Maud Gratuze, Ph.D.
Affiliations: | 2018-2022 | Neurology | Washington University, Saint Louis, St. Louis, MO |
| 2022- | Institute of Neurophysiopathology (INP) | CNRS & Aix-Marseille University |
Area:
Alzheimer's disease - Tau pathology - glia - TREM2 - ApoEGoogle:
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Publications
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| Canet G, Gratuze M, Zussy C, et al. (2024) Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice. Neurobiology of Disease. 106526 |
| Drieu A, Du S, Kipnis M, et al. (2023) Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration. Life Science Alliance. 6 |
| Parhizkar S, Gent G, Chen Y, et al. (2023) Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a -dependent manner in mice. Science Translational Medicine. 15: eade6285 |
| Xiong M, Wang C, Gratuze M, et al. (2023) Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy. Molecular Neurodegeneration. 18: 17 |
| Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, et al. (2022) TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron |
| Gratuze M, Jiang H, Wang C, et al. (2022) APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model. Annals of Neurology |
| Gratuze M, Chen Y, Parhizkar S, et al. (2021) Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of Experimental Medicine. 218 |
| Wang C, Xiong M, Gratuze M, et al. (2021) Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron |
| Gratuze M, Holtzman DM. (2021) Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits. Neuron. 109: 741-743 |
| Xiong M, Jiang H, Serrano JR, et al. (2021) APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science Translational Medicine. 13 |