutive GFAP-Cre and Synapsin 1-Cre expression. Neuroendocrinology. PMID 30636247 DOI: 10.1159/000496845 |
0.468 |
|
| 2019 |
Comes G, Fernandez-Gayol O, Molinero A, Giralt M, Capdevila M, Atrian S, Hidalgo J. Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE. Metallomics : Integrated Biometal Science. 11: 327-337. PMID 30543238 DOI: 10.1039/C8Mt00285A |
0.383 |
|
| 2019 |
Gayol OF, Sanchis P, Navarro-Sempere A, Aguilar K, Hidalgo J. Microarray study of the effects of a chronic high-fat diet on a brain-specific interleukin-6-deficient mouse European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.862 |
0.327 |
|
| 2019 |
Sanchis P, Vizueta J, Giralt M, Hidalgo J. Lack of microglial Interleukin-6 ameliorates the brain's response to traumatic brain injury European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.408 |
0.321 |
|
| 2018 |
Gubernatorova EO, Gorshkova EA, Namakanova OA, Zvartsev RV, Hidalgo J, Drutskaya MS, Tumanov AV, Nedospasov SA. Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation. Frontiers in Immunology. 9: 2718. PMID 30534125 DOI: 10.3389/Fimmu.2018.02718 |
0.395 |
|
| 2018 |
Giralt M, Molinero A, Hidalgo J. Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG in the Mouse. Methods in Molecular Biology (Clifton, N.J.). 1791: 227-232. PMID 30006713 DOI: 10.1007/978-1-4939-7862-5_17 |
0.339 |
|
| 2018 |
Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, et al. Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nature Communications. 9: 559. PMID 29422647 DOI: 10.1038/S41467-018-03050-0 |
0.388 |
|
| 2017 |
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, ... ... Hidalgo J, et al. Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nature Immunology. 18: 474. PMID 28323263 DOI: 10.1038/Ni0417-474B |
0.357 |
|
| 2017 |
Molinero A, Fernandez-Perez A, Mogas A, Giralt M, Comes G, Fernandez-Gayol O, Vallejo M, Hidalgo J. Role of muscle IL-6 in gender-specific metabolism in mice. Plos One. 12: e0173675. PMID 28319140 DOI: 10.1371/Journal.Pone.0173675 |
0.39 |
|
| 2017 |
Comes G, Manso Y, Escrig A, Fernandez-Gayol O, Sanchis P, Molinero A, Giralt M, Carrasco J, Hidalgo J. Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 18. PMID 28134760 DOI: 10.3390/Ijms18020251 |
0.402 |
|
| 2016 |
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, ... ... Hidalgo J, et al. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nature Immunology. PMID 27893700 DOI: 10.1038/Ni.3632 |
0.397 |
|
| 2016 |
Erta M, Giralt M, Jiménez S, Molinero A, Comes G, Hidalgo J. Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice. Brain Sciences. 6. PMID 27196935 DOI: 10.3390/Brainsci6020015 |
0.451 |
|
| 2016 |
Knudsen JG, Joensen E, Bertholdt L, Jessen H, van Hauen L, Hidalgo J, Pilegaard H. Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training. Physiological Reports. 4. PMID 27185906 DOI: 10.14814/Phy2.12788 |
0.418 |
|
| 2016 |
Pardo L, Schlüter A, Valor LM, Barco A, Giralt M, Golbano A, Hidalgo J, Jia P, Zhao Z, Jové M, Portero-Otin M, Ruiz M, Giménez-Llort L, Masgrau R, Pujol A, et al. Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury. Glia. PMID 26880229 DOI: 10.1002/Glia.22969 |
0.346 |
|
| 2016 |
Manso Y, Comes G, López-Ramos JC, Belfiore M, Molinero A, Giralt M, Carrasco J, Adlard PA, Bush AI, Delgado-García JM, Hidalgo J. Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26836194 DOI: 10.3233/Jad-151025 |
0.373 |
|
| 2015 |
Erta M, Giralt M, Esposito FL, Fernandez-Gayol O, Hidalgo J. Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior. Hormones and Behavior. 73: 64-74. PMID 26143620 DOI: 10.1016/J.Yhbeh.2015.06.016 |
0.443 |
|
| 2015 |
Knudsen JG, Bertholdt L, Joensen E, Lassen SB, Hidalgo J, Pilegaard H. Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training. Obesity (Silver Spring, Md.). 23: 1616-24. PMID 26109166 DOI: 10.1002/Oby.21139 |
0.313 |
|
| 2015 |
Guerra J, Ferrer B, Giralt M, Comes G, Carrasco J, Molinero A, Serrano AL, Hidalgo J. Muscular interleukin-6 differentially regulates skeletal muscle adaptation to high-fat diet in a sex-dependent manner. Cytokine. 74: 145-51. PMID 25982555 DOI: 10.1016/J.Cyto.2015.04.018 |
0.344 |
|
| 2015 |
Fernández-Fernández L, Esteban G, Giralt M, Valente T, Bolea I, Solé M, Sun P, Benítez S, Morelló JR, Reguant J, Ramírez B, Hidalgo J, Unzeta M. Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids. Food & Function. 6: 1251-60. PMID 25756794 DOI: 10.1039/C5Fo00052A |
0.302 |
|
| 2015 |
Almolda B, de Labra C, Barrera I, Gruart A, Delgado-Garcia JM, Villacampa N, Vilella A, Hofer MJ, Hidalgo J, Campbell IL, González B, Castellano B. Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain, Behavior, and Immunity. 45: 80-97. PMID 25449577 DOI: 10.1016/J.Bbi.2014.10.015 |
0.447 |
|
| 2015 |
Rodríguez-Rodríguez C, Telpoukhovskaia MA, Alí-Torres J, Rodríguez-Santiago L, Manso Y, Bailey GA, Hidalgo J, Sodupe M, Orvig C. Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models. Metallomics : Integrated Biometal Science. 7: 83-92. PMID 25325557 DOI: 10.1039/C4Mt00167B |
