Elly Hol - Publications

Affiliations: 
Utrecht University, Utrecht, Netherlands 
Area:
Glia Biology of Brain Diseases
Website:
http://www.ellyhollab.eu/elly-hol

130 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 van Bodegraven EJ, van Asperen JV, Sluijs JA, van Deursen CBJ, van Strien ME, Stassen OMJA, Robe PAJ, Hol EM. GFAP alternative splicing regulates glioma cell-ECM interaction in a DUSP4-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900916R. PMID 31480854 DOI: 10.1096/fj.201900916R  0.72
2019 Donega V, Burm SM, van Strien ME, van Bodegraven EJ, Paliukhovich I, Geut H, van de Berg WDJ, Li KW, Smit AB, Basak O, Hol EM. Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease. Acta Neuropathologica Communications. 7: 4. PMID 31159890 DOI: 10.1186/s40478-019-0736-0  0.48
2018 Hillen AEJ, Burbach JPH, Hol EM. Cell adhesion and matricellular support by astrocytes of the tripartite synapse. Progress in Neurobiology. PMID 29444459 DOI: 10.1016/j.pneurobio.2018.02.002  0.32
2017 Hendrickx DAE, van Scheppingen J, van der Poel M, Bossers K, Schuurman KG, van Eden CG, Hol EM, Hamann J, Huitinga I. Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions. Frontiers in Immunology. 8: 1810. PMID 29312322 DOI: 10.3389/fimmu.2017.01810  0.72
2017 Stassen OMJA, van Bodegraven EJ, Giuliani F, Moeton M, Kanski R, Sluijs JA, van Strien ME, Kamphuis W, Robe PAJ, Hol EM. GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile. Oncotarget. 8: 88104-88121. PMID 29152145 DOI: 10.18632/oncotarget.21540  0.72
2017 Iorio R, Damato V, Evoli A, Gessi M, Gaudino S, Di Lazzaro V, Spagni G, Sluijs JA, Hol EM. Clinical and immunological characteristics of the spectrum of GFAP autoimmunity: a case series of 22 patients. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 28951498 DOI: 10.1136/jnnp-2017-316583  0.72
2017 Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Eggen BJL, Möller T, Tamm JA, Abdourahman A, Hol EM, Kamphuis W, Bayer TA, De Deyn PP, Boddeke E. Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease. Neurobiology of Aging. PMID 28434692 DOI: 10.1016/j.neurobiolaging.2017.03.021  0.64
2016 Reemst K, Noctor SC, Lucassen PJ, Hol EM. The Indispensable Roles of Microglia and Astrocytes during Brain Development. Frontiers in Human Neuroscience. 10: 566. PMID 27877121 DOI: 10.3389/fnhum.2016.00566  0.64
2016 Jansen AH, van Hal M, Op den Kelder IC, Meier RT, de Ruiter AA, Schut MH, Smith DL, Grit C, Brouwer N, Kamphuis W, Boddeke HW, den Dunnen WF, van Roon WM, Bates GP, Hol EM, et al. Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific. Glia. PMID 27615381 DOI: 10.1002/glia.23050  0.64
2016 Kamphuis W, Kooijman L, Schetters S, Orre M, Hol EM. Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease. Biochimica Et Biophysica Acta. PMID 27425031 DOI: 10.1016/j.bbadis.2016.07.007  0.64
2016 Moeton M, Stassen OM, Sluijs JA, van der Meer VW, Kluivers LJ, van Hoorn H, Schmidt T, Reits EA, van Strien ME, Hol EM. GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions. Cellular and Molecular Life Sciences : Cmls. PMID 27141937 DOI: 10.1007/s00018-016-2239-5  1
2016 Osborn LM, Kamphuis W, Wadman WJ, Hol EM. Astrogliosis: an integral player in the pathogenesis of Alzheimer's Disease. Progress in Neurobiology. PMID 26797041 DOI: 10.1016/j.pneurobio.2016.01.001  1
2015 Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A. Astrocytes: a central element in neurological diseases. Acta Neuropathologica. PMID 26671410 DOI: 10.1007/s00401-015-1513-1  1
2015 van Dijk BJ, Vergouwen MD, Kelfkens MM, Rinkel GJ, Hol EM. Glial cell response after aneurysmal subarachnoid hemorrhage - Functional consequences and clinical implications. Biochimica Et Biophysica Acta. PMID 26493445 DOI: 10.1016/j.bbadis.2015.10.013  1
2015 Herrera Moro Chao D, Kallemeijn WW, Marques AR, Orre M, Ottenhoff R, van Roomen C, Foppen E, Renner MC, Moeton M, van Eijk M, Boot RG, Kamphuis W, Hol EM, Aten J, Overkleeft HS, et al. Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes. Plos One. 10: e0138107. PMID 26418157 DOI: 10.1371/journal.pone.0138107  1
