☰

Michael P. Murphy - Publications

Affiliations: 
MRC Mitochondrial Biology Unit University of Cambridge, Cambridge, England, United Kingdom 
Tree Info Similar researchers PubMed Report error

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A, Sauchanka O, Caldwell ST, Morris JL, Prime TA, Warrington S, Prudent J, Bates GR, ... ... Murphy MP, et al. Rapid and selective generation of HS within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biology. 55: 102429. PMID 35961099 DOI: 10.1016/j.redox.2022.102429  0.675
2022 Prag HA, Aksentijevic D, Dannhorn A, Giles AV, Mulvey JF, Sauchanka O, Du L, Bates G, Reinhold J, Kula-Alwar D, Xu Z, Pellerin L, Goodwin RJA, Murphy MP, Krieg T. Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury. Circulation Research. 101161CIRCRESAHA1213. PMID 35959683 DOI: 10.1161/CIRCRESAHA.121.320717  0.657
2022 Gruszczyk AV, Casey AM, James AM, Prag HA, Burger N, Bates GR, Hall AR, Allen FM, Krieg T, Saeb-Parsy K, Murphy MP. Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury. Redox Biology. 54: 102368. PMID 35749842 DOI: 10.1016/j.redox.2022.102368  0.345
2021 Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J. Structural basis for a complex I mutation that blocks pathological ROS production. Nature Communications. 12: 707. PMID 33514727 DOI: 10.1038/s41467-021-20942-w  0.655
2020 Deragon MA, McCaig WD, Patel PS, Haluska RJ, Hodges AL, Sosunov SA, Murphy MP, Ten VS, LaRocca TJ. Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis. Cell Death Discovery. 6: 132. PMID 33298902 DOI: 10.1038/s41420-020-00370-3  0.306
2020 Cvetko F, Caldwell ST, Higgins M, Suzuki T, Yamamoto M, Prag HA, Hartley RC, Dinkova-Kostova A, Murphy MP. Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. The Journal of Biological Chemistry. PMID 33298526 DOI: 10.1074/jbc.RA120.016551  0.323
2020 Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, ... ... Murphy MP, et al. Mechanism of succinate efflux upon reperfusion of the ischemic heart. Cardiovascular Research. PMID 32766828 DOI: 10.1093/Cvr/Cvaa148  0.644
2020 Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, ... ... Murphy MP, et al. Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo. Cardiovascular Drugs and Therapy. PMID 32648168 DOI: 10.1007/s10557-020-07033-6  0.349
2020 Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG. Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon. Redox Biology. 36: 101606. PMID 32604037 DOI: 10.1016/J.Redox.2020.101606  0.315
2020 Fortner KA, Blanco LP, Buskiewicz I, Huang N, Gibson PC, Cook DL, Pedersen HL, Yuen PST, Murphy MP, Perl A, Kaplan MJ, Budd RC. Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL- mice. Lupus Science & Medicine. 7. PMID 32343673 DOI: 10.1136/lupus-2020-000387  0.319
2020 Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, ... Murphy MP, et al. Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. Journal of Cellular and Molecular Medicine. PMID 32040259 DOI: 10.1111/jcmm.15043  0.307
2019 Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A. Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Scientific Reports. 9: 2850. PMID 30808950 DOI: 10.1038/s41598-019-39836-5  0.321
2019 Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology & Medicine. PMID 30731114 DOI: 10.1016/j.freeradbiomed.2019.01.034  0.368
2018 Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, ... ... Murphy MP, et al. Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo. Cell Chemical Biology. PMID 30713096 DOI: 10.1016/j.chembiol.2018.12.002  0.325
2018 Murphy MP, Hartley RC. Mitochondria as a therapeutic target for common pathologies. Nature Reviews. Drug Discovery. PMID 30393373 DOI: 10.1038/nrd.2018.174  0.318
2018 Pinho BR, Reis SD, Hartley RC, Murphy MP, Oliveira JMA. Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radical Biology & Medicine. PMID 30389496 DOI: 10.1016/j.freeradbiomed.2018.10.446  0.321
2018 Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP. Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. The Journal of Biological Chemistry. PMID 30232152 DOI: 10.1074/Jbc.Ra118.002579  0.302
2018 Pell VR, Spiroski AM, Mulvey J, Burger N, Costa ASH, Logan A, Gruszczyk AV, Rosa T, James AM, Frezza C, Murphy MP, Krieg T. Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation. Journal of Molecular and Cellular Cardiology. PMID 30118790 DOI: 10.1016/j.yjmcc.2018.08.010  0.33
2018 Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A, Ten VS. Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. Free Radical Biology & Medicine. 124: 517-524. PMID 30037775 DOI: 10.1016/J.Freeradbiomed.2018.06.040  0.384