0.307 |
|
| 2014 |
Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 26: 331-43. PMID 25132496 DOI: 10.1016/J.Ccr.2014.07.001 |
0.315 |
|
| 2014 |
Lago N, Quintana A, Carrasco J, Giralt M, Hidalgo J, Molinero A. Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary-adrenal (HPA) axis. Neurochemistry International. 74: 65-73. PMID 24969724 DOI: 10.1016/J.Neuint.2014.06.008 |
0.617 |
|
| 2014 |
Navia B, Ferrer B, Giralt M, Comes G, Carrasco J, Molinero A, Quintana A, Leclerc J, Viollet B, SeñarÃs RM, Hidalgo J. Interleukin-6 deletion in mice driven by aP2-Cre-ERT2 prevents against high-fat diet-induced gain weight and adiposity in female mice. Acta Physiologica (Oxford, England). 211: 585-96. PMID 24934978 DOI: 10.1111/Apha.12328 |
0.629 |
|
| 2014 |
Almolda B, Villacampa N, Manders P, Hidalgo J, Campbell IL, González B, Castellano B. Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury. Glia. 62: 1142-61. PMID 24691898 DOI: 10.1002/Glia.22668 |
0.442 |
|
| 2014 |
Ferrer B, Navia B, Giralt M, Comes G, Carrasco J, Molinero A, Quintana A, SeñarÃs RM, Hidalgo J. Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner. Brain, Behavior, and Immunity. 40: 121-30. PMID 24632224 DOI: 10.1016/J.Bbi.2014.03.001 |
0.618 |
|
| 2014 |
Lynes MA, Hidalgo J, Manso Y, Devisscher L, Laukens D, Lawrence DA. Metallothionein and stress combine to affect multiple organ systems. Cell Stress & Chaperones. 19: 605-11. PMID 24584987 DOI: 10.1007/S12192-014-0501-Z |
0.326 |
|
| 2014 |
Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J. Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2503-13. PMID 24523541 DOI: 10.1523/Jneurosci.2830-13.2014 |
0.451 |
|
| 2014 |
Knudsen JG, Murholm M, Carey AL, Biensø RS, Basse AL, Allen TL, Hidalgo J, Kingwell BA, Febbraio MA, Hansen JB, Pilegaard H. Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue. Plos One. 9: e84910. PMID 24416310 DOI: 10.1371/Journal.Pone.0084910 |
0.44 |
|
| 2014 |
Pifarré P, Gutierrez-Mecinas M, Prado J, Usero L, Roura-Mir C, Giralt M, Hidalgo J, GarcÃa A. Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions. Experimental Neurology. 251: 58-71. PMID 24211383 DOI: 10.1016/J.Expneurol.2013.10.021 |
0.317 |
|
| 2014 |
Almolda B, De Labra C, Barrera I, Gruart A, Delgado-garcia JM, Hofer M, Hidalgo J, Campbell IL, González B, Castellano B. Transgenic mice with astrocyte-targeted IL-10 production in the CNS presented a specific phenotype of microglia that correlates with changes in the hippocampal neuronal function Journal of Neuroimmunology. 275: 134. DOI: 10.1016/J.Jneuroim.2014.08.359 |
0.418 |
|
| 2013 |
Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. The Journal of Experimental Medicine. 210: 2921-37. PMID 24323356 DOI: 10.1084/Jem.20130699 |
0.371 |
|
| 2013 |
Penkowa M, Poulsen CB, Carrasco J, Hidalgo J. Retraction notice to “M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment” Exp Neurol 176 (2002) 308–321 Experimental Neurology. 247: 755. PMID 24137632 DOI: 10.1016/J.Expneurol.2013.02.015 |
0.321 |
|
| 2013 |
Lindegaard B, Matthews VB, Brandt C, Hojman P, Allen TL, Estevez E, Watt MJ, Bruce CR, Mortensen OH, Syberg S, Rudnicka C, Abildgaard J, Pilegaard H, Hidalgo J, Ditlevsen S, et al. Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice. Diabetes. 62: 3064-74. PMID 23670974 DOI: 10.2337/Db12-1095 |
0.405 |
|
| 2013 |
Giralt M, Ramos R, Quintana A, Ferrer B, Erta M, Castro-Freire M, Comes G, Sanz E, Unzeta M, Pifarré P, GarcÃa A, Campbell IL, Hidalgo J. Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6. Glia. 61: 587-600. PMID 23322593 DOI: 10.1002/Glia.22457 |
0.636 |
|
| 2013 |
Prado J, Pifarré P, Giralt M, Hidalgo J, GarcÃa A. Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury. Neurochemistry International. 62: 70-8. PMID 23178801 DOI: 10.1016/J.Neuint.2012.11.008 |
0.406 |
|
| 2013 |
Quintana A, Erta M, Ferrer B, Comes G, Giralt M, Hidalgo J. Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior. Brain, Behavior, and Immunity. 27: 162-73. PMID 23085146 DOI: 10.1016/J.Bbi.2012.10.011 |
0.647 |
|
| 2013 |
Lindeque JZ, Hidalgo J, Louw R, van der Westhuizen FH. Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise Metabolomics. 9: 418-432. DOI: 10.1007/S11306-012-0459-8 |
0.362 |
|
| 2012 |
Erta M, Quintana A, Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. International Journal of Biological Sciences. 8: 1254-66. PMID 23136554 DOI: 10.7150/Ijbs.4679 |
0.631 |
|
| 2012 |
Manso Y, Carrasco J, Comes G, Adlard PA, Bush AI, Hidalgo J. Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. 69: 3665-81. PMID 22766972 DOI: 10.1007/S00018-012-1045-Y |
0.334 |
|
| 2012 |
Manso Y, Carrasco J, Comes G, Meloni G, Adlard PA, Bush AI, Vašák M, Hidalgo J. Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. 69: 3683-700. PMID 22722772 DOI: 10.1007/S00018-012-1047-9 |
0.328 |
|
| 2012 |
