Benoit I. Giasson, Ph.D.
Affiliations: | Pharmacology | University of Pennsylvania, Philadelphia, PA, United States | |
| Neuroscience | University of Florida, Gainesville, Gainesville, FL, United States |
Area:
Neurodegeneration ,Parkinson’s disease, Neuronal Damage, Protein Aggregation,Kinases, Alpha-synuclein, TauWebsite:
http://ctrnd.med.ufl.edu/faculty/dr-benoit-giasson/Google:
"Benoit Giasson"Bio:
Post-Doc, Pathology and Laboratory Medicine (John Trojanowski), University of Pennsylvania, 2001-2003
Post-Doc, Pathology and Laboratory Medicine (Virginia Lee), University of Pennsylvania, 1998-2001
Ph.D., Biochemistry, McGill University, Canada- 1997
My research is focused on understanding the cellular mechanisms and molecular interactions involved as underlying causes of neurodegenerative diseases. A primary research interest is to expand the understanding of the regulation of protein levels, function, interactions and folding that affect protein aggregation in the nervous system.
Mean distance: 15.49 (cluster 24) | S | N | B | C | P |
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Walter E. Mushynski | grad student | 1991-1997 | McGill |
| Virginia Man-Yee Lee | post-doc | 1998-2001 | Penn |
| John Q. Trojanowski | post-doc | 2001-2003 | Penn |
Children
Sign in to add trainee| Amanda Sacino | grad student | University of Florida College of Medicine | |
| Zachary A Sorrentino | grad student | ||
| Yuxing Xia | grad student | University of Florida College of Medicine | |
| Grace Mary Lloyd | grad student | 2019- | University of Florida College of Medicine |
| Jason P. Covy | grad student | 2004-2010 | Penn |
| Chenere P. Ramsey | grad student | 2004-2010 | Penn |
BETA: Related publications
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Publications
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| Paterno G, Moore BD, Bell BM, et al. (2024) Novel Monoclonal Antibody Specific toward Amyloid-β Binds to a Unique Epitope within the N-Terminal Region. Antibodies (Basel, Switzerland). 13 |
| Lloyd GM, Quintin S, Sorrentino ZA, et al. (2024) A multiverse of α-synuclein: investigation of prion strain properties with carboxyl-terminal truncation specific antibodies in animal models. Acta Neuropathologica Communications. 12: 91 |
| Paterno G, Bell BM, Riley-DiPaolo A, et al. (2023) Polymerization of recombinant tau core fragments and seeding studies in cultured cells. Frontiers in Neuroscience. 17: 1268360 |
| Moore BD, Ran Y, Goodwin MS, et al. (2023) A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies. Molecular Therapy. Methods & Clinical Development. 31: 101146 |
| Smith ED, Vo Q, Giasson BI, et al. (2023) Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau. Acta Neuropathologica Communications. 11: 172 |
| Paterno G, Torrellas J, Bell BM, et al. (2023) Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites. International Journal of Molecular Sciences. 24 |
| Lloyd GM, Long B, Quintin S, et al. (2023) Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis. Acta Neuropathologica Communications. 11: 119 |
| Quintin S, Lloyd GM, Paterno G, et al. (2023) Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114. The Journal of Biological Chemistry. 104912 |
| Xia Y, Bell BM, Kim JD, et al. (2023) Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in Neuroscience. 17: 1181804 |
| Xia Y, Bell BM, Giasson BI. (2023) Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International Journal of Molecular Sciences. 24 |