Benoit I. Giasson, Ph.D.

Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Neurodegeneration ,Parkinson’s disease, Neuronal Damage, Protein Aggregation,Kinases, Alpha-synuclein, Tau
"Benoit Giasson"

Post-Doc, Pathology and Laboratory Medicine (John Trojanowski), University of Pennsylvania, 2001-2003
Post-Doc, Pathology and Laboratory Medicine (Virginia Lee), University of Pennsylvania, 1998-2001
Ph.D., Biochemistry, McGill University, Canada- 1997

My research is focused on understanding the cellular mechanisms and molecular interactions involved as underlying causes of neurodegenerative diseases. A primary research interest is to expand the understanding of the regulation of protein levels, function, interactions and folding that affect protein aggregation in the nervous system.

Mean distance: 15.49 (cluster 24)
Cross-listing: Chemistry Tree


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Walter E. Mushynski grad student 1991-1997 McGill
Virginia Man-Yee Lee post-doc 1998-2001 Penn
John Q. Trojanowski post-doc 2001-2003 Penn


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Jason P. Covy grad student 2004-2010 Penn
Chenere P. Ramsey grad student 2004-2010 Penn
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Williams T, Sorrentino Z, Weinrich M, et al. (2020) Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain Communications. 2: fcaa090
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, et al. (2020) Novel Monoclonal Antibodies Targeting the RRM2 domain of Human TDP-43 Protein. Neuroscience Letters. 135353
Butkovich LM, Houser MC, Chalermpalanupap T, et al. (2020) Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Chu WT, DeSimone JC, Riffe CJ, et al. (2020) Alpha-synuclein induces progressive changes in brain microstructure and sensory-evoked brain function that precedes locomotor decline. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Xia Y, Prokop S, Gorion KM, et al. (2020) Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. Acta Neuropathologica Communications. 8: 88
Sorrentino ZA, Giasson BI. (2020) The emerging role of α-synuclein truncation in aggregation and disease. The Journal of Biological Chemistry
Sorrentino ZA, Hass E, Vijayaraghavan N, et al. (2020) Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy. Neuroscience Letters. 135017
Lloyd GM, Trejo-Lopez JA, Xia Y, et al. (2020) Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease. Acta Neuropathologica Communications. 8: 31
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, et al. (2020) Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology
Sorrentino ZA, Xia Y, Gorion KM, et al. (2020) Carboxy-terminal truncations of mouse alpha-synuclein alter aggregation and prion-like seeding. Febs Letters
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