Fernández-Fernández L, Comes G, Bolea I, Valente T, Ruiz J, Murtra P, Ramirez B, Anglés N, Reguant J, Morelló JR, Boada M, Hidalgo J, Escorihuela RM, Unzeta M. LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease. Behavioural Brain Research. 228: 261-71. PMID 22119712 DOI: 10.1016/J.Bbr.2011.11.014 |
0.335 |
|
| 2012 |
Escobar J, Pereda J, Arduini A, Sandoval J, Moreno ML, Pérez S, Sabater L, Aparisi L, Cassinello N, Hidalgo J, Joosten LA, Vento M, López-Rodas G, Sastre J. Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol. Biochemical Pharmacology. 83: 122-30. PMID 22000995 DOI: 10.1016/J.Bcp.2011.09.028 |
0.315 |
|
| 2012 |
Brandt C, Jakobsen AH, Adser H, Olesen J, Iversen N, Kristensen JM, Hojman P, Wojtaszewski JF, Hidalgo J, Pilegaard H. IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice. Acta Physiologica (Oxford, England). 205: 224-35. PMID 21991887 DOI: 10.1111/J.1748-1716.2011.02373.X |
0.416 |
|
| 2011 |
Manso Y, Adlard PA, Carrasco J, Vašák M, Hidalgo J. Metallothionein and brain inflammation. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 1103-13. PMID 21678079 DOI: 10.1007/S00775-011-0802-Y |
0.392 |
|
| 2011 |
Señarís RM, Trujillo ML, Navia B, Comes G, Ferrer B, Giralt M, Hidalgo J. Interleukin-6 regulates the expression of hypothalamic neuropeptides involved in body weight in a gender-dependent way. Journal of Neuroendocrinology. 23: 675-686. PMID 21564350 DOI: 10.1111/J.1365-2826.2011.02158.X |
0.447 |
|
| 2011 |
Adser H, Wojtaszewski JFP, Jakobsen AH, Kiilerich K, Hidalgo J, Pilegaard H. Interleukin-6 modifies mRNA expression in mouse skeletal muscle Acta Physiologica. 202: 165-173. PMID 21352507 DOI: 10.1111/J.1748-1716.2011.02269.X |
0.418 |
|
| 2011 |
Pifarre P, Prado J, Baltrons MA, Giralt M, Gabarro P, Feinstein DL, Hidalgo J, Garcia A. Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis. Acta Neuropathologica. 121: 499-508. PMID 21234581 DOI: 10.1007/S00401-010-0795-6 |
0.333 |
|
| 2011 |
Pedersen L, Pilegaard H, Hansen J, Brandt C, Adser H, Hidalgo J, Olesen J, Pedersen BK, Hojman P. Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression. The Journal of Physiology. 589: 1409-20. PMID 21224226 DOI: 10.1113/Jphysiol.2010.200733 |
0.319 |
|
| 2010 |
Sandoval J, Pereda J, Rodriguez JL, Escobar J, Hidalgo J, Joosten LA, Franco L, Sastre J, López-Rodas G. Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis. Cellular and Molecular Life Sciences : Cmls. 67: 1687-97. PMID 20130956 DOI: 10.1007/S00018-010-0272-3 |
0.304 |
|
| 2010 |
Manso Y, Serra M, Comes G, Giralt M, Carrasco J, Cols N, Vasák M, González-Duarte P, Hidalgo J. The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs. Journal of Neuroscience Research. 88: 1708-18. PMID 20127815 DOI: 10.1002/Jnr.22342 |
0.358 |
|
| 2010 |
Huesa G, Baltrons MA, Gómez-Ramos P, Morán A, GarcÃa A, Hidalgo J, Francés S, Santpere G, Ferrer I, Galea E. Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice. Journal of Alzheimer's Disease : Jad. 19: 37-56. PMID 20061625 DOI: 10.3233/Jad-2010-1203 |
0.324 |
|
| 2010 |
Pifarré P, Prado J, Giralt M, Molinero A, Hidalgo J, Garcia A. Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury. Journal of Neurochemistry. 112: 807-17. PMID 20002517 DOI: 10.1111/J.1471-4159.2009.06518.X |
0.385 |
|
| 2010 |
Hidalgo J, Florit S, Giralt M, Ferrer B, Keller C, Pilegaard H. Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. Brain, Behavior, and Immunity. 24: 119-26. PMID 19748567 DOI: 10.1016/J.Bbi.2009.09.002 |
0.431 |
|
| 2010 |
Pedersen L, Pilegaard H, Adser H, Hidalgo J, Olesen J, Pedersen BK, Höjman P. Liver CXCL-1 Expression is Increased by Exercise and Regulated by IL-6 Medicine and Science in Sports and Exercise. 42: 89. DOI: 10.1249/01.Mss.0000389438.69878.57 |
0.362 |
|
| 2009 |
Valente T, Hidalgo J, Bolea I, Ramirez B, Anglés N, Reguant J, Morelló JR, Gutiérrez C, Boada M, Unzeta M. A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain. Journal of Alzheimer's Disease : Jad. 18: 849-65. PMID 19661617 DOI: 10.3233/Jad-2009-1188 |
0.33 |
|
| 2009 |
Quintana A, Müller M, Frausto RF, Ramos R, Getts DR, Sanz E, Hofer MJ, Krauthausen M, King NJ, Hidalgo J, Campbell IL. Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 183: 2079-88. PMID 19597000 DOI: 10.4049/Jimmunol.0900242 |
0.64 |
|
| 2009 |
Leick L, Hellsten Y, Fentz J, Lyngby SS, Wojtaszewski JF, Hidalgo J, Pilegaard H. PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice. American Journal of Physiology. Endocrinology and Metabolism. 297: E92-103. PMID 19401459 DOI: 10.1152/Ajpendo.00076.2009 |
0.329 |
|
| 2009 |
Sanz E, Quintana A, Hidalgo J, Marco JL, Unzeta M. PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] confers MAO-B independent neuroprotection in ER stress-induced cell death. Molecular and Cellular Neurosciences. 41: 19-31. PMID 19386233 DOI: 10.1016/J.Mcn.2009.01.005 |
0.543 |
|
| 2009 |
Sanz E, Quintana A, Valente T, Manso Y, Hidalgo J, Unzeta M. Monoamine oxidase-B activity is not involved in the neuroinflammatory response elicited by a focal freeze brain injury. Journal of Neuroscience Research. 87: 784-94. PMID 18831059 DOI: 10.1002/Jnr.21892 |
