Robert H. Scannevin
Affiliations: | Biogen-Idec, Washington, DC, United States |
Area:
NeuropathologyGoogle:
"Robert Scannevin"Mean distance: 14.18 (cluster 31) | S | N | B | C | P |
Cross-listing: Neuropathology Tree
Parents
Sign in to add mentor| James S. Trimmer | grad student | SUNY Stony Brook | |
| Richard L. Huganir | post-doc | Johns Hopkins Medical School |
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Publications
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| Lin EYS, Silvian LF, Marcotte DJ, et al. (2018) Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction. Scientific Reports. 8: 13438 |
| Brennan MS, Matos MF, Richter KE, et al. (2017) The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes. Scientific Reports. 7: 42054 |
| Peng H, Li H, Sheehy A, et al. (2016) Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments. Journal of Neuroimmunology. 299: 35-44 |
| Sevigny J, Chiao P, Bussière T, et al. (2016) The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 537: 50-6 |
| Scannevin RH, Chollate S, Brennan MS, et al. (2015) BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease. Neuropharmacology |
| Bell KF, Al-Mubarak B, Martel MA, et al. (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications. 6: 7066 |
| Parodi B, Rossi S, Morando S, et al. (2015) Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS. Acta Neuropathologica. 130: 279-95 |
| Brennan MS, Matos MF, Li B, et al. (2015) Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. Plos One. 10: e0120254 |
| Alfonso S, Kessels HW, Banos CC, et al. (2014) Synapto-depressive effects of amyloid beta require PICK1. The European Journal of Neuroscience. 39: 1225-33 |
| Scannevin RH, Chollate S, Jung MY, et al. (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. The Journal of Pharmacology and Experimental Therapeutics. 341: 274-84 |