2015 Manzine PR, Marcello E, Borroni B, Kamphuis W, Hol E, Padovani A, Nascimento CC, de Godoy Bueno P, Assis Carvalho Vale F, Iost Pavarini SC, Di Luca M, Cominetti MR. ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 20: 196-201. PMID 26220620 DOI: 10.3109/1354750X.2015.1062554  0.64
2015 Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ. Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathologica Communications. 3: 31. PMID 26001565 DOI: 10.1186/s40478-015-0203-5  0.64
2015 de Vrij J, Maas SL, Kwappenberg KM, Schnoor R, Kleijn A, Dekker L, Luider TM, de Witte LD, Litjens M, van Strien ME, Hol EM, Kroonen J, Robe PA, Lamfers ML, Schilham MW, et al. Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. International Journal of Cancer. Journal International Du Cancer. 137: 1630-42. PMID 25802036 DOI: 10.1002/ijc.29521  1
2015 Cuadrado E, Michailidou I, van Bodegraven EJ, Jansen MH, Sluijs JA, Geerts D, Couraud PO, De Filippis L, Vescovi AL, Kuijpers TW, Hol EM. Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release. Journal of Immunology (Baltimore, Md. : 1950). 194: 3623-33. PMID 25769924 DOI: 10.4049/jimmunol.1401334  1
2015 Kamphuis W, Kooijman L, Orre M, Stassen O, Pekny M, Hol EM. GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Glia. 63: 1036-56. PMID 25731615 DOI: 10.1002/glia.22800  1
2015 Hol EM, Pekny M. Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. Current Opinion in Cell Biology. 32: 121-30. PMID 25726916 DOI: 10.1016/j.ceb.2015.02.004  1
2015 Hol EM, Etienne-Manneville S. Editorial overview: cell architecture: intermediate filaments - from molecules to patients. Current Opinion in Cell Biology. 32: v-vi. PMID 25666354 DOI: 10.1016/j.ceb.2015.01.007  1
2015 Manzine PR, Marcello E, Borroni B, Kamphuis W, Hol E, Padovani A, Nascimento CC, de Godoy Bueno P, Assis Carvalho Vale F, Iost Pavarini SC, Di Luca M, Cominetti MR. ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects Biomarkers. DOI: 10.3109/1354750X.2015.1062554  1
2014 Michailidou I, de Vries HE, Hol EM, van Strien ME. Activation of endogenous neural stem cells for multiple sclerosis therapy. Frontiers in Neuroscience. 8: 454. PMID 25653584 DOI: 10.3389/fnins.2014.00454  1
2014 Kreft KL, van Meurs M, Wierenga-Wolf AF, Melief MJ, van Strien ME, Hol EM, Oostra BA, Laman JD, Hintzen RQ. Abundant kif21b is associated with accelerated progression in neurodegenerative diseases. Acta Neuropathologica Communications. 2: 144. PMID 25274010 DOI: 10.1186/s40478-014-0144-4  0.36
2014 Jansen AH, Reits EA, Hol EM. The ubiquitin proteasome system in glia and its role in neurodegenerative diseases. Frontiers in Molecular Neuroscience. 7: 73. PMID 25152710 DOI: 10.3389/fnmol.2014.00073  1
2014 Kanski R, Sneeboer MA, van Bodegraven EJ, Sluijs JA, Kropff W, Vermunt MW, Creyghton MP, De Filippis L, Vescovi A, Aronica E, van Tijn P, van Strien ME, Hol EM. Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network. Journal of Cell Science. 127: 4368-80. PMID 25128567 DOI: 10.1242/jcs.145912  1
2014 Orre M, Kamphuis W, Osborn LM, Jansen AH, Kooijman L, Bossers K, Hol EM. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiology of Aging. 35: 2746-60. PMID 25002035 DOI: 10.1016/j.neurobiolaging.2014.06.004  1
2014 Végh MJ, Heldring CM, Kamphuis W, Hijazi S, Timmerman AJ, Li KW, van Nierop P, Mansvelder HD, Hol EM, Smit AB, van Kesteren RE. Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer's disease. Acta Neuropathologica Communications. 2: 76. PMID 24974208 DOI: 10.1186/s40478-014-0076-z  1
2014 Cuadrado E, Vanderver A, Brown KJ, Sandza A, Takanohashi A, Jansen MH, Anink J, Herron B, Orcesi S, Olivieri I, Rice GI, Aronica E, Lebon P, Crow YJ, Hol EM, et al. Aicardi-Goutières syndrome harbours abundant systemic and brain-reactive autoantibodies. Annals of the Rheumatic Diseases. PMID 24906636 DOI: 10.1136/annrheumdis-2014-205396  1
