☰

Kathleen M. Frey, Ph.D. - Publications

Affiliations: 
2015- Pharmaceutical Sciences Long Island University Pharmacy 
Area:
Medicinal Chemistry, X-Ray crystallography, Structural biology, Molecular modeling, Structure-based drug design
Tree Info Similar researchers PubMed Report error

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hollander K, Chan AH, Frey KM, Hunker O, Ippolito JA, Spasov KA, Yeh YJ, Jorgensen WL, Ho YC, Anderson KS. Exploring Novel HIV-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise. Protein Science : a Publication of the Protein Society. e4814. PMID 37861472 DOI: 10.1002/pro.4814  0.621
2023 Lange K, Frey KM, Eck T, Janson CA, Gubler U, Goodey NM. Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate. Plos Neglected Tropical Diseases. 17: e0011303. PMID 37104530 DOI: 10.1371/journal.pntd.0011303  0.332
2022 Frey KM, Bertoletti N, Chan AH, Ippolito JA, Bollini M, Spasov KA, Jorgensen WL, Anderson KS. Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Frontiers in Molecular Biosciences. 9: 805187. PMID 35237658 DOI: 10.3389/fmolb.2022.805187  0.596
2020 Tabassum T, Azeem SM, Muwonge AN, Frey KM. Application of Structure-based Methods to Analyze Resistance Mutations for Chemically Diverse Non-Nucleoside Reverse Transcriptase Inhibitors. Current Hiv Research. PMID 32493197 DOI: 10.2174/1570162X18666200603141209  0.417
2019 Sasaki T, Gannam ZTK, Kudalkar SN, Frey KM, Lee WG, Spasov KA, Jorgensen WL, Anderson KS. Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. PMID 31281023 DOI: 10.1016/J.Bmcl.2019.06.047  0.618
2019 Frey KM, Tabassum T. Current structure-based methods for designing non-nucleoside reverse transcriptase inhibitors Future Virology. 14: 537-544. DOI: 10.2217/FVL-2019-0055  0.403
2017 Azeem SM, Muwonge AN, Thakkar N, Lam KW, Frey KM. Structure-based methods to predict mutational resistance to diarylpyrimidine non-nucleoside reverse transcriptase inhibitors. Journal of Molecular Graphics & Modelling. 79: 133-139. PMID 29156381 DOI: 10.1016/J.Jmgm.2017.10.023  0.563
2015 Frey KM. Structure-enhanced methods in the development of non-nucleoside inhibitors targeting HIV reverse transcriptase variants. Future Microbiology. PMID 26517310 DOI: 10.2217/Fmb.15.122  0.566
2015 Gray WT, Frey KM, Laskey SB, Mislak AC, Spasov KA, Lee WG, Bollini M, Siliciano RF, Jorgensen WL, Anderson KS. Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. Acs Medicinal Chemistry Letters. 6: 1075-9. PMID 26487915 DOI: 10.1021/Acsmedchemlett.5B00254  0.665
2015 Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL. Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 25: 4824-7. PMID 26166629 DOI: 10.1016/J.Bmcl.2015.06.074  0.611
2015 Frey KM, Puleo DE, Spasov KA, Bollini M, Jorgensen WL, Anderson KS. Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants. Journal of Medicinal Chemistry. 58: 2737-45. PMID 25700160 DOI: 10.1021/Jm501908A  0.631
2015 Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29. PMID 25686244 DOI: 10.1021/Acschembio.5B00014  0.768
2015 Reeve SM, Gainza P, Frey KM, Georgiev I, Donald BR, Anderson AC. Protein design algorithms predict viable resistance to an experimental antifolate. Proceedings of the National Academy of Sciences of the United States of America. 112: 749-54. PMID 25552560 DOI: 10.1073/Pnas.1411548112  0.775
2015 Sohl CD, Ryan M, Luo B, Frey K, Anderson KS. Abstract 2436: Understanding the molecular mechanism of targeted kinase inhibitor resistance mediated by the FGFR1 gatekeeper mutation Cancer Research. 75: 2436-2436. DOI: 10.1158/1538-7445.Am2015-2436  0.76
2015 Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Illuminating the molecular ,mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: The Achilles' heel of targeted therapy Acs Chemical Biology. 10: 1319-1329. DOI: 10.1021/acschembio.5b00014  0.734
2015 Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL. Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.06.074  0.501