0.582 |
|
| 2009 |
Hidalgo J, Chung R, Penkowa M, Vašák M. Structure and function of vertebrate metallothioneins Annual Review of Biochemistry. 279-317. DOI: 10.1039/9781847559531-00279 |
0.317 |
|
| 2008 |
Chung RS, Penkowa M, Dittmann J, King CE, Bartlett C, Asmussen JW, Hidalgo J, Carrasco J, Leung YK, Walker AK, Fung SJ, Dunlop SA, Fitzgerald M, Beazley LD, Chuah MI, et al. Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. The Journal of Biological Chemistry. 283: 15349-58. PMID 18334482 DOI: 10.1074/Jbc.M708446200 |
0.35 |
|
| 2008 |
Sanz E, Quintana A, Battaglia V, Toninello A, Hidalgo J, Ambrosio S, Valoti M, Marco JL, Tipton KF, Unzeta M. Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells. Journal of Neurochemistry. 105: 2404-17. PMID 18331475 DOI: 10.1111/J.1471-4159.2008.05326.X |
0.541 |
|
| 2008 |
West AK, Hidalgo J, Eddins D, Levin ED, Aschner M. Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. Neurotoxicology. 29: 489-503. PMID 18313142 DOI: 10.1016/J.Neuro.2007.12.006 |
0.341 |
|
| 2008 |
Vidal E, Tortosa R, Márquez M, Serafin A, Hidalgo J, Pumarola M. Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie. Brain Research. 1196: 140-50. PMID 18221736 DOI: 10.1016/J.Brainres.2007.12.034 |
0.411 |
|
| 2008 |
Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H. PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 294: E463-74. PMID 18073319 DOI: 10.1152/Ajpendo.00666.2007 |
0.31 |
|
| 2008 |
Quintana A, Molinero A, Borup R, Nielsen FC, Campbell IL, Penkowa M, Hidalgo J. Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Developmental Neurobiology. 68: 195-208. PMID 18000830 DOI: 10.1002/Dneu.20584 |
0.655 |
|
| 2007 |
Quintana A, Giralt M, Molinero A, Campbell IL, Penkowa M, Hidalgo J. Analysis of the cerebral transcriptome in mice subjected to traumatic brain injury: importance of IL-6. Neuroimmunomodulation. 14: 139-43. PMID 18073505 DOI: 10.1159/000110637 |
0.616 |
|
| 2007 |
Chung RS, Hidalgo J, West AK. New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration. Journal of Neurochemistry. 104: 14-20. PMID 17986229 DOI: 10.1111/J.1471-4159.2007.05026.X |
0.31 |
|
| 2007 |
Westberg JA, Serlachius M, Lankila P, Penkowa M, Hidalgo J, Andersson LC. Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling. Stroke. 38: 1025-30. PMID 17272771 DOI: 10.1161/01.Str.0000258113.67252.Fa |
0.399 |
|
| 2007 |
Quintana A, Molinero A, Florit S, Manso Y, Comes G, Carrasco J, Giralt M, Borup R, Nielsen FC, Campbell IL, Penkowa M, Hidalgo J. Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior. Journal of Neuroscience Research. 85: 2668-85. PMID 17131423 DOI: 10.1002/Jnr.21126 |
0.597 |
|
| 2007 |
Penkowa M, Hidalgo J, Aschner M. Immune and Inflammatory Responses in the Central Nervous System: Modulation by Astrocytes Neuroimmune Biology. 6. DOI: 10.1016/S1567-7443(07)10013-2 |
0.336 |
|
| 2006 |
Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes. 55: S48-54. PMID 17130644 DOI: 10.2337/Db06-S007 |
0.395 |
|
| 2006 |
Carrasco J, Adlard P, Cotman C, Quintana A, Penkowa M, Xu F, Van Nostrand WE, Hidalgo J. Metallothionein-I and -III expression in animal models of Alzheimer disease. Neuroscience. 143: 911-22. PMID 17027170 DOI: 10.1016/J.Neuroscience.2006.08.054 |
0.59 |
|
| 2006 |
Hidalgo J, Penkowa M, Espejo C, MartÃnez-Cáceres EM, Carrasco J, Quintana A, Molinero A, Florit S, Giralt M, Ortega-Aznar A. Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation. Experimental Biology and Medicine (Maywood, N.J.). 231: 1450-8. PMID 17018866 DOI: 10.1177/153537020623100902 |
0.582 |
|
| 2006 |
Penkowa M, Cáceres M, Borup R, Nielsen FC, Poulsen CB, Quintana A, Molinero A, Carrasco J, Florit S, Giralt M, Hidalgo J. Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I + II knockout mice. Journal of Neuroscience Research. 84: 1452-74. PMID 16941634 DOI: 10.1002/Jnr.21043 |
0.604 |
|
| 2006 |
Penkowa M, Tio L, Giralt M, Quintana A, Molinero A, Atrian S, Vasák M, Hidalgo J. Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury. Journal of Neuroscience Research. 83: 974-84. PMID 16493670 DOI: 10.1002/Jnr.20790 |
0.608 |
|
| 2006 |
Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, Hidalgo J, Smeitink J, Olckers A, Van der Westhuizen FH. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. The Biochemical Journal. 395: 405-15. PMID 16402917 DOI: 10.1042/Bj20051253 |
0.327 |
|
| 2005 |
Quintana A, Giralt M, Rojas S, Penkowa M, Campbell IL, Hidalgo J, Molinero A. Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. Journal of Neuroscience Research. 82: 701-16. PMID 16267827 DOI: 10.1002/Jnr.20680 |
0.639 |
|
| 2005 |
Keller P, Penkowa M, Keller C, Steensberg A, Fischer CP, Giralt M, Hidalgo J, Pedersen BK. Interleukin-6 receptor expression in contracting human skeletal muscle: regulating role of IL-6. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1181-3. PMID 15837717 DOI: 10.1096/Fj.04-3278Fje |
0.414 |
|
| 2005 |