2018 Martin JL, Gruszczyk AV, Beach TE, Murphy MP, Saeb-Parsy K. Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury. Pediatric Nephrology (Berlin, Germany). PMID 29860579 DOI: 10.1007/s00467-018-3984-5  0.311
2018 Bundgaard A, James AM, Joyce W, Murphy MP, Fago A. Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex I S-nitrosation. The Journal of Experimental Biology. PMID 29496783 DOI: 10.1242/jeb.174391  0.326
2017 Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630339 DOI: 10.1073/Pnas.1705406114  0.311
2016 Murphy MP. Understanding and preventing mitochondrial oxidative damage. Biochemical Society Transactions. 44: 1219-1226. PMID 27911703 DOI: 10.1042/BST20160108  0.393
2016 Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T. Succinate metabolism: a new therapeutic target for myocardial reperfusion injury. Cardiovascular Research. PMID 27194563 DOI: 10.1093/cvr/cvw100  0.343
2016 Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T. Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy. Circulation Research. 118: 898-906. PMID 26941425 DOI: 10.1161/Circresaha.115.306569  0.35
2016 Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP. A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury. Cell Metabolism. PMID 26777689 DOI: 10.1016/j.cmet.2015.12.009  0.35
2015 Robb EL, Gawel JM, Aksentijević D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA, Bright TP, James AM, Shattock MJ, Senn HM, Hartley RC, Murphy MP. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology & Medicine. 89: 883-894. PMID 26454075 DOI: 10.1016/j.freeradbiomed.2015.08.021  0.668
2015 Finichiu PG, Larsen DS, Evans C, Larsen L, Bright TP, Robb EL, Trnka J, Prime TA, James AM, Smith RA, Murphy MP. A mitochondria-targeted derivative of ascorbate: MitoC. Free Radical Biology & Medicine. 89: 668-678. PMID 26453920 DOI: 10.1016/j.freeradbiomed.2015.07.160  0.305
2015 Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJ. Redox Homeostasis and Mitochondrial Dynamics. Cell Metabolism. 22: 207-18. PMID 26166745 DOI: 10.1016/j.cmet.2015.06.006  0.31
2015 Dare AJ, Logan A, Prime TA, Rogatti S, Goddard M, Bolton EM, Bradley JA, Pettigrew GJ, Murphy MP, Saeb-Parsy K. The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. PMID 26140808 DOI: 10.1016/j.healun.2015.05.007  0.311
2015 Yancey DM, Guichard JL, Ahmed MI, Zhou L, Murphy MP, Johnson MS, Benavides GA, Collawn J, Darley-Usmar V, Dell'Italia LJ. Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload. American Journal of Physiology. Heart and Circulatory Physiology. 308: H651-63. PMID 25599572 DOI: 10.1152/Ajpheart.00638.2014  0.343
2014 Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord EN, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, ... ... Murphy MP, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515: 431-5. PMID 25383517 DOI: 10.1038/Nature13909  0.399
2014 Wang A, Keita Ã…V, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, et al. Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis. The American Journal of Pathology. 184: 2516-27. PMID 25034594 DOI: 10.1016/J.Ajpath.2014.05.019  0.301
2014 Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T. Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts. European Journal of Heart Failure. 16: 712-7. PMID 24891297 DOI: 10.1002/ejhf.100  0.353
2014 Chouchani ET, Methner C, Buonincontri G, Hu CH, Logan A, Sawiak SJ, Murphy MP, Krieg T. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. Plos One. 9: e94157. PMID 24705922 DOI: 10.1371/journal.pone.0094157  0.312
2014 Rogers C, Davis B, Neufer PD, Murphy MP, Anderson EJ, Robidoux J. A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids. Free Radical Biology & Medicine. 67: 330-41. PMID 24269897 DOI: 10.1016/J.Freeradbiomed.2013.11.012  0.3
2013 Murphy MP. Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum. Cell Metabolism. 18: 145-6. PMID 23931748 DOI: 10.1016/j.cmet.2013.07.006  0.306
2013 Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, ... ... Murphy MP, et al. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine. 19: 753-9. PMID 23708290 DOI: 10.1038/Nm.3212  0.371
2013 Reily C, Mitchell T, Chacko BK, Benavides G, Murphy MP, Darley-Usmar V. Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biology. 1: 86-93. PMID 23667828 DOI: 10.1016/J.Redox.2012.11.009  0.311
2013 Methner C, Lukowski R, Grube K, Loga F, Smith RA, Murphy MP, Hofmann F, Krieg T. Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G. Basic Research in Cardiology. 108: 337. PMID 23423145 DOI: 10.1007/s00395-013-0337-1  0.315
2013 Solesio ME, Prime TA, Logan A, Murphy MP, Del Mar Arroyo-Jimenez M, Jordán J, Galindo MF. The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease. Biochimica Et Biophysica Acta. 1832: 174-82. PMID 22846607 DOI: 10.1016/j.bbadis.2012.07.009  0.332
