R. B. Free, Ph.D.

Affiliations: 
2002 Ohio State University, Columbus, Columbus, OH 
Area:
Pharmacology, Neuroscience Biology
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"R. Free"
Mean distance: 35622
 

Parents

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Dennis B. McKay grad student 2002 Ohio State
 (Characterization and regulation of adrenal neuronal nicotinic acetylcholine receptors.)
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Publications

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Free RB, Cuoco CA, Xie B, et al. (2021) Pharmacological characterization of the imipridone anti-cancer drug ONC201 reveals a negative allosteric mechanism of action at the D dopamine receptor. Molecular Pharmacology
Moritz AE, Bonifazi A, Guerrero AM, et al. (2020) Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor. Acs Chemical Neuroscience
Schardien KA, Soto MS, Inbody L, et al. (2020) Investigation of G protein‐coupled receptor kinase 2 (GRK2) regulation of D 2 dopamine receptor signaling: effects of GRK2 functional domains and pharmacologic and genetic inhibition of GRK2 activity The Faseb Journal. 34: 1-1
Sanchez-Soto M, Schardien KA, Inbody L, et al. (2020) G protein‐coupled receptor kinase 2 can enhance beta‐arrestin recruitment to the D 2 dopamine receptor in the absence of receptor phosphorylation The Faseb Journal. 34: 1-1
Moritz AE, Inbody LR, Gandhi DM, et al. (2020) Structure‐Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site The Faseb Journal. 34: 1-1
Keck TM, Free RB, Day MM, et al. (2019) Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy. Journal of Medicinal Chemistry
Luderman KD, Conroy JL, Free RB, et al. (2018) Identification of positive allosteric modulators of the D1 dopamine receptor that act at diverse binding sites. Molecular Pharmacology
Madhukar N, Prabhu VV, Anantharaman L, et al. (2017) EXTH-43. DIFFERENTIATED PHARMACOLOGY OF THE IMIPRIDONE ONC201, THE FIRST SELECTIVE DRD2/3 ANTAGONIST IN CLINICAL NEURO-ONCOLOGY Neuro-Oncology. 19: vi81-vi82
Michino M, Free RB, Doyle TB, et al. (2015) Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors. Chemical Communications (Cambridge, England). 51: 8618-21
Meade JA, Free RB, Miller NR, et al. (2015) (-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling. Psychopharmacology. 232: 917-30
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