Irwin J. Kopin

Affiliations: 
National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States 
Area:
Dopamine, Parkinson's Disease
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"Irwin Kopin"
Mean distance: 13.74 (cluster 6)
 
SNBCP
Cross-listing: Neuropathology Tree

Parents

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Seymour S. Kety post-doc 1957-1963 NIMH
Julius Axelrod research scientist 1963-1968 NIMH

Children

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Fred Goodwin post-doc NINDS
Richard C. McCarty post-doc NINDS
George R. Breese post-doc 1966-1968 NIMH
John (Steven) Kizer post-doc 1972-1975 NIMH
Joseph J. Schildkraut research scientist 1966-1967 NIMH
BETA: Related publications

Publications

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Goldstein DS, Sullivan P, Holmes C, et al. (2015) Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy. Parkinsonism & Related Disorders. 21: 567-72
Goldstein DS, Sullivan P, Cooney A, et al. (2015) Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease. Journal of Neurochemistry. 133: 14-25
Goldstein DS, Kopin IJ, Sharabi Y, et al. (2015) Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society. 25: 61-7
Goldstein DS, Holmes C, Sullivan P, et al. (2015) Deficient vesicular storage: A common theme in catecholaminergic neurodegeneration Parkinsonism and Related Disorders
Goldstein DS, Kopin IJ, Sharabi Y. (2014) Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders. Pharmacology & Therapeutics. 144: 268-82
Goldstein DS, Sullivan P, Holmes C, et al. (2014) A vesicular sequestration to oxidative deamination shift in myocardial sympathetic nerves in Parkinson's disease. Journal of Neurochemistry
Goldstein DS, Sullivan P, Holmes C, et al. (2013) Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease. Journal of Neurochemistry. 126: 591-603
Goldstein DS, Sullivan P, Cooney A, et al. (2012) Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease. Journal of Neurochemistry. 123: 932-43
Goldstein DS, Holmes C, Kopin IJ, et al. (2011) Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. The Journal of Clinical Investigation. 121: 3320-30
Goldstein DS, Sullivan P, Holmes C, et al. (2011) Catechols in post-mortem brain of patients with Parkinson disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 18: 703-10
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