David L. Roman

University of Iowa, Iowa City, IA 
RGS Proteins, Drug Discovery & HTS
"David Roman"
Mean distance: 18.19 (cluster 11)


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Eric L. Barker grad student 1998-2004 Purdue
 (Molecular determinants of ligand interaction with serotonin transporters.)
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Brust TF, Hayes MP, Roman DL, et al. (2015) Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways. The Journal of Pharmacology and Experimental Therapeutics. 352: 480-93
Brust TF, Hayes MP, Roman DL, et al. (2015) New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochemical Pharmacology. 93: 85-91
Zhang X, Hagen J, Muniz VP, et al. (2013) RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. Plos One. 8: e80228
Monroy CA, Doorn JA, Roman DL. (2013) Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 26: 1832-9
Bodle CR, Mackie DI, Roman DL. (2013) RGS17: an emerging therapeutic target for lung and prostate cancers. Future Medicinal Chemistry. 5: 995-1007
Monroy CA, Mackie DI, Roman DL. (2013) A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation. Plos One. 8: e62247
Vermeer LM, Higgins CA, Roman DL, et al. (2013) Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay. Analytical Biochemistry. 432: 11-5
Higgins CA, Vermeer LM, Doorn JA, et al. (2012) Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli. Protein Expression and Purification. 84: 219-23
Roman DL, Traynor JR. (2011) Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction. Journal of Medicinal Chemistry. 54: 7433-40
Mackie DI, Roman DL. (2011) Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen. Journal of Biomolecular Screening. 16: 869-77
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