David Malcolm MacLean, PhD
Affiliations: | 2017- | Pharmacology and Physiology | University of Rochester Medical Center, Rochester, NY, United States |
Area:
Biophysics of iGluRs and ASICs, pharmacologyWebsite:
macleanlab.netGoogle:
"David MacLean"Mean distance: 16.58 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| John F. MacDonald | research assistant | 2004-2005 | University of Toronto |
| Derek Bowie | grad student | 2005-2011 | McGill |
| Vasanthi Jayaraman | post-doc | University of Texas-Houston Medical School |
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Publications
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| Purohit R, Couch T, Rook ML, et al. (2024) Proline substitutions in the ASIC1 β11-12 linker slow desensitization. Biophysical Journal |
| Purohit R, Couch T, MacLean DM. (2024) Proline substitutions in the ASIC1 β11-12 linker slow desensitization. Biorxiv : the Preprint Server For Biology |
| Allen JP, Garber KB, Perszyk R, et al. (2023) Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. Human Molecular Genetics |
| Chen J, Li L, Chen SR, et al. (2022) The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Reports. 38: 110308 |
| Rook ML, Ananchenko A, Musgaard M, et al. (2021) Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics. Frontiers in Cellular Neuroscience. 15: 761813 |
| Couch T, Berger K, Kneisley DL, et al. (2021) Topography and motion of the acid-sensing ion channel intracellular domains. Elife. 10 |
| Rook ML, Miaro M, Couch T, et al. (2021) Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. The Journal of General Physiology. 153 |
| Rook ML, Musgaard M, MacLean DM. (2020) Coupling structure with function in acid-sensing ion channels: Challenges in pursuit of proton sensors. The Journal of Physiology |
| Rook ML, Williamson A, Lueck JD, et al. (2020) β11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery. Elife. 9 |
| Durham RJ, Paudyal N, Carrillo E, et al. (2020) Conformational spread and dynamics in allostery of NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America |