Poulsen CB, Penkowa M, Borup R, Nielsen FC, Cáceres M, Quintana A, Molinero A, Carrasco J, Giralt M, Hidalgo J. Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis. Journal of Neurochemistry. 92: 417-32. PMID 15663489 DOI: 10.1111/J.1471-4159.2004.02877.X |
0.634 |
|
| 2005 |
Penkowa M, Keller P, Keller C, Hidalgo J, Giralt M, Pedersen BK. Exercise-induced metallothionein expression in human skeletal muscle fibres. Experimental Physiology. 90: 477-86. PMID 15640275 DOI: 10.1113/Expphysiol.2004.029371 |
0.31 |
|
| 2005 |
Penkowa M, Florit S, Giralt M, Quintana A, Molinero A, Carrasco J, Hidalgo J. Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures. Journal of Neuroscience Research. 79: 522-34. PMID 15614785 DOI: 10.1002/Jnr.20387 |
0.656 |
|
| 2004 |
Hidalgo J. Metallothioneins and brain injury: What transgenic mice tell us. Environmental Health and Preventive Medicine. 9: 87-94. PMID 21432316 DOI: 10.1007/Bf02898066 |
0.434 |
|
| 2004 |
Keller C, Keller P, Giralt M, Hidalgo J, Pedersen BK. Exercise normalises overexpression of TNF-alpha in knockout mice. Biochemical and Biophysical Research Communications. 321: 179-82. PMID 15358232 DOI: 10.1016/J.Bbrc.2004.06.129 |
0.35 |
|
| 2004 |
Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochemical and Biophysical Research Communications. 320: 449-54. PMID 15219849 DOI: 10.1016/J.Bbrc.2004.05.188 |
0.411 |
|
| 2004 |
Penkowa M, Quintana A, Carrasco J, Giralt M, Molinero A, Hidalgo J. Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide. Journal of Neuroscience Research. 77: 35-53. PMID 15197737 DOI: 10.1002/Jnr.20154 |
0.685 |
|
| 2003 |
Penkowa M, Camats J, Hadberg H, Quintana A, Rojas S, Giralt M, Molinero A, Campbell IL, Hidalgo J. Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. Journal of Neuroscience Research. 73: 481-96. PMID 12898533 DOI: 10.1002/Jnr.10681 |
0.661 |
|
| 2003 |
Penkowa M, Espejo C, Ortega-Aznar A, Hidalgo J, Montalban X, MartÃnez Cáceres EM. Metallothionein expression in the central nervous system of multiple sclerosis patients. Cellular and Molecular Life Sciences : Cmls. 60: 1258-66. PMID 12861391 DOI: 10.1007/S00018-003-3021-Z |
0.386 |
|
| 2003 |
Ceballos D, Lago N, Verdú E, Penkowa M, Carrasco J, Navarro X, Palmiter RD, Hidalgo J. Role of metallothioneins in peripheral nerve function and regeneration. Cellular and Molecular Life Sciences : Cmls. 60: 1209-16. PMID 12861386 DOI: 10.1007/S00018-003-3047-2 |
0.483 |
|
| 2003 |
Penkowa M, Giralt M, Lago N, Camats J, Carrasco J, Hernández J, Molinero A, Campbell IL, Hidalgo J. Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Experimental Neurology. 181: 130-48. PMID 12781987 DOI: 10.1016/S0014-4886(02)00051-1 |
0.499 |
|
| 2003 |
Carrasco J, Penkowa M, Giralt M, Camats J, Molinero A, Campbell IL, Palmiter RD, Hidalgo J. Role of metallothionein-III following central nervous system damage. Neurobiology of Disease. 13: 22-36. PMID 12758064 DOI: 10.1016/S0969-9961(03)00015-9 |
0.616 |
|
| 2003 |
Penkowa M, Hidalgo J. Treatment with metallothionein prevents demyelination and axonal damage and increases oligodendrocyte precursors and tissue repair during experimental autoimmune encephalomyelitis. Journal of Neuroscience Research. 72: 574-86. PMID 12749022 DOI: 10.1002/Jnr.10615 |
0.329 |
|
| 2003 |
Penkowa M, Camats J, Giralt M, Molinero A, Hernández J, Carrasco J, Campbell IL, Hidalgo J. Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia. 42: 287-306. PMID 12673834 DOI: 10.1002/Glia.10208 |
0.521 |
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| 2003 |
Molinero A, Penkowa M, Hernández J, Camats J, Giralt M, Lago N, Carrasco J, Campbell IL, Hidalgo J. Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6. Journal of Neuropathology and Experimental Neurology. 62: 315-28. PMID 12638735 DOI: 10.1093/Jnen/62.3.315 |
0.526 |
|
| 2003 |
Penkowa M, Espejo C, Martínez-Cáceres EM, Montalban X, Hidalgo J. Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis. Cellular and Molecular Life Sciences. 60: 185-197. PMID 12613667 DOI: 10.1007/S000180300013 |
0.396 |
|
| 2002 |
Espejo C, Penkowa M, Sáez-Torres I, Hidalgo J, García A, Montalban X, Martínez-Cáceres EM. Interferon-gamma regulates oxidative stress during experimental autoimmune encephalomyelitis. Experimental Neurology. 177: 21-31. PMID 12429207 DOI: 10.1006/Exnr.2002.7982 |
0.416 |
|
| 2002 |
Penkowa M, Poulsen C, Carrasco J, Hidalgo J. M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment. Experimental Neurology. 176: 308-21. PMID 12359172 DOI: 10.1006/Exnr.2002.7968 |
0.418 |
|
| 2002 |
Giralt M, Penkowa M, Hernández J, Molinero A, Carrasco J, Lago N, Camats J, Campbell IL, Hidalgo J. Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiology of Disease. 9: 319-38. PMID 11950277 DOI: 10.1006/Nbdi.2002.0480 |
0.527 |
|
| 2002 |
Hidalgo J, Penkowa M, Giralt M, Carrasco J, Molinero A. Metallothionein expression and oxidative stress in the brain. Methods in Enzymology. 348: 238-49. PMID 11885277 DOI: 10.1016/S0076-6879(02)48642-9 |
0.319 |
|
| 2002 |