2014 Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. Acs Medicinal Chemistry Letters. 5: 1259-62. PMID 25408842 DOI: 10.1021/Ml5003713  0.582
2014 Kumar VP, Cisneros JA, Frey KM, Castellanos-Gonzalez A, Wang Y, Gangjee A, White AC, Jorgensen WL, Anderson KS. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorganic & Medicinal Chemistry Letters. 24: 4158-61. PMID 25127103 DOI: 10.1016/J.Bmcl.2014.07.049  0.628
2014 Mislak AC, Frey KM, Bollini M, Jorgensen WL, Anderson KS. A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochimica Et Biophysica Acta. 1840: 2203-11. PMID 24726448 DOI: 10.1016/J.Bbagen.2014.04.001  0.651
2014 Frey KM, Gray WT, Spasov KA, Bollini M, Gallardo-Macias R, Jorgensen WL, Anderson KS. Structure-based evaluation of C5 derivatives in the catechol diether series targeting HIV-1 reverse transcriptase. Chemical Biology & Drug Design. 83: 541-9. PMID 24289305 DOI: 10.1111/Cbdd.12266  0.566
2013 Iyidogan P, Sullivan TJ, Chordia MD, Frey KM, Anderson KS. Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase. Acs Medicinal Chemistry Letters. 4: 1183-8. PMID 24900627 DOI: 10.1021/Ml4002979  0.571
2013 Lee WG, Gallardo-Macias R, Frey KM, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group. Journal of the American Chemical Society. 135: 16705-13. PMID 24151856 DOI: 10.1021/Ja408917N  0.595
2013 Kumar VP, Frey KM, Wang Y, Jain HK, Gangjee A, Anderson KS. Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5426-8. PMID 23927969 DOI: 10.1016/J.Bmcl.2013.07.037  0.619
2013 Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL. Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility. Bioorganic & Medicinal Chemistry Letters. 23: 5209-12. PMID 23899617 DOI: 10.1016/J.Bmcl.2013.06.093  0.5
2012 Frey KM, Bollini M, Mislak AC, Cisneros JA, Gallardo-Macias R, Jorgensen WL, Anderson KS. Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design. Journal of the American Chemical Society. 134: 19501-3. PMID 23163887 DOI: 10.1021/Ja3092642  0.649
2012 Kim J, Wang L, Li Y, Becnel KD, Frey KM, Garforth SJ, Prasad VR, Schinazi RF, Liotta DC, Anderson KS. Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. 22: 4064-4067. PMID 22595174 DOI: 10.1016/J.Bmcl.2012.04.078  0.567
2012 Frey KM, Viswanathan K, Wright DL, Anderson AC. Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance. Antimicrobial Agents and Chemotherapy. 56: 3556-62. PMID 22491688 DOI: 10.1128/Aac.06263-11  0.681
2012 Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL. Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes. Plos One. 7: e29434. PMID 22347365 DOI: 10.1371/Journal.Pone.0029434  0.597
2010 Frey KM, Georgiev I, Donald BR, Anderson AC. Predicting resistance mutations using protein design algorithms. Proceedings of the National Academy of Sciences of the United States of America. 107: 13707-12. PMID 20643959 DOI: 10.1073/Pnas.1002162107  0.67
2010 Frey KM, Lombardo MN, Wright DL, Anderson AC. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. Journal of Structural Biology. 170: 93-7. PMID 20026215 DOI: 10.1016/J.Jsb.2009.12.011  0.653
2009 Beierlein JM, Deshmukh L, Frey KM, Vinogradova O, Anderson AC. The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors. Biochemistry. 48: 4100-8. PMID 19323450 DOI: 10.1021/Bi802319W  0.761
2009 Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. Journal of Molecular Biology. 387: 1298-308. PMID 19249312 DOI: 10.1016/J.Jmb.2009.02.045  0.705
2009 deshmukh l, vinogradova o, beierlein j, frey k, anderson a. Solution structure of Bacillus anthracis dihydrofolate reductase Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kgk/Pdb  0.711
2008 Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase. Journal of Medicinal Chemistry. 51: 7532-40. PMID 19007108 DOI: 10.1021/Jm800776A  0.756
2008 Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC. Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium. Journal of Medicinal Chemistry. 51: 6839-52. PMID 18834108 DOI: 10.1021/Jm8009124  0.631
Show low-probability matches.