Robert H. Scannevin - Publications

Affiliations: 
Biogen-Idec, Washington, DC, United States 
Area:
Neuropathology

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Vincent BM, Tardiff DF, Piotrowski JS, Aron R, Lucas MC, Chung CY, Bacherman H, Chen Y, Pires M, Subramaniam R, Doshi DB, Sadlish H, Raja WK, Solís EJ, Khurana V, ... ... Scannevin RH, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Reports. 25: 2742-2754.e31. PMID 30517862 DOI: 10.1016/j.celrep.2018.11.028  0.8
2018 Lin EYS, Silvian LF, Marcotte DJ, Banos CC, Jow F, Chan TR, Arduini RM, Qian F, Baker DP, Bergeron C, Hession CA, Huganir RL, Borenstein CF, Enyedy I, Zou J, ... ... Scannevin RH, et al. Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction. Scientific Reports. 8: 13438. PMID 30194389 DOI: 10.1038/s41598-018-31680-3  1
2017 Scannevin RH, Alexander R, Mezzasalma Haarlander T, Burke SL, Singer M, Hou C, Zhang YM, Maguire D, Spurlino J, Deckman I, Carroll KI, Lewandowski F, Devine E, Dzordzorme K, Tounge B, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. The Journal of Biological Chemistry. PMID 28860188 DOI: 10.1074/jbc.M117.806075  0.8
2016 Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, ... ... Scannevin RH, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 537: 50-6. PMID 27582220 DOI: 10.1038/nature19323  1
2016 Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS. Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2. Proceedings of the National Academy of Sciences of the United States of America. PMID 27078105 DOI: 10.1073/pnas.1603907113  1
2016 Brennan MS, Patel H, Allaire N, Thai A, Cullen P, Ryan S, Lukashev M, Bista P, Huang R, Rhodes KJ, Scannevin RH. Pharmacodynamics of Dimethyl Fumarate are Tissue-specific and Involve NRF2-dependent and -independent Mechanisms. Antioxidants & Redox Signaling. PMID 26980071 DOI: 10.1089/ars.2015.6622  1
2015 Scannevin RH, Chollate S, Brennan MS, Snodgrass-Belt PA, Peng H, Xu L, Jung MY, Bussiere T, Arastu MF, Talreja T, Xin Z, Dunstan RW, Fahrer D, Rohde E, Dunah AW, et al. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease. Neuropharmacology. PMID 26690893 DOI: 10.1016/j.neuropharm.2015.12.006  1
2015 Gillard GO, Collette B, Anderson J, Chao J, Scannevin RH, Huss DJ, Fontenot JD. DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner. Journal of Neuroimmunology. 283: 74-85. PMID 26004161 DOI: 10.1016/j.jneuroim.2015.04.006  1
2015 Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, ... Scannevin RH, et al. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications. 6: 7066. PMID 25967870 DOI: 10.1038/ncomms8066  1
2015 Parodi B, Rossi S, Morando S, Cordano C, Bragoni A, Motta C, Usai C, Wipke BT, Scannevin RH, Mancardi GL, Centonze D, Kerlero de Rosbo N, Uccelli A. Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS. Acta Neuropathologica. 130: 279-95. PMID 25920452 DOI: 10.1007/s00401-015-1422-3  1
2015 Brennan MS, Matos MF, Li B, Hronowski X, Gao B, Juhasz P, Rhodes KJ, Scannevin RH. Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. Plos One. 10: e0120254. PMID 25793262 DOI: 10.1371/journal.pone.0120254  1
2014 Reick C, Ellrichmann G, Thöne J, Scannevin RH, Saft C, Linker RA, Gold R. Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation. Experimental Neurology. 257: 50-6. PMID 24731948 DOI: 10.1016/j.expneurol.2014.04.003  1
2014 Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R. Synapto-depressive effects of amyloid beta require PICK1. The European Journal of Neuroscience. 39: 1225-33. PMID 24713001 DOI: 10.1111/ejn.12499  1
2014 Fox RJ, Kita M, Cohan SL, Henson LJ, Zambrano J, Scannevin RH, O'Gorman J, Novas M, Dawson KT, Phillips JT. BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety. Current Medical Research and Opinion. 30: 251-62. PMID 24131282 DOI: 10.1185/03007995.2013.849236  1