Penkowa M, Giralt M, Camats J, Hidalgo J. Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. The Journal of Comparative Neurology. 444: 174-89. PMID 11835189 DOI: 10.1002/Cne.10149 |
0.433 |
|
| 2002 |
Giralt M, Penkowa M, Lago N, Molinero A, Hidalgo J. Metallothionein-1+2 protect the CNS after a focal brain injury. Experimental Neurology. 173: 114-28. PMID 11771944 DOI: 10.1006/Exnr.2001.7772 |
0.496 |
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| 2001 |
Penkowa M, Espejo C, Martı́nez-Cáceres EM, Poulsen CB, Montalban X, Hidalgo J. Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis Journal of Neuroimmunology. 119: 248-260. PMID 11585628 DOI: 10.1016/S0165-5728(01)00357-5 |
0.438 |
|
| 2001 |
Espejo C, Carrasco J, Hidalgo J, Penkowa M, Garcia A, Sáez-Torres I, Martı́nez-Cáceres EM. Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis. Neuroscience. 105: 1055-1065. PMID 11530242 DOI: 10.1016/S0306-4522(01)00252-4 |
0.422 |
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| 2001 |
Hidalgo J, Aschner M, Zatta P, Vašák M. Roles of the metallothionein family of proteins in the central nervous system Brain Research Bulletin. 55: 133-145. PMID 11470309 DOI: 10.1016/S0361-9230(01)00452-X |
0.359 |
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| 2001 |
Penkowa M, Hidalgo J. Metallothionein Treatment Reduces Proinflammatory Cytokines IL-6 and TNF-α and Apoptotic Cell Death during Experimental Autoimmune Encephalomyelitis (EAE) Experimental Neurology. 170: 1-14. PMID 11421579 DOI: 10.1006/Exnr.2001.7675 |
0.412 |
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| 2001 |
Penkowa M, Giralt M, Thomsen PS, Carrasco J, Hidalgo J. Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes Journal of Neurotrauma. 18: 447-463. PMID 11336445 DOI: 10.1089/089771501750171056 |
0.368 |
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| 2001 |
Giralt M, Carrasco J, Penkowa M, Morcillo MA, Santamarı́a J, Campbell IL, Hidalgo J. Astrocyte-Targeted Expression of Interleukin-3 and Interferon-α Causes Region-Specific Changes in Metallothionein Expression in the Brain Experimental Neurology. 168: 334-346. PMID 11259121 DOI: 10.1006/Exnr.2000.7601 |
0.5 |
|
| 2001 |
Penkowa M, Molinero A, Carrasco J, Hidalgo J. Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures. Neuroscience. 102: 805-818. PMID 11182244 DOI: 10.1016/S0306-4522(00)00515-7 |
0.407 |
|
| 2001 |
Montoliu C, Monfort P, Carrasco J, Palacios Ó, Capdevila M, Hidalgo J, Felipo V. Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons. Journal of Neurochemistry. 75: 266-273. PMID 10854270 DOI: 10.1046/J.1471-4159.2000.0750266.X |
0.322 |
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| 2000 |
Penkowa M, Giralt M, Carrasco J, Hadberg H, Hidalgo J. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia. 32: 271-285. PMID 11102968 DOI: 10.1002/1098-1136(200012)32:3<271::Aid-Glia70>3.0.Co;2-5 |
0.524 |
|
| 2000 |
Penkowa M, Hidalgo J. Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis. Glia. 32: 247-263. PMID 11102966 DOI: 10.1002/1098-1136(200012)32:3<247::Aid-Glia50>3.0.Co;2-T |
0.346 |
|
| 2000 |
Carrasco J, Penkowa M, Hadberg H, Molinero A, Hidalgo J. Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice. European Journal of Neuroscience. 12: 2311-2322. PMID 10947810 DOI: 10.1046/J.1460-9568.2000.00128.X |
0.419 |
|
| 2000 |
Hernández J, Carrasco J, Belloso E, Giralt M, Bluethmann H, Lee DK, Andrews GK, Hidalgo J. Metallothionein Induction By Restraint Stress: Role Of Glucocorticoids And Il-6 Cytokine. 12: 791-796. PMID 10843766 DOI: 10.1006/Cyto.1999.0629 |
0.457 |
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| 2000 |
Penkowa M, Hidalgo J. IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment. Experimental Neurology. 163: 72-84. PMID 10785446 DOI: 10.1006/Exnr.2000.7383 |
0.513 |
|
| 2000 |
Carrasco J, Giralt M, Penkowa M, Stalder AK, Campbell IL, Hidalgo J. Metallothioneins Are Upregulated in Symptomatic Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor-α Experimental Neurology. 163: 46-54. PMID 10785443 DOI: 10.1006/Exnr.1999.7335 |
0.457 |
|
| 2000 |
Giralt M, Molinero A, Carrasco J, Hidalgo J. Effect of dietary zinc deficiency on brain metallothionein-I and -III mRNA levels during stress and inflammation. Neurochemistry International. 36: 555-562. PMID 10762093 DOI: 10.1016/S0197-0186(99)00155-2 |
0.409 |
|
| 2000 |
Rojas P, Hidalgo J, Ebadi M, Rios C. Changes of metallothionein I + II proteins in the brain after 1-methyl-4-phenylpyridinium administration in mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 143-54. PMID 10659990 DOI: 10.1016/S0278-5846(99)00077-9 |
0.377 |
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| 2000 |
Penkowa M, Carrasco J, Giralt M, Molinero A, Hernández J, Campbell IL, Hidalgo J. Altered Central Nervous System Cytokine-Growth Factor Expression Profiles and Angiogenesis in Metallothionein-I+II Deficient Mice Journal of Cerebral Blood Flow & Metabolism. 20: 1174-1189. DOI: 10.1097/00004647-200008000-00003 |
