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Simon Dujardin - Publications

Affiliations: 
Harvard Medical School - Massachusetts General Hospital 
Area:
Alzheimer's disease
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kumar M, Quittot N, Dujardin S, Schlaffner CN, Viode A, Wiedmer A, Beerepoot P, Chun JE, Glynn C, Fernandes AR, Donahue C, Steen JA, Hyman BT. Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a Journal of Neurology. PMID 38236720 DOI: 10.1093/brain/awad378  0.857
2023 Welikovitch LA, Dujardin S, Dunn AR, Fernandes AR, Khasnavis A, Chibnik LB, Kaczorowski CC, Hyman BT. Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains. Iscience. 26: 105983. PMID 36756365 DOI: 10.1016/j.isci.2023.105983  0.839
2022 Dujardin S, Fernandes A, Bannon R, Commins C, De Los Santos M, Kamath TV, Hayashi M, Hyman BT. Tau propagation is dependent on the genetic background of mouse strains. Brain Communications. 4: fcac048. PMID 35350555 DOI: 10.1093/braincomms/fcac048  0.85
2021 Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, et al. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathology (Zurich, Switzerland). e13035. PMID 34779076 DOI: 10.1111/bpa.13035  0.8
2021 Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Molecular Neurobiology. PMID 34757590 DOI: 10.1007/s12035-021-02557-w  0.762
2021 Fernandes AR, Dujardin S, Maté de Gérando A, Hyman BT, Frosch MP. Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. Journal of Neuropathology and Experimental Neurology. PMID 34498073 DOI: 10.1093/jnen/nlab087  0.845
2021 Kamath TV, Klickstein N, Commins C, Fernandes AR, Oakley DH, Frosch MP, Hyman BT, Dujardin S. Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases. Brain Communications. 3: fcab096. PMID 34222869 DOI: 10.1093/braincomms/fcab096  0.814
2021 Cooper JM, Lathuiliere A, Migliorini M, Arai AL, Wani MM, Dujardin S, Muratoglu SC, Hyman BT, Strickland DK. Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. The Journal of Biological Chemistry. 100715. PMID 33930462 DOI: 10.1016/j.jbc.2021.100715  0.675
2021 Oakley DH, Klickstein N, Commins C, Chung M, Dujardin S, Bennett RE, Hyman BT, Frosch MP. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33893219 DOI: 10.1523/JNEUROSCI.2590-20.2021  0.834
2021 Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, et al. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 33514949 DOI: 10.1038/s41591-021-01251-7  0.796
2020 Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, et al. A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathologica. PMID 33319314 DOI: 10.1007/s00401-020-02249-0  0.661
2020 Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, et al. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. PMID 33188775 DOI: 10.1016/j.cell.2020.10.029  0.649
2020 Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathologica Communications. 8: 168. PMID 33076986 DOI: 10.1186/s40478-020-01049-7  0.749
2020 Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathologica Communications. 8: 137. PMID 32811565 DOI: 10.1186/S40478-020-01014-4  0.832
2020 Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 32572268 DOI: 10.1038/S41591-020-0938-9  0.805
2020 Kamath TV, Commins C, Klickstein N, Oakley D, Hyman BT, Dujardin S. Employing an in vitro biosensor assay to investigate tau seeding kinetics within cases of sporadic Alzheimer disease and in a model of tauopathy Alzheimer's & Dementia. 16. DOI: 10.1002/alz.047169  0.835
2020 Dujardin S, De Los Santos M, Fernandes AR, Bannon RN, Kamath TV, Commins C, Hyman BT. Tau propagation is dependent on the genetic background in multiple mouse strains Alzheimer's & Dementia. 16. DOI: 10.1002/alz.043059  0.792
2019 Dujardin S, Hyman BT. Tau Prion-Like Propagation: State of the Art and Current Challenges. Advances in Experimental Medicine and Biology. 1184: 305-325. PMID 32096046 DOI: 10.1007/978-981-32-9358-8_23  0.631
2019 Hanlon KS, Meltzer JC, Buzhdygan T, Cheng MJ, Sena-Esteves M, Bennett RE, Sullivan TP, Razmpour R, Gong Y, Ng C, Nammour J, Maiz D, Dujardin S, Ramirez SH, Hudry E, et al. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression. Molecular Therapy. Methods & Clinical Development. 15: 320-332. PMID 31788496 DOI: 10.1016/J.Omtm.2019.10.007  0.58
2019 Calvo-Rodriguez M, Hou SS, Snyder AC, Dujardin S, Shirani H, Nilsson KPR, Bacskai BJ. In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy. Acta Neuropathologica Communications. 7: 171. PMID 31703739 DOI: 10.1186/S40478-019-0832-1  0.38
