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David A. Nielsen, Ph.D. - Publications

Affiliations: 
1972-1976 Biochemistry University of Wisconsin, Madison, Madison, WI 
 1979-1984 Biochemistry and Molecular Biology University of Chicago, Chicago, IL 
 1984-1990 Biochemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 1990-1999 Laboratory of Human Genetics NIAAA/NIH, Bethesda, MD, United States 
 1990-2002 InforMax, Inc 
 2002-2008 Kreek Laboratory Rockefeller University, New York, NY, United States 
 2008- Baylor College of Medicine, Houston, TX 
Area:
Psychiatric Genetics
Website:
https://www.bcm.edu/people/view/david-nielsen-ph-d/b2271389-ffed-11e2-be68-080027880ca6
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122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wilkinson AV, Chen B, Swann AC, Graham DP, Nielsen DA, Kosten TR, Loukas A, Mantey DS, Bataineh BS, Harrell MB. Use of cigarettes and e-cigarettes, impulsivity and anxiety: Influences on suicidal ideation among youth and young adults in Texas. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 39028574 DOI: 10.1093/ntr/ntae163  0.303
2024 Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, et al. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Molecular Psychiatry. PMID 38491344 DOI: 10.1038/s41380-024-02472-1  0.373
2023 Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann AC, Lipsky RK, Kosten TR, Aslan M, et al. Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. Jama Psychiatry. PMID 37938835 DOI: 10.1001/jamapsychiatry.2023.4141  0.351
2023 Aloi MS, Poblete GF, Oldham J, Patriquin MA, Nielsen DA, Kosten TR, Salas R. miR-124-3p target genes identify globus pallidus role in suicide ideation recovery in borderline personality disorder. Npj Mental Health Research. 2: 8. PMID 37712050 DOI: 10.1038/s44184-023-00027-w  0.355
2023 Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann A, Lipsky RK, Kosten T, Aslan M, et al. Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. Medrxiv : the Preprint Server For Health Sciences. PMID 37034805 DOI: 10.1101/2023.03.22.23286865  0.37
2023 Bigdeli TB, Barr PB, Rajeevan N, Graham DP, Li Y, Meyers JL, Gorman BR, Peterson RE, Sayward F, Radhakrishnan K, Natarajan S, Nielsen DA, Wilkinson AV, Malhotra AK, Zhao H, et al. Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Medrxiv : the Preprint Server For Health Sciences. PMID 36945597 DOI: 10.1101/2023.03.06.23286866  0.35
2022 Kosten TR, Domingo CB, Haile CN, Nielsen DA. A Clinical Trial of Entolimod a TLR-5 Adjuvant for Vaccines Using Diphtheria or Tetanus as Carrier Proteins. Vaccines. 10. PMID 36298456 DOI: 10.3390/vaccines10101592  0.329
2022 Poblete G, Nguyen T, Gosnell S, Sofela O, Patriquin M, Mathew SJ, Swann A, Nielsen DA, Kosten TR, Salas R. A Novel Approach to Link Genetics and Human MRI Identifies AKAP7-Dependent Subicular/Prefrontal Functional Connectivity as Altered in Suicidality. Chronic Stress (Thousand Oaks, Calif.). 6: 24705470221083700. PMID 35340866 DOI: 10.1177/24705470221083700  0.377
2022 Nielsen DA, Walker R, Graham DP, Nielsen EM, Hamon SC, Hillhouse M, Shmueli-Blumberg D, Lawson WB, Shores-Wilson K, Settles-Reaves BD, Rotrosen J, Trivedi MH, Saxon AJ, Ling W, Kosten TR. Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene. European Journal of Clinical Pharmacology. PMID 35218405 DOI: 10.1007/s00228-022-03302-5  0.473
2021 Thomas PS, Nielsen EM, Spellicy CJ, Harding MJ, Ye A, Patriquin M, Hamon SC, Kosten TR, Nielsen DA. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatric Genetics. 31: 88-94. PMID 33953123 DOI: 10.1097/YPG.0000000000000279  0.47