2013 Sheikh SI, Nestorov I, Russell H, O'Gorman J, Huang R, Milne GL, Scannevin RH, Novas M, Dawson KT. Tolerability and pharmacokinetics of delayed-release dimethyl fumarate administered with and without aspirin in healthy volunteers. Clinical Therapeutics. 35: 1582-1594.e9. PMID 24139424 DOI: 10.1016/j.clinthera.2013.08.009  1
2013 Shook BC, Chakravarty D, Barbay JK, Wang A, Leonard K, Alford V, Powell MT, Rassnick S, Scannevin RH, Carroll K, Wallace N, Crooke J, Ault M, Lampron L, Westover L, et al. Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 2688-91. PMID 23522563 DOI: 10.1016/j.bmcl.2013.02.078  1
2012 Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. The Journal of Pharmacology and Experimental Therapeutics. 341: 274-84. PMID 22267202 DOI: 10.1124/jpet.111.190132  1
2012 Shook BC, Rassnick S, Wallace N, Crooke J, Ault M, Chakravarty D, Barbay JK, Wang A, Powell MT, Leonard K, Alford V, Scannevin RH, Carroll K, Lampron L, Westover L, et al. Design and characterization of optimized adenosine Aâ‚‚A/A₁ receptor antagonists for the treatment of Parkinson's disease. Journal of Medicinal Chemistry. 55: 1402-17. PMID 22239465 DOI: 10.1021/jm201640m  1
2011 Peng H, Talreja T, Xin Z, Cuervo JH, Kumaravel G, Humora MJ, Xu L, Rohde E, Gan L, Jung MY, Shackett MN, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, ... ... Scannevin RH, et al. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. Acs Medicinal Chemistry Letters. 2: 786-91. PMID 24900267 DOI: 10.1021/ml200175q  1
2011 Xin Z, Peng H, Zhang A, Talreja T, Kumaravel G, Xu L, Rohde E, Jung MY, Shackett MN, Kocisko D, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, ... ... Scannevin RH, et al. Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach. Bioorganic & Medicinal Chemistry Letters. 21: 7277-80. PMID 22061640 DOI: 10.1016/j.bmcl.2011.10.047  1
2011 Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell. 147: 615-28. PMID 22036569 DOI: 10.1016/j.cell.2011.09.036  1
2011 Wilson LJ, Wang B, Yang SM, Scannevin RH, Burke SL, Karnachi P, Rhodes KJ, Murray WV. Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy. Bioorganic & Medicinal Chemistry Letters. 21: 6485-90. PMID 21925881 DOI: 10.1016/j.bmcl.2011.08.068  1
2011 Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, ... Scannevin RH, et al. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain : a Journal of Neurology. 134: 678-92. PMID 21354971 DOI: 10.1093/brain/awq386  1
2011 Shook BC, Charavarty D, Barbay JK, Wang A, Leonard K, Alford V, Powell M, Beauchamp DA, Rassnick S, Scannevin R, Carroll K, Wallace N, Crooke J, Ault M, Lampron L, et al. Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A 2A receptor antagonists Medchemcomm. 2: 950-965. DOI: 10.1039/c1md00082a  1
2010 Shook BC, Rassnick S, Hall D, Rupert KC, Heintzelman GR, Hansen K, Chakravarty D, Bullington JL, Scannevin RH, Magliaro B, Westover L, Carroll K, Lampron L, Russell R, Branum S, et al. Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 2864-7. PMID 20347304 DOI: 10.1016/j.bmcl.2010.03.042  1
2010 Shook BC, Rassnick S, Chakravarty D, Wallace N, Ault M, Crooke J, Barbay JK, Wang A, Leonard K, Powell MT, Alford V, Hall D, Rupert KC, Heintzelman GR, Hansen K, ... ... Scannevin RH, et al. Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 2868-71. PMID 20338760 DOI: 10.1016/j.bmcl.2010.03.024  1
2010 Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, ... ... Scannevin R, et al. Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 2264-9. PMID 20188554 DOI: 10.1016/j.bmcl.2010.02.006  1
2010 Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC. Heat shock protein 90: inhibitors in clinical trials. Journal of Medicinal Chemistry. 53: 3-17. PMID 20055425 DOI: 10.1021/jm9004708  1
2009 Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics. 8: 921-9. PMID 19372565 DOI: 10.1158/1535-7163.MCT-08-0758  1