2014 Clairembault T, Kamphuis W, Leclair-Visonneau L, Rolli-Derkinderen M, Coron E, Neunlist M, Hol EM, Derkinderen P. Enteric GFAP expression and phosphorylation in Parkinson's disease. Journal of Neurochemistry. 130: 805-15. PMID 24749759 DOI: 10.1111/jnc.12742  1
2014 Moeton M, Kanski R, Stassen OM, Sluijs JA, Geerts D, van Tijn P, Wiche G, van Strien ME, Hol EM. Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2942-54. PMID 24696300 DOI: 10.1096/fj.13-245837  1
2014 van Strien ME, Sluijs JA, Reynolds BA, Steindler DA, Aronica E, Hol EM. Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker CD271. Stem Cells Translational Medicine. 3: 470-80. PMID 24604282 DOI: 10.5966/sctm.2013-0038  1
2014 Kamphuis W, Middeldorp J, Kooijman L, Sluijs JA, Kooi EJ, Moeton M, Freriks M, Mizee MR, Hol EM. Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease. Neurobiology of Aging. 35: 492-510. PMID 24269023 DOI: 10.1016/j.neurobiolaging.2013.09.035  1
2014 Orre M, Kamphuis W, Osborn LM, Melief J, Kooijman L, Huitinga I, Klooster J, Bossers K, Hol EM. Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice. Neurobiology of Aging. 35: 1-14. PMID 23954174 DOI: 10.1016/j.neurobiolaging.2013.07.008  1
2014 Kanski R, van Strien ME, van Tijn P, Hol EM. A star is born: new insights into the mechanism of astrogenesis. Cellular and Molecular Life Sciences : Cmls. 71: 433-47. PMID 23907612 DOI: 10.1007/s00018-013-1435-9  1
2013 Mamber C, Kozareva DA, Kamphuis W, Hol EM. Shades of gray: The delineation of marker expression within the adult rodent subventricular zone. Progress in Neurobiology. 111: 1-16. PMID 23994259 DOI: 10.1016/j.pneurobio.2013.07.003  1
2013 van den Berge SA, van Strien ME, Hol EM. Resident adult neural stem cells in Parkinson's disease--the brain's own repair system? European Journal of Pharmacology. 719: 117-27. PMID 23872414 DOI: 10.1016/j.ejphar.2013.04.058  1
2013 Orre M, Kamphuis W, Dooves S, Kooijman L, Chan ET, Kirk CJ, Dimayuga Smith V, Koot S, Mamber C, Jansen AH, Ovaa H, Hol EM. Reactive glia show increased immunoproteasome activity in Alzheimer's disease. Brain : a Journal of Neurology. 136: 1415-31. PMID 23604491 DOI: 10.1093/brain/awt083  1
2013 Cuadrado E, Jansen MH, Anink J, De Filippis L, Vescovi AL, Watts C, Aronica E, Hol EM, Kuijpers TW. Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome. Brain : a Journal of Neurology. 136: 245-58. PMID 23365100 DOI: 10.1093/brain/aws321  1
2013 Smolders J, Schuurman KG, van Strien ME, Melief J, Hendrickx D, Hol EM, van Eden C, Luchetti S, Huitinga I. Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue. Journal of Neuropathology and Experimental Neurology. 72: 91-105. PMID 23334593 DOI: 10.1097/NEN.0b013e31827f4fcc  1
2013 Wirz KT, Bossers K, Stargardt A, Kamphuis W, Swaab DF, Hol EM, Verhaagen J. Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model. Neurobiology of Aging. 34: 1328-42. PMID 23245294 DOI: 10.1016/j.neurobiolaging.2012.11.008  1
2012 Mamber C, Kamphuis W, Haring NL, Peprah N, Middeldorp J, Hol EM. GFAPδ expression in glia of the developmental and adolescent mouse brain. Plos One. 7: e52659. PMID 23285135 DOI: 10.1371/journal.pone.0052659  1
2012 Kamphuis W, Mamber C, Moeton M, Kooijman L, Sluijs JA, Jansen AH, Verveer M, de Groot LR, Smith VD, Rangarajan S, Rodríguez JJ, Orre M, Hol EM. GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease. Plos One. 7: e42823. PMID 22912745 DOI: 10.1371/journal.pone.0042823  1
2012 van den Berge SA, Kevenaar JT, Sluijs JA, Hol EM. Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis. Parkinson's Disease. 2012: 420957. PMID 22577599 DOI: 10.1155/2012/420957  1
2012 Kamphuis W, Orre M, Kooijman L, Dahmen M, Hol EM. Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model. Glia. 60: 615-29. PMID 22262260 DOI: 10.1002/glia.22295  1