2020 Poblete GF, Gosnell SN, Meyer M, Fang M, Nguyen T, Patriquin MA, Nielsen D, Kosten T, Salas R. Process Genes List: An Approach to Link Genetics and Human Brain Imaging. Journal of Neuroscience Methods. 108695. PMID 32201351 DOI: 10.1016/J.Jneumeth.2020.108695  0.427
2020 Shorter DI, Zhang X, Domingo CB, Nielsen EM, Kosten TR, Nielsen DA. Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an genetic variant. The American Journal of Drug and Alcohol Abuse. 1-10. PMID 31914324 DOI: 10.1080/00952990.2019.1674864  0.544
2020 Salas R, Poblete G, Nguyen T, Patriquin M, Nielsen D, Kosten T. A Novel Strategy to Identify Genetic/Brain Imaging Interactions Suggests Habenular Connectivity is Associated With Suicidality Biological Psychiatry. 87: S35. DOI: 10.1016/J.Biopsych.2020.02.111  0.428
2019 Kampangkaew JP, Spellicy CJ, Nielsen EM, Harding MJ, Ye A, Hamon SC, Kosten TR, Nielsen DA. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. The American Journal On Addictions. PMID 31087723 DOI: 10.1111/Ajad.12891  0.517
2019 Deng H, Desai PV, Mohite S, Okusaga OO, Zhang XY, Nielsen DA, Kosten TR. Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users. Journal of Studies On Alcohol and Drugs. 80: 230-235. PMID 31014468 DOI: 10.15288/Jsad.2019.80.230  0.403
2019 Nielsen DA, Deng H, Patriquin MA, Harding MJ, Oldham J, Salas R, Fowler JC, Frueh BC. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European Archives of Psychiatry and Clinical Neuroscience. PMID 30923939 DOI: 10.1007/S00406-019-01009-W  0.305
2018 Patel MM, Nielsen DA, Kosten TR, De La Garza R, Newton TF, Verrico CD. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. The American Journal On Addictions. PMID 30126012 DOI: 10.1111/Ajad.12788  0.547
2018 Deng H, Verrico CD, Kosten TR, Nielsen DA. Psychosis and synthetic cannabinoids. Psychiatry Research. 268: 400-412. PMID 30125871 DOI: 10.1016/J.Psychres.2018.08.012  0.436
2018 Kosten TR, Graham DP, Nielsen DA. Opioid Use Disorder After Self-medicating Pain From Traumatic Brain Injury. Jama Psychiatry. PMID 29710138 DOI: 10.1001/Jamapsychiatry.2018.0098  0.419
2018 Kosten TR, Graham DP, Nielsen DA. Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. Jama Psychiatry. PMID 29710079 DOI: 10.1001/Jamapsychiatry.2018.0101  0.438
2018 Zhang X, Nielsen DA, Domingo CB, Shorter DI, Nielsen EM, Kosten TR. Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin. Addiction Biology. PMID 29498170 DOI: 10.1111/Adb.12611  0.535
2017 Curtis K, Viswanath H, Velasquez KM, Molfese DL, Harding MJ, Aramayo E, Baldwin PR, Ambrosi E, Madan A, Patriquin M, Frueh BC, Fowler JC, Kosten TR, Nielsen DA, Salas R. Increased habenular connectivity in opioid users is associated with an α5 subunit nicotinic receptor genetic variant. The American Journal On Addictions. PMID 28857330 DOI: 10.1111/Ajad.12607  0.467
2017 Patriquin MA, Hamon SC, Harding MJ, Nielsen EM, Newton TF, De La Garza R, Nielsen DA. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric Genetics. PMID 28590957 DOI: 10.1097/YPG.0000000000000178  0.399
2017 Nielsen DA, Shorter D, Domingo C, Harding M, Nielsen EM, Kosten T. Adrenoceptor variants moderate treatment response of doxazosin for cocaine use disorder Drug and Alcohol Dependence. 171: e152. DOI: 10.1016/J.Drugalcdep.2016.08.420  0.517
2017 Blokhina E, Krupitsky E, Kibitov A, Verbitskaya E, Kosten T, Nielsen DA, Zvartau E. The role of genetic polymorphisms on patient response to opioid use disorder therapy with naltrexone and guanfacine Drug and Alcohol Dependence. 171: e21. DOI: 10.1016/J.Drugalcdep.2016.08.072  0.478