0.505 |
|
| 1999 |
Carrasco J, Giralt M, Molinero A, Penkowa M, Moos T, Hidalgo J. Metallothionein (MT)-III : Generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains Journal of Neurotrauma. 16: 1115-1129. PMID 10595827 DOI: 10.1089/Neu.1999.16.1115 |
0.345 |
|
| 1999 |
Penkowa M, Nielsen H, Hidalgo J, Bernth N, Moos T. Distribution of metallothionein I + II and vesicular zinc in the developing central nervous system: Correlative study in the rat The Journal of Comparative Neurology. 412: 303-318. PMID 10441758 DOI: 10.1002/(Sici)1096-9861(19990920)412:2<303::Aid-Cne9>3.0.Co;2-G |
0.355 |
|
| 1999 |
Acarin L, González B, Hidalgo J, Castro AJ, Castellano B. Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression. Neuroscience. 92: 827-39. PMID 10426525 DOI: 10.1016/S0306-4522(99)00022-6 |
0.339 |
|
| 1999 |
Acarin L, Carrasco J, González B, Hidalgo J, Castellano B. Expression of growth inhibitory factor (metallothionein-III) mRNA and protein following excitotoxic immature brain injury Journal of Neuropathology and Experimental Neurology. 58: 389-397. PMID 10218634 DOI: 10.1097/00005072-199904000-00009 |
0.372 |
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| 1999 |
Penkowa M, Giralt M, Moos T, Thomsen PS, Hernández J, Hidalgo J. Impaired inflammatory response to glial cell death in genetically metallothionein-I- and -II-deficient mice. Experimental Neurology. 156: 149-164. PMID 10192786 DOI: 10.1006/Exnr.1998.7009 |
0.427 |
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| 1999 |
Penkowa M, Moos T, Carrasco J, Hadberg H, Molinero A, Bluethmann H, Hidalgo J. Strongly compromised inflammatory response to brain injury in interleukin‐6‐deficient mice Glia. 25: 343-357. PMID 10028917 DOI: 10.1002/(Sici)1098-1136(19990215)25:4<343::Aid-Glia4>3.0.Co;2-V |
0.505 |
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| 1999 |
Penkowa M, Carrasco J, Giralt M, Moos T, Hidalgo J. CNS Wound Healing Is Severely Depressed in Metallothionein I- and II-Deficient Mice The Journal of Neuroscience. 19: 2535-2545. DOI: 10.1523/Jneurosci.19-07-02535.1999 |
0.405 |
|
| 1999 |
Lee DK, Carrasco J, Hidalgo J, Andrews GK. Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochemical Journal. 337: 59-65. DOI: 10.1042/Bj3370059 |
0.368 |
|
| 1998 |
Molinero A, Carrasco J, Hernandez J, Hidalgo J. Effect of nitric oxide synthesis inhibition on mouse liver and brain metallothionein expression. Neurochemistry International. 33: 559-566. PMID 10098726 DOI: 10.1016/S0197-0186(98)00065-5 |
0.418 |
|
| 1998 |
Armario A, Hernández J, Bluethmann H, Hidalgo J. IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6. Journal of Neuroimmunology. 92: 160-9. PMID 9916891 DOI: 10.1016/S0165-5728(98)00199-4 |
0.445 |
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| 1998 |
Carrasco J, Hernandez J, Gonzalez B, Campbell IL, Hidalgo J. Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6 Experimental Neurology. 153: 184-194. PMID 9784278 DOI: 10.1006/Exnr.1998.6861 |
0.482 |
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| 1998 |
Agullo L, Garcia A, Hidalgo J. Metallothionein-I+II induction by zinc and copper in primary cultures of rat microglia. Neurochemistry International. 33: 237-242. PMID 9759918 DOI: 10.1016/S0197-0186(98)00022-9 |
0.406 |
|
| 1998 |
Carrasco J, Hernandez J, Bluethmann H, Hidalgo J. Interleukin-6 and tumor necrosis factor-α type 1 receptor deficient mice reveal a role of IL-6 and TNF-α on brain metallothionein-I and -III regulation Molecular Brain Research. 57: 221-234. PMID 9675420 DOI: 10.1016/S0169-328X(98)00087-4 |
0.5 |
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| 1998 |
Hernández J, Hidalgo J. Endotoxin and intracerebroventricular injection of IL-1 and IL-6 induce rat brain metallothionein-I and -II. Neurochemistry International. 32: 369-373. PMID 9596561 DOI: 10.1016/S0197-0186(97)00096-X |
0.468 |
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| 1997 |
Houben R, Troppmair J, Hidalgo J, Rapp UR. Differential gene expression in apoptotic 32Dcl3 cells: induction of metallothionein. Apoptosis. 2: 40-46. PMID 14646563 DOI: 10.1023/A:1026483508306 |
0.414 |
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| 1997 |
Hidalgo J, Belloso E, Hernandez J, Gasull T, Molinero A. Role of Glucocorticoids on Rat Brain Metallothionein-I and -III Response to Stress. Stress. 1: 231-240. PMID 9787247 DOI: 10.3109/10253899709013743 |
0.4 |
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| 1997 |
Penkowa M, Hidalgo J, Moos T. Increased astrocytic expression of metallothioneins I + II in brainstem of adult rats treated with 6-aminonicotinamide. Brain Research. 774: 256-259. PMID 9452221 DOI: 10.1016/S0006-8993(97)81716-7 |
0.351 |
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| 1997 |
Vela JM, Hidalgo J, González B, Castellano B. Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse. Brain Research. 767: 345-55. PMID 9367267 DOI: 10.1016/S0006-8993(97)00628-8 |