2012 Vedam-Mai V, van Battum EY, Kamphuis W, Feenstra MG, Denys D, Reynolds BA, Okun MS, Hol EM. Deep brain stimulation and the role of astrocytes. Molecular Psychiatry. 17: 124-31, 115. PMID 21625231 DOI: 10.1038/mp.2011.61  1
2012 Van Den Berge SA, Van Strien ME, Korecka JA, Dijkstra AA, Sluijs JA, Kooijman L, Eggers R, De Filippis L, Vescovi AL, Verhaagen J, Van De Berg WDJ, Hol EM. Reply: Quantitative evaluation of the human subventricular zone Brain. 135: e222. DOI: 10.1093/brain/aws088  1
2012 Vedam-Mai V, Van Battum EY, Kamphuis W, Feenstra MGP, Denys D, Reynolds BA, Okun MS, Hol EM. Unravelling the actions of deep brain stimulation: Potential role for astrocytes Molecular Psychiatry. 17: 115. DOI: 10.1038/mp.2011.184  1
2012 Vedam-Mai V, Okun MS, Hol EM. The potential role of nonneuronal cells in the deep brain stimulation mechanism: What are glia? what are their functions? Could they be players in deep brain stimulation? Deep Brain Stimulation: a New Frontier in Psychiatry. 205-215. DOI: 10.1007/978-3-642-30991-5_19  1
2011 van den Berge SA, van Strien ME, Korecka JA, Dijkstra AA, Sluijs JA, Kooijman L, Eggers R, De Filippis L, Vescovi AL, Verhaagen J, van de Berg WD, Hol EM. The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain. Brain : a Journal of Neurology. 134: 3249-63. PMID 22075520 DOI: 10.1093/brain/awr256  1
2011 van Strien ME, van den Berge SA, Hol EM. Migrating neuroblasts in the adult human brain: a stream reduced to a trickle. Cell Research. 21: 1523-5. PMID 21691300 DOI: 10.1038/cr.2011.101  1
2011 Hoogerhout P, Kamphuis W, Brugghe HF, Sluijs JA, Timmermans HA, Westdijk J, Zomer G, Boog CJ, Hol EM, van den Dobbelsteen GP. A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques. Plos One. 6: e19110. PMID 21526148 DOI: 10.1371/journal.pone.0019110  1
2011 Middeldorp J, Hol EM. GFAP in health and disease. Progress in Neurobiology. 93: 421-43. PMID 21219963 DOI: 10.1016/j.pneurobio.2011.01.005  1
2011 Bugiani M, Boor I, van Kollenburg B, Postma N, Polder E, van Berkel C, van Kesteren RE, Windrem MS, Hol EM, Scheper GC, Goldman SA, van der Knaap MS. Defective glial maturation in vanishing white matter disease. Journal of Neuropathology and Experimental Neurology. 70: 69-82. PMID 21157376 DOI: 10.1097/NEN.0b013e318203ae74  1
2011 van Tijn P, Kamphuis W, Marlatt MW, Hol EM, Lucassen PJ. Presenilin mouse and zebrafish models for dementia: focus on neurogenesis. Progress in Neurobiology. 93: 149-64. PMID 21056616 DOI: 10.1016/j.pneurobio.2010.10.008  1
2010 Mamber C, Verhaagen J, Hol EM. In vivo targeting of subventricular zone astrocytes. Progress in Neurobiology. 92: 19-32. PMID 20441785 DOI: 10.1016/j.pneurobio.2010.04.007  1
2010 Boer K, Middeldorp J, Spliet WG, Razavi F, van Rijen PC, Baayen JC, Hol EM, Aronica E. Immunohistochemical characterization of the out-of frame splice variants GFAP Delta164/Deltaexon 6 in focal lesions associated with chronic epilepsy. Epilepsy Research. 90: 99-109. PMID 20430588 DOI: 10.1016/j.eplepsyres.2010.03.014  1
2010 Mihaescu R, Detmar SB, Cornel MC, van der Flier WM, Heutink P, Hol EM, Rikkert MG, van Duijn CM, Janssens AC. Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives. Journal of Alzheimer's Disease : Jad. 20: 967-80. PMID 20182048 DOI: 10.3233/JAD-2010-1410  1
2010 van den Berge SA, Middeldorp J, Zhang CE, Curtis MA, Leonard BW, Mastroeni D, Voorn P, van de Berg WD, Huitinga I, Hol EM. Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-delta. Aging Cell. 9: 313-26. PMID 20121722 DOI: 10.1111/j.1474-9726.2010.00556.x  1
2010 Middeldorp J, Boer K, Sluijs JA, De Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM. GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex. Development (Cambridge, England). 137: 313-21. PMID 20040497 DOI: 10.1242/dev.041632  1
2009 Middeldorp J, van den Berge SA, Aronica E, Speijer D, Hol EM. Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer. Plos One. 4: e7663. PMID 19888461 DOI: 10.1371/journal.pone.0007663  1