2016 Kibitov АО, Krupitsky ЕМ, Blokhina ЕА, Verbitskaya ЕV, Brodyansky VМ, Alekseeva NP, Bushara NМ, Yaroslavtseva ТS, Palatkin VY, Masalov DV, Burakov АМ, Romanova ТN, Sulimov GY, Grinenko AY, Kosten Т, ... Nielsen D, et al. A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova. 116: 36-48. PMID 28300812 DOI: 10.17116/Jnevro201611611236-48  0.354
2016 Wachman EM, Hayes MJ, Sherva R, Brown MS, Shrestha H, Logan BA, Heller NA, Nielsen DA, Farrer LA. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. The American Journal On Addictions. PMID 27983768 DOI: 10.1111/Ajad.12483  0.321
2016 Sharp C, Fowler JC, Salas R, Nielsen D, Allen J, Oldham J, Kosten T, Mathew S, Madan A, Frueh BC, Fonagy P. Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings. Bulletin of the Menninger Clinic. 80: 187-212. PMID 27583809 DOI: 10.1521/Bumc.2016.80.3.187  0.414
2016 Shorter D, Nielsen DA, Hamon SC, Nielsen EM, Kosten TR, Newton TF, De La Garza R. The α-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals. Pharmacogenetics and Genomics. PMID 27379509 DOI: 10.1097/Fpc.0000000000000234  0.528
2015 Azadeh S, Hobbs BP, Ma L, Nielsen DA, Moeller FG, Baladandayuthapani V. Integrative Bayesian Analysis of Neuroimaging-Genetic Data with Application to Cocaine Dependence. Neuroimage. PMID 26484829 DOI: 10.1016/J.Neuroimage.2015.10.033  0.358
2015 Bauer IE, Graham DP, Soares JC, Nielsen DA. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. 1-8. PMID 26265436 DOI: 10.2217/pgs.15.72  0.374
2015 Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Variations in opioid receptor genes in neonatal abstinence syndrome. Drug and Alcohol Dependence. PMID 26233486 DOI: 10.1016/J.Drugalcdep.2015.07.001  0.329
2015 Patriquin MA, Bauer IE, Soares JC, Graham DP, Nielsen DA. Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatric Genetics. PMID 26146874 DOI: 10.1097/YPG.0000000000000095  0.39
2015 Liu S, Maili L, Lane SD, Schmitz JM, Spellicy CJ, Cunningham KA, Moeller FG, Nielsen DA. Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity. Psychiatric Genetics. PMID 26110342 DOI: 10.1097/Ypg.0000000000000094  0.379
2015 Brewer AJ, Nielsen DA, Spellicy CJ, Hamon SC, Gingrich J, Thompson-Lake DG, Nielsen EM, Mahoney JJ, Kosten TR, Newton TF, De La Garza R. Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenetics and Genomics. 25: 296-304. PMID 25850966 DOI: 10.1097/Fpc.0000000000000137  0.531
2015 Bauer IE, Soares JC, Nielsen DA. The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. 24: 15-23. PMID 25823631 DOI: 10.1111/ajad.12172  0.362
2015 Nielsen DA, Hamon S, Harding M, Nielsen EM, Kosten T, Newton TF, De La Garza R. Ubjective responses to acute cocaine are moderated by variants of the serotonergic system Drug and Alcohol Dependence. 156: e162-e163. DOI: 10.1016/J.Drugalcdep.2015.07.443  0.507
2015 Schmitz J, Liu S, Green C, Lane SD, Kosten T, Gerard Moeller F, Nielsen DA. The influence of dopamine B-hydroxylase gene polymorphism −1021C Ç T on levodopa/carbidopa treatment for cocaine dependence: A preliminary study Drug and Alcohol Dependence. 146: e90. DOI: 10.1016/J.Drugalcdep.2014.09.613  0.522
2015 Nielsen DA, Walker R, Hamon S, Harding M, Ling W, Kosten T. Pharmacogenetics of buprenorphine therapy of cocaine addiction Drug and Alcohol Dependence. 146: e51-e52. DOI: 10.1016/J.Drugalcdep.2014.09.511  0.498
2014 Nielsen DA, Nielsen EM, Dasari T, Spellicy CJ. Pharmacogenetics of addiction therapy. Methods in Molecular Biology (Clifton, N.J.). 1175: 589-624. PMID 25150877 DOI: 10.1007/978-1-4939-0956-8_15  0.346