2008 Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH. Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke; a Journal of Cerebral Circulation. 39: 3372-7. PMID 18927459 DOI: 10.1161/STROKEAHA.108.514026  1
2008 Yang SM, Scannevin RH, Wang B, Burke SL, Wilson LJ, Karnachi P, Rhodes KJ, Lagu B, Murray WV. beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. Design, synthesis, and lead identification. Bioorganic & Medicinal Chemistry Letters. 18: 1135-9. PMID 18086526 DOI: 10.1016/j.bmcl.2007.11.119  1
2008 Yang SM, Scannevin RH, Wang B, Burke SL, Huang Z, Karnachi P, Wilson LJ, Rhodes KJ, Lagu B, Murray WV. beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents. Bioorganic & Medicinal Chemistry Letters. 18: 1140-5. PMID 18083558 DOI: 10.1016/j.bmcl.2007.11.129  1
2008 Zhang YM, Fan X, Chakaravarty D, Xiang B, Scannevin RH, Huang Z, Ma J, Burke SL, Karnachi P, Rhodes KJ, Jackson PF. 1-Hydroxy-2-pyridinone-based MMP inhibitors: synthesis and biological evaluation for the treatment of ischemic stroke. Bioorganic & Medicinal Chemistry Letters. 18: 409-13. PMID 17981034 DOI: 10.1016/j.bmcl.2007.10.045  1
2008 Zhang YM, Fan X, Yang SM, Scannevin RH, Burke SL, Rhodes KJ, Jackson PF. Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs). Bioorganic & Medicinal Chemistry Letters. 18: 405-8. PMID 17980583 DOI: 10.1016/j.bmcl.2007.10.049  1
2007 Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang X, Lo EH. Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neuroscience Letters. 417: 1-5. PMID 17386975 DOI: 10.1016/j.neulet.2007.01.017  1
2007 Murata Y, Rosell A, Wang X, Scannevin RH, Rhodes K, Katayama Y, Lo EH. Efficacy of minocyline for delayed tissue plasminogen activator treatment after embolic focal ischemia in rats Journal of Cerebral Blood Flow and Metabolism. 27: BP35-01U.  1
2006 Zhang YM, Fan X, Xiang B, Chakravarty D, Scannevin R, Burke S, Karnachi P, Rhodes K, Jackson P. Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors Bioorganic and Medicinal Chemistry Letters. 16: 3096-3100. DOI: 10.1016/j.bmcl.2006.03.065  1
2004 Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lü Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, et al. Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Neuron. 41: 587-98. PMID 14980207 DOI: 10.1016/S0896-6273(04)00049-2  1
2001 Manganas LN, Wang Q, Scannevin RH, Antonucci DE, Rhodes KJ, Trimmer JS. Identification of a trafficking determinant localized to the Kv1 potassium channel pore. Proceedings of the National Academy of Sciences of the United States of America. 98: 14055-9. PMID 11698661 DOI: 10.1073/pnas.241403898  1
2001 Liao D, Scannevin RH, Huganir R. Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6008-17. PMID 11487624  1
2000 Scannevin RH, Huganir RL. Postsynaptic organization and regulation of excitatory synapses. Nature Reviews. Neuroscience. 1: 133-41. PMID 11252776 DOI: 10.1038/35039075  1
2000 Chung HJ, Xia J, Scannevin RH, Zhang X, Huganir RL. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7258-67. PMID 11007883  1
2000 Lim ST, Antonucci DE, Scannevin RH, Trimmer JS. A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons. Neuron. 25: 385-97. PMID 10719893  1
1997 Murakoshi H, Shi G, Scannevin RH, Trimmer JS. Phosphorylation of the Kv2.1 K+ channel alters voltage-dependent activation. Molecular Pharmacology. 52: 821-8. PMID 9351973  1
1997 Scannevin RH, Trimmer JS. Cytoplasmic domains of voltage-sensitive K+ channels involved in mediating protein-protein interactions. Biochemical and Biophysical Research Communications. 232: 585-9. PMID 9126317 DOI: 10.1006/bbrc.1997.6333  1
1996 Scannevin RH, Murakoshi H, Rhodes KJ, Trimmer JS. Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel. The Journal of Cell Biology. 135: 1619-32. PMID 8978827 DOI: 10.1083/jcb.135.6.1619  1
Show low-probability matches.