Benoit I. Giasson, Ph.D.

Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Neurodegeneration ,Parkinson’s disease, Neuronal Damage, Protein Aggregation,Kinases, Alpha-synuclein, Tau
"Benoit Giasson"

Post-Doc, Pathology and Laboratory Medicine (John Trojanowski), University of Pennsylvania, 2001-2003
Post-Doc, Pathology and Laboratory Medicine (Virginia Lee), University of Pennsylvania, 1998-2001
Ph.D., Biochemistry, McGill University, Canada- 1997

My research is focused on understanding the cellular mechanisms and molecular interactions involved as underlying causes of neurodegenerative diseases. A primary research interest is to expand the understanding of the regulation of protein levels, function, interactions and folding that affect protein aggregation in the nervous system.

Mean distance: 15.49 (cluster 24)
Cross-listing: Chemistry Tree


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Walter E. Mushynski grad student 1991-1997 McGill
Virginia Man-Yee Lee post-doc 1998-2001 Penn
John Q. Trojanowski post-doc 2001-2003 Penn


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Jason P. Covy grad student 2004-2010 Penn
Chenere P. Ramsey grad student 2004-2010 Penn
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Xia Y, Prokop S, Bell BM, et al. (2022) Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice. Communications Biology. 5: 446
Moore BD, Levites Y, Xu G, et al. (2022) Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts. Free Neuropathology. 3
Lloyd GM, Sorrentino ZA, Quintin S, et al. (2022) Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice. Acta Neuropathologica
Xia Y, Lloyd GM, Giasson BI. (2021) Targeted proteolytic products of τ and α-synuclein in neurodegeneration. Essays in Biochemistry. 65: 905-912
Koller EJ, Ibanez KR, Vo Q, et al. (2021) Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation. Neuropathology and Applied Neurobiology
Lloyd GM, Dhillon JS, Gorion KM, et al. (2021) Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model. Molecular Neurodegeneration. 16: 63
Hass EW, Sorrentino ZA, Xia Y, et al. (2021) Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies. Acta Neuropathologica Communications. 9: 146
Xia Y, Bell BM, Giasson BI. (2021) Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation. Scientific Reports. 11: 17069
Xia Y, Prokop S, Giasson BI. (2021) "Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies. Molecular Neurodegeneration. 16: 37
Hass EW, Sorrentino ZA, Lloyd GM, et al. (2021) Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy. Acta Neuropathologica Communications. 9: 80
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