2014 Graham DP, Nielsen DA, Kosten TR, Davis LL, Hamner MB, Makotkine I, Yehuda R. Examining the utility of using genotype and functional biology in a clinical pharmacology trial: pilot testing dopamine β-hydroxylase, norepinephrine, and post-traumatic stress disorder. Psychiatric Genetics. 24: 181-2. PMID 24983834 DOI: 10.1097/Ypg.0000000000000039  0.478
2014 Frazier TW, Youngstrom EA, Frankel BA, Zunta-Soares GB, Sanches M, Escamilla M, Nielsen DA, Soares JC. Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes. Brain and Behavior. 4: 418-30. PMID 24944871 DOI: 10.1002/Brb3.226  0.324
2014 Liu S, Green CE, Lane SD, Kosten TR, Moeller FG, Nielsen DA, Schmitz JM. The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. Pharmacogenetics and Genomics. 24: 370-3. PMID 24809448 DOI: 10.1097/Fpc.0000000000000055  0.54
2014 Anastasio NC, Liu S, Maili L, Swinford SE, Lane SD, Fox RG, Hamon SC, Nielsen DA, Cunningham KA, Moeller FG. Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity. Translational Psychiatry. 4: e369. PMID 24618688 DOI: 10.1038/Tp.2013.131  0.369
2014 Spellicy CJ, Harding MJ, Hamon SC, Mahoney JJ, Reyes JA, Kosten TR, Newton TF, De La Garza R, Nielsen DA. A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. Genes, Brain, and Behavior. 13: 559-64. PMID 24528631 DOI: 10.1111/Gbb.12121  0.558
2014 Verrico CD, Nielsen D, Spellicy C, Hamon S, Kosten T, Newton TF, Ii RDLG. Fatty acid amide hydrolase gene variant influences acute responses to cocaine Drug and Alcohol Dependence. 140: e234. DOI: 10.1016/J.Drugalcdep.2014.02.648  0.505
2014 Spellicy CJ, Nielsen DA, Hamon S, Kosten T, Harding M. Interaction of gender and genetics in response to cocaine vaccine Drug and Alcohol Dependence. 140: e214. DOI: 10.1016/J.Drugalcdep.2014.02.595  0.481
2014 Shutter TR, Shorter D, Nielsen DA, Kosten T. Attenuation of depressive symptoms associated with MTHFR during a cocaine vaccine trial Drug and Alcohol Dependence. 140: e207. DOI: 10.1016/J.Drugalcdep.2014.02.577  0.456
2014 Shorter D, Nielsen DA, Newton TF, De La Garza R, Kosten T. Association between α-1 adrenergic receptor (ADRA1A) genotype and subjective cocaine effect in cocaine-dependent individuals Drug and Alcohol Dependence. 140: e207. DOI: 10.1016/J.Drugalcdep.2014.02.575  0.527
2014 Nielsen DA, Spellicy C, Hamon S, Harding M, Mahoney JJ, Kosten T, De La Garza Ii R, Newton TF. Genetic variants of the dopaminergic system associated with subjective responses to cocaine Drug and Alcohol Dependence. 140: e161. DOI: 10.1016/J.Drugalcdep.2014.02.455  0.552
2014 Liu S, Nielsen DA, Lane SD, Schmitz J, Baladandayuthapani V, Cunningham K, Moeller F. Cocaine dependence moderates the relationship between serotonin transporter polymorphisms and measures of impulsivity Drug and Alcohol Dependence. 140: e126. DOI: 10.1016/J.Drugalcdep.2014.02.359  0.37
2014 Brewer A, Nielsen DA, Spellicy C, Hamon S, Gingrich J, Mahoney JJ, Kosten T, Newton TF, Garza RDL. Subjective effects produced by cocaine are in association with genetic variants of DAT1 Drug and Alcohol Dependence. 140: e19-e20. DOI: 10.1016/J.Drugalcdep.2014.02.075  0.53
2013 Nielsen DA, Hamon SC, Kosten TR. The κ-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial. Psychiatric Genetics. 23: 225-32. PMID 23995774 DOI: 10.1097/Ypg.0000000000000008  0.535
2013 Shorter D, Nielsen DA, Huang W, Harding MJ, Hamon SC, Kosten TR. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 1401-7. PMID 23849431 DOI: 10.1016/J.Euroneuro.2013.05.014  0.566
2013 Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Pharmacogenetics and Genomics. 23: 333-40. PMID 23635803 DOI: 10.1097/Fpc.0B013E328361C39D  0.547
