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Benoit I. Giasson, Ph.D.

Affiliations: 
Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Neurodegeneration ,Parkinson’s disease, Neuronal Damage, Protein Aggregation,Kinases, Alpha-synuclein, Tau
Website:
http://ctrnd.med.ufl.edu/faculty/dr-benoit-giasson/
Google:
"Benoit Giasson"
Bio:

Post-Doc, Pathology and Laboratory Medicine (John Trojanowski), University of Pennsylvania, 2001-2003
Post-Doc, Pathology and Laboratory Medicine (Virginia Lee), University of Pennsylvania, 1998-2001
Ph.D., Biochemistry, McGill University, Canada- 1997

My research is focused on understanding the cellular mechanisms and molecular interactions involved as underlying causes of neurodegenerative diseases. A primary research interest is to expand the understanding of the regulation of protein levels, function, interactions and folding that affect protein aggregation in the nervous system.

Mean distance: 15.49 (cluster 24)
 		SNBCP
Cross-listing: Chemistry Tree

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Parents

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Walter E. Mushynski grad student 1991-1997 McGill
Virginia Man-Yee Lee post-doc 1998-2001 Penn
John Q. Trojanowski post-doc 2001-2003 Penn

Children

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Amanda Sacino grad student University of Florida College of Medicine
Zachary A Sorrentino grad student
Yuxing Xia grad student University of Florida College of Medicine
Grace Mary Lloyd grad student 2019- University of Florida College of Medicine
Jason P. Covy grad student 2004-2010 Penn
Chenere P. Ramsey grad student 2004-2010 Penn

Collaborators

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Publications

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Paterno G, Bell BM, Riley-DiPaolo A, et al. (2023) Polymerization of recombinant tau core fragments and seeding studies in cultured cells. Frontiers in Neuroscience. 17: 1268360
Moore BD, Ran Y, Goodwin MS, et al. (2023) A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies. Molecular Therapy. Methods & Clinical Development. 31: 101146
Smith ED, Vo Q, Giasson BI, et al. (2023) Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau. Acta Neuropathologica Communications. 11: 172
Paterno G, Torrellas J, Bell BM, et al. (2023) Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites. International Journal of Molecular Sciences. 24
Lloyd GM, Long B, Quintin S, et al. (2023) Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis. Acta Neuropathologica Communications. 11: 119
Quintin S, Lloyd GM, Paterno G, et al. (2023) Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114. The Journal of Biological Chemistry. 104912
Xia Y, Bell BM, Kim JD, et al. (2023) Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in Neuroscience. 17: 1181804
Xia Y, Bell BM, Giasson BI. (2023) Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International Journal of Molecular Sciences. 24
Croft CL, Paterno G, Vause AR, et al. (2022) Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance. Npj Parkinson's Disease. 8: 173
Paterno G, Bell BM, Gorion KM, et al. (2022) Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology. Acta Neuropathologica Communications. 10: 94
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