2009 Eggermont LH, Swaab DF, Hol EM, Scherder EJ. Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia. Journal of Neurology, Neurosurgery, and Psychiatry. 80: 802-4. PMID 19531688 DOI: 10.1136/jnnp.2008.158444  1
2009 Martinian L, Boer K, Middeldorp J, Hol EM, Sisodiya SM, Squier W, Aronica E, Thom M. Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologies. Neuropathology and Applied Neurobiology. 35: 394-405. PMID 19508443 DOI: 10.1111/j.1365-2990.2009.00996.x  1
2009 Leonard BW, Mastroeni D, Grover A, Liu Q, Yang K, Gao M, Wu J, Pootrakul D, van den Berge SA, Hol EM, Rogers J. Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. The Journal of Comparative Neurology. 515: 269-94. PMID 19425077 DOI: 10.1002/cne.22040  1
2009 Middeldorp J, Kamphuis W, Sluijs JA, Achoui D, Leenaars CH, Feenstra MG, van Tijn P, Fischer DF, Berkers C, Ovaa H, Quinlan RA, Hol EM. Intermediate filament transcription in astrocytes is repressed by proteasome inhibition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2710-26. PMID 19332645 DOI: 10.1096/fj.08-127696  1
2009 Eggermont LH, Swaab DF, Hol EM, Scherder EJ. Observation of hand movements by older persons with dementia: effects on cognition: a pilot study. Dementia and Geriatric Cognitive Disorders. 27: 366-74. PMID 19321984 DOI: 10.1159/000209311  1
2009 Eggermont LH, Knol DL, Hol EM, Swaab DF, Scherder EJ. Hand motor activity, cognition, mood, and the rest-activity rhythm in dementia: a clustered RCT. Behavioural Brain Research. 196: 271-8. PMID 18926856 DOI: 10.1016/j.bbr.2008.09.012  1
2009 Fischer DF, van Dijk R, van Tijn P, Hobo B, Verhage MC, van der Schors RC, Li KW, van Minnen J, Hol EM, van Leeuwen FW. Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. Neurobiology of Aging. 30: 847-63. PMID 18760506 DOI: 10.1016/j.neurobiolaging.2008.06.009  1
2009 Andreiuolo F, Junier MP, Hol EM, Miquel C, Chimelli L, Leonard N, Chneiweiss H, Daumas-Duport C, Varlet P. GFAPdelta immunostaining improves visualization of normal and pathologic astrocytic heterogeneity. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 29: 31-9. PMID 18564099 DOI: 10.1111/j.1440-1789.2008.00936.x  1
2008 van Someren EW, Riemersma-van der Lek RF, Twisk J, Hol EM, Hoogendijk WJ, Swaab DF. [Symptomatic treatment of patients with dementia: light, but not melatonin, is probably worthwhile]. Nederlands Tijdschrift Voor Geneeskunde. 152: 2435. PMID 19055145  1
2008 Perng MD, Wen SF, Gibbon T, Middeldorp J, Sluijs J, Hol EM, Quinlan RA. Glial fibrillary acidic protein filaments can tolerate the incorporation of assembly-compromised GFAP-delta, but with consequences for filament organization and alphaB-crystallin association. Molecular Biology of the Cell. 19: 4521-33. PMID 18685083 DOI: 10.1091/mbc.E08-03-0284  1
2008 Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. Jama. 299: 2642-55. PMID 18544724 DOI: 10.1001/jama.299.22.2642  1
2008 van Tijn P, Hol EM, van Leeuwen FW, Fischer DF. The neuronal ubiquitin-proteasome system: murine models and their neurological phenotype. Progress in Neurobiology. 85: 176-93. PMID 18448229 DOI: 10.1016/j.pneurobio.2008.03.001  1
2008 Zouambia M, Fischer DF, Hobo B, De Vos RA, Hol EM, Varndell IM, Sheppard PW, Van Leeuwen FW. Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses. Proteomics. 8: 1221-36. PMID 18283660 DOI: 10.1002/pmic.200700679  1
2008 Krol HA, Krawczyk PM, Bosch KS, Aten JA, Hol EM, Reits EA. Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation. Plos One. 3: e1503. PMID 18231590 DOI: 10.1371/journal.pone.0001503  1
2007 Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB. Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain : a Journal of Neurology. 130: 2267-76. PMID 17711980 DOI: 10.1093/brain/awm175  1
2007 Korecka JA, Verhaagen J, Hol EM. Cell-replacement and gene-therapy strategies for Parkinson's and Alzheimer's disease. Regenerative Medicine. 2: 425-46. PMID 17635050 DOI: 10.2217/17460751.2.4.425  1