2013 Graham DP, Helmer DA, Harding MJ, Kosten TR, Petersen NJ, Nielsen DA. Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans. Journal of Psychiatric Research. 47: 835-42. PMID 23478049 DOI: 10.1016/J.Jpsychires.2013.02.006  0.443
2013 Kosten TR, Domingo CB, Hamon SC, Nielsen DA. DBH gene as predictor of response in a cocaine vaccine clinical trial. Neuroscience Letters. 541: 29-33. PMID 23458673 DOI: 10.1016/J.Neulet.2013.02.037  0.526
2013 Kosten TR, Wu G, Huang W, Harding MJ, Hamon SC, Lappalainen J, Nielsen DA. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase. Biological Psychiatry. 73: 219-24. PMID 22906516 DOI: 10.1016/J.Biopsych.2012.07.011  0.546
2013 Krupitsky E, Zvartau E, Blokhina E, Nielsen D, Kosten T, Woody G. P.6.d.004 Pharmacogenetics of treatment of opioid dependence with oral naltrexone and long acting sustained release naltrexone implant European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70916-7  0.424
2012 Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. Frontiers in Psychiatry. 3: 109. PMID 23335901 DOI: 10.3389/Fpsyt.2012.00109  0.537
2012 Haile CN, De La Garza R, Mahoney JJ, Nielsen DA, Kosten TR, Newton TF. The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. Plos One. 7: e47702. PMID 23144826 DOI: 10.1371/Journal.Pone.0047702  0.509
2012 Nielsen DA, Harding MJ, Hamon SC, Huang W, Kosten TR. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Genes, Brain, and Behavior. 11: 1001-8. PMID 22925276 DOI: 10.1111/J.1601-183X.2012.00839.X  0.544
2012 Nielsen DA, Utrankar A, Reyes JA, Simons DD, Kosten TR. Epigenetics of drug abuse: predisposition or response. Pharmacogenomics. 13: 1149-60. PMID 22909205 DOI: 10.2217/Pgs.12.94  0.464
2012 Nielsen DA, Huang W, Hamon SC, Maili L, Witkin BM, Fox RG, Cunningham KA, Moeller FG. Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. Frontiers in Psychiatry. 3: 60. PMID 22712019 DOI: 10.3389/Fpsyt.2012.00060  0.365
2012 Nielsen DA, Kreek MJ. Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug and Alcohol Dependence. 123: S33-41. PMID 22542464 DOI: 10.1016/J.Drugalcdep.2012.03.026  0.513
2012 Nielsen DA, Ho A, Bahl A, Varma P, Kellogg S, Borg L, Kreek MJ. Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls. Drug and Alcohol Dependence. 124: 113-20. PMID 22265192 DOI: 10.1016/J.Drugalcdep.2011.12.022  0.534
2012 Nielsen DA, Proudnikov D, Kreek MJ. The Genetics of Impulsivity The Oxford Handbook of Impulse Control Disorders. DOI: 10.1093/oxfordhb/9780195389715.013.0080  0.368
2011 Yuferov V, Nielsen DA, Levran O, Randesi M, Hamon S, Ho A, Morgello S, Kreek MJ. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenetics and Genomics. 21: 185-96. PMID 20808262 DOI: 10.1097/Fpc.0B013E32833Eecbc  0.481
2011 Rouault M, Nielsen DA, Ho A, Kreek MJ, Yuferov V. Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addiction Biology. 16: 334-46. PMID 20731629 DOI: 10.1111/J.1369-1600.2010.00248.X  0.499
2010 Nielsen DA, Ji F, Yuferov V, Ho A, He C, Ott J, Kreek MJ. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatric Genetics. 20: 207-14. PMID 20520587 DOI: 10.1097/Ypg.0B013E32833A2106  0.516
2010 Nielsen DA, Hamon S, Yuferov V, Jackson C, Ho A, Ott J, Kreek MJ. Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Human Genetics. 127: 639-49. PMID 20237803 DOI: 10.1007/S00439-010-0807-6  0.49
2010 Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Annals of the New York Academy of Sciences. 1187: 184-207. PMID 20201854 DOI: 10.1111/J.1749-6632.2009.05275.X  0.58
2010 Briant JA, Nielsen DA, Proudnikov D, Londono D, Ho A, Ott J, Kreek MJ. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Psychiatric Genetics. 20: 65-72. PMID 20032820 DOI: 10.1097/Ypg.0B013E32833511F6  0.545
