Michael Finley

Affiliations: 
ETS Screening Merck, Semoy, Centre-Val de Loire, France 
Area:
high throughput screening, ion channels
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"Michael Finley"
Mean distance: 13.18 (cluster 11)
 
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Publications

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Wall MJ, Subasinghe NL, Winters MP, et al. (2018) Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Ca 2.2) blockers for the treatment of pain. Bioorganic & Medicinal Chemistry Letters
Finley M, Cassaday J, Kreamer T, et al. (2016) Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5. Journal of Biomolecular Screening
Parsons WH, Calvo RR, Cheung W, et al. (2015) Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). Journal of Medicinal Chemistry. 58: 3859-74
Winters MP, Subasinghe N, Wall M, et al. (2014) Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2057-61
Winters MP, Subasinghe N, Wall M, et al. (2014) Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel. Bioorganic & Medicinal Chemistry Letters. 24: 2053-6
McComsey DF, Smith-Swintosky VL, Parker MH, et al. (2013) Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30
Subasinghe NL, Wall MJ, Winters MP, et al. (2012) A novel series of pyrazolylpiperidine N-type calcium channel blockers. Bioorganic & Medicinal Chemistry Letters. 22: 4080-3
Finley MF, Lubin ML, Neeper MP, et al. (2010) An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists. Assay and Drug Development Technologies. 8: 685-94
Parker MH, Smith-Swintosky VL, McComsey DF, et al. (2009) Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Journal of Medicinal Chemistry. 52: 7528-36
Mathes C, Friis S, Finley M, et al. (2009) QPatch: the missing link between HTS and ion channel drug discovery. Combinatorial Chemistry & High Throughput Screening. 12: 78-95
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