0.305 |
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| 1997 |
Hernandez J, Carrasco J, Arbonés M, Hidalgo J. IFN-γR -/- mice show an enhanced liver and brain metallothionein I+II response to endotoxin but not to immobilization stress Journal of Endotoxin Research. 4: 363-370. DOI: 10.1177/096805199700400508 |
0.342 |
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| 1997 |
Hernández J, Molinero A, Campbell IL, Hidalgo J. Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice Molecular Brain Research. 48: 125-131. DOI: 10.1016/S0169-328X(97)00087-9 |
0.503 |
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| 1996 |
Belloso E, Hernandez J, Giralt M, Kille P, Hidalgo J. Effect of Stress on Mouse and Rat Brain Metallothionein I and III mRNA Levels Neuroendocrinology. 64: 430-439. PMID 8990076 DOI: 10.1159/000127149 |
0.383 |
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| 1996 |
De Lisle RC, Sarras MP, Hidalgo J, Andrews GK. Metallothionein is a component of exocrine pancreas secretion: Implications for zinc homeostasis American Journal of Physiology - Cell Physiology. 271. PMID 8897816 DOI: 10.1152/Ajpcell.1996.271.4.C1103 |
0.359 |
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| 1996 |
Gasull T, Hidalgo J. Evidence for a high molecular weight cytosolic factor that binds brain and liver metallothionein. Neurochemical Research. 21: 969-974. PMID 8895852 DOI: 10.1007/Bf02532348 |
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| 1996 |
Hernandez J, Giralt M, Belloso E, Rebollo DV, Romero B, Hidalgo J. Interactions between metallothionein inducers in rat liver and primary cultures of rat hepatocytes. Chemico-Biological Interactions. 100: 27-40. PMID 8599853 DOI: 10.1016/0009-2797(95)03683-0 |
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| 1995 |
Ibánez E, Vidal F, Hidalgo J. Early mouse preimplantation development is unaffected by microinjection of metallothionein antibodies Zygote. 3: 81-84. PMID 7613878 DOI: 10.1017/S0967199400002410 |
0.311 |
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| 1994 |
Gasull T, Giralt M, Hernandez J, Martinez P, Bremner I, Hidalgo J. Regulation of metallothionein concentrations in rat brain: Effect of glucocorticoids, zinc, copper, and endotoxin American Journal of Physiology - Endocrinology and Metabolism. 266: E760-E767. PMID 8203514 DOI: 10.1152/Ajpendo.1994.266.5.E760 |
0.355 |
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| 1994 |
Hidalgo J, García A, Oliva AM, Giralt M, Gasull T, González B, Milnerowicz H, Wood A, Bremner I. Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain. Chemico-Biological Interactions. 93: 197-219. PMID 7923440 DOI: 10.1016/0009-2797(94)90020-5 |
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| 1994 |
Gasull T, Giralt M, Garcia A, Hidalgo J. Regulation of metallothionein‐I+II levels in specific brain areas and liver in the rat: Role of catecholamines Glia. 12: 135-143. PMID 7868187 DOI: 10.1002/Glia.440120207 |
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| 1994 |
Hidalgo J, Gasull T, Giralt M, Armario A. Brain metallothionein in stress. Biological Signals. 3: 198-210. PMID 7834015 DOI: 10.1159/000109546 |
0.368 |
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| 1991 |
Hidalgo J, Campmany L, Martí O, Armario A. Metallothionein-I induction by stress in specific brain areas Neurochemical Research. 16: 1145-1148. PMID 1795759 DOI: 10.1007/Bf00966593 |
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| 1990 |
Hidalgo J, Borrás M, Garvey JS, Armario A. Liver, brain, and heart metallothionein induction by stress Journal of Neurochemistry. 55: 651-654. PMID 2370551 DOI: 10.1111/J.1471-4159.1990.Tb04182.X |
0.321 |
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| 1988 |
Hidalgo J, Campmany L, Borras M, Garvey JS, Armario A. Metallothionein response to stress in rats: role in free radical scavenging American Journal of Physiology - Endocrinology and Metabolism. 255: 18/4. PMID 3177638 DOI: 10.1152/Ajpendo.1988.255.4.E518 |
0.309 |
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| 1988 |
Hidalgo J, Giralt M, Garvey JS, Armario A. Physiological role of glucocorticoids on rat serum and liver metallothionein in basal and stress conditions American Journal of Physiology - Endocrinology and Metabolism. 254: 17/1. PMID 2827514 DOI: 10.1152/Ajpendo.1988.254.1.E71 |
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| 1986 |
Hidalgo J, Armario A, Flos R, Garvey JS. Restraint stress induced changes in rat liver and serum metallothionein and in Zn metabolism Experientia. 42: 1006-1010. PMID 3758297 DOI: 10.1007/Bf01940708 |
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| 1986 |
Hidalgo J, Armario A, Flos R, Dingman A, Garvey JS. The influence of restraint stress in rats on metallothionein production and corticosterone and glucagon secretion Life Sciences. 39: 611-616. PMID 3736339 DOI: 10.1016/0024-3205(86)90041-X |
0.305 |
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