2009 Yuferov V, Ji F, Nielsen DA, Levran O, Ho A, Morgello S, Shi R, Ott J, Kreek MJ. A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1185-97. PMID 18923396 DOI: 10.1038/Npp.2008.187  0.568
2009 Kreek MJ, Schlussman SD, Reed B, Zhang Y, Nielsen DA, Levran O, Zhou Y, Butelman ER. Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology. 56: 32-43. PMID 18725235 DOI: 10.1016/j.neuropharm.2008.07.042  0.526
2009 Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 867-73. PMID 18650805 DOI: 10.1038/Npp.2008.108  0.473
2009 Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone (Neuropsychopharmacology (2008) DOI: 10.1038/npp.2008.108) Neuropsychopharmacology. 34: 1087. DOI: 10.1038/Npp.2008.155  0.438
2008 Levran O, Londono D, O'Hara K, Nielsen DA, Peles E, Rotrosen J, Casadonte P, Linzy S, Randesi M, Ott J, Adelson M, Kreek MJ. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes, Brain, and Behavior. 7: 720-9. PMID 18518925 DOI: 10.1111/J.1601-183X.2008.00410.X  0.543
2008 Oosterhuis BE, LaForge KS, Proudnikov D, Ho A, Nielsen DA, Gianotti R, Barral S, Gordon D, Leal SM, Ott J, Kreek MJ. Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 793-8. PMID 18270997 DOI: 10.1002/Ajmg.B.30716  0.515
2008 Nielsen DA, Ji F, Yuferov V, Ho A, Chen A, Levran O, Ott J, Kreek MJ. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Molecular Psychiatry. 13: 417-28. PMID 18195715 DOI: 10.1038/Sj.Mp.4002147  0.549
2008 Nielsen DA, Barral S, Proudnikov D, Kellogg S, Ho A, Ott J, Kreek MJ. TPH2 and TPH1: association of variants and interactions with heroin addiction. Behavior Genetics. 38: 133-50. PMID 18181017 DOI: 10.1007/S10519-007-9187-7  0.53
2008 Nielsen D, Yuferov V, Hamon S, Jackson C, Ott J, Kreek MJ. 55. Increased DNA methylation in the promoter region of the μ-opioid receptor gene (ORPM1) in lymphocytes of Caucasian methadone maintained former heroin addicts Brain Behavior and Immunity. 22: 16-17. DOI: 10.1016/J.Bbi.2008.04.056  0.496
2007 Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. Journal of Neurochemistry. 103: 77-87. PMID 17877633 DOI: 10.1111/J.1471-4159.2007.04738.X  0.502
2007 Nielsen DA, Leidner M, Haynes C, Krauthammer M, Kreek MJ. The BiolAD-DB system : an informatics system for clinical and genetic data. Molecular Diagnosis & Therapy. 11: 15-9. PMID 17286447 DOI: 10.1007/Bf03256219  0.432
2005 Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience. 8: 1450-7. PMID 16251987 DOI: 10.1038/Nn1583  0.482
2005 Yuferov V, Nielsen D, Butelman E, Kreek MJ. Microarray studies of psychostimulant-induced changes in gene expression. Addiction Biology. 10: 101-18. PMID 15849024 DOI: 10.1080/13556210412331308976  0.522
2005 Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacological Reviews. 57: 1-26. PMID 15734726 DOI: 10.1124/Pr.57.1.1  0.58
2004 Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics. 14: 793-804. PMID 15608558 DOI: 10.1097/00008571-200412000-00002  0.567
2004 Kreek MJ, Nielsen DA, LaForge KS. Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Medicine. 5: 85-108. PMID 15001815 DOI: 10.1385/Nmm:5:1:085  0.541
2001 Roy A, Rylander G, Forslund K, Asberg M, Mazzanti CM, Goldman D, Nielsen DA. Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims. Neuropsychobiology. 43: 233-6. PMID 11340361 DOI: 10.1159/000054895  0.404
2001 Roy A, Rylander G, Forslund K, Asberg M, Mazzanti CM, Goldman D, Nielsen DA, Imai K, Harada S, Kawanishi Y, Tachikawa H, Okubo T, Suzuki T, Brambilla P, Harenski K, et al. Contents Vol. 43, 2001 Neuropsychobiology. 43: 281-282. DOI: 10.1159/000054905  0.352
