Area:
hippocampus, navigation
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High-probability grants
According to our matching algorithm, Jeffrey L. Gauthier is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2006 — 2007 |
Gauthier, Jeffrey L [⬀] |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Large-Scale Recording and Imaging in the Primate Retina @ University of California San Diego
[unreadable] DESCRIPTION (provided by applicant): The visual world is largely processed in parallel visual system circuitry, and the fundamental units of parallel processing are discrete cell types. Distinct cell types representing different aspects of the visual scene are first found in the retina, yet what these types are or where they project in the brain is only partially understood. A critical limitation has been that distinguishing cell types requires recording the physiology and anatomy of many cells at once. We propose to develop for the first time a technique to simultaneously record the physiology of hundreds of primate retinal ganglion cells (RGCs) in conjunction with anatomical visualization of recorded cells. This technique will establish the morphological cell types of RGCs identified physiologically, including a new class recently observed in our recordings, thereby establishing those cells' brain projections and revealing which visual processing tasks they participate in. It is not coincidental or arbitrary that different physiological cell classes have unique morphologies; surely their structure serves their function. By comparing the anatomy and physiology of many cells at once, we will determine how the dendritic branching patterns of RGCs shape their spatial light sensitivity. [unreadable] [unreadable]
|
0.951 |
2012 — 2014 |
Gauthier, Jeffrey Lee [⬀] |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Examining the Integration of Inputs by the Subiculum During Virtual Navigation
DESCRIPTION (provided by applicant): Spatial navigation in rodents is a widely used paradigm for studies of cognition, learning, and memory in the mammalian brain. The subiculum is an important output structure for circuits that underlie navigation, yet few studies have examined its physiology in behaving animals. This proposal aims to identify how an individual subiculum neuron integrates information during navigation from its pre-synaptic inputs in the CA1 region of the hippocampus. CA1 neurons form a spatial map of the environment that is sensitive to small changes; for example, moving from a circular chamber to a square chamber can drastically alter the representation in CA1. The subiculum, on the other hand, seems to form stable maps that do not undergo substantial changes in different environments, despite receiving a major input from CA1. How the subiculum maintains a stable representation remains an open question. To investigate these mechanisms in the context of navigation, the Tank lab has recently developed new technology for calcium imaging and electrophysiological recordings to be performed in the brain of awake mice during navigation in a virtual environment. This technology consists of a spherical treadmill that allows for motion in two dimensions, a virtual reality environment controlled by the motion of the animal on the spherical treadmill, and interchangeable equipment allowing for either electrophysiological recordings or optical imaging. A major advantage of this experimental setup over conventional methods for studying navigation is that the animal is head-fixed, yet allowed to navigate within a virtual environment, providing stability for calcium imaging or whole cell recordings. It is also advantageous because the virtual environment can be dynamically altered during navigation tasks, providing complete control over the animal's experience. This proposal takes advantage of these new technologies in order to understand how the subiculum forms a map of the environment. In aim 1, optical imaging of calcium activity will be used to characterize what kinds of environmental alterations change the CA1 representation but preserve the map in the subiculum. Aim 2 will address the anatomical organization of subiculum circuitry by tracing mono-synaptic inputs to a single subiculum neuron. These neurons include inputs from CA1 and recurrent connections within the subiculum. In aim 3, these techniques will be combined in a single animal. The spatial representation in individual subiculum neurons will be compared to the representation of mono-synaptic inputs in CA1 and subiculum. This comparison will shed light on how subiculum neurons integrate incoming signals to form a stable representation. Unraveling this computation will help to understand the role of the hippocampal formation more generally.
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1 |