2007 Tan Z, Sun X, Hou FS, Oh HW, Hilgenberg LG, Hol EM, van Leeuwen FW, Smith MA, O'Dowd DK, Schreiber SS. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death and Differentiation. 14: 1721-32. PMID 17571083 DOI: 10.1038/sj.cdd.4402180  1
2007 van Tijn P, de Vrij FM, Schuurman KG, Dantuma NP, Fischer DF, van Leeuwen FW, Hol EM. Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease. Journal of Cell Science. 120: 1615-23. PMID 17405812 DOI: 10.1242/jcs.03438  1
2006 Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA, Unmehopa UA, Huitinga I, Hol EM, Swaab DF. Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR. Neuroendocrinology. 84: 386-95. PMID 17135716 DOI: 10.1159/000097487  1
2006 Hol EM, Fischer DF, Ovaa H, Scheper W. Ubiquitin proteasome system as a pharmacological target in neurodegeneration. Expert Review of Neurotherapeutics. 6: 1337-47. PMID 17009921 DOI: 10.1586/14737175.6.9.1337  1
2006 van Leeuwen FW, Hol EM, Fischer DF. Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system. Journal of Alzheimer's Disease : Jad. 9: 319-25. PMID 16914870  1
2006 Wittmann J, Hol EM, Jäck HM. hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Molecular and Cellular Biology. 26: 1272-87. PMID 16449641 DOI: 10.1128/MCB.26.4.1272-1287.2006  1
2006 Bao AM, Fischer DF, Wu YH, Hol EM, Balesar R, Unmehopa UA, Zhou JN, Swaab DF. A direct androgenic involvement in the expression of human corticotropin-releasing hormone. Molecular Psychiatry. 11: 567-76. PMID 16446741 DOI: 10.1038/sj.mp.4001800  1
2006 van Leeuwen FW, van Tijn P, Sonnemans MA, Hobo B, Mann DM, Van Broeckhoven C, Kumar-Singh S, Cras P, Leuba G, Savioz A, Maat-Schieman ML, Yamaguchi H, Kros JM, Kamphorst W, Hol EM, et al. Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies. Neurology. 66: S86-92. PMID 16432153 DOI: 10.1212/01.wnl.0000193882.46003.6d  1
2006 Fischer DF, Hol EM, Hobo B, van Leeuwen FW. Alzheimer-associated APP+1 transgenic mice: frameshift beta-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology. Neurobiology of Aging. 27: 1445-50. PMID 16214267 DOI: 10.1016/j.neurobiolaging.2005.09.010  1
2005 Hol EM, van Leeuwen FW, Fischer DF. The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1. Trends in Molecular Medicine. 11: 488-95. PMID 16213790 DOI: 10.1016/j.molmed.2005.09.001  1
2005 Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN, van Leeuwen FW, Hol EM. Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1451-8. PMID 16126912 DOI: 10.1096/fj.04-3395.com  1
2005 Roelofs RF, Fischer DF, Houtman SH, Sluijs JA, Van Haren W, Van Leeuwen FW, Hol EM. Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton. Glia. 52: 289-300. PMID 16001427 DOI: 10.1002/glia.20243  1
2005 Scheper W, Hol EM. Protein quality control in Alzheimer's disease: a fatal saviour. Current Drug Targets. Cns and Neurological Disorders. 4: 283-92. PMID 15975030 DOI: 10.2174/1568007054038166  1
2005 Ishunina TA, van Beurden D, van der Meulen G, Unmehopa UA, Hol EM, Huitinga I, Swaab DF. Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease. Neurobiology of Aging. 26: 173-94. PMID 15582747 DOI: 10.1016/j.neurobiolaging.2004.03.010  1
2005 Gerez L, de Haan A, Hol EM, Fischer DF, van Leeuwen FW, van Steeg H, Benne R. Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B. Neurobiology of Aging. 26: 145-55. PMID 15582744 DOI: 10.1016/j.neurobiolaging.2004.03.011  1
2004 de Vrij FM, Fischer DF, van Leeuwen FW, Hol EM. Protein quality control in Alzheimer's disease by the ubiquitin proteasome system. Progress in Neurobiology. 74: 249-70. PMID 15582222 DOI: 10.1016/j.pneurobio.2004.10.001  1
2004 Fratta P, Engel WK, Van Leeuwen FW, Hol EM, Vattemi G, Askanas V. Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology. 63: 1114-7. PMID 15452314  1
2004 van Dijk R, Fischer DF, Sluijs JA, Sonnemans MA, Hobo B, Mercken L, Mann DM, Hol EM, van Leeuwen FW. Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40. Journal of Neurochemistry. 90: 712-23. PMID 15255950 DOI: 10.1111/j.1471-4159.2004.02528.x  1