2001 Roy A, Rylander G, Forslund K, Asberg M, Mazzanti CM, Goldman D, Nielsen DA, Imai K, Harada S, Kawanishi Y, Tachikawa H, Okubo T, Suzuki T, Brambilla P, Harenski K, et al. Subject Index Vol. 43, 2001 Neuropsychobiology. 43: 279-280. DOI: 10.1159/000054904  0.381
1999 Nielsen DA, Mazzanti CM, Linnoila M, Goldman D. Serotonin transporter and seasonal variation in serotonin function (2) Neuropsychopharmacology. 20: 507-508. PMID 26468552 DOI: 10.1016/S0893-133X(98)00073-6  0.4
1999 Rotondo A, Schuebel KE, Bergen AW, Aragon R, Virkkunen M, Linnoila M, Goldman D, Nielsen DA. Identification of four variants in the tryptophan hydroxylase promoter and association to behavior Molecular Psychiatry. 4: 360-368. PMID 10483053 DOI: 10.1038/Sj.Mp.4000578  0.477
1999 Han L, Nielsen DA, Rosenthal NE, Jefferson K, Kaye W, Murphy D, Altemus M, Humphries J, Cassano G, Rotondo A, Virkkunen M, Linnoila M, Goldman D. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biological Psychiatry. 45: 615-9. PMID 10088048 DOI: 10.1016/S0006-3223(98)00122-X  0.426
1999 Roy A, Rylander G, Forslund K, Asberg M, Mazzanti C, Goldman D, Nielsen D. Excess TPH 17 779C allele in surviving cotwins of monozygotic twin suicide victims European Neuropsychopharmacology. 10: 217. DOI: 10.1016/S0924-977X(00)80131-5  0.405
1998 Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Archives of General Psychiatry. 55: 593-602. PMID 9672049 DOI: 10.1001/Archpsyc.55.7.593  0.461
1998 New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. American Journal of Medical Genetics. 81: 13-7. PMID 9514581 DOI: 10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O  0.3
1997 Jönsson EG, Goldman D, Spurlock G, Gustavsson JP, Nielsen DA, Linnoila M, Owen MJ, Sedvall GC. Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. European Archives of Psychiatry and Clinical Neuroscience. 247: 297-302. PMID 9477008 DOI: 10.1007/Bf02922258  0.452
1997 Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. The American Journal of Psychiatry. 154: 1451-3. PMID 9326831 DOI: 10.1176/Ajp.154.10.1451  0.445
1997 Rotondo A, Nielsen DA, Nakhai B, Hulihan-Giblin B, Bolos A, Goldman D. Agonist-promoted down-regulation and functional desensitization in two naturally occurring variants of the human serotonin1A receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 17: 18-26. PMID 9194046 DOI: 10.1016/S0893-133X(97)00021-3  0.437
1997 Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D. Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Brain Research. Molecular Brain Research. 45: 145-8. PMID 9105682 DOI: 10.1016/S0169-328X(96)00304-X  0.456
1997 Rotondo A, Schuebel K, Nielsen D, Michelini S, Lezza A, Coli E, Bouanani S, Mauri M, Dell’Osso L, Cassano G, Goldman D. Tryptophan hydroxylase promoter polymorphisms and anorexia nervosa Biological Psychiatry. 42: 99S. DOI: 10.1016/S0006-3223(97)87285-X  0.454
1996 Raleigh M, Nielsen D, Goldman D, Linnoila M, McGuire M. Individual differences in 5-HT1A receptors and aggressive behavior in monkeys European Neuropsychopharmacology. 6: 21. DOI: 10.1016/0924-977X(96)87396-2  0.411
1996 Goldman D, Nielsen D, Okada M, Adamson M, Lappalainen J, Malhotra N, Pesonen U, Koulu M, Eggert M, Virkkunen M, Ozaki N, Linnoila M. Molecular genetics of impaired impulse control and early onset alcoholism Biological Psychiatry. 39: 561. DOI: 10.1016/0006-3223(96)84157-6  0.42
1995 McCarthy MM, Nielsen DA, Goldman D. Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain. Regulatory Peptides. 59: 163-70. PMID 8584751 DOI: 10.1016/0167-0115(95)00102-H  0.429