2012 Pelletier M, Lepow TS, Billingham LK, Murphy MP, Siegel RM. New tricks from an old dog: mitochondrial redox signaling in cellular inflammation. Seminars in Immunology. 24: 384-92. PMID 23391428 DOI: 10.1016/j.smim.2013.01.002  0.305
2012 Smith RA, Hartley RC, Cochemé HM, Murphy MP. Mitochondrial pharmacology. Trends in Pharmacological Sciences. 33: 341-52. PMID 22521106 DOI: 10.1016/j.tips.2012.03.010  0.317
2012 Murphy MP. Mitochondrial thiols in antioxidant protection and redox signaling: distinct roles for glutathionylation and other thiol modifications. Antioxidants & Redox Signaling. 16: 476-95. PMID 21954972 DOI: 10.1089/ars.2011.4289  0.311
2011 Smith RA, Murphy MP. Mitochondria-targeted antioxidants as therapies. Discovery Medicine. 11: 106-14. PMID 21356165  0.338
2010 Porteous CM, Logan A, Evans C, Ledgerwood EC, Menon DK, Aigbirhio F, Smith RA, Murphy MP. Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. Biochimica Et Biophysica Acta. 1800: 1009-17. PMID 20621583 DOI: 10.1016/J.Bbagen.2010.06.001  0.331
2009 Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, ... ... Murphy MP, et al. A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. 106: 10764-9. PMID 19528654 DOI: 10.1073/Pnas.0903250106  0.389
2009 Cochemé HM, Murphy MP. Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria. Methods in Enzymology. 456: 395-417. PMID 19348901 DOI: 10.1016/S0076-6879(08)04422-4  0.316
2008 Smith RA, Adlam VJ, Blaikie FH, Manas AR, Porteous CM, James AM, Ross MF, Logan A, Cochemé HM, Trnka J, Prime TA, Abakumova I, Jones BA, Filipovska A, Murphy MP. Mitochondria-targeted antioxidants in the treatment of disease. Annals of the New York Academy of Sciences. 1147: 105-11. PMID 19076435 DOI: 10.1196/annals.1427.003  0.324
2008 Murphy MP. Targeting lipophilic cations to mitochondria. Biochimica Et Biophysica Acta. 1777: 1028-31. PMID 18439417 DOI: 10.1016/j.bbabio.2008.03.029  0.32
2008 Cochemé HM, Murphy MP. Complex I is the major site of mitochondrial superoxide production by paraquat. The Journal of Biological Chemistry. 283: 1786-98. PMID 18039652 DOI: 10.1074/jbc.M708597200  0.34
2007 Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas AR, Porteous CM, Adlam VJ, Smith RA, Murphy MP. Mitochondrial targeting of quinones: therapeutic implications. Mitochondrion. 7: S94-102. PMID 17449335 DOI: 10.1016/j.mito.2007.02.007  0.331
2007 Murphy MP, Smith RA. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annual Review of Pharmacology and Toxicology. 47: 629-56. PMID 17014364 DOI: 10.1146/annurev.pharmtox.47.120505.105110  0.326
2005 Adlam VJ, Harrison JC, Porteous CM, James AM, Smith RA, Murphy MP, Sammut IA. Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1088-95. PMID 15985532 DOI: 10.1096/fj.05-3718com  0.383
2005 James AM, Cochemé HM, Murphy MP. Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mechanisms of Ageing and Development. 126: 982-6. PMID 15923020 DOI: 10.1016/j.mad.2005.03.026  0.35
2005 Filipovska A, Kelso GF, Brown SE, Beer SM, Smith RA, Murphy MP. Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria. The Journal of Biological Chemistry. 280: 24113-26. PMID 15831495 DOI: 10.1074/jbc.M501148200  0.326
2005 James AM, Cochemé HM, Smith RA, Murphy MP. Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. The Journal of Biological Chemistry. 280: 21295-312. PMID 15788391 DOI: 10.1074/jbc.M501527200  0.335
2004 Green K, Brand MD, Murphy MP. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes. 53: S110-8. PMID 14749275 DOI: 10.2337/Diabetes.53.2007.S110  0.302
2003 Jauslin ML, Meier T, Smith RA, Murphy MP. Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1972-4. PMID 12923074 DOI: 10.1096/fj.03-0240fje  0.301
2003 Taylor ER, Hurrell F, Shannon RJ, Lin TK, Hirst J, Murphy MP. Reversible glutathionylation of complex I increases mitochondrial superoxide formation. The Journal of Biological Chemistry. 278: 19603-10. PMID 12649289 DOI: 10.1074/jbc.M209359200  0.335
2002 Echtay KS, Murphy MP, Smith RA, Talbot DA, Brand MD. Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. The Journal of Biological Chemistry. 277: 47129-35. PMID 12372827 DOI: 10.1074/Jbc.M208262200  0.306
2002 Kelso GF, Porteous CM, Hughes G, Ledgerwood EC, Gane AM, Smith RA, Murphy MP. Prevention of mitochondrial oxidative damage using targeted antioxidants. Annals of the New York Academy of Sciences. 959: 263-74. PMID 11976201 DOI: 10.1111/j.1749-6632.2002.tb02098.x  0.341
2002 Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP. Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. The Journal of Biological Chemistry. 277: 17048-56. PMID 11861642 DOI: 10.1074/Jbc.M110797200  0.305
Show low-probability matches.