2004 de Pril R, Fischer DF, Maat-Schieman ML, Hobo B, de Vos RA, Brunt ER, Hol EM, Roos RA, van Leeuwen FW. Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases. Human Molecular Genetics. 13: 1803-13. PMID 15198995 DOI: 10.1093/hmg/ddh188  1
2004 Breuer S, Pech K, Buss A, Spitzer C, Ozols J, Hol EM, Heussen N, Noth J, Schwaiger FW, Schmitt AB. Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions. Bmc Neuroscience. 5: 15. PMID 15099403 DOI: 10.1186/1471-2202-5-15  1
2003 Fischer DF, De Vos RA, Van Dijk R, De Vrij FM, Proper EA, Sonnemans MA, Verhage MC, Sluijs JA, Hobo B, Zouambia M, Steur EN, Kamphorst W, Hol EM, Van Leeuwen FW. Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2014-24. PMID 14597671 DOI: 10.1096/fj.03-0205com  1
2003 Wisman LA, van Muiswinkel FL, de Graan PN, Hol EM, Bär PR. Cells over-expressing EAAT2 protect motoneurons from excitotoxic death in vitro. Neuroreport. 14: 1967-70. PMID 14561930 DOI: 10.1097/01.wnr.0000093583.33576.e2  1
2003 Hol EM, Roelofs RF, Moraal E, Sonnemans MA, Sluijs JA, Proper EA, de Graan PN, Fischer DF, van Leeuwen FW. Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms. Molecular Psychiatry. 8: 786-96. PMID 12931206 DOI: 10.1038/sj.mp.4001379  1
2003 Hol EM, van Dijk R, Gerez L, Sluijs JA, Hobo B, Tonk MT, de Haan A, Kamphorst W, Fischer DF, Benne R, van Leeuwen FW. Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology. The Journal of Biological Chemistry. 278: 39637-43. PMID 12900421 DOI: 10.1074/jbc.M302295200  1
2003 Hope AD, de Silva R, Fischer DF, Hol EM, van Leeuwen FW, Lees AJ. Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression. Journal of Neurochemistry. 86: 394-404. PMID 12871580 DOI: 10.1046/j.1471-4159.2003.01844.x  1
2003 Schmitt AB, Breuer S, Liman J, Buss A, Schlangen C, Pech K, Hol EM, Brook GA, Noth J, Schwaiger FW. Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat. Bmc Neuroscience. 4: 8. PMID 12756057 DOI: 10.1186/1471-2202-4-8  1
2002 van Leeuwen FW, Gerez L, Benne R, Hol EM. +1 Proteins and aging. The International Journal of Biochemistry & Cell Biology. 34: 1502-5. PMID 12200043 DOI: 10.1016/S1357-2725(02)00043-2  1
2002 McPhaul LW, Wang J, Hol EM, Sonnemans MA, Riley N, Nguyen V, Yuan QX, Lue YH, Van Leeuwen FW, French SW. Molecular misreading of the ubiquitin B gene and hepatic mallory body formation. Gastroenterology. 122: 1878-85. PMID 12055595  1
2002 Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP. Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. The Journal of Cell Biology. 157: 417-27. PMID 11980917 DOI: 10.1083/jcb.200111034  1
2001 De Vrij FM, Sluijs JA, Gregori L, Fischer DF, Hermens WT, Goldgaber D, Verhaagen J, Van Leeuwen FW, Hol EM. Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2680-8. PMID 11726544 DOI: 10.1096/fj.01-0438com  1
2000 van Leeuwen FW, Fischer DF, Kamel D, Sluijs JA, Sonnemans MA, Benne R, Swaab DF, Salehi A, Hol EM. Molecular misreading: a new type of transcript mutation expressed during aging. Neurobiology of Aging. 21: 879-91. PMID 11124436 DOI: 10.1016/S0197-4580(00)00151-2  1
2000 Van Leeuwen FW, Hol EM, Hermanussen RW, Sonnemans MA, Moraal E, Fischer DF, Evans DA, Chooi KF, Burbach JP, Murphy D. Molecular misreading in non-neuronal cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1595-602. PMID 10928994  1
2000 van Leeuwen FW, Fischer DF, Benne R, Hol EM. Molecular misreading. A new type of transcript mutation in gerontology. Annals of the New York Academy of Sciences. 908: 267-81. PMID 10911966  1
1999 van Leeuwen FW, Hol EM. Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. Journal of Neural Transmission. Supplementum. 57: 137-59. PMID 10666673  1
1999 Hol EM, Schwaiger FW, Werner A, Schmitt A, Raivich G, Kreutzberg GW. Regulation of the LIM-type homeobox gene islet-1 during neuronal regeneration. Neuroscience. 88: 917-25. PMID 10363827 DOI: 10.1016/S0306-4522(98)00263-2  1