1995 Nakhai B, Nielsen DA, Linnoila M, Goldman D. Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochemical and Biophysical Research Communications. 210: 530-6. PMID 7755630 DOI: 10.1006/Bbrc.1995.1692  0.456
1995 Nielsen DA, Novoradovsky A, Goldman D. SSCP primer design based on single-strand DNA structure predicted by a DNA folding program. Nucleic Acids Research. 23: 2287-91. PMID 7610057 DOI: 10.1093/Nar/23.12.2287  0.41
1995 Linnoila M, Virkkunen M, Higley JD, Hall FS, Weight F, Nielsen D, Goldman D. S-7-2 Clinical, nonhuman primate and rodent studies on impulse control European Neuropsychopharmacology. 5: 178. DOI: 10.1016/0924-977X(95)90177-F  0.401
1994 Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Archives of General Psychiatry. 51: 34-8. PMID 7506517 DOI: 10.1001/Archpsyc.1994.03950010034005  0.451
1993 Linnoila M, Higley D, Nielsen D, Andreason P, Suomi S, Goldman D, Virkkunen M. Serotonin and impulse control: From clinic to clone European Neuropsychopharmacology. 3: 161. DOI: 10.1016/0924-977X(93)90001-3  0.406
1990 Nielsen DA, Shapiro DJ. Estradiol and estrogen receptor-dependent stabilization of a minivitellogenin mRNA lacking 5,100 nucleotides of coding sequence. Molecular and Cellular Biology. 10: 371-6. PMID 2294409 DOI: 10.1128/Mcb.10.1.371  0.5
1990 Nielsen DA, Shapiro DJ. Insights into hormonal control of messenger RNA stability. Molecular Endocrinology (Baltimore, Md.). 4: 953-7. PMID 2284008 DOI: 10.1210/Mend-4-7-953  0.49
1989 Nielsen DA, Chang TC, Shapiro DJ. A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells. Analytical Biochemistry. 179: 19-23. PMID 2757194 DOI: 10.1016/0003-2697(89)90193-0  0.468
1989 Shapiro DJ, Barton MC, McKearin DM, Chang TC, Lew D, Blume J, Nielsen DA, Gould L. Estrogen regulation of gene transcription and mRNA stability. Recent Progress in Hormone Research. 45: 29-58; discussion 58. PMID 2682843 DOI: 10.1016/B978-0-12-571145-6.50006-6  0.493
1987 Shapiro DJ, Blume JE, Nielsen DA. Regulation of messenger RNA stability in eukaryotic cells. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 6: 221-6. PMID 3606588 DOI: 10.1002/Bies.950060507  0.483
1986 Nielsen DA, Shapiro DJ. Preparation of capped RNA transcripts using T7 RNA polymerase. Nucleic Acids Research. 14: 5936. PMID 3526287 DOI: 10.1093/Nar/14.14.5936  0.459
1983 Nielsen DA, Chou J, MacKrell AJ, Casadaban MJ, Steiner DF. Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 5198-202. PMID 6310564 DOI: 10.1073/Pnas.80.17.5198  0.46
1982 Nielsen DA, Lernmark A, Berelowitz M, Bloom GD, Steiner DF. Sorting of pancreatic islet cell subpopulations by light scattering using a fluorescence-activated cell sorter. Diabetes. 31: 299-306. PMID 6130019 DOI: 10.2337/Diab.31.4.299  0.447
1981 Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. Expression of major histocompatibility antigens on pancreatic islet cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 6456-60. PMID 7031653 DOI: 10.1073/Pnas.78.10.6456  0.451
1980 Steiner DF, Patzelt C, Chan SJ, Quinn PS, Tager HS, Nielsen D, Lernmark A, Noyes BE, Agarwal KL, Gabbay KH, Rubenstein AH. Formation of biologically active peptides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 210: 45-59. PMID 6107930 DOI: 10.1098/Rspb.1980.0117  0.631
1978 Lernmark A, Nielsen DA, Steiner DF. Cation-dependent phosphatase activites in a rat pancreatic islet plasma membrane fraction prepared by one-step gradient centrifugation. Journal of Supramolecular Structure. 9: 327-36. PMID 34753 DOI: 10.1002/Jss.400090304  0.442
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