2019 Colin M, Dujardin S, Schraen-Maschke S, Meno-Tetang G, Duyckaerts C, Courade JP, Buée L. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta Neuropathologica. PMID 31686182 DOI: 10.1007/S00401-019-02087-9  0.845
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.825
2019 Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature Neuroscience. 22: 57-64. PMID 30559471 DOI: 10.1038/S41593-018-0289-8  0.835
2019 Dujardin S, Commins C, Kamath TV, De Los Santos M, Dooley PM, Moore BD, Jean-Gilles D, Clark R, Kennedy M, Hyman BT. RELEVANCE OF TAU SEEDING FOR THE CLINICAL HETEROGENEITY OF ALZHEIMER’S DISEASE: IMPLICATION FOR THERAPEUTIC PERSPECTIVES Alzheimer's & Dementia. 15: P1623. DOI: 10.1016/J.Jalz.2019.06.4854  0.8
2018 Dujardin S, Bégard S, Caillierez R, Lachaud C, Carrier S, Lieger S, Gonzalez JA, Deramecourt V, Déglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathologica Communications. 6: 132. PMID 30497516 DOI: 10.1186/S40478-018-0637-7  0.858
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  0.872
2018 DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, et al. Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo. Brain : a Journal of Neurology. PMID 29733334 DOI: 10.1093/Brain/Awy117  0.794
2018 Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. The Embo Journal. PMID 29472250 DOI: 10.15252/Embj.201798049  0.864
2017 Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Naini SMA, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP. What is the evidence that tau pathology spreads through prion-like propagation? Acta Neuropathologica Communications. 5: 99. PMID 29258615 DOI: 10.1186/S40478-017-0488-7  0.846
2017 Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Enhanced Tau Aggregation in the Presence of Amyloid β. The American Journal of Pathology. PMID 28500862 DOI: 10.1016/J.Ajpath.2017.03.011  0.816
2017 Colin M, Tardivel M, Bégard S, Bousset L, Dujardin S, Richetin K, Deglon N, Melki R, Buee L. Tau Spreading: How Are Tau Assemblies Transferred From Cell To Cell? Alzheimers & Dementia. 13: 906. DOI: 10.1016/J.Jalz.2017.07.320  0.786
2016 Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M. Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies. Acta Neuropathologica Communications. 4: 117. PMID 27809932 DOI: 10.1186/S40478-016-0386-4  0.805
2016 Buee L, Dujardin S, Tardivel M, Begard S, Caillierez R, Bousset L, Melki R, Colin M. The ins and outs of tau propagation Neurobiology of Aging. 39. DOI: 10.1016/J.Neurobiolaging.2016.01.071  0.815
2015 Dujardin S, Colin M, Buée L. Invited review: Animal models of tauopathies and their implications for research/translation into the clinic. Neuropathology and Applied Neurobiology. 41: 59-80. PMID 25428793 DOI: 10.1111/Nan.12200  0.799
2015 Buee L, Colin M, Dujardin S, Badin RA, Bemelmans A, Jan C, Camp NV, Deglon N, Hantraye P. Non-human primate model of tauopathy Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.07.060  0.681
2014 Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M. Ectosomes: a new mechanism for non-exosomal secretion of tau protein. Plos One. 9: e100760. PMID 24971751 DOI: 10.1371/Journal.Pone.0100760  0.812
2014 Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L. Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathologica Communications. 2: 14. PMID 24479894 DOI: 10.1186/2051-5960-2-14  0.834
2014 Dujardin S, Brouillet E, Hantraye P, Colin M, Buée L. Which Tau species are toxic? Consequences for therapeutic approaches Neurobiology of Aging. 35: S4. DOI: 10.1016/J.Neurobiolaging.2014.01.042  0.76
2013 Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1358-68. PMID 23609018 DOI: 10.1038/Mt.2013.66  0.832
2013 Buee L, Dujardin S, Bégard S, Raphaëlle C, Lécolle K, Dufour N, Auregan G, Winderickx J, Philippe H, Deglon N, Colin M. In vivo tau spreading relies on the transsynaptic transfer of soluble wild-type tau species Alzheimers & Dementia. 9: 142. DOI: 10.1016/J.Jalz.2013.04.090  0.792
2012 Deramecourt V, Lebert F, Maurage CA, Fernandez-Gomez FJ, Dujardin S, Colin M, Sergeant N, Buée-Scherrer V, Clot F, Ber IL, Brice A, Pasquier F, Buée L. Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S. Journal of Alzheimer's Disease : Jad. 31: 741-9. PMID 22699846 DOI: 10.3233/Jad-2012-120160  0.764
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