1998 Hol EM, Neubauer A, de Kleijn DP, Sluijs JA, Ramdjielal RD, Sonnemans MA, van Leeuwen FW. Dinucleotide deletions in neuronal transcripts: a novel type of mutation in non-familial Alzheimer's disease and Down syndrome patients. Progress in Brain Research. 117: 379-95. PMID 9932421  1
1998 van Leeuwen FW, Burbach JP, Hol EM. Mutations in RNA: a first example of molecular misreading in Alzheimer's disease. Trends in Neurosciences. 21: 331-5. PMID 9720597 DOI: 10.1016/S0166-2236(98)01280-6  1
1998 van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Köycü S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Peter J, Burbach H, Hol EM. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science (New York, N.Y.). 279: 242-7. PMID 9422699 DOI: 10.1126/science.279.5348.242  1
1996 Hol EM, Houweling DA, Sodaar P, Bär PRD. Differential effects of ACTH-related peptides and forskolin on rat Schwann cell proliferation and low affinity NGF receptor expression Neuroscience Research Communications. 19: 37-45. DOI: 10.1002/(SICI)1520-6769(199607)19:1<37::AID-NRC161>3.0.CO;2-C  1
1995 Hol EM, Bar PR, Cavaletti G, Tredici G, Windebank AJ, Gordon SA, Russell JW. Cisplatin neuropathy Neurology. 45: 596-597. PMID 7898730  1
1995 Hol EM, Gispen WH, Bär PR. ACTH-related peptides: receptors and signal transduction systems involved in their neurotrophic and neuroprotective actions. Peptides. 16: 979-93. PMID 7479345 DOI: 10.1016/0196-9781(95)00017-E  1
1994 Hol EM, Verhage M, Gispen WH, Bär PR. The role of calcium and cAMP in the mechanism of action of two melanocortins: alpha MSH and the ACTH4-9 analogue Org 2766. Brain Research. 662: 109-16. PMID 7859062 DOI: 10.1016/0006-8993(94)90802-8  1
1994 Hol EM, Mandys V, Sodaar P, Gispen WH, Bär PR. Protection by an ACTH4-9 analogue against the toxic effects of cisplatin and taxol on sensory neurons and glial cells in vitro. Journal of Neuroscience Research. 39: 178-85. PMID 7837287 DOI: 10.1002/jnr.490390208  1
1994 Hol EM, Sodaar P, Bär PR. Dorsal root ganglia as an in vitro model for melanocortin-induced neuritogenesis. Pharmacological and mechanistic aspects. Annals of the New York Academy of Sciences. 739: 74-86. PMID 7832498  1
1994 Hol EM, Gispen WH, Bär PR. Involvement of calcium and cAMP in the mechanism of action of two melanocortins: alpha MSH and an ACTH-(4-9) analogue. Annals of the New York Academy of Sciences. 739: 324-7. PMID 7832486  1
1993 Plantinga LC, Verhaagen J, Edwards PM, Hol EM, Bär PR, Gispen WH. The expression of B-50/GAP-43 in Schwann cells is upregulated in degenerating peripheral nerve stumps following nerve injury. Brain Research. 602: 69-76. PMID 8448659 DOI: 10.1016/0006-8993(93)90243-G  1
1993 Hol EM, Hermens WT, Verhaagen J, Gispen WH, Bär PR. alpha MSH but not Org 2766 induces expression of c-fos in cultured rat spinal cord cells. Neuroreport. 4: 651-4. PMID 8394152  1
1993 Hol EM, van Essen EH, Gispen WH, Bär PR. alpha-MSH and ACTH4-9 analogue Org 2766 induce a cAMP increase in cultured rat spinal cord cells. Annals of the New York Academy of Sciences. 680: 533-5. PMID 8390185  1
1993 Bär PR, Renkema GH, Veraart CM, Hol EM, Gispen WH. Nimodipine protects cultured spinal cord neurones from depolarization-induced inhibition of neurite outgrowth. Cell Calcium. 14: 293-9. PMID 8370065 DOI: 10.1016/0143-4160(93)90050-G  1
1993 Bär PR, Hol EM, Gispen WH. Trophic effects of melanocortins on neuronal cells in culture. Annals of the New York Academy of Sciences. 692: 284-6. PMID 8215033  1
1992 van Woudenberg AD, Hol EM, Wiegant VM. Endorphin-like immunoreactivities in uncultured and cultured human peripheral blood mononuclear cells. Life Sciences. 50: 705-14. PMID 1371179 DOI: 10.1016/0024-3205(92)90473-3  1
1992 van der Neut R, Hol EM, Gispen WH, Bär PR. Stimulation by melanocortins of neurite outgrowth from spinal and sensory neurons in vitro. Peptides. 13: 1109-15. PMID 1337376 DOI: 10.1016/0196-9781(92)90015-U  1
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